LOCUS       NM_001134750            2902 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus PNKD metallo-beta-lactamase domain containing
            (Pnkd), transcript variant 1, mRNA.
ACCESSION   NM_001134750
VERSION     NM_001134750.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien
            RW, Jan LY, Fu YH and Ptacek LJ.
  TITLE     Protein mutated in paroxysmal dyskinesia interacts with the active
            zone protein RIM and suppresses synaptic vesicle exocytosis
  JOURNAL   Proc Natl Acad Sci U S A 112 (10), 2935-2941 (2015)
   PUBMED   25730884
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Tao TQ, Wang XR, Liu M, Xu FF and Liu XH.
  TITLE     Myofibrillogenesis regulator-1 attenuated
            hypoxia/reoxygenation-induced apoptosis by inhibiting the PERK/Nrf2
            pathway in neonatal rat cardiomyocytes
  JOURNAL   Apoptosis 20 (3), 285-297 (2015)
   PUBMED   25542256
  REMARK    GeneRIF: MR-1 attenuated hypoxia/reoxygenation-induced apoptosis by
            inhibiting the PERK/Nrf2 pathway in neonatal rat cardiomyocytes.
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN,
            Hess EJ, Fu YH, Edwards RH and Ptacek LJ.
  TITLE     Dopamine dysregulation in a mouse model of paroxysmal
            nonkinesigenic dyskinesia
  JOURNAL   J Clin Invest 122 (2), 507-518 (2012)
   PUBMED   22214848
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Liu X, Li T, Sun S, Xu F and Wang Y.
  TITLE     Role of myofibrillogenesis regulator-1 in myocardial hypertrophy
  JOURNAL   Am J Physiol Heart Circ Physiol 290 (1), H279-H285 (2006)
   PUBMED   16100249
  REMARK    GeneRIF: results demonstrate the functional role and direct effect
            of myofibrillogenesis regulator-1 (MR-1) in cardiac hypertrophy.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC168228.1 and CK600421.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-789               BC168228.1         1-789
            790-1403            CK600421.1         1-614
            1404-2902           BC168228.1         1587-3085
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..2902
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /note="PNKD metallo-beta-lactamase domain containing"
                     /db_xref="GeneID:100188944"
                     /db_xref="RGD:2300155"
     exon            1..74
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1165
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /EC_number="3.1.2.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myofibrillogenesis regulator 1; paroxysmal nonkinesiogenic
                     dyskinesia; probable hydrolase PNKD; paroxysmal
                     nonkinesigenic dyskinesia; PNKD, MBL domain containing"
                     /codon_start=1
                     /product="probable hydrolase PNKD isoform 1"
                     /protein_id="NP_001128222.1"
                     /db_xref="GeneID:100188944"
                     /db_xref="RGD:2300155"
                     /translation="MAAVVAATALKGRGARNARVLRGILSGATANKASQNRTRALQSH
                     SSPECKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARN
                     RFPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAGLAVAVDPSDPRAVQASIEK
                     ERVNLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGR
                     LQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGTAETMLSSLD
                     TVLDLGDDTLLWPGHEYAEENLGFAGVVEPENVARERKMQWVQRQRMERKSTCPSTLG
                     EERAYNPFLRTHCLALQEALGPGPGPTSDDGCSRAQLLEELRRLKDMHKSK"
     exon            75..243
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..359
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..472
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..531
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..624
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..788
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..875
