LOCUS       NM_032081               1534 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus pancreatic lipase-related protein 1 (Pnliprp1),
            mRNA.
ACCESSION   NM_032081
VERSION     NM_032081.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Berton,A., Sebban-Kreuzer,C., Rouvellac,S., Lopez,C. and Crenon,I.
  TITLE     Individual and combined action of pancreatic lipase and pancreatic
            lipase-related proteins 1 and 2 on native versus homogenized milk
            fat globules
  JOURNAL   Mol Nutr Food Res 53 (12), 1592-1602 (2009)
   PUBMED   19824014
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Elinson,N., Amichay,D. and Birk,R.Z.
  TITLE     Leptin directly regulates exocrine pancreas lipase and two related
            proteins in the rat
  JOURNAL   Br J Nutr 96 (4), 691-696 (2006)
   PUBMED   17010228
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Yamashita,S., Wakazono,K., Sugimura,T. and Ushijima,T.
  TITLE     Profiling and selection of genes differentially expressed in the
            pylorus of rat strains with different proliferative responses and
            stomach cancer susceptibility
  JOURNAL   Carcinogenesis 23 (6), 923-928 (2002)
   PUBMED   12082013
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Bull,J.H., Ellison,G., Patel,A., Muir,G., Walker,M., Underwood,M.,
            Khan,F. and Paskins,L.
  TITLE     Identification of potential diagnostic markers of prostate cancer
            and prostatic intraepithelial neoplasia using cDNA microarray
  JOURNAL   Br J Cancer 84 (11), 1512-1519 (2001)
   PUBMED   11384102
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Roussel,A., de Caro,J., Bezzine,S., Gastinel,L., de Caro,A.,
            Carriere,F., Leydier,S., Verger,R. and Cambillau,C.
  TITLE     Reactivation of the totally inactive pancreatic lipase RP1 by
            structure-predicted point mutations
  JOURNAL   Proteins 32 (4), 523-531 (1998)
   PUBMED   9726421
REFERENCE   6  (bases 1 to 1534)
  AUTHORS   Kullman,J., Gisi,C. and Lowe,M.E.
  TITLE     Dexamethasone-regulated expression of pancreatic lipase and two
            related proteins in AR42J cells
  JOURNAL   Am J Physiol 270 (5 Pt 1), G746-G751 (1996)
   PUBMED   8967484
REFERENCE   7  (bases 1 to 1534)
  AUTHORS   Payne,R.M., Sims,H.F., Jennens,M.L. and Lowe,M.E.
  TITLE     Rat pancreatic lipase and two related proteins: enzymatic
            properties and mRNA expression during development
  JOURNAL   Am J Physiol 266 (5 Pt 1), G914-G921 (1994)
   PUBMED   8203536
REFERENCE   8  (bases 1 to 1534)
  AUTHORS   Wicker-Planquart,C. and Puigserver,A.
