LOCUS       NM_012625                745 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus pro-melanin-concentrating hormone (Pmch), mRNA.
ACCESSION   NM_012625
VERSION     NM_012625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 745)
  AUTHORS   Ruiz-Viroga,V., de Ceglia,M., Morelli,L., Castano,E.M., Calvo,E.B.,
            Suarez,J., Rodriguez de Fonseca,F., Galeano,P. and Lagos,P.
  TITLE     Acute intrahippocampal administration of melanin-concentrating
            hormone impairs memory consolidation and decreases the expression
            of MCHR-1 and TrkB receptors
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 123, 110703 (2023)
   PUBMED   36565982
  REMARK    GeneRIF: Acute intrahippocampal administration of
            melanin-concentrating hormone impairs memory consolidation and
            decreases the expression of MCHR-1 and TrkB receptors.
REFERENCE   2  (bases 1 to 745)
  AUTHORS   Kokay,I.C., Grattan,D.R. and Murray,J.F.
  TITLE     Prolactin maintains transient melanin-concentrating hormone
            expression in the medial preoptic area during established lactation
  JOURNAL   J Neuroendocrinol 32 (2), e12827 (2020)
   PUBMED   31917877
  REMARK    GeneRIF: Prolactin maintains transient melanin-concentrating
            hormone expression in the medial preoptic area during established
            lactation.
REFERENCE   3  (bases 1 to 745)
  AUTHORS   Noble,E.E., Wang,Z., Liu,C.M., Davis,E.A., Suarez,A.N., Stein,L.M.,
            Tsan,L., Terrill,S.J., Hsu,T.M., Jung,A.H., Raycraft,L.M.,
            Hahn,J.D., Darvas,M., Cortella,A.M., Schier,L.A., Johnson,A.W.,
            Hayes,M.R., Holschneider,D.P. and Kanoski,S.E.
  TITLE     Hypothalamus-hippocampus circuitry regulates impulsivity via
            melanin-concentrating hormone
  JOURNAL   Nat Commun 10 (1), 4923 (2019)
   PUBMED   31664021
  REMARK    GeneRIF: A hypothalamus to telencephalon neural pathway for
            regulating impulsivity involved communication from
            melanin-concentrating hormone (MCH)-expressing lateral hypothalamic
            neurons to the ventral hippocampus subregion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 745)
  AUTHORS   Costa,H.C., Da-Silva,J.M., Diniz,G.B., Motta-Teixeira,L.C.,
            Da-Silva,R.J., Battagello,D.S., Sita,L.V., de-Moraes Machado,C.,
            Horta-Junior,J.A.C. and Bittencourt,J.C.
  TITLE     Characterisation and origins of melanin-concentrating hormone
            immunoreactive fibres of the posterior lobe of the pituitary and
            median eminence during lactation in the Long-Evans rat
  JOURNAL   J Neuroendocrinol 31 (9), e12723 (2019)
   PUBMED   31034718
  REMARK    GeneRIF: Characterisation and origins of melanin-concentrating
            hormone immunoreactive fibres of the posterior lobe of the
            pituitary and median eminence during lactation in the Long-Evans
            rat.
REFERENCE   5  (bases 1 to 745)
  AUTHORS   Ferreira,J.G.P., Duarte,J.C.G., Diniz,G.B. and Bittencourt,J.C.
  TITLE     Litter size determines the number of melanin-concentrating hormone
            neurons in the medial preoptic area of Sprague Dawley lactating
            dams
  JOURNAL   Physiol Behav 181, 75-79 (2017)
   PUBMED   28867197
  REMARK    GeneRIF: results show that the number of Melanin Concentrating
            hormone-immunoreactive neurons in the Medial Preoptic Area is
            positively correlated with the number of pups in the litter and
            that artificially reducing the number of pups can also decrease the
            number of MCH-immunoreactive neurons in the MPOA.
REFERENCE   6  (bases 1 to 745)
  AUTHORS   Takahashi,K., Suzuki,H., Totsune,K., Murakami,O., Satoh,F.,
            Sone,M., Sasano,H., Mouri,T. and Shibahara,S.
