LOCUS       NM_017037               1817 bp    mRNA    linear   ROD 03-MAY-2024
DEFINITION  Rattus norvegicus peripheral myelin protein 22 (Pmp22), transcript
            variant 3, mRNA.
ACCESSION   NM_017037
VERSION     NM_017037.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Shen,Y., Cheng,Z., Chen,S., Zhang,Y., Chen,Q. and Yi,S.
  TITLE     Dysregulated miR-29a-3p/PMP22 Modulates Schwann Cell Proliferation
            and Migration During Peripheral Nerve Regeneration
  JOURNAL   Mol Neurobiol 59 (2), 1058-1072 (2022)
   PUBMED   34837628
  REMARK    GeneRIF: Dysregulated miR-29a-3p/PMP22 Modulates Schwann Cell
            Proliferation and Migration During Peripheral Nerve Regeneration.
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Gautier,B., Hajjar,H., Soares,S., Berthelot,J., Deck,M., Abbou,S.,
            Campbell,G., Ceprian,M., Gonzalez,S., Fovet,C.M., Schutza,V.,
            Jouvenel,A., Rivat,C., Zerah,M., Francois,V., Le Guiner,C.,
            Aubourg,P., Fledrich,R. and Tricaud,N.
  TITLE     AAV2/9-mediated silencing of PMP22 prevents the development of
            pathological features in a rat model of Charcot-Marie-Tooth disease
            1 A
  JOURNAL   Nat Commun 12 (1), 2356 (2021)
   PUBMED   33883545
  REMARK    GeneRIF: AAV2/9-mediated silencing of PMP22 prevents the
            development of pathological features in a rat model of
            Charcot-Marie-Tooth disease 1 A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Pantera,H., Moran,J.J., Hung,H.A., Pak,E., Dutra,A. and Svaren,J.
  TITLE     Regulation of the neuropathy-associated Pmp22 gene by a distal
            super-enhancer
  JOURNAL   Hum Mol Genet 27 (16), 2830-2839 (2018)
   PUBMED   29771329
  REMARK    GeneRIF: Our data show a significant decrease in Pmp22 transcript
            expression using allele-specific internal controls. Moreover, the
            P2 promoter of the Pmp22 gene, which is used in other cell types,
            is affected, but we find that the Schwann cell-specific P1 promoter
            is disproportionately more sensitive to loss of the super-enhancer.
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Poitelon,Y., Matafora,V., Silvestri,N., Zambroni,D., McGarry,C.,
            Serghany,N., Rush,T., Vizzuso,D., Court,F.A., Bachi,A., Wrabetz,L.
            and Feltri,M.L.
  TITLE     A dual role for Integrin alpha6beta4 in modulating hereditary
            neuropathy with liability to pressure palsies
  JOURNAL   J Neurochem 145 (3), 245-257 (2018)
   PUBMED   29315582
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Lee,J.S., Chang,E.H., Koo,O.J., Jwa,D.H., Mo,W.M., Kwak,G.,
            Moon,H.W., Park,H.T., Hong,Y.B. and Choi,B.O.
  TITLE     Pmp22 mutant allele-specific siRNA alleviates demyelinating
            neuropathic phenotype in vivo
  JOURNAL   Neurobiol Dis 100, 99-107 (2017)
   PUBMED   28108290
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Dieperink,M.E., O'Neill,A., Magnoni,G., Wollmann,R.L.,
            Heinrikson,R.L., Zucher-Neely,H.A. and Stefansson,K.
  TITLE     SAG: a Schwann cell membrane glycoprotein
  JOURNAL   J Neurosci 12 (6), 2177-2185 (1992)
   PUBMED   1376775
REFERENCE   7  (bases 1 to 1817)
  AUTHORS   Snipes,G.J., Suter,U., Welcher,A.A. and Shooter,E.M.
  TITLE     Characterization of a novel peripheral nervous system myelin
            protein (PMP-22/SR13)
  JOURNAL   J Cell Biol 117 (1), 225-238 (1992)
   PUBMED   1556154
REFERENCE   8  (bases 1 to 1817)
  AUTHORS   Welcher,A.A., De Leon,M., Suter,U., Snipes,G.J., Meakin,S.O. and
            Shooter,E.M.
  TITLE     Isolation of transcriptionally regulated sequences associated with
            neuronal and non-neuronal cell interactions
  JOURNAL   Prog Brain Res 94, 163-176 (1992)
   PUBMED   1287719
  REMARK    Review article
REFERENCE   9  (bases 1 to 1817)
  AUTHORS   Spreyer,P., Kuhn,G., Hanemann,C.O., Gillen,C., Schaal,H., Kuhn,R.,
            Lemke,G. and Muller,H.W.
  TITLE     Axon-regulated expression of a Schwann cell transcript that is
            homologous to a 'growth arrest-specific' gene
  JOURNAL   EMBO J 10 (12), 3661-3668 (1991)
   PUBMED   1935894
REFERENCE   10 (bases 1 to 1817)
  AUTHORS   Welcher,A.A., Suter,U., De Leon,M., Snipes,G.J. and Shooter,E.M.
