LOCUS       NM_001134753             635 bp    mRNA    linear   ROD 01-FEB-2021
DEFINITION  Rattus norvegicus PNKD metallo-beta-lactamase domain containing
            (Pnkd), transcript variant 3, mRNA.
ACCESSION   NM_001134753
VERSION     NM_001134753.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 635)
  AUTHORS   Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien
            RW, Jan LY, Fu YH and Ptacek LJ.
  TITLE     Protein mutated in paroxysmal dyskinesia interacts with the active
            zone protein RIM and suppresses synaptic vesicle exocytosis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 112 (10), 2935-2941 (2015)
   PUBMED   25730884
REFERENCE   2  (bases 1 to 635)
  AUTHORS   Tao TQ, Wang XR, Liu M, Xu FF and Liu XH.
  TITLE     Myofibrillogenesis regulator-1 attenuated
            hypoxia/reoxygenation-induced apoptosis by inhibiting the PERK/Nrf2
            pathway in neonatal rat cardiomyocytes
  JOURNAL   Apoptosis 20 (3), 285-297 (2015)
   PUBMED   25542256
  REMARK    GeneRIF: MR-1 attenuated hypoxia/reoxygenation-induced apoptosis by
            inhibiting the PERK/Nrf2 pathway in neonatal rat cardiomyocytes.
REFERENCE   3  (bases 1 to 635)
  AUTHORS   Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN,
            Hess EJ, Fu YH, Edwards RH and Ptacek LJ.
  TITLE     Dopamine dysregulation in a mouse model of paroxysmal
            nonkinesigenic dyskinesia
  JOURNAL   J. Clin. Invest. 122 (2), 507-518 (2012)
   PUBMED   22214848
REFERENCE   4  (bases 1 to 635)
  AUTHORS   Liu X, Li T, Sun S, Xu F and Wang Y.
  TITLE     Role of myofibrillogenesis regulator-1 in myocardial hypertrophy
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 290 (1), H279-H285 (2006)
   PUBMED   16100249
  REMARK    GeneRIF: results demonstrate the functional role and direct effect
            of myofibrillogenesis regulator-1 (MR-1) in cardiac hypertrophy.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC168228.1, BI395664.1 and AA924823.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223783.1, BI395664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BC168228.1         1-12
            13-259              BI395664.1         1-247
            260-635             AA924823.1         1-376               c
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..635
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /note="PNKD metallo-beta-lactamase domain containing"
                     /db_xref="GeneID:100188944"
                     /db_xref="RGD:2300155"
     exon            1..74
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.0.8"
     CDS             8..436
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /EC_number="3.1.2.6"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myofibrillogenesis regulator 1; paroxysmal nonkinesiogenic
                     dyskinesia; probable hydrolase PNKD; paroxysmal
                     nonkinesigenic dyskinesia; PNKD, MBL domain containing"
                     /codon_start=1
                     /product="probable hydrolase PNKD isoform 3"
                     /protein_id="NP_001128225.1"
                     /db_xref="GeneID:100188944"
                     /db_xref="RGD:2300155"
                     /translation="MAAVVAATALKGRGARNARVLRGILSGATANKASQNRTRALQSH
                     SSPECKEEPEPLSPELEYIPRKRGKNPMKAVGLAWAIGFPCGILFFVLTKQEVDKDRL
                     KQMKARQNMRVSNTGEYESQRFRASPQQAQFPEVGSGVQT"
     exon            75..243
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.0.8"
     exon            244..620
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      
        1 cccgaacatg gcggcggtgg tagctgctac ggcgctgaag ggccgggggg cgagaaatgc
       61 ccgcgtcctc cgggggatcc tctctggagc gacagctaac aaggcttccc agaacaggac
      121 cagagcactg cagagccaca gctcaccaga atgcaaggag gagcctgagc ccctctcccc
      181 tgagctagaa tacattccca gaaagagggg caagaacccc atgaaagctg tgggactagc
      241 ctgggccatc ggcttcccct gtggtatcct cttcttcgtc ctcaccaagc aggaagtgga
      301 caaggaccgc ttgaagcaga tgaaggctcg tcagaacatg cgggtgtcca acacgggcga
      361 gtatgagagc cagaggttca gggcttcgcc ccaacaagcc cagttccctg aagttgggtc
      421 tggagtacag acctgagtaa ggatcattgc aaccttgtgc tagactttat tgactgatgt
      481 gtagccaact gtgttcattg ctcctgaggc ccaccagagg gcgcatgatg cccaaaccgc
      541 tgccagcacc cacctcttct tccacatggt agaaggagtc aaatgcaaat aaagttatta
      601 agtcctggct tggaagggaa aaaaaaaaaa aaaaa
//
