LOCUS       NM_001106973            1841 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus phosphomannomutase 2 (Pmm2), mRNA.
ACCESSION   NM_001106973 XM_001078730 XM_220141
VERSION     NM_001106973.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Cromphout K, Keldermans L, Snellinx A, Collet JF, Grunewald S, De
            Geest N, Sciot R, Vanschaftingen E, Jaeken J, Matthijs G and
            Hartmann D.
  TITLE     Tissue distribution of the murine phosphomannomutases Pmm1 and Pmm2
            during brain development
  JOURNAL   Eur J Neurosci 22 (4), 991-996 (2005)
   PUBMED   16115222
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Bjursell C, Erlandson A, Nordling M, Nilsson S, Wahlstrom J,
            Stibler H, Kristiansson B and Martinsson T.
  TITLE     PMM2 mutation spectrum, including 10 novel mutations, in a large
            CDG type 1A family material with a focus on Scandinavian families
  JOURNAL   Hum Mutat 16 (5), 395-400 (2000)
   PUBMED   11058896
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Kondo I, Mizugishi K, Yoneda Y, Hashimoto T, Kuwajima K, Yuasa I,
            Shigemoto K and Kuroda Y.
  TITLE     Missense mutations in phosphomannomutase 2 gene in two Japanese
            families with carbohydrate-deficient glycoprotein syndrome type 1
  JOURNAL   Clin Genet 55 (1), 50-54 (1999)
   PUBMED   10066032
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474017.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001078730.1, XM_220141.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168922.1, FQ148930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1841
                     /gene="Pmm2"
                     /note="phosphomannomutase 2"
                     /db_xref="GeneID:302915"
                     /db_xref="RGD:1309366"
     exon            1..118
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..793
                     /gene="Pmm2"
                     /EC_number="5.4.2.8"
                     /codon_start=1
                     /product="phosphomannomutase 2"
                     /protein_id="NP_001100443.1"
                     /db_xref="GeneID:302915"
                     /db_xref="RGD:1309366"
                     /translation="MATLCLFDMDGTLTAPRQKITKEMDGFLQKLRQKTKIGVVGGSD
                     FEKLQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCKQNIQGHLGEAVIQDLINYCLSY
                     IAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKEHIRQKFVADLRKE
                     FAGKGLTFSIGGQISFDVFPDGWDKRYCLRHLEQAGYKTIYFFGDKTMPGGNDHEIFT
                     DPRTVGYTVTAPEDTRRICEELFP"
     exon            119..230
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..307
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..399
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..499
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..575
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..691
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..831
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1841
                     /gene="Pmm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggagcgg acccggaagt tccgggtgga gttccgggtg ccaacgagtc ttctgactgg
       61 agaaatggcc acgctctgtc tctttgacat ggatgggacc ttgactgccc cgcggcagaa
      121 aattacaaaa gaaatggatg gctttcttca aaaattgaga cagaagacca agattggagt
      181 ggtaggtggg tcagattttg agaagctgca agagcaactg ggaaatgatg tggttgagaa
      241 atacgattat gtgtttccag agaatggctt ggtagcgtac aaagatggga agctattgtg
      301 taaacagaat attcaaggtc atctggggga ggctgtgatc caagacctga tcaactactg
      361 tctgagctac attgcaaaaa ttaaactccc taagaaaagg ggaactttca ttgaattccg
      421 aaatggcatg ttgaatgtgt cccccattgg aagaagctgc agccaagaag aacgaattga
      481 gttctatgag ctcgataaaa aagaacatat acggcaaaag tttgtagcag acctcaggaa
      541 ggagtttgca gggaaaggcc tcacgttctc cataggcggc cagatcagct ttgatgtgtt
      601 tcctgatggt tgggacaagc gctattgcct gaggcacctg gagcaagctg gctataagac
      661 catttatttc tttggagaca agactatgcc aggtggcaat gaccatgaga tcttcacaga
      721 ccccagaact gtgggctaca cagtgacagc acctgaagac acacgcagga tctgtgagga
      781 gctcttccct taaccgcaga ggaatgcact cctggtcaac aacactgaaa ggggcatcgg
      841 atgatgaaaa cgacaagcca tccagaatca tccatctggg ataggactga agacttccat
      901 gacatgctcc cactctgcag tctgtggtgg aggctggggc atgaccaaag ggctaatgtc
      961 tgttttcaag ccagcttccc atctgtgagc cgcagaccag tgtgatctgc ctgaggtaga
     1021 tggccaagcg acagctgatc ccacagtttg cacctccact ggcttggccg tctctgtttg
     1081 ctacatctga aagccagact gctctcctgt ctccagcagg aggggaagac agaggaccca
     1141 acaaaccaga acctcgctgt ggtcctcttt aacccccaag ctgcccaacc caggtaacag
     1201 acacagttcc tgaggcatca gaggcagctt cgtggtcaca gcaacaggag ctcccagtct
     1261 ccagcctctc agagtgcaca tgcctccccc agaaccttag ggacagcctt ccgtgatcac
     1321 ttcccaggca gagcttctca tgcctgtaaa cggttctgca gcctgactcc tcgtcgggag
     1381 cctccagcca ctgtgtgttt ccattgcact acccttggct gcccacatgg gcacctgctg
     1441 ctggcgcctg cacctctgtc catcccctca ggagagtgcc aggacctcag cctgtggcat
     1501 ccttgggttt tatagcagtg ctgtgaaaca ctacagggac tgtccctctc ttctcagtca
     1561 gatctcttta accctcagtg tctaatgggt gtctacccag gtttgcagag aatttgggtt
     1621 ctgagggcct ctcccggctc tgctctagtg atgctggagc ccctatctgt cctggctgtg
     1681 gcagttccca gccggcccag aggctgcgtg ctacctgcag gtccagtgcc tcctgccatg
     1741 tcaggtggac tccaggcctt gccagttcct acagcggcta tcacagatcc cctcccccac
     1801 tggcttcatt caactgtccc acctaataaa gagcctctgc t
//
