LOCUS       NM_001008352            1000 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus phosphomevalonate kinase (Pmvk), mRNA.
ACCESSION   NM_001008352 XM_227421
VERSION     NM_001008352.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1000)
  AUTHORS   Wang J, Liu Y, Liu F, Huang C, Han S, Lv Y, Liu CJ, Zhang S, Qin Y,
            Ling L, Gao M, Yu S, Li C, Huang M, Liao S, Hu X, Lu Z, Liu X,
            Jiang T, Tang Z, Zhang H, Guo AY and Liu M.
  TITLE     Loss-of-function Mutation in PMVK Causes Autosomal Dominant
            Disseminated Superficial Porokeratosis
  JOURNAL   Sci Rep 6, 24226 (2016)
   PUBMED   27052676
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1000)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1000)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1000)
  AUTHORS   Kovacs WJ, Tape KN, Shackelford JE, Duan X, Kasumov T, Kelleher JK,
            Brunengraber H and Krisans SK.
  TITLE     Localization of the pre-squalene segment of the isoprenoid
            biosynthetic pathway in mammalian peroxisomes
  JOURNAL   Histochem Cell Biol 127 (3), 273-290 (2007)
   PUBMED   17180682
REFERENCE   5  (bases 1 to 1000)
  AUTHORS   Waterham HR.
  TITLE     Defects of cholesterol biosynthesis
  JOURNAL   FEBS Lett 580 (23), 5442-5449 (2006)
   PUBMED   16876788
  REMARK    Review article
REFERENCE   6  (bases 1 to 1000)
  AUTHORS   Hogenboom S, Romeijn GJ, Houten SM, Baes M, Wanders RJ and Waterham
            HR.
  TITLE     Absence of functional peroxisomes does not lead to deficiency of
            enzymes involved in cholesterol biosynthesis
  JOURNAL   J Lipid Res 43 (1), 90-98 (2002)
   PUBMED   11792727
REFERENCE   7  (bases 1 to 1000)
  AUTHORS   Gupta SD, Mehan RS, Tansey TR, Chen HT, Goping G, Goldberg I and
            Shechter I.
  TITLE     Differential binding of proteins to peroxisomes in rat hepatoma
            cells: unique association of enzymes involved in isoprenoid
            metabolism
  JOURNAL   J Lipid Res 40 (9), 1572-1584 (1999)
   PUBMED   10484604
REFERENCE   8  (bases 1 to 1000)
  AUTHORS   Olivier LM, Chambliss KL, Gibson KM and Krisans SK.
  TITLE     Characterization of phosphomevalonate kinase: chromosomal
            localization, regulation, and subcellular targeting
  JOURNAL   J Lipid Res 40 (4), 672-679 (1999)
   PUBMED   10191291
REFERENCE   9  (bases 1 to 1000)
  AUTHORS   Chambliss KL, Slaughter CA, Schreiner R, Hoffmann GF and Gibson KM.
  TITLE     Molecular cloning of human phosphomevalonate kinase and
            identification of a consensus peroxisomal targeting sequence
  JOURNAL   J Biol Chem 271 (29), 17330-17334 (1996)
   PUBMED   8663599
REFERENCE   10 (bases 1 to 1000)
  AUTHORS   Ramachandran,C.K. and Shah,S.N.
  TITLE     Studies on mevalonate kinase, phosphomevalonate kinase and
            pyrophosphomevalonate decarboxylase in developing rat brain
  JOURNAL   J Neurochem 28 (4), 751-757 (1977)
   PUBMED   197206
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086349.1.
            
            On Dec 16, 2004 this sequence version replaced XM_227421.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086349.1, FQ220630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1000
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1000
                     /gene="Pmvk"
                     /note="phosphomevalonate kinase"
                     /db_xref="GeneID:310645"
                     /db_xref="RGD:1310812"
     exon            1..143
                     /gene="Pmvk"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..633
                     /gene="Pmvk"
                     /EC_number="2.7.4.2"
                     /codon_start=1
                     /product="phosphomevalonate kinase"
                     /protein_id="NP_001008353.1"
                     /db_xref="GeneID:310645"
                     /db_xref="RGD:1310812"
                     /translation="MAPLGASPRLVLLFSGKRKSGKDFVTERLQSRLGGNICAVLRLS
                     GPLKEQYAREHGLDFQKLLDASTYKETYRRDMICWGEEKRQADPGFFCRKIVEGVSQP
                     IWLVSDTRRMSDIQWFQEAYGALTQTVRVVASEQSRQQRGWVFTRGVDDAESECGLDS
                     FGDFDWVIENHGDEQCLEDQLENLLEFIHAKLQR"
     exon            144..207
                     /gene="Pmvk"
                     /inference="alignment:Splign:2.1.0"
     exon            208..360
                     /gene="Pmvk"
                     /inference="alignment:Splign:2.1.0"
     exon            361..490
                     /gene="Pmvk"
                     /inference="alignment:Splign:2.1.0"
     exon            491..975
                     /gene="Pmvk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggggtccg aagtgtcagc tgtaggcctg gtgaagcttg gtggccccat ggccccgctc
       61 ggagcttccc cgcgtctggt gttgctgttt agcgggaaga gaaaatccgg gaaggacttc
      121 gtgaccgaga ggctgcagag cagacttgga ggtaacatct gtgctgtcct gcggctctct
      181 ggtccactca aggagcagta cgctcgggag catggcttgg acttccagaa acttctggac
      241 gcaagcactt acaaggagac ctatcggagg gacatgatct gttgggggga ggagaagcgc
      301 caggctgacc caggcttctt ctgccggaag attgtggaag gcgtgtccca gcctatctgg
      361 ctggtgagtg acacacggag gatgtctgac atccagtggt ttcaggaggc ctacggggct
      421 ttgacacaga ccgtccgagt agtagcctcg gagcagagtc gacagcaacg gggctgggtg
      481 ttcacacgag gggtggacga tgctgagtca gaatgtggcc tggacagctt tggggacttt
      541 gactgggtca ttgagaacca cggagatgaa cagtgcctgg aggatcagtt ggagaacctt
      601 ctggaattta ttcatgccaa acttcagcgc tgaggcttga ggggtgagca gagactgatg
      661 gaccgggcga accctgcttc taccagatgt gggtgcccag tcccggctga ggtcagaaaa
      721 cagacaaacg gtctggcttt aaacttccag aggaatgagg aggatgctcg tgggtaatgg
      781 caaataaaga aacctccggt gtgtgtgtct tccctggaga ggacacttac agggcaaagg
      841 ccaatgcatt agttttgcgt gagacagaaa cattaccatg cgcatggtaa ggcaggcctg
      901 cagaactgtg gtggtgttgc ttccccgtgt gtaagctctc agccctggaa tcctaataaa
      961 cctccttgga gcacaaaaaa aaaaaaaaaa aaaaaaaaaa
//