  TITLE     Melanin-concentrating hormone in human and rat
  JOURNAL   Neuroendocrinology 61 (5), 493-498 (1995)
   PUBMED   7617126
REFERENCE   7  (bases 1 to 745)
  AUTHORS   Parkes,D. and Vale,W.
  TITLE     Secretion of melanin-concentrating hormone and neuropeptide-EI from
            cultured rat hypothalamic cells
  JOURNAL   Endocrinology 131 (4), 1826-1831 (1992)
   PUBMED   1327720
REFERENCE   8  (bases 1 to 745)
  AUTHORS   Thompson,R.C. and Watson,S.J.
  TITLE     Nucleotide sequence and tissue-specific expression of the rat
            melanin concentrating hormone gene
  JOURNAL   DNA Cell Biol 9 (9), 637-645 (1990)
   PUBMED   2261081
REFERENCE   9  (bases 1 to 745)
  AUTHORS   Nahon,J.L., Presse,F., Bittencourt,J.C., Sawchenko,P.E. and Vale,W.
  TITLE     The rat melanin-concentrating hormone messenger ribonucleic acid
            encodes multiple putative neuropeptides coexpressed in the
            dorsolateral hypothalamus
  JOURNAL   Endocrinology 125 (4), 2056-2065 (1989)
   PUBMED   2477226
REFERENCE   10 (bases 1 to 745)
  AUTHORS   Vaughan,J.M., Fischer,W.H., Hoeger,C., Rivier,J. and Vale,W.
  TITLE     Characterization of melanin-concentrating hormone from rat
            hypothalamus
  JOURNAL   Endocrinology 125 (3), 1660-1665 (1989)
   PUBMED   2759038
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012625.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214578.1, M29712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840118
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000007.1  24399404-24399709
            307-505             JAXUCZ010000007.1  24400030-24400228
            506-745             JAXUCZ010000007.1  24400481-24400720
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..745
                     /gene="Pmch"
                     /note="pro-melanin-concentrating hormone"
                     /db_xref="GeneID:24659"
                     /db_xref="RGD:3358"
     exon            1..306
                     /gene="Pmch"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..555
                     /gene="Pmch"
                     /note="pro-MCH"
                     /codon_start=1
                     /product="pro-MCH precursor"
                     /protein_id="NP_036757.2"
                     /db_xref="GeneID:24659"
                     /db_xref="RGD:3358"
                     /translation="MAKMSLSSYMLMLAFSLFSHGILLSASKSIRNVEDDIVFNTFRM
                     GKAFQKEDTAERSVVAPSLEGYKNDESGFMKDEDDKTTKNTGSKQNLVTHGLPLSLAV
                     KPYLALKGPAVFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYR
                     PCWQV"
     exon            307..505
                     /gene="Pmch"
                     /inference="alignment:Splign:2.1.0"
     exon            506..745
                     /gene="Pmch"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagagtgt ggcattctcc ccacattctc cttcggcttt acggagcagc aaacaggatg
       61 gcgaagatga gcctctcttc ctacatgtta atgctggcct tttctttgtt ttctcacggc
      121 attttacttt cggcctccaa gtccatcagg aacgtagaag acgacatagt atttaataca
      181 ttcaggatgg ggaaagcctt tcagaaggaa gataccgcag aaagatcggt tgttgctcct
      241 tctctggaag gatacaaaaa tgatgagagc ggcttcatga aggatgaaga tgacaagacc
      301 acaaagaaca caggctccaa gcagaatctc gtaactcacg gtctgcccct cagtctggct
      361 gtaaaacctt acctcgctct gaaaggacca gcagtcttcc cagctgagaa tggagttcag
      421 aatactgagt ccacacagga aaagagggaa attggggatg aagaaaactc agctaaattt
      481 cccataggaa ggagagattt tgacatgctc aggtgtatgc tgggacgagt ctaccgaccc
      541 tgttggcaag tctgatacct gctggtccac aacatccttt cagaagaaaa cgattcattg
      601 caagtggaga gaaaagccct taatgttgat gtaacttgtg tatcatccta aatgtctgtt
      661 ttaaaagaaa ctggttacaa tatgtaaatg ctatgtaaat gatatgcttt gacttgtgca
      721 ttaaacttca caaaaattct gcata
//
