LOCUS       NM_013161               1484 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus pancreatic lipase (Pnlip), mRNA.
ACCESSION   NM_013161
VERSION     NM_013161.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1484)
  AUTHORS   Szabo,A., Xiao,X., Haughney,M., Spector,A., Sahin-Toth,M. and
            Lowe,M.E.
  TITLE     A novel mutation in PNLIP causes pancreatic triglyceride lipase
            deficiency through protein misfolding
  JOURNAL   Biochim Biophys Acta 1852 (7), 1372-1379 (2015)
   PUBMED   25862608
REFERENCE   2  (bases 1 to 1484)
  AUTHORS   Behar,D.M., Basel-Vanagaite,L., Glaser,F., Kaplan,M., Tzur,S.,
            Magal,N., Eidlitz-Markus,T., Haimi-Cohen,Y., Sarig,G., Bormans,C.,
            Shohat,M. and Zeharia,A.
  TITLE     Identification of a novel mutation in the PNLIP gene in two
            brothers with congenital pancreatic lipase deficiency
  JOURNAL   J Lipid Res 55 (2), 307-312 (2014)
   PUBMED   24262094
REFERENCE   3  (bases 1 to 1484)
  AUTHORS   Harrison,E.H.
  TITLE     Mechanisms involved in the intestinal absorption of dietary vitamin
            A and provitamin A carotenoids
  JOURNAL   Biochim Biophys Acta 1821 (1), 70-77 (2012)
   PUBMED   21718801
  REMARK    Review article
REFERENCE   4  (bases 1 to 1484)
  AUTHORS   Xiao,X., Ross,L.E., Miller,R.A. and Lowe,M.E.
  TITLE     Kinetic properties of mouse pancreatic lipase-related protein-2
            suggest the mouse may not model human fat digestion
  JOURNAL   J Lipid Res 52 (5), 982-990 (2011)
   PUBMED   21382969
REFERENCE   5  (bases 1 to 1484)
  AUTHORS   Muramatsu,Y., Yamada,T., Taniguchi,Y., Ogino,T., Kose,H.,
            Matsumoto,K. and Sasaki,Y.
  TITLE     Pnlip encoding pancreatic lipase is a possible candidate for
            intramuscular fat accumulation QTL in OLETF rat
  JOURNAL   Res Commun Mol Pathol Pharmacol 120-121 (1-6), 23-31 (2007)
   PUBMED   21469501
  REMARK    GeneRIF: Pnlip encoding pancreatic lipase is a possible candidate
            for intramuscular fat accumulation QTL in OLETF rat.
REFERENCE   6  (bases 1 to 1484)
  AUTHORS   Kullman,J., Gisi,C. and Lowe,M.E.
  TITLE     Dexamethasone-regulated expression of pancreatic lipase and two
            related proteins in AR42J cells
  JOURNAL   Am J Physiol 270 (5 Pt 1), G746-G751 (1996)
   PUBMED   8967484
REFERENCE   7  (bases 1 to 1484)
  AUTHORS   Jennens,M.L. and Lowe,M.E.
  TITLE     Rat GP-3 is a pancreatic lipase with kinetic properties that differ
            from colipase-dependent pancreatic lipase
  JOURNAL   J Lipid Res 36 (11), 2374-2382 (1995)
   PUBMED   8656075
REFERENCE   8  (bases 1 to 1484)
  AUTHORS   Payne,R.M., Sims,H.F., Jennens,M.L. and Lowe,M.E.
  TITLE     Rat pancreatic lipase and two related proteins: enzymatic
            properties and mRNA expression during development
  JOURNAL   Am J Physiol 266 (5 Pt 1), G914-G921 (1994)
   PUBMED   8203536
REFERENCE   9  (bases 1 to 1484)
  AUTHORS   Wishart,M.J., Andrews,P.C., Nichols,R., Blevins,G.T. Jr.,
            Logsdon,C.D. and Williams,J.A.
  TITLE     Identification and cloning of GP-3 from rat pancreatic acinar
            zymogen granules as a glycosylated membrane-associated lipase
  JOURNAL   J Biol Chem 268 (14), 10303-10311 (1993)
   PUBMED   8486693
REFERENCE   10 (bases 1 to 1484)
  AUTHORS   Hjorth,A., Carriere,F., Cudrey,C., Woldike,H., Boel,E.,
            Lawson,D.M., Ferrato,F., Cambillau,C., Dodson,G.G., Thim,L. et al.
