LOCUS       NM_001395052            6741 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus plexin D1 (Plxnd1), mRNA.
ACCESSION   NM_001395052 XM_006237035
VERSION     NM_001395052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6741)
  AUTHORS   Zhou,Y.F., Chen,A.Q., Wu,J.H., Mao,L., Xia,Y.P., Jin,H.J., He,Q.W.,
            Miao,Q.R., Yue,Z.Y., Liu,X.L., Huang,M., Li,Y.N. and Hu,B.
  TITLE     Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by
            regulating endothelial DLL4 and filopodia formation in a rat model
            of ischemic stroke
  JOURNAL   FASEB J 33 (4), 4947-4961 (2019)
   PUBMED   30653356
REFERENCE   2  (bases 1 to 6741)
  AUTHORS   Zhou,Y.F., Li,P.C., Wu,J.H., Haslam,J.A., Mao,L., Xia,Y.P.,
            He,Q.W., Wang,X.X., Lei,H., Lan,X.L., Miao,Q.R., Yue,Z.Y., Li,Y.N.
            and Hu,B.
  TITLE     Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving
            cerebral perfusion and restoring functional loss after stroke in
            aged rats
  JOURNAL   Neurobiol Aging 70, 102-116 (2018)
   PUBMED   30007159
  REMARK    GeneRIF: Study found that depletion of Sema3E/PlexinD1 signaling
            with lentivirus-mediated PlexinD1-specific-shRNA improves tissue
            survival and functional outcome following stroke. Sema3E/PlexinD1
            inhibition not only increases cortical perfusion but also
            ameliorates blood-brain barrier damage.
REFERENCE   3  (bases 1 to 6741)
  AUTHORS   Plein,A., Calmont,A., Fantin,A., Denti,L., Anderson,N.A.,
            Scambler,P.J. and Ruhrberg,C.
  TITLE     Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac
            outflow tract septation
  JOURNAL   J Clin Invest 125 (7), 2661-2676 (2015)
   PUBMED   26053665
REFERENCE   4  (bases 1 to 6741)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (bases 1 to 6741)
  AUTHORS   Tata,A., Stoppel,D.C., Hong,S., Ben-Zvi,A., Xie,T. and Gu,C.
  TITLE     An image-based RNAi screen identifies SH3BP1 as a key effector of
            Semaphorin 3E-PlexinD1 signaling
  JOURNAL   J Cell Biol 205 (4), 573-590 (2014)
   PUBMED   24841563
REFERENCE   6  (bases 1 to 6741)
  AUTHORS   Ding,J.B., Oh,W.J., Sabatini,B.L. and Gu,C.
  TITLE     Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse
            formation in the striatum
  JOURNAL   Nat Neurosci 15 (2), 215-223 (2011)
   PUBMED   22179111
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6741)
  AUTHORS   Zhang,Y., Singh,M.K., Degenhardt,K.R., Lu,M.M., Bennett,J.,
            Yoshida,Y. and Epstein,J.A.
  TITLE     Tie2Cre-mediated inactivation of plexinD1 results in congenital
            heart, vascular and skeletal defects
  JOURNAL   Dev Biol 325 (1), 82-93 (2009)
   PUBMED   18992737
REFERENCE   8  (bases 1 to 6741)
  AUTHORS   Chung,L., Yang,T.L., Huang,H.R., Hsu,S.M., Cheng,H.J. and
            Huang,P.H.
  TITLE     Semaphorin signaling facilitates cleft formation in the developing
            salivary gland
  JOURNAL   Development 134 (16), 2935-2945 (2007)
   PUBMED   17626059
REFERENCE   9  (bases 1 to 6741)
  AUTHORS   Toyofuku,T., Yabuki,M., Kamei,J., Kamei,M., Makino,N., Kumanogoh,A.
            and Hori,M.
  TITLE     Semaphorin-4A, an activator for T-cell-mediated immunity,
            suppresses angiogenesis via Plexin-D1
  JOURNAL   EMBO J 26 (5), 1373-1384 (2007)
   PUBMED   17318185
REFERENCE   10 (bases 1 to 6741)
  AUTHORS   Gitler,A.D., Lu,M.M. and Epstein,J.A.
