LOCUS       NM_001399795            2919 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus PMS1 homolog 2, mismatch repair system component
            (Pms2), transcript variant 1, mRNA.
ACCESSION   NM_001399795 XM_006248862
VERSION     NM_001399795.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2919)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   2  (bases 1 to 2919)
  AUTHORS   Borras,E., Pineda,M., Cadinanos,J., Del Valle,J., Brieger,A.,
            Hinrichsen,I., Cabanillas,R., Navarro,M., Brunet,J., Sanjuan,X.,
            Musulen,E., van der Klift,H., Lazaro,C., Plotz,G., Blanco,I. and
            Capella,G.
  TITLE     Refining the role of PMS2 in Lynch syndrome: germline mutational
            analysis improved by comprehensive assessment of variants
  JOURNAL   J Med Genet 50 (8), 552-563 (2013)
   PUBMED   23709753
REFERENCE   3  (bases 1 to 2919)
  AUTHORS   Bourn,R.L., De Biase,I., Pinto,R.M., Sandi,C., Al-Mahdawi,S.,
            Pook,M.A. and Bidichandani,S.I.
  TITLE     Pms2 suppresses large expansions of the (GAA.TTC)n sequence in
            neuronal tissues
  JOURNAL   PLoS One 7 (10), e47085 (2012)
   PUBMED   23071719
REFERENCE   4  (bases 1 to 2919)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
REFERENCE   5  (bases 1 to 2919)
  AUTHORS   Norris,A.M., Gentry,M., Peehl,D.M., D'Agostino,R. Jr. and
            Scarpinato,K.D.
  TITLE     The elevated expression of a mismatch repair protein is a predictor
            for biochemical recurrence after radical prostatectomy
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (1), 57-64 (2009)
   PUBMED   19124481
REFERENCE   6  (bases 1 to 2919)
  AUTHORS   Kim,N., Bozek,G., Lo,J.C. and Storb,U.
  TITLE     Different mismatch repair deficiencies all have the same effects on
            somatic hypermutation: intact primary mechanism accompanied by
            secondary modifications
  JOURNAL   J Exp Med 190 (1), 21-30 (1999)
   PUBMED   10429667
REFERENCE   7  (bases 1 to 2919)
  AUTHORS   Yao,X., Buermeyer,A.B., Narayanan,L., Tran,D., Baker,S.M.,
            Prolla,T.A., Glazer,P.M., Liskay,R.M. and Arnheim,N.
  TITLE     Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6850-6855 (1999)
   PUBMED   10359802
REFERENCE   8  (bases 1 to 2919)
  AUTHORS   Winter,D.B., Phung,Q.H., Umar,A., Baker,S.M., Tarone,R.E.,
            Tanaka,K., Liskay,R.M., Kunkel,T.A., Bohr,V.A. and Gearhart,P.J.
  TITLE     Altered spectra of hypermutation in antibodies from mice deficient
            for the DNA mismatch repair protein PMS2
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6953-6958 (1998)
   PUBMED   9618520
REFERENCE   9  (bases 1 to 2919)
  AUTHORS   Prolla,T.A., Baker,S.M., Harris,A.C., Tsao,J.L., Yao,X.,
            Bronner,C.E., Zheng,B., Gordon,M., Reneker,J., Arnheim,N.,
            Shibata,D., Bradley,A. and Liskay,R.M.
  TITLE     Tumour susceptibility and spontaneous mutation in mice deficient in
            Mlh1, Pms1 and Pms2 DNA mismatch repair
  JOURNAL   Nat Genet 18 (3), 276-279 (1998)
   PUBMED   9500552
REFERENCE   10 (bases 1 to 2919)
  AUTHORS   Nicolaides,N.C., Papadopoulos,N., Liu,B., Wei,Y.F., Carter,K.C.,
            Ruben,S.M., Rosen,C.A., Haseltine,W.A., Fleischmann,R.D.,
            Fraser,C.M. et al.
