LOCUS       NP_001009535             919 aa            linear   ROD 23-MAR-2023
DEFINITION  PMS1 protein homolog 1 [Rattus norvegicus].
ACCESSION   NP_001009535
VERSION     NP_001009535.1
DBSOURCE    REFSEQ: accession NM_001009535.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 919)
  AUTHORS   Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille
            D and Mechali M.
  TITLE     MCM9 Is Required for Mammalian DNA Mismatch Repair
  JOURNAL   Mol Cell 59 (5), 831-839 (2015)
   PUBMED   26300262
REFERENCE   2  (residues 1 to 919)
  AUTHORS   Li GM.
  TITLE     Mechanisms and functions of DNA mismatch repair
  JOURNAL   Cell Res 18 (1), 85-98 (2008)
   PUBMED   18157157
  REMARK    Review article
REFERENCE   3  (residues 1 to 919)
  AUTHORS   Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y,
            Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M and Kawakami
            Y.
  TITLE     Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in
            patients with pancreatic cancer, dermatomyositis and polymyositis
  JOURNAL   Int J Cancer 116 (6), 925-933 (2005)
   PUBMED   15856462
REFERENCE   4  (residues 1 to 919)
  AUTHORS   Jacob S and Praz F.
  TITLE     DNA mismatch repair defects: role in colorectal carcinogenesis
  JOURNAL   Biochimie 84 (1), 27-47 (2002)
   PUBMED   11900875
  REMARK    Review article
REFERENCE   5  (residues 1 to 919)
  AUTHORS   Vinson RK and Hales BF.
  TITLE     Expression of base excision, mismatch, and recombination repair
            genes in the organogenesis-stage rat conceptus and effects of
            exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide
  JOURNAL   Teratology 64 (6), 283-291 (2001)
   PUBMED   11754170
REFERENCE   6  (residues 1 to 919)
  AUTHORS   Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng
            B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A and Liskay
            RM.
  TITLE     Tumour susceptibility and spontaneous mutation in mice deficient in
            Mlh1, Pms1 and Pms2 DNA mismatch repair
  JOURNAL   Nat Genet 18 (3), 276-279 (1998)
   PUBMED   9500552
REFERENCE   7  (residues 1 to 919)
  AUTHORS   Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM,
            Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM et al.
  TITLE     Mutations of two PMS homologues in hereditary nonpolyposis colon
            cancer
  JOURNAL   Nature 371 (6492), 75-80 (1994)
   PUBMED   8072530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061722.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061722.1, SRR8487231.175697.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132295, SAMD00132300
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     Protein         1..919
                     /product="PMS1 protein homolog 1"
                     /note="PMS1 postmeiotic segregation increased 1"
                     /calculated_mol_wt=103597
     Region          1..318
                     /region_name="mutl"
                     /note="DNA mismatch repair protein MutL; TIGR00585"
                     /db_xref="CDD:273155"
     Region          560..631
                     /region_name="HMG-box_SF"
                     /note="high mobility group (HMG)-box domain superfamily;
                     cl00082"
                     /db_xref="CDD:469606"
     Site            order(562,564..568,571..572,579,591..592,595,598..599,606,
                     610,613,617,620)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438789"
     CDS             1..919
                     /gene="Pms1"
                     /coded_by="NM_001009535.1:85..2844"
                     /db_xref="GeneID:494322"
                     /db_xref="RGD:1359511"
ORIGIN      
        1 mkqlpaatvr llsssqtits vvsvvkelie nsldagansi dvklenygfd kieirdngag
       61 ikavdvpvma vkyytskiss hedlqtltty gfrgealgai cnvaevvvtt rtaaddfstq
      121 yvldgsghil sqkpshlgqg ttvtvlklfk nlpvrrqfys tpkkckdelk nvqdllisya
      181 vlkpdlritf vhnkaviwqk srvpdhrmal msvlgtavmg nmesveryce dsqihlrglf
      241 pkhdadhnst slstpersfi finsrpvhqk dilklirhyy nlkclkestr lypifflkid
      301 vpsaevdinl tpdksqvllq nkesvliale nllmtcygpl pttesyennr vdvssanvvi
      361 settetdvlf nkmessgnky pnadtlaipf qndesrkntd hhlneqinig hcdghfsgey
      421 shinkdtfqn iprnnlssea nqskhseths adsiehiqge ngrsgtgeng edgkktlpek
      481 aleicaddws kgnvfnsmge niepvkilvp qkslsckvtn shpnpepenl svgpgsrtsn
      541 vidnrpgqlt aydlissrav kkpmsacalf iqdhrtqfla enpktgledv taqikaqwet
      601 lseeekhkye ekakkdlery nnqmkkaieq eaqvslkdgr kklratgawg ctqrhkvkdl
      661 snqpkldelf qsqnekksen ikitkipfsm enlkvnfnkq kevdleekde iclihslkfp
      721 dawlvtsrad vmllnpyrve eallfkrlle nhkflaepld kpivlteslf ngsdylevlh
      781 kmstveercr gsvylcdprl tangfkirlt pgvssaenyl eiegmakclp fygvmdlkei
      841 lnaivnknak eiyecrprkv inylegeavr lsrqlpmylp qedvqdliyk mkhqfgkeik
      901 gcvhgrpflh hlihlpgts
//