  TITLE     Primary structure of rat pancreatic lipase mRNA
  JOURNAL   FEBS Lett 296 (1), 61-66 (1992)
   PUBMED   1730292
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X61925.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X61925.1, FQ232772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1534
                     /gene="Pnliprp1"
                     /note="pancreatic lipase-related protein 1"
                     /db_xref="GeneID:84028"
                     /db_xref="RGD:620792"
     exon            1..72
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1494
                     /gene="Pnliprp1"
                     /EC_number="3.1.1.3"
                     /note="PL-RP1; inactive pancreatic lipase-related protein
                     1"
                     /codon_start=1
                     /product="inactive pancreatic lipase-related protein 1
                     precursor"
                     /protein_id="NP_114470.1"
                     /db_xref="GeneID:84028"
                     /db_xref="RGD:620792"
                     /translation="MLTLWTVSLFLLGAAQGKEVCYDNLGCFSDAEPWAGTAIRPLKL
                     LPWSPEKINTRFLLYTNENPTAFQTLQLSDPLTIGASNFQVARKTRFIIHGFIDKGEE
                     NWVVDMCKNMFQVEEVNCICVDWKKGSQTTYTQAANNVRVVGAQVAQMIDILVKNYSY
                     SPSKVHLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEANFEGTPEEVRLDPSDADFVD
                     VIHTDAAPLIPFLGFGTNQMSGHLDFFPNGGQSMPGCKKNALSQIVDIDGIWSGTRDF
                     VACNHLRSYKYYLESILNPDGFAAYPCASYKDFESNKCFPCPDQGCPQMGHYADKFAG
                     KSGDEPQKFFLNTGEAKNFARWRYRVSLILSGRMVTGQVKVALFGSKGNTRQYDIFRG
                     IIKPGATHSSEFDAKLDVGTIEKVKFLWNNQVINPSFPKVGAAKITVQKGEERTEYNF
                     CSEETVREDTLLTLLPCETSDTV"
     exon            73..121
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..276
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..402
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..537
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..646
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..766
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..886
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1005
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1135
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1244
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1412
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1532
                     /gene="Pnliprp1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1531
                     /gene="Pnliprp1"
ORIGIN      
        1 aacaagcacc tggctcctgt gaccacacca gtcaccttag gatctgcatc tccatcagct
       61 gaaaaagcag agatgctgac cctctggaca gtctctcttt tcctactggg agcagctcag
      121 ggaaaagagg tttgctatga taaccttgga tgcttttctg acgctgagcc ctgggcaggg
      181 acagctatca ggcccctcaa acttctccca tggagccctg agaagatcaa cactcgcttc
      241 ctgctgtaca ccaatgagaa cccaactgct tttcagactc tccagctttc tgacccattg
      301 accattgggg cctcaaattt tcaagttgcc aggaagactc ggtttatcat ccatggcttc
      361 atagacaaag gagaggaaaa ctgggtggtt gacatgtgca agaacatgtt ccaagtggag
      421 gaggtgaact gcatctgtgt ggactggaag aaaggttctc agactaccta cacacaggct
      481 gccaacaatg tgcgagtagt gggtgcccag gtagctcaga tgatcgacat ccttgtgaaa
      541 aactacagct actcgccttc caaagtccac ctcattggcc acagcctagg agcccacgtg
      601 gccggggaag caggaagtcg gactccaggt ctaggcagaa ttacaggact ggatcctgta
      661 gaagcaaact tcgagggcac tcctgaagag gtccggcttg acccctcgga tgctgacttt
      721 gttgatgtga ttcacacaga tgcagctccc ttgatcccgt tcttgggctt cggaacaaac
      781 caaatgtcag ggcaccttga cttcttcccc aacggaggac agagcatgcc cgggtgcaag
      841 aagaatgctc tgtcccagat tgtagacatc gatggcatct ggtcaggaac ccgggacttt
      901 gtggcttgta accacctgag aagctacaag tactacttgg agagcatcct taaccctgat
      961 gggttcgctg catacccctg tgcttcctac aaggactttg agtctaacaa atgcttcccc
     1021 tgcccagatc aaggctgccc acagatgggt cactatgccg ataagtttgc cggcaagtca
     1081 ggtgacgagc cacagaagtt cttcttgaac acaggagaag ccaagaactt tgcacgctgg
     1141 aggtaccgtg tttccttgat actgtctgga agaatggtca cagggcaagt caaagtggct
     1201 ctgtttggaa gtaagggcaa tacacgccag tacgatatct tcaggggaat tatcaagcct
     1261 ggtgctacac attccagtga gtttgatgcc aagctcgacg tgggaacaat tgagaaagtc
     1321 aagtttctct ggaacaatca agtgataaac ccaagcttcc ccaaagtggg cgcagccaag
     1381 atcactgtgc aaaagggaga ggagcggacg gagtacaact tctgtagtga agagaccgtg
     1441 agagaagaca ctctgctcac tctcttgcct tgtgaaacct cagacacagt gtgacctctt
     1501 agtgacacca ataaaatcat cagctgcact taaa
//
