LOCUS       NM_001009535            3009 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus PMS1 homolog 1, mismatch repair system component
            (Pms1), mRNA.
ACCESSION   NM_001009535
VERSION     NM_001009535.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille
            D and Mechali M.
  TITLE     MCM9 Is Required for Mammalian DNA Mismatch Repair
  JOURNAL   Mol Cell 59 (5), 831-839 (2015)
   PUBMED   26300262
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Li GM.
  TITLE     Mechanisms and functions of DNA mismatch repair
  JOURNAL   Cell Res 18 (1), 85-98 (2008)
   PUBMED   18157157
  REMARK    Review article
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y,
            Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M and Kawakami
            Y.
  TITLE     Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in
            patients with pancreatic cancer, dermatomyositis and polymyositis
  JOURNAL   Int J Cancer 116 (6), 925-933 (2005)
   PUBMED   15856462
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Jacob S and Praz F.
  TITLE     DNA mismatch repair defects: role in colorectal carcinogenesis
  JOURNAL   Biochimie 84 (1), 27-47 (2002)
   PUBMED   11900875
  REMARK    Review article
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Vinson RK and Hales BF.
  TITLE     Expression of base excision, mismatch, and recombination repair
            genes in the organogenesis-stage rat conceptus and effects of
            exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide
  JOURNAL   Teratology 64 (6), 283-291 (2001)
   PUBMED   11754170
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng
            B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A and Liskay
            RM.
  TITLE     Tumour susceptibility and spontaneous mutation in mice deficient in
            Mlh1, Pms1 and Pms2 DNA mismatch repair
  JOURNAL   Nat Genet 18 (3), 276-279 (1998)
   PUBMED   9500552
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM,
            Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM et al.
  TITLE     Mutations of two PMS homologues in hereditary nonpolyposis colon
            cancer
  JOURNAL   Nature 371 (6492), 75-80 (1994)
   PUBMED   8072530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061722.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061722.1, SRR8487231.175697.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132295, SAMD00132300
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..3009
                     /gene="Pms1"
                     /note="PMS1 homolog 1, mismatch repair system component"
                     /db_xref="GeneID:494322"
                     /db_xref="RGD:1359511"
     exon            1..78
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..216
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2844
                     /gene="Pms1"
                     /note="PMS1 postmeiotic segregation increased 1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1"
                     /protein_id="NP_001009535.1"
                     /db_xref="GeneID:494322"
                     /db_xref="RGD:1359511"
                     /translation="MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGANSIDVKL
                     ENYGFDKIEIRDNGAGIKAVDVPVMAVKYYTSKISSHEDLQTLTTYGFRGEALGAICN
                     VAEVVVTTRTAADDFSTQYVLDGSGHILSQKPSHLGQGTTVTVLKLFKNLPVRRQFYS
                     TPKKCKDELKNVQDLLISYAVLKPDLRITFVHNKAVIWQKSRVPDHRMALMSVLGTAV
                     MGNMESVERYCEDSQIHLRGLFPKHDADHNSTSLSTPERSFIFINSRPVHQKDILKLI
                     RHYYNLKCLKESTRLYPIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLLM
                     TCYGPLPTTESYENNRVDVSSANVVISETTETDVLFNKMESSGNKYPNADTLAIPFQN
                     DESRKNTDHHLNEQINIGHCDGHFSGEYSHINKDTFQNIPRNNLSSEANQSKHSETHS
                     ADSIEHIQGENGRSGTGENGEDGKKTLPEKALEICADDWSKGNVFNSMGENIEPVKIL
                     VPQKSLSCKVTNSHPNPEPENLSVGPGSRTSNVIDNRPGQLTAYDLISSRAVKKPMSA
                     CALFIQDHRTQFLAENPKTGLEDVTAQIKAQWETLSEEEKHKYEEKAKKDLERYNNQM
                     KKAIEQEAQVSLKDGRKKLRATGAWGCTQRHKVKDLSNQPKLDELFQSQNEKKSENIK
                     ITKIPFSMENLKVNFNKQKEVDLEEKDEICLIHSLKFPDAWLVTSRADVMLLNPYRVE
                     EALLFKRLLENHKFLAEPLDKPIVLTESLFNGSDYLEVLHKMSTVEERCRGSVYLCDP
                     RLTANGFKIRLTPGVSSAENYLEIEGMAKCLPFYGVMDLKEILNAIVNKNAKEIYECR
                     PRKVINYLEGEAVRLSRQLPMYLPQEDVQDLIYKMKHQFGKEIKGCVHGRPFLHHLIH
                     LPGTS"