  TITLE     PlexinD1 and semaphorin signaling are required in endothelial cells
            for cardiovascular development
  JOURNAL   Dev Cell 7 (1), 107-116 (2004)
   PUBMED   15239958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 17, 2022 this sequence version replaced NM_001395052.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.19359.1,
                                           SRR26643290.17588.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1350              JAXUCZ010000004.1  150713838-150715187 c
            1351-1527           JAXUCZ010000004.1  150701165-150701341 c
            1528-1659           JAXUCZ010000004.1  150698981-150699112 c
            1660-1760           JAXUCZ010000004.1  150698692-150698792 c
            1761-1890           JAXUCZ010000004.1  150698479-150698608 c
            1891-2068           JAXUCZ010000004.1  150697137-150697314 c
            2069-2177           JAXUCZ010000004.1  150696937-150697045 c
            2178-2280           JAXUCZ010000004.1  150696523-150696625 c
            2281-2385           JAXUCZ010000004.1  150692990-150693094 c
            2386-2475           JAXUCZ010000004.1  150690681-150690770 c
            2476-2569           JAXUCZ010000004.1  150690389-150690482 c
            2570-2724           JAXUCZ010000004.1  150689794-150689948 c
            2725-2876           JAXUCZ010000004.1  150689133-150689284 c
            2877-2976           JAXUCZ010000004.1  150688463-150688562 c
            2977-3116           JAXUCZ010000004.1  150688242-150688381 c
            3117-3284           JAXUCZ010000004.1  150687807-150687974 c
            3285-3375           JAXUCZ010000004.1  150687635-150687725 c
            3376-3633           JAXUCZ010000004.1  150687201-150687458 c
            3634-3783           JAXUCZ010000004.1  150686958-150687107 c
            3784-3898           JAXUCZ010000004.1  150686303-150686417 c
            3899-4006           JAXUCZ010000004.1  150684572-150684679 c
            4007-4119           JAXUCZ010000004.1  150684383-150684495 c
            4120-4224           JAXUCZ010000004.1  150683710-150683814 c
            4225-4355           JAXUCZ010000004.1  150683188-150683318 c
            4356-4554           JAXUCZ010000004.1  150682782-150682980 c
            4555-4701           JAXUCZ010000004.1  150681125-150681271 c
            4702-4858           JAXUCZ010000004.1  150680841-150680997 c
            4859-4962           JAXUCZ010000004.1  150680333-150680436 c
            4963-5026           JAXUCZ010000004.1  150680193-150680256 c
            5027-5061           JAXUCZ010000004.1  150679731-150679765 c
            5062-5166           JAXUCZ010000004.1  150679409-150679513 c
            5167-5330           JAXUCZ010000004.1  150679043-150679206 c
            5331-5478           JAXUCZ010000004.1  150678039-150678186 c
            5479-5619           JAXUCZ010000004.1  150677143-150677283 c
            5620-5694           JAXUCZ010000004.1  150676576-150676650 c
            5695-6741           JAXUCZ010000004.1  150675377-150676423 c
FEATURES             Location/Qualifiers
     source          1..6741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..6741
                     /gene="Plxnd1"
                     /note="plexin D1"
                     /db_xref="GeneID:312652"
                     /db_xref="RGD:1310796"
     exon            1..1350
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..5811
