LOCUS       NM_001003673            1760 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus peptidase, mitochondrial processing subunit alpha
            (Pmpca), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001003673 XM_215989
VERSION     NM_001003673.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1760)
  AUTHORS   Jobling,R.K., Assoum,M., Gakh,O., Blaser,S., Raiman,J.A.,
            Mignot,C., Roze,E., Durr,A., Brice,A., Levy,N., Prasad,C.,
            Paton,T., Paterson,A.D., Roslin,N.M., Marshall,C.R.,
            Desvignes,J.P., Roeckel-Trevisiol,N., Scherer,S.W., Rouleau,G.A.,
            Megarbane,A., Isaya,G., Delague,V. and Yoon,G.
  TITLE     PMPCA mutations cause abnormal mitochondrial protein processing in
            patients with non-progressive cerebellar ataxia
  JOURNAL   Brain 138 (Pt 6), 1505-1517 (2015)
   PUBMED   25808372
REFERENCE   2  (bases 1 to 1760)
  AUTHORS   Mossmann,D., Meisinger,C. and Vogtle,F.N.
  TITLE     Processing of mitochondrial presequences
  JOURNAL   Biochim Biophys Acta 1819 (9-10), 1098-1106 (2012)
   PUBMED   22172993
  REMARK    Review article
REFERENCE   3  (bases 1 to 1760)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 1760)
  AUTHORS   Greene,A.W., Grenier,K., Aguileta,M.A., Muise,S., Farazifard,R.,
            Haque,M.E., McBride,H.M., Park,D.S. and Fon,E.A.
  TITLE     Mitochondrial processing peptidase regulates PINK1 processing,
            import and Parkin recruitment
  JOURNAL   EMBO Rep 13 (4), 378-385 (2012)
   PUBMED   22354088
REFERENCE   5  (bases 1 to 1760)
  AUTHORS   Kitada,S., Shimokata,K., Niidome,T., Ogishima,T. and Ito,A.
  TITLE     A putative metal-binding site in the beta subunit of rat
            mitochondrial processing peptidase is essential for its catalytic
            activity
  JOURNAL   J Biochem 117 (6), 1148-1150 (1995)
   PUBMED   7490252
REFERENCE   6  (bases 1 to 1760)
  AUTHORS   Kleiber,J., Kalousek,F., Swaroop,M. and Rosenberg,L.E.
  TITLE     The general mitochondrial matrix processing protease from rat
            liver: structural characterization of the catalytic subunit
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 7978-7982 (1990)
   PUBMED   2236012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079004.1 and CB806391.1.
            
            On Oct 18, 2004 this sequence version replaced XM_215989.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079004.1, M57728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1719              BC079004.1         1-1719
            1720-1760           CB806391.1         215-255
FEATURES             Location/Qualifiers
     source          1..1760
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1760
                     /gene="Pmpca"
                     /note="peptidase, mitochondrial processing subunit alpha"
                     /db_xref="GeneID:296588"
                     /db_xref="RGD:727897"
     exon            1..74
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1581
                     /gene="Pmpca"
                     /EC_number="3.4.24.64"
                     /note="P-55; alpha-MPP; mitochondrial processing peptidase
                     alpha subunit, mitochondrial; peptidase (mitochondrial
                     processing) alpha; peptidase, mitochondrial processing
                     alpha subunit; inactive zinc metalloprotease alpha"
                     /codon_start=1
                     /product="mitochondrial-processing peptidase subunit
                     alpha"
                     /protein_id="NP_001003673.1"
                     /db_xref="GeneID:296588"
                     /db_xref="RGD:727897"
                     /translation="MATAVWAAARLLRGSAALCARPKFGSPAHRRFSSGATYPNIPLS