  TITLE     A myelin protein is encoded by the homologue of a growth
            arrest-specific gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 7195-7199 (1991)
   PUBMED   1714591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017037.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X62431.1, SRR26643298.61156.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000010.1  48294932-48295099
            169-285             JAXUCZ010000010.1  48299023-48299139
            286-385             JAXUCZ010000010.1  48300406-48300505
            386-526             JAXUCZ010000010.1  48318088-48318228
            527-1817            JAXUCZ010000010.1  48323650-48324940
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..1817
                     /gene="Pmp22"
                     /gene_synonym="Gas-3"
                     /note="peripheral myelin protein 22"
                     /db_xref="GeneID:24660"
                     /db_xref="RGD:3359"
     exon            1..168
                     /gene="Pmp22"
                     /gene_synonym="Gas-3"
                     /inference="alignment:Splign:2.1.0"
     exon            169..285
                     /gene="Pmp22"
                     /gene_synonym="Gas-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..690
                     /gene="Pmp22"
                     /gene_synonym="Gas-3"
                     /note="SAG; PMP-22; SR13 myelin protein; schwann cell
                     membrane glycoprotein"
                     /codon_start=1
                     /product="peripheral myelin protein 22"
                     /protein_id="NP_058733.2"
                     /db_xref="GeneID:24660"
                     /db_xref="RGD:3359"
                     /translation="MLLLLLGILFLHIAVLVLLFVSTIVSQWLVGNGHRTDLWQNCTT
                     SALGAVQHCYSSSVSEWLQSVQATMILSVIFSVLSLFLFFCQLFTLTKGGRFYITGVF
                     QILAGLCVMSAAAIYTVRHSEWHVNNDYSYGFAYILAWVAFPLALLSGIIYVILRKRE
                     "
     exon            286..385
                     /gene="Pmp22"
                     /gene_synonym="Gas-3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..526
                     /gene="Pmp22"
                     /gene_synonym="Gas-3"
                     /inference="alignment:Splign:2.1.0"
     exon            527..1817
                     /gene="Pmp22"
                     /gene_synonym="Gas-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttacaggg agctccacca gagaacatct cagggagcct ggctggaagc agcagagctc
       61 cgagtctggt ctgctgtgag catccgctgt cctgcgggga gggctcccat ccctggctct
      121 cgattgcaaa gaaatccaag cggaggaagg gcgtacacca ttggtctggc accgctccac
      181 cgagcccgag cccaactccc agccaccatg cttctactct tgttggggat cctgttcctt
      241 cacatcgcgg tgctagtgtt gctcttcgtc tccaccatcg tcagccaatg gctcgtgggc
      301 aatggacaca ggactgatct ctggcagaac tgtaccacat ccgccttggg agccgtccag
      361 cactgctact cctcatctgt gagcgaatgg cttcagtctg tccaggccac catgatcctg
      421 tctgtcatct tcagcgtcct gtccctgttc ctgttcttct gccagctctt cactctcacc
      481 aaaggcggcc gcttttacat cactggagtc ttccaaatcc ttgctggtct gtgtgtgatg
      541 agtgcagcgg ccatctacac agtgagacac agtgagtggc atgtcaacaa cgactactcc
      601 tatggctttg cttacatcct ggcctgggtg gctttcccgc tggccctcct tagtggcatc
      661 atctacgtga tcctgcggaa acgcgaatga ggcgcccgac gcaccatccg tctaggctct
      721 gagcgtgcat agggtacaca gggagggagg aaggaaacca gaaaaccaaa ccaaccaacc
      781 caaaagagct agcccccaaa cccaaacgca agccaaacca aacagaacac agttgagtgg
      841 ggattgctgt cgattgaaga tgtatataat atctatggtt tataaaacct atttataaca
      901 ctttttacat acatgtacat aggattgttt gctttttatg ttgaccgtca gcctcgtgtt
      961 gaatcttaaa cgactctaca tcctaacact ataaccaagc tcagtatttt cgttttgttt
     1021 cgtttttttc atctttttgt tttgctcaga cataaaaaaa aaaaatccac gtggccccct
     1081 ttcatctgaa agcagatccc tccctcccat tcaacctcat aggataacca aagtgcgggg
     1141 acaaacccca gatggccaga ggccttcaca ctatgggtga cccagtgaat ttagcaggaa
     1201 taatccgctg cccgaatcaa tgtgtgaagc cctaagcact cacagacgaa acgccctgac
     1261 cagagccctc tgcgaaacca atagctggtg gctgcggaac acttgaccct gaaggcggag
     1321 tactggggcc acatgtttaa atgagacgtc agagacaagc aatctgtgaa atggtgctat
     1381 agatttacca ttccttgtta ttactaatca tttaaaccac tcactggaaa ctcaattaac
     1441 agttttatga cctacagcag aacagagacc cgatacaaac ggttcgtaac tgctttcgta
     1501 catagctagg ctgttgttat tactacaata aataaatctc aaagccttcg tcactcccac
     1561 agttttctca cggtcggagc atcaggacga gcgtctagac ccttgggact agcaaattcc
     1621 ctggctttct gggtctagag tgttctgtgc ctccaaggac tgtctagcga tgacttgtat
     1681 tggccaccaa ctgtagatgt atatacggtg tccttctgat gctaagactc cagacctttc
     1741 ttggttttgc ttgctttttc tgattttata ccaactgtgt ggactaagat gcattaaaat
     1801 aaacatcaga gtaactc
//