                     /gene="Plxnd1"
                     /codon_start=1
                     /product="plexin-D1 precursor"
                     /protein_id="NP_001381981.2"
                     /db_xref="GeneID:312652"
                     /db_xref="RGD:1310796"
                     /translation="MAPRAAGGAPPSARAAAAVPLPPRSHSRCPGLLPLPLLLLLGAA
                     RAGALEIQRRFPSPTPTNNFALDGTAGTVYLAAVNRLYQLSGANLSLEAEATVGPVPD
                     SPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVACGSIYQGLCQLRRRGNISA
                     LAVSFPPAAPTAEPVTVFPSMLNVAANHPNASTVGLVLPPASGTGGSRLLVGATYTGY
                     GSAFFPRNRSLEDHRFENTPEISIRSLDARGDLAKLFTFDLNPSDDNILKIKQGAKEQ
                     HKLGFVRAFLHPAVPPHSAHPYAYLALNSEARAGDKDSQARSLLARICLPRGAGGDAK
                     KLTESYIQLGLQCAGGAGRGDLYSRLVSVFPAREQFFAVFERPQGTPGARNAPAALCA
                     FRFADVQAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACESKRNIQLQPEQLDCGAA
                     HLQHPLTILQPLRASPVFRAPGLTAVAVANANNYTAVFLGTATGRLLKISLNESMQVV
                     SRRVLTVAYGEPVHHVMQFDPMDPGYLYLMTSHQMARVKVAACEVHSTCGDCVGAADA
                     YCGWCTLETRCTFKQDCANSSLPHFWTSASEGPSRCPAMTVLPSEIDVHRDYTGMILQ
                     ISGSLPSLSGMEMACDYGNGVRTVARVPGPAYGHQIAYCNLLPRAQFPPFPAGQDHVT
                     VEMSVRVKGHNIVSANFTIYDCSRIGQVYPHTACTSCLSTQWPCSWCIQLHSCVSNQS
                     RCQDSPNPTSPQDCPQIVPSPLAPVPTGGSQDILVPLTKAAFFHGTSLQCSFGLEENF
                     EAVWANDSLVRCNQVVLHTTQKSQVFPLSLKLKGPPDRFLDSPNPMTVVVYNCAMGSP
                     DCSQCLGREDLGHLCVWNDGCRLRGPLQPLSGTCPAPEIRAIEPLSGPLNGGTLLTIR
                     GKNLGRRLSDVAHGVWIGNVACEPLADRYTVSEEIVCATGPAPGAFSDVVTVNVSKEG
                     RSREQFSYVLPRVHSLEPSMGPKAGGTRITIHGSDLNVGSMLQVLVNDTDPCTDLTRT
                     ATSITCTVPRGTLPSPVPVCVRFESRGCVHGNLTFWYMQNPVITAISPGRSPVSGGRT
                     ITVAGERFHMVQNVSMAVHHIGREPTFCKVLNSTLIICPSPGALSNASAPVDFFINGR
                     AYADEAAEELLDPAEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQD
                     SLGLESHEYHIKIGQVSCDIQIISDRVIHCSVNESLGTAEGQLPITIQVGNFNQTIAT
                     LQLGGSETAIVVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIRE
                     EIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSKTL
                     NSQGGSPPQETHPLLGEWNIPEHCRPSMEEGISLFSSLLNNKHFLIVFVHALEQQKDF
                     AVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKML
                     TNWMSICMYGCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLNEEWLLRENIE
                     AKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEW
                     FASSTQSYVLRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLTDKKDNTLGRVKDL
                     DTEKYFHLVLPTDELVEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAIL
                     SIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFD
                     IEKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQI
                     QDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARR
                     TQLQYKFEQVVALMENNIYECYSEA"
     exon            1351..1527
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1659
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1760
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1890
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2068
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2177
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2280