                     SPLPGVPKPIFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTLGILINSGSRYEAK
                     YLSGIAHFLEKLAFSSTARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLD
                     TVVGLLADVVLHPRLTDEEIEMTRMAVQFELEDLNMRPDPEPLLTEMIHEAAFRENTV
                     GLHRFCPVENIGKIDREVLHSYLKNYYTPDRMVLAGVGVEHEHLVECARKYLLGVQPA
                     WGAPGAVDVDSSVAQYTGGIIKVERDMSNVSLGPTPIPELTHIMVGLESCSFLEEDFI
                     PFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNVLNRHHWMYNATSYHHSYEDTGLLCIH
                     ASADPRQVREMVEIITKEFILMGRTVDLVELERAKTQLMSMLMMNLESRPVIFEDVGR
                     QVLATHSRKLPHELCTLIRNVKPEDIKRVASKMLRGKPAVAALGDLTDLPTYEHIQAA
                     LSSRDGRLPRTYRLFR"
     exon            75..277
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            278..357
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            358..440
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            441..535
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            536..636
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            637..900
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            901..993
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1112
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1203
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1266
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1411
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1760
                     /gene="Pmpca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgatgg cgacggcagt gtgggcggct gcgcggctac ttcggggttc tgcggcgctg
       61 tgcgcgcggc ccaagttcgg ttctcctgca cacagacggt tcagcagtgg cgccacctac
      121 cccaacatcc ctctctcttc tcccttgccc ggagtgccca agcctatttt tgctacagtt
      181 gatggacagg aaaagtttga aaccaaagtc accactctgg acaatgggct tcgtgtggca
      241 tctcaaaata agtttggaca gttctgtacc ttaggaattc ttattaattc aggatcacga
      301 tatgaagcga aatatcttag tggaattgct cattttctgg aaaaattggc attttcgtct
      361 accgctcgat ttgacagcaa agatgaaatt ctgcttaccc tggaaaaaca tggtggtatc
      421 tgtgactgcc agacctcgag agacaccacc atgtatgctg tgtctgctga cagcaaaggc
      481 ttggacactg tggtgggcct gctggctgat gtggttctgc acccccgcct gacagatgag
      541 gaaattgaga tgacgaggat ggctgttcag tttgaacttg aggacctgaa catgagacct
      601 gacccagagc cactgctcac cgagatgatt catgaagctg cttttaggga gaacacggtg
      661 ggcctgcacc ggttttgtcc tgtagagaac atagggaaga ttgaccgaga agtgctgcat
      721 tcctacctga agaactacta cacccccgac cgcatggtgc ttgctggagt gggcgtggag
      781 catgagcacc tggtcgaatg tgccagaaag tacctcctgg gagtgcagcc tgcctgggga
      841 gctccgggag ctgtggatgt tgacagctca gtggcacagt acacgggggg gatcatcaag
      901 gtggagagag acatgtcaaa tgtcagcctt ggccccaccc cgattccaga gctcacacat
      961 atcatggtgg ggctagagag ctgctccttc ctggaggagg atttcatccc ctttgctgtg
     1021 ttgaatatga tgatgggagg cgggggctcc ttctcggccg gagggcctgg caaaggcatg
     1081 ttctccaggc tctacctcaa cgtgctcaat cggcaccact ggatgtataa tgcaacctcc
     1141 taccaccaca gctatgaaga cacaggcctc ctgtgcatcc atgccagcgc agaccctcga
     1201 caggttcgag aaatggtaga aatcatcaca aaggagttta ttttgatggg ccgaacggtg
     1261 gatttggtgg agctggagcg ggccaagaca cagctgatgt ccatgctcat gatgaacttg
     1321 gagtccaggc ctgtgatctt tgaggatgtg gggaggcagg tgttggctac acattcaaga
     1381 aagctgcccc atgagctgtg cacactcatt cgcaatgtga agccggaaga tatcaagagg
     1441 gttgcttcca agatgctccg aggcaagcct gctgtggccg ctctgggtga tttgactgac
     1501 ctgcccacgt atgaacacat ccaggcagcg ctgtccagca gagatgggcg cctgcccaga
     1561 acataccggc tgttccggta gagccctcca gggcaggctg cagagtgctt ctgtgcatgt
     1621 tactgttggt gtggacactg cataagaata gctagctctg tgaacagtgc caacagggaa
     1681 gctctggaaa cttgaatgaa agttactgtt gccactgcac ctttgtgtct ctcaaacacc
     1741 aagtggcttg ttcttcatct
//