  TITLE     Mutations of two PMS homologues in hereditary nonpolyposis colon
            cancer
  JOURNAL   Nature 371 (6492), 75-80 (1994)
   PUBMED   8072530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jan 14, 2022 this sequence version replaced XM_006248862.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160858.1, SRR26643293.83727.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000012.1  15814616-15814720   c
            106-245             JAXUCZ010000012.1  15812831-15812970   c
            246-332             JAXUCZ010000012.1  15811202-15811288   c
            333-435             JAXUCZ010000012.1  15810944-15811046   c
            436-619             JAXUCZ010000012.1  15809772-15809955   c
            620-787             JAXUCZ010000012.1  15807919-15808086   c
            788-885             JAXUCZ010000012.1  15806891-15806988   c
            886-985             JAXUCZ010000012.1  15805169-15805268   c
            986-1070            JAXUCZ010000012.1  15802243-15802327   c
            1071-1226           JAXUCZ010000012.1  15800647-15800802   c
            1227-2061           JAXUCZ010000012.1  15797728-15798562   c
            2062-2229           JAXUCZ010000012.1  15795925-15796092   c
            2230-2330           JAXUCZ010000012.1  15795218-15795318   c
            2331-2500           JAXUCZ010000012.1  15794932-15795101   c
            2501-2919           JAXUCZ010000012.1  15790478-15790896   c
FEATURES             Location/Qualifiers
     source          1..2919
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2919
                     /gene="Pms2"
                     /note="PMS1 homolog 2, mismatch repair system component"
                     /db_xref="GeneID:288479"
                     /db_xref="RGD:1305483"
     exon            1..105
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2644
                     /gene="Pms2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mismatch repair endonuclease PMS2; PMS2 postmeiotic
                     segregation increased 2"
                     /codon_start=1
                     /product="mismatch repair endonuclease PMS2 isoform 1"
                     /protein_id="NP_001386724.1"
                     /db_xref="GeneID:288479"
                     /db_xref="RGD:1305483"
                     /translation="MEPTEGASTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIE
                     NSVDAGATSIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIREFADLTQVE
                     TFGFRGEALSSLCALSDVTISTCHVSASIGTRLVLDHNGKIIQKTPCPRPKGTTVSVQ
                     NLFYTLPVRHKEFQRNIKKEYAKMVQVLQAYCIISAGIRVSCTNQLGQGKRQPVVCTS
                     GSSGMKENIGSVFGQKQLQSLVPFVQLPPSDSVCEEYCLSACGTPQSPFRISGFISQC
                     THGAGRSSTDRQFFFINQRPCDPAKVSRLVNEVYHMYNRHQYPFVVLNVSVDSECVDI
                     NVTPDKRQILLQEEKLLLAVLKTSLMGMFDSDANKLSVNQQPLLNVEGNLVKLHTAEV
                     GEQENSPSLRITAEEKRVASVSRLREAYSLHRTTETKSWGPETPELKQSFPSQKRGVS
                     SSCPSDIISYRGLCGSQDKLVSPTDSPGDCMDREKGEKDSGLSSTSAGSEEGFSTPEV
                     ASSFSSDCNVSSPEDRPSQENTNCGEQFLEVDDHLSGTGHHLKPEDNGYKCRASLPPT
                     RLSPSNAKRFRTEDRPSNVGVPQNTSAAEVDVAVKINKKIVLLDFSLSSLAKQMKQLQ
                     HLKQQSKSEHNYRKFRAKICPGENQAAEDELRREIRKSMFAEMEILGQFNLGFIVTKL
                     KEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKN
                     GFDFIIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMCRPSRVRQMF
                     ASRACRKSVMIGTALSASEMKKLISHMGEMDHPWNCPHGRPTMRHIANLDVISQN"
     exon            106..245
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..332
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..435
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..619
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..787
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..885
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..985
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1070
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1226