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2385
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2475
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2569
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2724
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2876
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2976
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3116
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3284
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3375
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3633
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3783
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3898
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3899..4006
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4119
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4224
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4355
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4356..4554
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4555..4701
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4702..4858
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4859..4962
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            4963..5026
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5061
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5166
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5167..5330
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5331..5478
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5479..5619
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5620..5694
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            5695..6741
                     /gene="Plxnd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgccgcg ccgcgcagcc cgcgctcgcc tggatggctc ctcgcgccgc gggcggcgca
       61 ccccctagcg cccgggccgc tgcggcggtc cccttgcctc cgcgctctca ctcgcggtgc
      121 cccggtctgc tgccgctgcc tctgctgctg ctgcttgggg cggcacgggc gggcgcccta
      181 gagatacagc gccgcttccc ctcgcccacg cccaccaaca acttcgccct ggacggcacg
      241 gcgggcaccg tatacctggc ggcggtgaac cgcctgtacc agctgtccgg tgccaacttg
      301 agcctggagg ccgaggcgac cgtgggtccg gtgccggaca gcccgctgtg tcacgccccg
      361 cagctcccgc aggcctcgtg cgagcacccg cggcgcctca cggacaacta caacaaaatc
      421 ttgcagttgg acccgggcca gggtctggtg gtcgcgtgcg gctccatcta ccagggtctg
      481 tgccaactga ggcgccgggg caacatctca gccctggctg tgagctttcc gcctgccgcg
      541 ccgaccgcag aaccggtcac cgtgttcccc agcatgctca acgtggccgc caaccacccc
      601 aacgcgtcca ccgtgggact agtgctgccg ccggcctccg gcaccggggg cagccgtctg
      661 ctcgtgggcg ccacgtacac cggctacgga agcgctttct tcccgcgcaa ccgtagccta
      721 gaagaccacc gcttcgagaa cacgcccgag atctctatcc gctccctgga cgcgcgtgga
      781 gacttggcta agctcttcac cttcgacctc aacccgtcgg acgacaacat actgaagatc
      841 aaacagggag ccaaggagca gcacaagctg ggcttcgtgc gtgccttctt gcacccggcg
      901 gtgccaccgc acagcgcgca tccctacgcg tacctggcgc tcaacagcga ggcgcgtgcg
      961 ggcgataaag acagccaggc gcgcagcctg ctggcgcgca tctgcctgcc ccgcggcgcg
     1021 ggtggcgacg ccaagaagct caccgagtcc tacatccaac tgggcttgca gtgcgcgggc
     1081 ggcgcgggcc ggggtgacct ctacagccgc ctcgtgtcgg tcttccccgc gcgcgagcag
     1141 ttcttcgctg tcttcgagcg gccccagggc accccaggtg cccgcaacgc cccggccgcg
     1201 ctctgcgcct tccgcttcgc cgacgtgcag gccgccattc gtgcagcgcg caccgcctgc
     1261 tttgtggagc cggcgccgga cgtggtggcg gtgctggaca gcgtggttca gggcaccgga
