LOCUS       NM_017275               1619 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus pregnancy up-regulated nonubiquitous CaM kinase
            (Pnck), mRNA.
ACCESSION   NM_017275
VERSION     NM_017275.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Tokumitsu,H., Iwabu,M., Ishikawa,Y. and Kobayashi,R.
  TITLE     Differential regulatory mechanism of Ca2+/calmodulin-dependent
            protein kinase kinase isoforms
  JOURNAL   Biochemistry 40 (46), 13925-13932 (2001)
   PUBMED   11705382
  REMARK    GeneRIF: Residues 129-151 of recombinant CaM-KK beta participate in
            the release of the autoinhibitory domain from its catalytic core,
            resulting in generation of autonomous activity.
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Hook,S.S. and Means,A.R.
  TITLE     Ca(2+)/CaM-dependent kinases: from activation to function
  JOURNAL   Annu Rev Pharmacol Toxicol 41, 471-505 (2001)
   PUBMED   11264466
  REMARK    Review article
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Naito,Y., Watanabe,Y., Yokokura,H., Sugita,R., Nishio,M. and
            Hidaka,H.
  TITLE     Isoform-specific activation and structural diversity of calmodulin
            kinase I
  JOURNAL   J Biol Chem 272 (51), 32704-32708 (1997)
   PUBMED   9405489
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Yokokura,H., Terada,O., Naito,Y. and Hidaka,H.
  TITLE     Isolation and comparison of rat cDNAs encoding
            Ca2+/calmodulin-dependent protein kinase I isoforms
  JOURNAL   Biochim Biophys Acta 1338 (1), 8-12 (1997)
   PUBMED   9074610
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017275.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB004267.1, SRR26360194.2401531.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000021.1  156524442-156524653 c
            213-282             JAXUCZ010000021.1  156523914-156523983 c
            283-414             JAXUCZ010000021.1  156523435-156523566 c
            415-489             JAXUCZ010000021.1  156523018-156523092 c
            490-628             JAXUCZ010000021.1  156522786-156522924 c
            629-752             JAXUCZ010000021.1  156522484-156522607 c
            753-828             JAXUCZ010000021.1  156522202-156522277 c
            829-941             JAXUCZ010000021.1  156521995-156522107 c
            942-1020            JAXUCZ010000021.1  156521837-156521915 c
            1021-1108           JAXUCZ010000021.1  156521678-156521765 c
            1109-1253           JAXUCZ010000021.1  156521405-156521549 c
            1254-1619           JAXUCZ010000021.1  156520753-156521118 c
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1619
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /note="pregnancy up-regulated nonubiquitous CaM kinase"
                     /db_xref="GeneID:29660"
                     /db_xref="RGD:69249"
     exon            1..212
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            213..282
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1246
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /EC_number="2.7.11.17"
                     /note="calcium/calmodulin-dependent protein kinase 1,
                     beta; caMKI-beta; caM-KI beta; caM kinase IB; caM kinase I
                     beta; Protein Kinase-like; pregnancy up-regulated
                     non-ubiquitously-expressed CaM kinase homolog; pregnancy
                     upregulated non-ubiquitously expressed CaM kinase"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1B"
                     /protein_id="NP_058971.1"
                     /db_xref="GeneID:29660"
                     /db_xref="RGD:69249"
                     /translation="MLLLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALK
                     CIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRI
                     MERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGL
                     SKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDP
                     ELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQHLWISGDAAL
                     DRDILGSVSEQIQKNFARTHWKRAFNATSFLRHIRKLGQSPEGEEASRQGMTRHSHPG
                     LGTSQSPKW"
     exon            283..414
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            415..489
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            490..628
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            629..752
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            753..828
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            829..941
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1020
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1108
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1253
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1619
                     /gene="Pnck"
                     /gene_synonym="Camk1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggcatctt agctccgcag cccaccaccc tcacacacac ctgtgacgcc cggcgcgccc
       61 ccctgcccgc acgcgcacag cccacgcagc tctggacaca ggcggctgag gttgcggagt
      121 ccccccacgc tgaggcgcca ggggccaagc agcgattagg gggctgcgtg ggtggctgtg
      181 gtcgtgacag gtggctgcaa gcagggtcgc agacatgctg ctgctcaaga aacagacgga
      241 ggacatcagc agtgtctatg agatccggga gaagctgggc tcgggtgcct tctctgaggt
      301 gatgctggcc caggaaaggg gctctgctca tcttgtggcc ctcaagtgca ttcccaagaa
      361 agcacttcgg ggcaaggagg ccctggtgga gaatgagatc gcagtactcc gcaggattag
      421 ccaccccaac attgtggctc tggaggacgt ccacgagagc ccttcccatc tctacttggc
      481 catggagctg gtaacaggtg gtgaactgtt tgaccgaatc atggagcggg gctcctacac
      541 agagaaggat gcgagccacc ttgtagggca ggtccttggt gctgtctcct accttcatag
      601 cctgggcatc gtgcaccggg acctcaagcc tgaaaacctc ctctatgcca caccttttga
      661 ggactccaag atcatggtct ctgactttgg cctgtccaaa attcaagctg gcaacatgct
      721 aggcacagcc tgtgggaccc caggatatgt ggccccagag ctcctggagc agaaacccta
      781 cgggaaggcc gtagatgtgt gggccctggg tgtcatctcc tacatcctgc tgtgtgggta
      841 cccccccttc tatgatgaga gcgatcctga actcttcagc cagattctga gggccagcta
      901 cgagtttgac tctccctttt gggatgacat ctcagaatca gccaaagact tcattcggca
      961 ccttctggaa cgtgatcccc agaagaggtt cacctgccaa caggccttac agcatctctg
     1021 gatctctggg gatgcagcct tggacaggga catcctaggt tctgtcagtg agcagatcca
     1081 gaagaatttt gccaggaccc actggaagcg tgcattcaat gccacatcat tcctacgtca
     1141 catccgtaag ctgggacaga gcccagaggg tgaggaggcc tccaggcagg gtatgacccg
     1201 tcacagccac ccaggccttg ggactagcca gtctcccaag tggtgacaac caggtggatg
     1261 ccaaggaagg ccaagtggac tgactcctag cttttctttc ctccagccct tttgatctcc
     1321 ttccctgatc cttgtccccc ggactggcct ctgttggaaa gtccaagacc gtgggtgtga
     1381 tgcatggcac tggggtatgg ggcttcccaa gtatgtcccc agcctctgtc ctttgttgct
     1441 gccaccctct atggaaactg aggaggtatt caaaaatgga tttgggggcc atccttcctg
     1501 caccttgcac gcacatatgc attgcgtggc tgttctgtgc tttgctgact gtgggtggtc
     1561 ctgcttgtgt tgtagccctt tagttcctcc tctttccaac caataaagac aaacagaac
//