     exon            217..399
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..502
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..666
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..783
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..906
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1050
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1907
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2387
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2518
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2679
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2977
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagggcctg ctgctccggg tctactgagt gcctgcagcg gtgggtggtg aatctcataa
       61 cctctcgcga gctagaaggc taggatgaaa cagttgcctg cagcgacagt tcgcctcctg
      121 tccagttctc agacaatcac ttcagtggtc agtgttgtga aagagctcat tgaaaactcc
      181 ttggatgccg gagccaacag cattgatgtt aaactggaga actatgggtt tgataaaatt
      241 gagattcggg acaatggtgc gggcatcaag gctgtggatg tccctgtcat ggcagtaaag
      301 tactacacct ccaagatcag cagtcatgaa gaccttcaaa ctctcacaac ctatggtttc
      361 cgtggtgaag ccttgggggc aatatgcaat gttgcagagg tggtagtgac aacaaggaca
      421 gctgctgatg actttagcac ccagtatgtt ttagatggca gtggccacat actttctcag
      481 aagccttcac atcttggtca aggtacaact gtaacggttc taaagttgtt taagaatctt
      541 cctgtaagga gacaatttta ttcaacccca aaaaagtgta aagatgaact aaaaaatgta
      601 caggatcttc tcataagcta cgctgtcctg aaacctgacc taaggattac ttttgtacat
      661 aataaggcag ttatttggca gaaaagtaga gttccagatc acaggatggc tctaatgtcg
      721 gttctgggaa ctgctgtcat gggcaacatg gagtctgttg agcggtactg tgaagactct
      781 cagattcacc tacgtggatt atttccaaag catgatgcag accacaattc cacaagtctt
      841 tcaaccccag agagaagttt catctttatt aatagtcgac cagtacatca aaaagatata
      901 ctaaagttaa tccgacatta ttataacctg aagtgcctaa aggaatctac ccgcttgtac
      961 cccattttct ttctgaaaat tgatgttcct tcagctgagg tggatataaa tctaacacca
     1021 gataaaagtc aagtgctatt acagaataag gaatctgttt taattgctct tgaaaatctg
     1081 ctgatgacct gttatggacc actacccact acagagtctt atgaaaataa cagagtagat
     1141 gtttcctcag ctaatgttgt cattagtgaa acaacagaaa cagatgtgct ttttaataaa
     1201 atggaatcat ccggaaataa atacccaaat gctgatactt tggctattcc cttccaaaat
     1261 gatgaatcta gaaaaaacac tgaccatcat ttaaacgaac agataaatat aggtcactgt
     1321 gatggtcatt ttagtggtga atattctcac attaataagg acacgtttca aaatatccct
     1381 aggaataatt tatcatcaga ggctaatcag agtaaacaca gtgagactca ttctgcagat
     1441 tctattgagc atatccaagg agaaaatggc aggagtggta caggagaaaa tggggaagat
     1501 ggaaaaaaaa cacttcctga gaaagctctg gaaatctgtg cagacgactg gagcaaggga
     1561 aatgtgttta attcaatggg agagaatatc gaacctgtga aaattttagt gccacaaaag
     1621 agcttatcat gtaaagtgac taatagtcac ccaaaccctg aaccagagaa tctcagtgtt
     1681 ggtcctggta gcagaacatc aaatgttatt gataacaggc ctgggcagct tacagcctat
     1741 gacttaatta gcagtcgagc agtcaagaag cccatgtcag cctgtgccct gttcattcaa
     1801 gaccaccgca ctcagttcct cgcagagaat cccaagactg gtttggagga tgtgacagca
     1861 caaattaaag cacagtggga gacactgagt gaagaggaaa aacacaaata tgaggaaaag
     1921 gctaaaaaag acttggaacg atacaataac caaatgaaga aagccattga acaggaagca
     1981 caagtgtcat taaaagatgg caggaaaaag ctaagagcca ctggtgcgtg gggctgcaca
     2041 cagagacaca aggtgaaaga cttgtctaac cagccaaaac tggacgagct cttccagtcc
     2101 cagaatgaaa agaagagtga aaatattaaa ataacaaaga tccccttttc tatggaaaac
     2161 ttaaaagtga actttaacaa acaaaaggaa gttgacttag aggagaagga tgagatttgc
     2221 ctgatccaca gtctcaagtt tcctgatgca tggctggtca catccagagc agatgtcatg
     2281 ttgctgaacc catacagagt ggaggaagcc ctgctattta aaagacttct tgagaatcat
     2341 aaattccttg cagaaccgct agataagcca atcgtattaa cagagagtct ttttaatggg
     2401 tctgattatt tagaagtttt acataaaatg tcgacagttg aggaaagatg ccgtggatca
     2461 gtttacctgt gtgaccctcg tctcacagca aatggcttca agatcagatt gacaccagga
     2521 gtttccagtg ctgagaacta cttggaaata gaaggcatgg ctaagtgcct cccgttctat
     2581 ggagtaatgg atctaaagga aattcttaat gctatagtaa acaaaaacgc aaaggagatt
     2641 tatgaatgta gacctcgaaa agtgataaat tatctggagg gagaagccgt ccgcctatcc
     2701 agacagctac ccatgtactt accgcaagag gatgtccagg atcttatcta taaaatgaag
     2761 caccagttcg gaaaagaaat taaagggtgt gttcatggtc gcccatttct tcatcatttg
     2821 atccatcttc caggaacttc atgattaagt ttatgaccat tagttactat ggaaattgat
     2881 gtggctctca aacttgtact aaaatgatta tttgtatact ggaaaagatt ttttaaagtt
     2941 gtaaaatatg tataaataaa cgacgtggac tataaaaaaa aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaaaaa
//