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..991
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..2879
                     /gene="Pnkd"
                     /gene_synonym="Mr-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgaacatg gcggcggtgg tagctgctac ggcgctgaag ggccgggggg cgagaaatgc
       61 ccgcgtcctc cgggggatcc tctctggagc gacagctaac aaggcttccc agaacaggac
      121 cagagcactg cagagccaca gctcaccaga atgcaaggag gagcctgagc ccctctcccc
      181 tgagctagaa tacattccca gaaagagggg caagaacccc atgaaagctg tgggactagc
      241 ctggtacagc ctgtacaccc ggacctggct cgggtacctc ttctaccgac agcagctccg
      301 gagggctcgg aatcgctttc ccaaaggcca ctccaaaact cagcccagac tcttcaatgg
      361 agtgaaggtg cttcccatcc ctgtcctctc ggacaactac agctacctca tcatcgacac
      421 ccaggctggg ctggcagtgg ctgtggaccc ctcagacccg agggctgtgc aggcttctat
      481 tgaaaaggaa agagttaact tggttgccat tctctgtacc cacaagcact gggaccacag
      541 tggaggaaac cgtgacctca gccggcggca cagggactgt cgagtgtatg ggagccctca
      601 ggatggtatc ccctacctca cccatcccct gtgtcatcaa gatgtggtca gcgtgggacg
      661 acttcagatt cgagccctgg ctacccctgg ccacacccaa ggccatctgg tctacctgct
      721 ggatggggag ccctacaagg gtccctcctg cctcttctca ggggacctgc tcttcctctc
      781 tggctgtgga cggaccttcg aaggcacagc agagaccatg ctgagctcac tggacactgt
      841 gttggacctg ggcgatgaca ccctgctgtg gcctggacat gaatatgcag aagagaacct
      901 gggctttgcg ggtgtggtgg agcccgagaa cgtggctcgt gagaggaaga tgcagtgggt
      961 acagaggcaa cggatggaac gcaagagcac atgcccatcc accctgggag aggagcgcgc
     1021 ctacaaccca ttcctgagaa cccactgcct ggcactacag gaggctctgg ggcccgggcc
     1081 tggccccacc agtgatgatg gctgctcccg ggcccagctc ctggaggagc tgcgccggct
     1141 gaaggacatg cataagagca agtgaatagc cccagttcag gctctccctt ctgcagggag
     1201 agcacaccca ccacccacac ctcgccatcc tcttcatcac taatcctacc accaccattg
     1261 gtgccctagg cagcactaat cctccagact ggccagagag ggcagagccc gggcaatggg
     1321 acctagagga ggaagcagtg ggaggctcag agaccccacg aaggacagat ggtgtttaag
     1381 gtaaaaggaa ggaagcgcct ggaacatctc cagactttgc accttcaagg atctgcctcc
     1441 cttcccctac ttgtggacca atagccagac catgaaggct gctgttggct cctgctccag
     1501 aggccacact agaacccagg agaacagagc ctagtctaga ccaggctaat ctgtcttcca
     1561 ccttacccca tgcaggattg tcaccccccc ccaaaatgat ctaaagtgtg gtgcctggga
     1621 aagtggtcac caacaggggc agccaaactc tgggtgactg agactctaaa ctccacccta
     1681 actaccttgc taagacattg ccaggcagag ccattcctaa gaacacccaa gggctggaag
     1741 cctgcctctg gccaatccct gcctcagtgg atgccctgaa ggccagagag aaaggttcct
     1801 gattgccatg gaatcttctg cttcaggcca gggagtcagg atgctgggac accatgcaca
     1861 tctgttctgg gtctgccact ggcctctgcc cctgccctgg gtcatagggc ctgcctctcc
     1921 aggggagagg gaactgtggt ctgcctcaga gatctgcttc tccttttggc ccttggtctt
     1981 gggaatccct gcctgcctcc tgtcttactt aacctctctt gctttatcct cggccctttt
     2041 cctctctaag tcattagagg ctgacctttc tttcagccct ggtactcatt tgcagtttgc
     2101 caaaaacctt cattcccacg tgatttccca caggatcccg gggccccttg ctggcagtgt
     2161 gcagaaagca gaggtctagg agcaggaagc tcctgtgagc ggcagcttcc aggacttcag
     2221 gcctgggtat accccactgc tcacccccct ccagatctgc tgatcctctg gtctcaggtc
     2281 aaggaccctt tgtggccgcg ggagcactat ggtcgttcag caggcacacc ttgggttagc
     2341 caggagccac atctttctgt gtcagagcct tccactgggc tgcgcgatgc cctctgtagt
     2401 tcctctgaga cgcccctgcc ctcagtttcc cctttcatct gacttcggct gccctctcca
     2461 gccccagcct ttggaactca ctctagcaat accaccagac tagttagcct tcccggcccc
     2521 caagacactt gcggtttcat gcctttgtgc ctttcgctca cgcggtttct tcagctggaa
     2581 tgccttcccg ctcctcccgc ctcctctgcc tggcaagccc ctattagcct ctcccaggcc
     2641 cctccctccc ccaggaaggc accctccacc cctctcttcc gggctacctc tgcaccgtgt
     2701 aaatgcttct ctcgtggcac ctatcacact gtattttact tgtttacatg tttgtctccc
     2761 cttctagact gtgaatcctt aagggcatgg actgtatctt atgcatctct gtatttctgc
     2821 gcctagcacg gtgcctggca cacagtaggc gctcaataaa tgttgaatga atgatttaaa
     2881 aaaaaaaaaa aaaaaaaaaa aa
//
