LOCUS       NM_001413584            2268 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus prostate transmembrane protein, androgen induced
            1 (Pmepa1), transcript variant 1, mRNA.
ACCESSION   NM_001413584 XM_006235689
VERSION     NM_001413584.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Xu,X., Hirata,H., Shiraki,M., Kamohara,A., Nishioka,K.,
            Miyamoto,H., Kukita,T. and Kukita,A.
  TITLE     Prostate transmembrane protein androgen induced 1 is induced by
            activation of osteoclasts and regulates bone resorption
  JOURNAL   FASEB J 33 (3), 4365-4375 (2019)
   PUBMED   30557043
  REMARK    GeneRIF: In sites of bone destruction observed in rats with
            adjuvant-induced arthritis, a marked high level of Pmepa1
            expression was associated with the osteoclasts' resorbing bone.
REFERENCE   2  (bases 1 to 2268)
  AUTHORS   Funakubo,N., Xu,X., Kukita,T., Nakamura,S., Miyamoto,H. and
            Kukita,A.
  TITLE     Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in
            osteoclastogenesis
  JOURNAL   J Cell Physiol 233 (4), 3105-3118 (2018)
   PUBMED   28802000
  REMARK    GeneRIF: Pmepa1 is induced by RANK-p38 MAPK pathway signaling.
REFERENCE   3  (bases 1 to 2268)
  AUTHORS   Nakano,N., Maeyama,K., Sakata,N., Itoh,F., Akatsu,R., Nakata,M.,
            Katsu,Y., Ikeno,S., Togawa,Y., Vo Nguyen,T.T., Watanabe,Y., Kato,M.
            and Itoh,S.
  TITLE     C18 ORF1, a novel negative regulator of transforming growth
            factor-beta signaling
  JOURNAL   J Biol Chem 289 (18), 12680-12692 (2014)
   PUBMED   24627487
REFERENCE   4  (bases 1 to 2268)
  AUTHORS   Watanabe,Y., Itoh,S., Goto,T., Ohnishi,E., Inamitsu,M., Itoh,F.,
            Satoh,K., Wiercinska,E., Yang,W., Shi,L., Tanaka,A., Nakano,N.,
            Mommaas,A.M., Shibuya,H., Ten Dijke,P. and Kato,M.
  TITLE     TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad
            proteins from active participation in TGF-beta signaling
  JOURNAL   Mol Cell 37 (1), 123-134 (2010)
   PUBMED   20129061
REFERENCE   5  (bases 1 to 2268)
  AUTHORS   Giannini,G., Ambrosini,M.I., Di Marcotullio,L., Cerignoli,F.,
            Zani,M., MacKay,A.R., Screpanti,I., Frati,L. and Gulino,A.
  TITLE     EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a
            conserved gene family and is overexpressed and amplified in breast
            and ovarian cancer
  JOURNAL   Mol Carcinog 38 (4), 188-200 (2003)
   PUBMED   14639658
REFERENCE   6  (bases 1 to 2268)
  AUTHORS   Xu,L.L., Shi,Y., Petrovics,G., Sun,C., Makarem,M., Zhang,W.,
            Sesterhenn,I.A., McLeod,D.G., Sun,L., Moul,J.W. and Srivastava,S.
  TITLE     PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell
            growth inhibitory function and decreased expression during prostate
            cancer progression
  JOURNAL   Cancer Res 63 (15), 4299-4304 (2003)
   PUBMED   12907594
REFERENCE   7  (bases 1 to 2268)
  AUTHORS   Rae,F.K., Hooper,J.D., Nicol,D.L. and Clements,J.A.
  TITLE     Characterization of a novel gene, STAG1/PMEPA1, upregulated in
            renal cell carcinoma and other solid tumors
  JOURNAL   Mol Carcinog 32 (1), 44-53 (2001)
   PUBMED   11568975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 3, 2022 this sequence version replaced XM_006235689.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.989970.1,
                                           SRR22582416.1583438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               JAXUCZ010000003.1  182478198-182478649 c
            453-610             JAXUCZ010000003.1  182437987-182438144 c
            611-661             JAXUCZ010000003.1  182432045-182432095 c
            662-2268            JAXUCZ010000003.1  182430193-182431799 c
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2268
                     /gene="Pmepa1"
                     /gene_synonym="Tmepai"
                     /note="prostate transmembrane protein, androgen induced 1"
                     /db_xref="GeneID:311676"
                     /db_xref="RGD:1308255"
     exon            1..452
                     /gene="Pmepa1"
                     /gene_synonym="Tmepai"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1186
