LOCUS       NM_001008385            2745 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus phorbol-12-myristate-13-acetate-induced protein 1
            (Pmaip1), mRNA.
ACCESSION   NM_001008385 XM_579188
VERSION     NM_001008385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2745)
  AUTHORS   Gao,Y., Huang,A., Zhao,Y. and Du,Y.
  TITLE     PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway
            in osteoporosis
  JOURNAL   Hum Cell 37 (4), 1024-1038 (2024)
   PUBMED   38691334
  REMARK    GeneRIF: PMAIP1 regulates autophagy in osteoblasts via the
            AMPK/mTOR pathway in osteoporosis.
REFERENCE   2  (bases 1 to 2745)
  AUTHORS   Miura,R., Mimura,I., Saigusa,H., Yamazaki,T., Tanemoto,F.,
            Kurata,Y., Sato,D., Tanaka,T. and Nangaku,M.
  TITLE     Chromatin remodeling factor, INO80, inhibits PMAIP1 in renal
            tubular cells via exchange of histone variant H2A.Z. for H2A
  JOURNAL   Sci Rep 13 (1), 13235 (2023)
   PUBMED   37580530
  REMARK    GeneRIF: Chromatin remodeling factor, INO80, inhibits PMAIP1 in
            renal tubular cells via exchange of histone variant H2A.Z. for H2A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2745)
  AUTHORS   Su,D., Guan,L., Gao,Q., Li,Q., Shi,C., Liu,Y., Sun,L., Lu,C., Ma,X.
            and Zhao,J.
  TITLE     ROCK1/p53/NOXA signaling mediates cardiomyocyte apoptosis in
            response to high glucose in vitro and vivo
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (4), 936-946 (2017)
   PUBMED   28131915
  REMARK    GeneRIF: These findings reveal a novel regulatory mechanism of
            ROCK1/p53/NOXA signaling in modulating cardiomyocyte apoptosis in
            vitro and maternal diabetes-induced congenital heart defects in
            vivo.
REFERENCE   4  (bases 1 to 2745)
  AUTHORS   Ishihara,Y. and Shimamoto,N.
  TITLE     Sulfaphenazole attenuates myocardial cell apoptosis accompanied
            with cardiac ischemia-reperfusion by suppressing the expression of
            BimEL and Noxa
  JOURNAL   J Pharmacol Sci 119 (3), 251-259 (2012)
   PUBMED   22785021
  REMARK    GeneRIF: The expression levels of BimEL and Noxa were elevated 3 h
            after reperfusion.
REFERENCE   5  (bases 1 to 2745)
  AUTHORS   Lin,C.L., Tseng,H.C., Chen,R.F., Chen,W.P., Su,M.J., Fang,K.M. and
            Wu,M.L.
  TITLE     Intracellular zinc release-activated ERK-dependent GSK-3beta-p53
            and Noxa-Mcl-1 signaling are both involved in cardiac
            ischemic-reperfusion injury
  JOURNAL   Cell Death Differ 18 (10), 1651-1663 (2011)
   PUBMED   21660051
  REMARK    GeneRIF: Intracellular zinc release-activated ERK-dependent
            GSK-3beta-p53 and Noxa-Mcl-1 signaling are both involved in cardiac
            ischemic-reperfusion injury.
REFERENCE   6  (bases 1 to 2745)
  AUTHORS   Seo,Y.W., Shin,J.N., Ko,K.H., Cha,J.H., Park,J.Y., Lee,B.R.,
            Yun,C.W., Kim,Y.M., Seol,D.W., Kim,D.W., Yin,X.M. and Kim,T.H.
  TITLE     The molecular mechanism of Noxa-induced mitochondrial dysfunction
            in p53-mediated cell death
  JOURNAL   J Biol Chem 278 (48), 48292-48299 (2003)
   PUBMED   14500711
REFERENCE   7  (bases 1 to 2745)
  AUTHORS   Villunger,A., Michalak,E.M., Coultas,L., Mullauer,F., Bock,G.,
            Ausserlechner,M.J., Adams,J.M. and Strasser,A.
