LOCUS       NM_001107922            5275 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus peptidase M20 domain containing 2 (Pm20d2), mRNA.
ACCESSION   NM_001107922 XM_001064002 XM_232864
VERSION     NM_001107922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5275)
  AUTHORS   Veiga-da-Cunha,M., Chevalier,N., Stroobant,V., Vertommen,D. and Van
            Schaftingen,E.
  TITLE     Metabolite proofreading in carnosine and homocarnosine synthesis:
            molecular identification of PM20D2 as beta-alanyl-lysine
            dipeptidase
  JOURNAL   J Biol Chem 289 (28), 19726-19736 (2014)
   PUBMED   24891507
  REMARK    GeneRIF: PM20D2 hydrolyzed beta-alanyl-lysine,
            beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and
            gamma-aminobutyryl-ornithine as its best substrates.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001107922.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.12914.1,
                                           SRR26643289.14910.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-666               JAXUCZ010000005.1  52381867-52382532   c
            667-815             JAXUCZ010000005.1  52379879-52380027   c
            816-958             JAXUCZ010000005.1  52375825-52375967   c
            959-1113            JAXUCZ010000005.1  52373562-52373716   c
            1114-1249           JAXUCZ010000005.1  52371154-52371289   c
            1250-1357           JAXUCZ010000005.1  52366516-52366623   c
            1358-5275           JAXUCZ010000005.1  52362384-52366301   c
FEATURES             Location/Qualifiers
     source          1..5275
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..5275
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /note="peptidase M20 domain containing 2"
                     /db_xref="GeneID:313130"
                     /db_xref="RGD:1307853"
     exon            1..666
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1512
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /EC_number="3.4.13.4"
                     /note="aminoacylase 1-like 2; peptidase M20
                     domain-containing protein 2"
                     /codon_start=1
                     /product="xaa-Arg dipeptidase"
                     /protein_id="NP_001101392.2"
                     /db_xref="GeneID:313130"
                     /db_xref="RGD:1307853"
                     /translation="MGPVVERPAERCTSSATELELLKQRAAERIDEAAERLGALSRAI
                     WSAPELAYEEHRAHGELTRFFEREPPAASWAVQPHFGLPTAFRAEWAPPEAAAGPGAL
                     QLAFLCEYDALPALGHACGHNLIAEVGAAAALGLRAALESIAAPPPVKVIVLGTPAEE
                     EGGGKIDLIKAGAFENLDVVFMAHPSQENAAYLPDVAEHDVTVKYYGKASHAAAYPWE
                     GVNALDAAVLAYNNLSALRQQMKPTWRVHGIIKNGGVKPNIIPSYSELLYYFRAPSMK
                     ELHVLTKKAEDSFRAAALATGCTVEIKSEAHDYYNVIPNKTLCSAYMENGKKLGVEFI
                     SEDAVLNGPSGSTDFGNVSFVVPGIHPYFYIGTDALNHTEEYTEAAGSQAAQWYTLRT
                     AKALAMTALDVIFKPQLLEGIRKEFKSKLQEEQLLNTPA"
     exon            667..815
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..958
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1113
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1249
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1357
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..5275
                     /gene="Pm20d2"