     1321 ccggcctgcg agagcaaacg caacatacag ctgcagccgg agcagctgga ctgtggagca
     1381 gcccaccttc agcacccact gaccatcctg cagccactga gggcatcgcc ggtgttccgt
     1441 gctccagggc tcacggccgt ggctgtggcc aatgctaaca actacacagc tgtctttctg
     1501 ggcactgcca cggggaggct cctcaagatc agcctgaatg agagcatgca ggtagtaagc
     1561 cggcgggtgc tgactgtggc ctacggggag cccgtgcacc atgtcatgca gtttgacccc
     1621 atggatcctg gttacctgta cctgatgaca tcccaccaga tggcccgagt gaaggtggcg
     1681 gcgtgtgagg tacactccac ctgcggggac tgtgtgggcg cggccgatgc ctactgtggc
     1741 tggtgtactc tggagacccg gtgcacattc aagcaggatt gtgccaactc cagcctgcca
     1801 catttctgga ccagtgccag tgagggcccc agccgctgcc ctgccatgac agtactgccg
     1861 tctgagattg atgtgcaccg ggactacacg ggtatgatct tacagatctc aggaagccta
     1921 cccagcctca gcggtatgga gatggcttgt gactacggaa atggcgttcg aacagtggcc
     1981 cgagtacccg gccctgccta tggtcatcag attgcctatt gcaacctcct gcccagggcc
     2041 cagttcccac cctttcctgc tggccaggac cacgtgactg ttgagatgtc tgtcagggtc
     2101 aaaggacaca acattgtctc agccaatttc accatctacg actgcagccg gattggacaa
     2161 gtctaccccc atacagcctg taccagctgc ctgtcgacac agtggccttg ctcctggtgc
     2221 atccagctgc actcctgtgt ctccaaccag tctcggtgcc aggactcacc aaaccctacg
     2281 agcccccagg actgtcccca gatcgtgccc tcgcccctgg cacctgtgcc cacgggtggc
     2341 tcgcaagaca tcctggtgcc tctgactaag gccgccttct tccatggcac ctccctccag
     2401 tgcagctttg ggctggaaga gaactttgag gctgtgtggg cgaatgactc gctggtccgc
     2461 tgcaaccaag tggtgctgca tacaacccag aagagccagg tgtttccact gagcctgaag
     2521 ctgaaggggc cacctgaccg attcctagat agtcctaacc ccatgacagt tgtggtctac
     2581 aattgtgcta tgggcagccc cgactgttcc cagtgcctgg gccgtgagga cctgggtcac
     2641 ctctgtgttt ggaatgatgg ctgtcgtctg agagggcccc tgcagccact ctctggcacc
     2701 tgcccagctc ctgaaatccg agcgattgag cctctgagtg gccccttgaa cggtgggacc
     2761 ttgctgacca tccgcggcaa gaacctgggc cgtaggctca gtgacgtggc acatggtgtg
     2821 tggattggca atgtggcctg tgaacccctg gctgacagat acacggtttc agaggagatc
     2881 gtgtgtgcca cagggcccgc cccaggggct ttctcagacg tggtaacggt gaatgtctcc
     2941 aaggaaggca ggtctcggga acagttctcc tatgtgctgc ccagggtcca ctcactggag
     3001 ccttccatgg gcccaaaggc agggggcaca agaatcacca ttcacggcag tgacctcaac
     3061 gtgggctcca tgctccaggt cctggtgaac gacacggacc cctgcacgga tcttacgcgc
     3121 actgccacca gcatcacctg cactgtgcca aggggtaccc tgccctctcc agtgcctgtg
     3181 tgtgtgcgct tcgagagccg gggctgcgtg cacggaaacc tcaccttctg gtacatgcag
     3241 aacccagtca tcacagccat cagcccaggc cgcagccccg tcagtggcgg caggaccatc
     3301 accgtggctg gcgaacgttt ccacatggta cagaacgtat caatggccgt acaccacatt
     3361 ggccgggagc ccacgttctg caaggttctc aactccacac tcatcatctg cccatccccc
     3421 ggagccctga gcaatgcttc agcacccgta gacttcttca tcaatggccg ggcctatgca
     3481 gacgaagcag ctgaggagct gctggaccct gcagaggcac agcggggcag ccggttccgc
     3541 ctagactacc tccccaaccc ccagttctcc acagccaaga gggagaagtg gatcaagcat
     3601 cacccaggag agccgctcac cctcgtcatc cataaggagc aagacagcct ggggctggag
     3661 agccatgagt atcacatcaa gattggccag gtgtcctgtg acattcagat catctcagac
     3721 agagtcatcc actgctcagt caacgagtca ctgggcacgg ccgaagggca gctgcccatc
     3781 acaatccagg tggggaactt caaccagacc atcgccaccc tgcaactggg gggcagcgag
     3841 acggccatcg tggtttccat tgtcatttgc agtgtcctgt tactgctgtc tgtggttgct
     3901 ctgttcgtct tctgcaccaa gagccgccgt gctgagcgct attggcagaa gaccctgctg
     3961 cagatggaag aaatggagtc tcagatccga gaggagatcc gcaaaggctt tgcggagctg