                     /gene="Pmepa1"
                     /gene_synonym="Tmepai"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane, prostate androgen induced RNA;
                     transmembrane prostate androgen-induced protein"
                     /codon_start=1
                     /product="protein TMEPAI isoform 1"
                     /protein_id="NP_001400513.1"
                     /db_xref="GeneID:311676"
                     /db_xref="RGD:1308255"
                     /translation="MGVNGTAAAAAAGQPNVSCACNCQRSLFPSMEITELEFVQIVVI
                     VVVMMVMVVMITCLLSHYKLSARSFISRHSQARRRDDGGLSSEGCLWPSESTVSGGMP
                     EPQVYAPPRPTDRLAVPPFVQRSRFQPTYPYLQHEIALPPTISLSDGEEPPPYQGPCT
                     LQLRDPEQQLELNRESVRAPPNRTIFDSDLIDSSMLGGPCPPSSNSGISATCYSSGGR
                     MEGPPPTYSEVIGHYPGSSFQQHQQSNGQSSLLEGTRLHHPHIAPLENKEKEKQKGHP
                     L"
     exon            453..610
                     /gene="Pmepa1"
                     /gene_synonym="Tmepai"
                     /inference="alignment:Splign:2.1.0"
     exon            611..661
                     /gene="Pmepa1"
                     /gene_synonym="Tmepai"
                     /inference="alignment:Splign:2.1.0"
     exon            662..2268
                     /gene="Pmepa1"
                     /gene_synonym="Tmepai"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagaccgt ctgcctgcct ccgaccgcgg gcgcgcggcg caacccgatc tccttggact
       61 tgaatgagga gcaggcggcg gcgctcagct gcggatcggc cggcgcgcag gctgagcccg
      121 gcggccccgc gccccggccg cccgcccgtg ccccgcacgc cgcccgcggc cacggcccgc
      181 cgccccgggg ctcccgctcg gcggccgggg gacccagctc gccccgggga cctcggcggc
      241 gccccgagcc cgcgccgcgc tgctcgctgt atgcggggcc cgagccccgc gcgccggccg
      301 gagccgcccc cgcgccccgc gcctcgcgcc ccgcgccgcc cgtgaccgct tgatgggggt
      361 caacggcacc gccgccgcag ccgccgccgg gcagcccaat gtctcctgcg cgtgcaactg
      421 ccagcgctct ttgttcccca gcatggagat cacggagctg gagttcgtgc agatcgtggt
      481 catcgtggtc gtgatgatgg tgatggtggt gatgatcacg tgcctgctga gccactacaa
      541 gctgtcagcc cgctccttca tcagccgaca cagccaggcc cggaggagag acgacggagg
      601 actgtcctcg gaaggatgcc tctggccgtc ggagagcacg gtgtcaggcg gaatgccgga
      661 gccacaggtc tatgccccac ctcggcccac tgaccgcctc gctgtgcccc ccttcgtcca
      721 gcggagccgt ttccagccca cctaccccta cctgcagcac gaaattgccc tgccacccac
      781 catctcgctg tctgatgggg aggagccccc accctaccag ggcccctgca ccctccagtt
      841 acgggacccg gagcaacagc tggagctgaa ccgagagtct gtgcgcgcgc cccccaaccg
      901 gaccatcttc gacagtgacc tcatagacag cagcatgctg gggggcccct gtccccccag
      961 cagtaactcc ggcatcagcg ctacctgcta tagcagcggc gggcgcatgg aggggcctcc
     1021 tcccacctac agtgaggtca ttggtcacta cccgggctcc tccttccagc agcaccagca
     1081 aagtaacggg cagtcctccc tgctagaagg gacccggctc catcaccctc acattgcccc
     1141 actggagaac aaggagaagg agaaacagaa aggtcaccct ctctaggagc gggggcctgg
     1201 ggcacctcta ggcaaaaccg caaaaaagaa aaaaaaacac tccgcacttc ttaagagaga
     1261 agagagagga aggcagggga cacacaggct gtaaggcgtg tgctagttct ccggtctgtg
     1321 tataaatatt tacatgttct gtgtggtctg aatgcagaag ctcagaaagc ttgcaaaaaa
     1381 agaaagaaaa gaaagaaaga aagaaagata gaaagaaaga aagaaagaaa gaaagaaaga
     1441 aagaaagaaa gaaagaaaga aagaaagaaa aaatgaaaaa gataccatgt ttctttgttg
     1501 agccctgtct tggaggcaaa agagaaaatg ctccaccagt cttttcttca ttgttcttag
     1561 ttgagctctg tgcgtgaatg cttaactcct tttgtttatg aaggttttac ttaactttaa
     1621 agacatattt gcacaaaacc tttgtttaag atctgcaata ttatatatat atataaatat
     1681 atataaaata agagactctg tatgtgggag agcaggagta tttttgtatt agaagaggcc
     1741 tattcaaaaa aaaagttgtt ttctgaacta gaagagaaaa aaaatggcaa ttttttgagt
     1801 gccaactctg aaagtgtgta ttaccttgta aagaaaaaaa gaccctacaa agcaggggtt
     1861 tagagctatt tatataaatg ttgatatttt gcactatttt ttaatataat atatcagtgc
     1921 ttgtttgatg gaaacgtcta gagagtgtgt tgagacttgg agaaatgttg agtttcagtc
     1981 tgaacagagc agcagggggg gtgtcccccc actcccccac ccccaccccg gggctcagag
     2041 gaccccccca ctgtgcagga aagccaggct ccccagggcc atgctcctgc aagccaatgg
     2101 atgcttctgt ccagacaggc tgtgaacagt tacacattcc ctgccgaagg ggacccatgt
     2161 cgtcgtccct ctgggttaca gctgagacag gaccgccggc ccccgccccc tccccacgga
     2221 ggcacccagt tcctttccca atatgaaaat aaactgttac tgaaggaa
//