  TITLE     p53- and drug-induced apoptotic responses mediated by BH3-only
            proteins puma and noxa
  JOURNAL   Science 302 (5647), 1036-1038 (2003)
   PUBMED   14500851
REFERENCE   8  (bases 1 to 2745)
  AUTHORS   Shibue,T., Takeda,K., Oda,E., Tanaka,H., Murasawa,H., Takaoka,A.,
            Morishita,Y., Akira,S., Taniguchi,T. and Tanaka,N.
  TITLE     Integral role of Noxa in p53-mediated apoptotic response
  JOURNAL   Genes Dev 17 (18), 2233-2238 (2003)
   PUBMED   12952892
REFERENCE   9  (bases 1 to 2745)
  AUTHORS   Jansson,A.K., Emterling,A.M., Arbman,G. and Sun,X.F.
  TITLE     Noxa in colorectal cancer: a study on DNA, mRNA and protein
            expression
  JOURNAL   Oncogene 22 (30), 4675-4678 (2003)
   PUBMED   12879012
REFERENCE   10 (bases 1 to 2745)
  AUTHORS   Oda,E., Ohki,R., Murasawa,H., Nemoto,J., Shibue,T., Yamashita,T.,
            Tokino,T., Taniguchi,T. and Tanaka,N.
  TITLE     Noxa, a BH3-only member of the Bcl-2 family and candidate mediator
            of p53-induced apoptosis
  JOURNAL   Science 288 (5468), 1053-1058 (2000)
   PUBMED   10807576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Oct 7, 2022 this sequence version replaced NM_001008385.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.38030.1,
                                           SRR26643290.51835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JAXUCZ010000018.1  62255970-62256188
            220-381             JAXUCZ010000018.1  62257973-62258134
            382-2745            JAXUCZ010000018.1  62260021-62262384
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2745
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /note="phorbol-12-myristate-13-acetate-induced protein 1"
                     /db_xref="GeneID:492821"
                     /db_xref="RGD:1359266"
     exon            1..219
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..485
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /note="protein Noxa"
                     /codon_start=1
                     /product="phorbol-12-myristate-13-acetate-induced protein
                     1"
                     /protein_id="NP_001008386.1"
                     /db_xref="GeneID:492821"
                     /db_xref="RGD:1359266"
                     /translation="MPGRKARRNAPLNPTRAELPPEFAAQLRKIGDKVYCTWSAPDIT
                     AVLAQMPGKKSRKSTMRRSPSPTRVPADLKDECDQLRRIGDKVNLRQKLLNFISKLFN
                     LIT"
     exon            220..381
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /inference="alignment:Splign:2.1.0"
     exon            382..2745
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatctgagaa gattccaggg ttgctgctgc tttaccgaag ctccgtgcgc ctggctcgag
       61 gcactcgcgg accatctcgc gcagcccaag ctctggggga gccccagagt ccagattggg
      121 gatctaagtc ccctgtacgc agcggagatc gccgcggcgt ttctgagatg cccgggagaa
      181 aggcgcgtcg gaacgcgcca ttgaacccaa cgcgggcaga gttaccgcct gaattcgcag
      241 ctcagctcag gaagattgga gataaagtgt actgcacgtg gagtgcaccg gacataactg
      301 cggttctggc gcagatgcct ggcaagaagt cgcgaaagag cacgatgaga agaagcccaa