     4021 cagacagata tgacagatct caccaaggag ctgaaccgca gccagggcat ccccttcttg
     4081 gagtacaagc actttgtgac tcgtaccttc ttccccaagt gctcttccct ctatgaagag
     4141 cggtatgtgc tgccctcgaa gaccctcaac tcccaaggtg gctcccctcc acaggaaacc
     4201 cacccactgc tgggagagtg gaatatccct gaacactgtc ggcccagcat ggaggaggga
     4261 atcagtctgt tctcctcgct gctcaacaac aagcacttcc ttattgtctt tgttcatgct
     4321 ctggagcagc agaaggactt cgctgtgcgt gacaggtgca gcctggcatc actgttgacc
     4381 attgcactgc atggcaagct ggagtactac acgagcatca tgaaggagct gctggtggat
     4441 ctcatcgacg cctcagcagc caagaacccc aagctcatgt tgcggcgcac cgagtccgtg
     4501 gtggagaaga tgcttaccaa ctggatgtcc atctgcatgt atggctgcct gagggaaaca
     4561 gtaggtgagc cgttcttcct gctgttatgc gccatcaagc agcagatcaa caaaggttcc
     4621 atcgacgcca tcacaggcaa agcccgatac acacttaatg aggagtggct gctgagagag
     4681 aacattgagg ccaagccccg gaacctgaac gtgtccttcc agggctgtgg tatggattca
     4741 ctgagcgtgc gggccatgga cactgacacg ctgacgcagg tgaaagagaa gatcctggaa
     4801 gccttctgca agaatgtacc gtactcgcag tggccgcggg cggaggacgt ggacctcgaa
     4861 tggtttgcct caagcaccca gagctacgtc ctccgggacc tggatgacac gtcagtggtg
     4921 gaggacggcc gtaagaaact gaacacgcta gcccactaca agatacctga gggtgcctcc
     4981 ctagccatga gcctcacaga caagaaggac aataccctgg gccgagtgaa agacttggac
     5041 acagaaaagt atttccattt ggtgctacct acggatgagc tggtagagcc taagaagtct
     5101 caccggcaga gccaccgcaa gaaagtgttg ccagagatct acctgacccg cctgctgtcc
     5161 accaagggca cactgcagaa gttcttggat gatttgttca aggctatcct gagcatccga
     5221 gaggataagc ccccgctggc cgtcaagtat ttctttgact tcctagagga acaggcggag
     5281 aagagaggca tctctgaccc tgacaccttg cacatctgga agaccaacag ccttcccctc
     5341 cgcttctggg tgaacatctt aaaaaatccc cagtttgtct tcgacataga gaagacagac
     5401 cacatcgatg cctgcctgtc tgtcatcgcc caggccttca tagatgcctg ctccatctct
     5461 gacctgcagc tgggcaagga ctcacccacc aacaagcttc tgtacgcgaa ggagatcccc
     5521 gagtaccgga agattgtaca gcgctattac aaacagatcc aggacatgac gccactcagc
     5581 gagcaggaaa tgaacgcaca cctggctgag gagtcccgga aataccagaa tgagttcaac
     5641 acaaatgtgg ccatggctga gatctataaa tatgctaaga ggtatcgccc acagatcatg
     5701 gctgccctgg aggccaaccc cactgcccgc aggacccagc tgcagtacaa gtttgaacag
     5761 gtggtcgctc tgatggaaaa taatatctat gagtgttaca gcgaggcctg atgcagaaga
     5821 gtgacccgag ctgccgccag ggagaccgca cacaggccac ttgggcctcc acttggtttc
     5881 ttccccacac ccctcacttg ggctgggaac tgacaaagag gagcctgctg ggctaggagg
     5941 ggacactggc ctcagtgtcc ggctgcagag ctctcagcct tgtcccctcc acctgcccaa
     6001 gacccgaccg actctgggat gaaggccttg actatcgatc gctgccagtc cctgataaga
     6061 ctttccctgc caaccaggac agcccagccg tgcctgcccg ctcactctgt ttcaggcggc
     6121 ttggcacatg ttgggagagg cggccatatc ccagaacact acctcatcca cctggcagag
     6181 ggatttctgc ttcagccacc aagcagttgt ctatgtccct catccagagg gggccctggc
     6241 caccaacagt tccaagcagg gtcagctgtt tgctgtccca tcggccagtg gcagcatggg
     6301 cagtgcccat tgcccacaga atggtggaga gggggtcagg ctgggagctc ctggtcccca
     6361 cgaaaggagg aaggtgaagg tgcgagctgt agctggacta cttgatcttc ctgcaagtgt
     6421 ttctaaagag caccactttt ttgttttttg tttgtttttt tttaagaaaa aaaatctttt
     6481 atatattaaa aaaaaaacaa aaacaaatct tatgcaccaa ctgtgaatag ctgctgcttg
     6541 tgcagatccc caggggctcc cggtgacaca ctggaaatga ctgttccagg ggacagaaaa
     6601 cactcatctg tccccagcac aggctccccc ttccccccac agctactagg actggctcac
     6661 agcccaaggg ggctgggctg gagggaaagg ctgggatgct ctggaacatt ctttacaata
     6721 aaagcctgcc gggaaaacct a
//
