LOCUS       NM_057206               1545 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus pancreatic lipase related protein 2 (Pnliprp2),
            mRNA.
ACCESSION   NM_057206
VERSION     NM_057206.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   Kuge,H., Miyamoto,I., Yagyu,K.I. and Honke,K.
  TITLE     PLRP2 selectively localizes synaptic membrane proteins via
            acyl-chain remodeling of phospholipids
  JOURNAL   J Lipid Res 61 (12), 1747-1763 (2020)
   PUBMED   32963038
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 1545)
  AUTHORS   Harrison,E.H.
  TITLE     Mechanisms involved in the intestinal absorption of dietary vitamin
            A and provitamin A carotenoids
  JOURNAL   Biochim Biophys Acta 1821 (1), 70-77 (2012)
   PUBMED   21718801
  REMARK    Review article
REFERENCE   4  (bases 1 to 1545)
  AUTHORS   Xiao,X., Ross,L.E., Miller,R.A. and Lowe,M.E.
  TITLE     Kinetic properties of mouse pancreatic lipase-related protein-2
            suggest the mouse may not model human fat digestion
  JOURNAL   J Lipid Res 52 (5), 982-990 (2011)
   PUBMED   21382969
REFERENCE   5  (bases 1 to 1545)
  AUTHORS   Eydoux,C., Spinelli,S., Davis,T.L., Walker,J.R., Seitova,A.,
            Dhe-Paganon,S., De Caro,A., Cambillau,C. and Carriere,F.
  TITLE     Structure of human pancreatic lipase-related protein 2 with the lid
            in an open conformation
  JOURNAL   Biochemistry 47 (36), 9553-9564 (2008)
   PUBMED   18702514
REFERENCE   6  (bases 1 to 1545)
  AUTHORS   Andersson,L., Carriere,F., Lowe,M.E., Nilsson,A. and Verger,R.
  TITLE     Pancreatic lipase-related protein 2 but not classical pancreatic
            lipase hydrolyzes galactolipids
  JOURNAL   Biochim Biophys Acta 1302 (3), 236-240 (1996)
   PUBMED   8765145
REFERENCE   7  (bases 1 to 1545)
  AUTHORS   Kullman,J., Gisi,C. and Lowe,M.E.
  TITLE     Dexamethasone-regulated expression of pancreatic lipase and two
            related proteins in AR42J cells
  JOURNAL   Am J Physiol 270 (5 Pt 1), G746-G751 (1996)
   PUBMED   8967484
REFERENCE   8  (bases 1 to 1545)
  AUTHORS   Jennens,M.L. and Lowe,M.E.
  TITLE     Rat GP-3 is a pancreatic lipase with kinetic properties that differ
            from colipase-dependent pancreatic lipase
  JOURNAL   J Lipid Res 36 (11), 2374-2382 (1995)
   PUBMED   8656075
REFERENCE   9  (bases 1 to 1545)
  AUTHORS   Payne,R.M., Sims,H.F., Jennens,M.L. and Lowe,M.E.
  TITLE     Rat pancreatic lipase and two related proteins: enzymatic
            properties and mRNA expression during development
  JOURNAL   Am J Physiol 266 (5 Pt 1), G914-G921 (1994)
   PUBMED   8203536
REFERENCE   10 (bases 1 to 1545)
  AUTHORS   Wishart,M.J., Andrews,P.C., Nichols,R., Blevins,G.T. Jr.,
            Logsdon,C.D. and Williams,J.A.