                     /gene_synonym="Acy1l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccgaggcg cctagacttg ccgagggctg ctgaggacag ctaagcgttg ccaagagcag
       61 ccaagcgctg ccaaggtgcc gagcattgca taggtctggc aaggactgcc gagcggcgcc
      121 gagcgttgcc gaagactgac aagacagcgg agggccgccg agcgccgccg agccttacaa
      181 agggctgact aggatagacc gtagcacgcc cgtgccatgg gtccggtggt ggagcggccg
      241 gccgagcggt gcacgagcag cgccacggag ctggagctgc tgaagcagcg cgcggccgag
      301 cgcatcgacg aggcggcgga gcgcctgggc gcgctgagcc gcgccatctg gagcgctccc
      361 gagctggcct acgaagagca ccgcgcgcac ggcgagctca cgcgcttctt cgagcgcgag
      421 ccgccggccg cctcgtgggc cgtgcagccg cacttcgggc tccccaccgc cttccgagcg
      481 gagtgggcgc cgcccgaggc cgcggcgggg cccggcgcgc tgcagctggc tttcctgtgc
      541 gagtacgacg cgctgccagc cctgggccac gcctgcggcc acaacctcat cgcggaggtc
      601 ggagcggctg cggcgctcgg cctgcgggct gcgctggaga gcatcgctgc gccgccgccg
      661 gtcaaggtaa ttgtcctggg aacccctgca gaagaagaag gtggtggcaa aattgatcta
      721 atcaaagcgg gtgcttttga aaaccttgat gttgttttta tggctcaccc gtctcaagag
      781 aatgccgcct acctgccgga tgtggccgag catgacgtga ctgtgaaata ctacggaaaa
      841 gcatctcacg ctgctgctta cccttgggag ggggtgaacg ccttggacgc cgccgttctt
      901 gcctataaca acctctctgc gttaagacaa cagatgaaac caacctggag agttcatggt
      961 ataattaaaa acggcggggt caagcccaac atcatcccct cttactctga attactctat
     1021 tacttccgtg cgccctcaat gaaagagctc cacgttctga ccaaaaaggc ggaagattcc
     1081 ttcagagccg cggctttggc tacaggctgc acagtagaaa ttaaaagcga agcccacgat
     1141 tattacaacg ttattccaaa caagacactg tgcagcgcgt atatggagaa tgggaagaag
     1201 ctgggagtag agttcatttc agaagatgca gtgctgaacg gcccttcagg ctccactgat
     1261 tttggaaatg tcagttttgt ggttcccggg attcatccat acttttacat cgggactgat
     1321 gccttgaacc acacggaaga gtacacagaa gccgcaggat cacaggcagc tcagtggtac
     1381 actttgcgca cagccaaggc gctggcgatg actgcactgg acgtcatctt taagcctcag
     1441 ttgctggaag gaatcagaaa ggagtttaaa tcgaaacttc aagaagagca gcttttaaat
     1501 acaccagcat agaaggaaga cttcgggacc gctcaggaaa cattgttttg tttgtttggt
     1561 ttttacctcc attgtttttc aatgaaatag agcagtcttg gtgaggacag gaaataggaa
     1621 agacactatc tcactctaga tttaatggag tctctgatgc ttcaggcact ggtgtgtgat
     1681 accatctgtt aagccagatg atacctgatc tgtaacattt ggaaatgttt tgtaaatgta
     1741 tctgttgtat agtgttacaa gtcccaaagg tcccagaact taacactcat gaactctgtg
     1801 gttcagagta gcgaatgtct tctcaggagt ttagattggg gggaatttat taagtctaac
     1861 tgtatctggg tctaaagaaa aacttataat aaaaatacac tttcagacac tcttagaatt
     1921 tccactacaa agacttagct tttaacactt agagaggaga ggagaaggag gagtgggagg
     1981 ggagggggag gaaaaggggg aaaggaggga gaggaggtga tgctctttat ttacacgcaa
     2041 ttactccaag aagtggcata ggggcaggag agtttttcca gcggggtagg gtgttgtgtg
     2101 ttcttacagg agtaggcagg gtagtacagg ctaggtgtgc tctgatctcc agtgtcctgc
     2161 acggttccca ctacccagca gcccctcagg agagtcccaa agctggccca ggagtaatat
     2221 gaacctgtgg ccttggaaag gaggctctgt agttcagact gtgactcagt taaacttcct
     2281 gagatttctc tggactttct cttttgcctt ctcccctcac tctctggttt gtgtcgccac
     2341 agcatttgta gaaccacaga agacagttgc ttttttctag gtggaaacct gaaacgtcag
     2401 tggttgtcag tagaaacact gtcaacagta actctggtga ggagatgggg agggagtcag
     2461 ttaaagccaa caacgtttcc tgattcttac tttagcatga atttggtttt ggtggggctg
     2521 aatttaagac cagtcttcct ttctgcctct cccctcccgc tctcctctag ctgcagtcct
     2581 gcagctgctg cctcacaaac gctgggatga tagccatgag caccgcacac ccacccttta