      361 gcccaacccg ggtgccagca gacctgaagg acgagtgtga tcaactgcgg agaattggag
      421 acaaagtgaa tttacggcag aaacttctga attttatttc caagctcttc aatttaataa
      481 cctgagtcct tcataaactt ttgcaagaag ggacctccca ggaaggaagt tcccccagtt
      541 ggcgcaaatg tctggtattg aatggactgt gatgagaggg aaacactggc ttgcttttgg
      601 ttccctgagc agggaggggt gatgaaggag acggaaatga gtttcttggg aaagttttcg
      661 gtaatcattc tttgagatgt gataacgtga aaccatgctt atttttattt ttaaaaacaa
      721 gaagagagga gttgtggagg tagggaagta actagtaata atctgtcttt tcagggttgt
      781 tctggtgttt ttgccaaagg ttgtcaagaa taataggagg gggcatgatg agtggttaca
      841 ttgtatgtgg acagacatac aggattgctt tttgacaact ccaggacaat gtactgttta
      901 gctccatcct cataatcttc taagaggaaa catttcattt ttttataaca ctgaatatta
      961 tagtgaaaat tgattttata ggtcactaca agtttaactg tattgtgtct gtttagatga
     1021 cttttaagtg ttactgtaac cgttaactgg agagtatggg gagactaagt aactggggaa
     1081 attagaacta tagcaaagtc cataggtacc agtcttgcag cttgaatagt atgtgataaa
     1141 gtgagagttt ggattttata taacctgaga caatggagaa acaaactttt agaagttgat
     1201 gtaattaaaa cttagtaatt cataggaagt ttttaaaatt ttataacctg ccacagatat
     1261 ttcttagaag tttttttttt tttttttccc ttgtttctgt ttttggagac agggtttctc
     1321 tgagtagccc tggctatcct ggaactcccc ctgtggacca ggctggcctc ggaaatccac
     1381 cagggccttg cgcttcctag gcaagcgctc taccactgag ctaaatcccc aaccccgaaa
     1441 tccacctttc tttacctccc aggtgctggg attaaaggca ggcaccagca tccctgggtg
     1501 cagagtttca ttttaaattt ggcctataaa tgggaaactc agtagcaaat cagtcctggt
     1561 cagcagaggc aagagacttg agtagacttt cccaaaatgc aggtgaccag cagatacatg
     1621 attcagagac gtggaaatga aaaccatcac cagatgattg tctgggtttg cctgttactg
     1681 gaagggaaag atagcaagca gagtaaggac tttttgtata tttttgctag tagcgtaagg
     1741 taggaccttt attttgttaa aaaacagcat tgaggctact ttaattgcta ataaatgaac
     1801 caccttaaac ccagctgtcc caccactgag aaagcacgca aaggtgctaa tccgtctgct
     1861 gattatactt ctgtattctt ttttatctgt atcacacaag acaaggaaac aaccaatcaa
     1921 gggctgaaag gatttttaaa cgtggaaaca gaaacagaaa tgagtcttaa aaggcaggaa
     1981 atgatatttg tcaaaacatg gatgttacat atcccagatg cttcacttgt cacttaaaat
     2041 tttgacagaa gtcaaagtga actgataaga tgattaggga ggaggagtgg gatgtgagaa
     2101 aagggccaat caattttaga ctgaaaactg gaagggtgtt ctgttatttt accctagagg
     2161 tgactacagt tgatgtatac ttgacaataa ctgaaaaggt attgcctgtt ctggccacaa
     2221 ggacttgatg cctaccagaa gttgatgggg tatgctaata actgggggaa tctttcccca
     2281 cagtatccat gtgttgaaac taagcccata agcacgttta atttgtcagt tgactaaaac
     2341 caaaaattgt ccaaaacatt gagaaagtcc ctcacgattg agttttatca ggaatgatat
     2401 ttattttacc tatttataat ttaaatattt tgtttacttt ctgcatgtgt atcagtttta
     2461 tttttgtttt gagacaaggg tctcgtgacc atgggaaggg tgtctgtcat gtggttagtc
     2521 actttggatg aagttacctc agtagttagt gggcctcagc attaaggttg tttactctga
     2581 agtttttttt tttgttgttg ttgttttttt acctgaaggt agacatcttg cccaatgggt
     2641 atttatggtc tgtgactgta tttatatgta tgcttctgaa aactgatact gtagcctcaa
     2701 ctattaaata aaggttgata ctgaagcaac tgttgaaaaa tgcca
//