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..2061
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2229
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2330
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2500
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2919
                     /gene="Pms2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggtggccc aggagacgcg tctccgtgag agcggcgcgc gaagtctccc ggggagactg
       61 agactggagg agtgctgctt ccatggaacc aactgagggc gcgagtacag aatgtgctaa
      121 ggccatcaag cctattgatg ggaagtcagt ccatcagatt tgctctgggc aggtggtact
      181 cagtttaagc actgctgtga aggagttgat agaaaatagt gtagatgccg gtgctactag
      241 tattgatcta aggcttaaag actatggagt ggacctcatt gaagtttcag acaatggatg
      301 tggggtagaa gaagaaaact ttgaaggtct agctctgaaa catcacacct ctaagattcg
      361 agagtttgcc gacctcacgc aggttgaaac tttcggcttt cggggggaag ctctgagctc
      421 tctgtgtgca ctgagtgatg tcactatatc tacctgccat gtgtctgcaa gcattgggac
      481 tcgactggtg ttggaccata atgggaaaat catccagaaa actccctgcc cacggcctaa
      541 aggaaccaca gtcagcgtgc agaacttatt ttacacccta cccgtacgtc acaaagagtt
      601 tcaaaggaac attaaaaagg agtatgccaa aatggtccag gtcttacagg cgtactgcat
      661 catttcagcc ggcatccgtg tgagctgcac taatcagctc ggacagggga aacggcagcc
      721 tgtggtgtgc acgagcggaa gctccggcat gaaggaaaat atcgggtctg tgttcggcca
      781 gaagcagctg cagagcctcg ttccttttgt gcagctgccc cctagtgact ccgtctgtga
      841 agagtactgc ctgagcgctt gtgggacccc gcagagtcct ttccgcattt caggcttcat
      901 ttcacagtgc acgcatggtg ccgggaggag ttcaacagac agacagtttt tcttcatcaa
      961 tcagcggcct tgtgacccag cgaaggtctc tagactggtg aatgaggtct accacatgta
     1021 taatcggcac cagtatccat ttgtcgttct taacgtgtcc gtggactcgg aatgtgtgga
     1081 tattaacgtg accccagata aaaggcagat tttactacag gaagagaagc ttttgctggc
     1141 agttttaaag acgtccttga tgggaatgtt cgacagtgat gcaaacaagc ttagtgtcaa
     1201 ccagcagccg ctgctgaatg tcgaaggtaa cttagtaaag ctacataccg cagaagtagg
     1261 agagcaagag aactctcctt cattgaggat cacagcggaa gagaaaaggg tagcatctgt
     1321 gtctaggctg agagaggcct attctcttca tcgtaccaca gagaccaagt cttggggccc
     1381 agagactcct gaactgaaac agagttttcc aagtcagaaa aggggtgtat catcatcttg
     1441 tccttcagac atcatctctt atagaggcct gtgtggctca caggacaaat tggtgagtcc
     1501 cacggatagc cctggtgact gtatggacag agaaaaagga gaaaaggact cagggcttag
     1561 cagcacctca gctggctctg aggaagggtt cagcacccca gaagtggcca gtagctttag
     1621 cagtgactgc aacgtgagct ccccagagga cagaccttct caggaaaaca caaactgtgg
     1681 cgagcagttc cttgaagtgg atgaccacct ttcaggtaca ggacaccatt tgaagccaga
     1741 agacaatgga tataaatgtc gagcttcact tccaccaact cggctctctc cctcaaatgc
     1801 taagcgtttc aggacagagg acaggccttc aaatgttggc gttcctcaga acacctcagc
     1861 agctgaggtt gacgtagctg taaaaattaa taagaaaata gtgctccttg acttctctct
     1921 gagctcttta gctaaacaaa tgaagcagtt acagcacctg aagcagcaga gcaaaagcga
     1981 acacaattac aggaaattta gggccaagat ttgccctgga gaaaatcaag cagcagaaga
     2041 tgaactcaga agagagatta ggaagtcgat gttcgcagag atggagatct tgggtcagtt
     2101 taacctggga ttcatcgtaa ccaaactgaa ggaggacctc ttcctggtgg accagcacgc
     2161 cgccgacgag aagtacaact ttgagatgct gcagcagcac acggtgctcc aggctcagag
     2221 gctcatcact ccccagactc tgaacttaac tgctgtcaat gaagctgtgc tgatagaaaa
     2281 tctggaaata ttcagaaaga atggctttga ctttatcatt gatgaagatg ctccagtcac
     2341 tgaaagggct aaactgattt ccttacccac tagtaaaaac tggacctttg gaccccaaga
     2401 tatcgatgaa ctgatcttta tgctcagtga cagccctggg gtcatgtgcc ggccctcgag
     2461 agtcagacag atgtttgctt cccgagcgtg tcggaagtct gtgatgattg gaaccgctct
     2521 cagtgcaagt gagatgaaga agctcatctc ccacatgggt gagatggacc acccctggaa
     2581 ctgcccccac ggaaggccga ccatgaggca cattgcaaat ctggatgtca tctcccagaa
     2641 ctgactgacc gcttgtggga tagagctcat tacagattgt tctgtttgga gagatggttt
     2701 tacgtaatct gattatcgtt gttcaaaaac tagcatgcta ctttaatgta ctggatccat
     2761 ttaaaaactg tgtagccagg cataatggcc tgtgcttctg gcctagctac ttgggagagc
     2821 caccccagga gtttgagact atcctgagct acattggtga gactctaatt caaggacaaa
     2881 aatatatata tattttgaaa ccttttcacc atgtctgca
//