     2641 gtgtgaactt gttgcacatg attaaagtgt gaaaaagctg gcgaaaccaa ctcttaggcg
     2701 gttggggcgg cgttctagaa tcaaaagggg aaggacacag ggaacatttg gcttttgtgg
     2761 tggaagcaag gcactctccc tgagtgacgc cagctgtcac ctggaaggct aaccatctgt
     2821 gaccttccag tctctaattc ctatttgatg agtatttcag aactgtgaga ggggttgctc
     2881 ccggctctac cctgacttga tataggccgg cgtttgcttg cttacttgct tttgtgcagc
     2941 tagtatacta agaatagttt ttgcattttt agaggaaaaa taaaaccacc actaccacaa
     3001 agaataaggt atttaccgtc tggccctttg ggggtggggg tggagcgctc gggcccagtc
     3061 tatcaggtgg tttctgattt ctattctctc aggttttctt gagaagcctc aagccctgta
     3121 ttggaaacac ttgagtgtgt agatggggct ccctgacaga gcggtctgga cttcccactc
     3181 tctgctttgt ctttctagac agaagcctgt ttccgctccc ctcaccctgc ccctcaccac
     3241 aagtcctcag acttgcctct gtgcacacta ctctttctgt cttctcataa caacattgag
     3301 aactcgatct ttcatgacac cctgtgtctg gataatcata accgagttca tcatattaaa
     3361 tatgaatttt gtataaagag ggactatcaa tgaaagcctc aatcaaaaca tcagacatgt
     3421 cagagatgcg gtttttattg accgacttaa gtctcctgag tagccgttct atgtgttcct
     3481 cacagcctaa gggatagggg tttttgccga ttgctttagt tttgggtttt gcagggctgg
     3541 atattgagac cagggcttca cacacgcaaa cccagaactc tcgcactgag ctgcatcccc
     3601 agcccggggc agggcgttgg cctcatttgc taggatctgg aaccatccta gaacagctgt
     3661 tgttacagac gtagcccagc ctctgagaat cacacagctg tggctcttat gtgtgccctg
     3721 tgtttggttt cctttttttt ttttttaaac taaaattgaa ttttacttct gcataaacaa
     3781 tgccagcttt aggtaggtaa ggatgggaag gcgctatgtt atctgtgttt ctggttggag
     3841 gctgttgttg tacagtgggc ctcgtctgct cttttatctt tccgtgtgca ccacttacac
     3901 catgtactta cgcatgcctt ctcctaactg tcccctgggg gaggcattaa gtcagtacac
     3961 tctagaacga gtaagtttca ctaatggttt aagtgtaatt acgatctgaa atttattttt
     4021 cttttccaac ttaatcttaa ggaagttcga atacaggacc tgtacagtat gtgttaaagt
     4081 tcctttttcc taaatgcctg agacccgtgg tgtttcagat tttagaataa aaaatgtttt
     4141 gaaatatttg catctattat gtaatctata ttttatacat atatacacat atgtatatac
     4201 atatagggag gggggaagag agatatggaa cccaaataga gctataaaat tcctttatgc
     4261 ttcacacgca cttgccctgt gcacatagct tgagggaaac tgcgctcaat gttttagtgt
     4321 ctgagggtga ccgacctgca gatcatagga ggccagttgt gcggttttca cccgggtcat
     4381 gccattcaag gttggaattc tggagcattt ccggtttcag gttaagtgtg ttcaacccgg
     4441 actgttaact agtaagttgc tgtgtgttct atgactgtag ctaatgttta gcttgcctca
     4501 aattttttga attgattttt agtcttaaat tctccttaat ggatgagcta cacggggaat
     4561 tttcttcttt ttaaccatgt ctctgtagca taattactgg ggtaaagtag actctgcatg
     4621 ttcttgtgag gatgtaaaca tgaaggggac ccacagtctc ccgagggtct gtagattcat
     4681 tgttgctgct gctgttaaac tgtgcagtct caacatctga atgggcaaat attcgcagaa
     4741 cactggagac aggcaaagag caccggaccc tgtgcttggt gctacgtcct cccaggattt
     4801 ggttcatatg gaccacatcc caaactgcct tgggaagttt tgaggaaggg cttctaaaat
     4861 attttaaaac atgtgaatca cttctgtctg tttaaacaga aaaaaaaagt tgatgtcagg
     4921 tcatttttag aagaatagtt ctctcacttt atagtatctt ttttaaagaa agaaaacctt
     4981 tccgagggct tttgtgttct gtgatttcta acttttactt gaagcagtct tctgaagcat
     5041 gtcccacgcc attggactaa ctcgatgggg actgtcctct ctgtgcccat tagcaatctc
     5101 cagtcagcca taagatggga taaactactt tgctactact gtaggcctct gtggtctaac
     5161 agcatagctg aggatggtgt gttcgggtgt gtcagtattt tcaaaagcaa tctctgctat
     5221 tgtgattata attatttttg ttttaataga tgcatattaa aatttgtaga aaaaa
//