  TITLE     A structural domain (the lid) found in pancreatic lipases is absent
            in the guinea pig (phospho)lipase
  JOURNAL   Biochemistry 32 (18), 4702-4707 (1993)
   PUBMED   8490016
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013161.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984043, SAMN16418988
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                JAXUCZ010000001.1  267784610-267784637
            29-74               JAXUCZ010000001.1  267784724-267784769
            75-229              JAXUCZ010000001.1  267785871-267786025
            230-352             JAXUCZ010000001.1  267787158-267787280
            353-487             JAXUCZ010000001.1  267787810-267787944
            488-599             JAXUCZ010000001.1  267789060-267789171
            600-719             JAXUCZ010000001.1  267790160-267790279
            720-839             JAXUCZ010000001.1  267790393-267790512
            840-958             JAXUCZ010000001.1  267791173-267791291
            959-1088            JAXUCZ010000001.1  267793590-267793719
            1089-1197           JAXUCZ010000001.1  267794035-267794143
            1198-1362           JAXUCZ010000001.1  267794736-267794900
            1363-1484           JAXUCZ010000001.1  267797674-267797795
FEATURES             Location/Qualifiers
     source          1..1484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1484
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /note="pancreatic lipase"
                     /db_xref="GeneID:25702"
                     /db_xref="RGD:3360"
     exon            1..28
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1426
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /EC_number="3.1.1.3"
                     /note="pancreatic triacylglycerol lipase; pancreatic
                     triglyceride lipase; PL"
                     /codon_start=1
                     /product="pancreatic triacylglycerol lipase precursor"
                     /protein_id="NP_037293.2"
                     /db_xref="GeneID:25702"
                     /db_xref="RGD:3360"
                     /translation="MLMLWTFAVLLGAVAGKEVCFDKLGCFSDDAPWSGTIDRPLKAL
                     PWSPAQINTRFLLYTNENQDNYQKITSDASSIRNSNFKTNRKTRIIIHGFIDKGEENW
                     LSDMCKNMFKVESVNCICVDWKGGSRATYTQATQNVRVVGAEVALLVNVLKSDLGYSP
                     DNVHLIGHSLGSHVAGEAGKRTFGAIGRITGLDAAEPYFQGTPEEVRLDPTDAQFVDA
                     IHTDAAPIIPNLGFGMSQTVGHLDFFPNGGMEMPGCQKNILSQIVDIDGIWEGTRDFA
                     ACNHLRSYKYYTDSIVNPTGFSGFSCSSYNVFSANKCFPCGSEGCPQMGHYADKYPGK
                     TKELYQKFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGNGGNSKQYEVFKGS
                     LHPGDTHVKEFDSDVDVGDLQKVKFIWYNNVINPTLPKVGASRISVERNDGRVFNFCS
                     QDTVREDVLLTLSAC"
     exon            29..74
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            75..229
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            230..352
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            353..487
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            488..599
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            600..719
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            720..839
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            840..958
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1088
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1197
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1362
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1484
                     /gene="Pnlip"
                     /gene_synonym="PANLI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccatagaa cccgacggat ccgccacgat gctgatgctg tggacatttg cagtgctgct
       61 gggagcagta gctggaaaag aagtttgctt tgacaaactc ggctgcttca gtgatgatgc
      121 cccgtggtca ggaaccatag acagacccct gaaagcactg ccctggagcc cagcacaaat
      181 caacacccgc tttctcctct acaccaacga gaaccaagac aactaccaga aaattacttc
      241 agatgcatcg agtatcagaa actccaattt caaaacgaac agaaaaaccc gcatcattat
      301 ccacggcttc attgacaagg gagaggagaa ctggctatct gacatgtgca agaacatgtt
      361 caaagtggag agtgtgaact gcatctgtgt ggactggaaa ggtggctccc gggctacata
      421 cacccaggct acccagaacg tccgggtcgt gggtgcagaa gtggcattat tggttaacgt
      481 tctgaagtct gacctcggct actcacctga caacgtccac ctgattggcc acagcctggg
      541 ttcccacgtt gctggggagg caggaaagag gacattcgga gctattggga ggatcacagg
      601 gttggacgcg gctgaacctt acttccaggg cacacctgaa gaagtccgtc tggaccccac
      661 cgatgcccag tttgtggatg caattcacac agatgctgca cccatcatcc ccaacttagg
      721 atttggaatg agccagactg tgggtcacct agatttcttt cctaatggag ggatggaaat
      781 gcctggatgt cagaagaata tcctttccca aatcgttgac atcgacggga tctgggaagg
      841 aactcgcgac tttgctgcct gtaaccactt gagaagctac aaatattaca ccgacagtat
      901 cgtcaacccg actggcttct ctggcttctc ctgtagctct tacaatgttt tttctgcaaa
      961 taagtgcttc ccatgtggga gtgaaggatg cccacagatg ggtcactatg ctgacaaata
     1021 ccctgggaag acaaaagaac tctaccagaa attttacctg aacactggtg acaagagcaa
     1081 cttcgcacgt tggcggtacc aggtgactgt caccctctct ggacagaagg tcactgggca
     1141 cattctagtt tctttgtttg gaaatggagg aaactctaaa cagtatgaag ttttcaaggg
     1201 ctctctgcat ccaggtgaca ctcatgtcaa ggaatttgac tctgatgtgg atgttggaga
     1261 tttgcagaaa gttaaattta tttggtacaa caatgtgatc aacccaactc tacccaaagt
     1321 gggagcatca aggatttcag tggaacgaaa tgacggcaga gtgttcaact tctgtagtca
     1381 agatacagtg agggaggatg tcctgcttac actgtctgca tgttagaagg ctgctgatgt
     1441 gtgaccacca agtcccactg taataaagtc tagtatcaaa gcca
//