  TITLE     Identification and cloning of GP-3 from rat pancreatic acinar
            zymogen granules as a glycosylated membrane-associated lipase
  JOURNAL   J Biol Chem 268 (14), 10303-10311 (1993)
   PUBMED   8486693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L09216.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1545
                     /gene="Pnliprp2"
                     /note="pancreatic lipase related protein 2"
                     /db_xref="GeneID:117554"
                     /db_xref="RGD:620793"
     exon            1..166
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1527
                     /gene="Pnliprp2"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.26"
                     /function="triacylglycerol acyl-hydrolase"
                     /note="PL-RP2; secretory glycoprotein GP-3; galactolipase;
                     triacylglycerol lipase; cytotoxic T lymphocyte lipase"
                     /codon_start=1
                     /product="pancreatic lipase-related protein 2 precursor"
                     /protein_id="NP_476554.1"
                     /db_xref="GeneID:117554"
                     /db_xref="RGD:620793"
                     /translation="MPRGVSGNLFPSVQMLLCWIVSLLLATVGGKEVCYGHLGCFSND
                     KPWAGMLQRPLKIFPWSPEDIDTRFLLYTNENPNNYQKISATEPDTIKFSNFQLDRKT
                     RFIVHGFIDKGEDGWLLDMCKKMFQVEKVNCICVDWRRGSRTEYTQASYNTRVVGAEI
                     AFLVQVLSTEMGYSPENVHLIGHSLGAHVVGEAGRRLEGHVGRITGLDPAEPCFQGLP
                     EEVRLDPSDAMFVDVIHTDSAPIIPYLGFGMSQKVGHLDFFPNGGKEMPGCQKNILST
                     IVDINGIWEGTQNFVACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQQNDCFPCPEE
                     GCPKMGHYADQFEGKTATVEQTVYLNTGDSGNFTRWRYKVSVTLSGAKKLSGYILVAL
                     YGNNGNSKQYEIFKGSLKPEARHVRDIDVDINVGEIQKVKFLWNNKVINLFRPTLGAS
                     QITVQSGVDGKEYNFCSSDTVREDVLQSLYPC"
     exon            167..321
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..447
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..582
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..694
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..814
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..934
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1053
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1183
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1295
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1463
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1545
                     /gene="Pnliprp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgttcac attccgcagt gcactctaga attaactgct tctttgagtc tggcctctgc
       61 tggcctcatc cttatcctat gcctaggggt gtcagtggaa atctgtttcc atctgtgcag
      121 atgttgctct gctggatcgt cagtcttctg ttggccactg tcggagggaa agaggtttgc
      181 tatggacacc ttggctgctt ttccaatgac aagccctggg cagggatgct tcagcggcct
      241 ttgaagatat tcccttggtc cccagaggac atcgatacac gctttcttct gtacacaaat
      301 gagaatccaa ataactacca aaaaatctct gccaccgaac cagacaccat caagttttcc
      361 aacttccaac tggaccgcaa gacgcgtttc atcgtccatg gattcataga caagggagag
      421 gatggctggt tgctggacat gtgcaagaaa atgtttcaag tggagaaagt gaactgtatt
      481 tgcgtcgatt ggaggcgagg atccaggact gaatacaccc aagcctccta caacactcgg
      541 gtcgtgggcg ctgagattgc cttcctagtg caagtgttat cgacagagat ggggtacagc
      601 ccagagaatg ttcatctcat cggccacagc ctgggcgcac acgtggttgg ggaggcaggc
      661 aggaggctgg agggccatgt gggcaggatt acagggctgg accctgcaga gccctgtttc
      721 caaggcctgc cagaggaagt tcggttggac ccatcggatg ccatgtttgt agacgtgatc
      781 cacacagata gtgctcccat aattccctat ctaggttttg gaatgagcca aaaggtcgga
      841 catctggatt tcttccccaa tggagggaag gaaatgccag gatgtcagaa aaacatcctt
      901 tccaccattg ttgatatcaa cgggatatgg gaaggaactc aaaactttgt agcctgcaac
      961 cacctgcgga gctacaagta ctacgccagc agcatcctca accccgacgg cttcctgggg
     1021 tacccttgct cttcctatga gaagttccag cagaatgact gcttcccttg tccagaagaa
     1081 gggtgtccca aaatggggca ctatgctgat caatttgagg ggaaaaccgc tactgtggaa
     1141 caaaccgttt atctgaatac aggagatagt ggtaacttta ctcgttggag atacaaagta
     1201 tcagtcacac tgtcaggagc aaagaaactg agtgggtaca tcttggttgc tctgtacgga
     1261 aataatggaa actcaaagca gtatgaaatt ttcaaaggat ccctcaaacc ggaagcaagg
     1321 catgttcgtg acattgatgt ggacatcaat gttggagaaa tccagaaggt taagttcctc
     1381 tggaacaaca aggtgataaa tctcttccgg cccactctgg gagcttcgca gatcacagtg
     1441 caaagtggtg tagacgggaa agagtacaac ttctgtagca gcgacactgt gcgtgaagac
     1501 gtcttacagt cgctttatcc ttgttaaaga tgtgcccgtg actct
//
