LOCUS       NM_001108188            8414 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus plexin B1 (Plxnb1), mRNA.
ACCESSION   NM_001108188 XM_001075514 XM_006226570 XM_006243882 XM_236640
VERSION     NM_001108188.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8414)
  AUTHORS   Wang,N., Liu,X., Tang,Z., Wei,X., Dong,H., Liu,Y., Wu,H., Wu,Z.,
            Li,X., Ma,X. and Guo,Z.
  TITLE     Increased BMSC exosomal miR-140-3p alleviates bone degradation and
            promotes bone restoration by targeting Plxnb1 in diabetic rats
  JOURNAL   J Nanobiotechnology 20 (1), 97 (2022)
   PUBMED   35236339
  REMARK    GeneRIF: Increased BMSC exosomal miR-140-3p alleviates bone
            degradation and promotes bone restoration by targeting Plxnb1 in
            diabetic rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8414)
  AUTHORS   McDermott,J.E., Goldblatt,D. and Paradis,S.
  TITLE     Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and
            glutamatergic synapse development in the mammalian hippocampus
  JOURNAL   Mol Cell Neurosci 92, 50-66 (2018)
   PUBMED   29981480
REFERENCE   3  (bases 1 to 8414)
  AUTHORS   Bulloj,A., Maminishkis,A., Mizui,M. and Finnemann,S.C.
  TITLE     Semaphorin4D-PlexinB1 Signaling Attenuates Photoreceptor Outer
            Segment Phagocytosis by Reducing Rac1 Activity of RPE Cells
  JOURNAL   Mol Neurobiol 55 (5), 4320-4332 (2018)
   PUBMED   28624895
  REMARK    GeneRIF: These results demonstrate a novel physiological function
            for sema4D/plxnB1 signaling in retinal pigment epithelium
            phagocytosis.
REFERENCE   4  (bases 1 to 8414)
  AUTHORS   Liu,X.L., Song,J., Liu,K.J., Wang,W.P., Xu,C., Zhang,Y.Z. and
            Liu,Y.
  TITLE     Role of inhibition of osteogenesis function by Sema4D/Plexin-B1
            signaling pathway in skeletal fluorosis in vitro
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 35 (5), 712-715 (2015)
   PUBMED   26489627
  REMARK    GeneRIF: Skeletal fluorosis in vitro is caused by inhibition of
            osteogenesis via Sema4D/Plexin-B1 signaling pathway.
REFERENCE   5  (bases 1 to 8414)
  AUTHORS   Kuzirian,M.S., Moore,A.R., Staudenmaier,E.K., Friedel,R.H. and
            Paradis,S.
  TITLE     The class 4 semaphorin Sema4D promotes the rapid assembly of
            GABAergic synapses in rodent hippocampus
  JOURNAL   J Neurosci 33 (21), 8961-8973 (2013)
   PUBMED   23699507
REFERENCE   6  (bases 1 to 8414)
  AUTHORS   Lin,X., Ogiya,M., Takahara,M., Yamaguchi,W., Furuyama,T.,
            Tanaka,H., Tohyama,M. and Inagaki,S.
  TITLE     Sema4D-plexin-B1 implicated in regulation of dendritic spine
            density through RhoA/ROCK pathway
  JOURNAL   Neurosci Lett 428 (1), 1-6 (2007)
   PUBMED   17950529
REFERENCE   7  (bases 1 to 8414)
  AUTHORS   Barberis,D., Casazza,A., Sordella,R., Corso,S., Artigiani,S.,
            Settleman,J., Comoglio,P.M. and Tamagnone,L.
  TITLE     p190 Rho-GTPase activating protein associates with plexins and it
            is required for semaphorin signalling
  JOURNAL   J Cell Sci 118 (Pt 20), 4689-4700 (2005)
   PUBMED   16188938
  REMARK    GeneRIF: p190 transiently associates with plexins, and its RhoGAP
            activity is increased in response to semaphorin stimulation. We
            conclude that p190-RhoGAP is crucially involved in semaphorin
            signalling to the actin cytoskeleton, via interaction with plexins.
REFERENCE   8  (bases 1 to 8414)
  AUTHORS   Masuda,K., Furuyama,T., Takahara,M., Fujioka,S., Kurinami,H. and
            Inagaki,S.
  TITLE     Sema4D stimulates axonal outgrowth of embryonic DRG sensory
            neurones
  JOURNAL   Genes Cells 9 (9), 821-829 (2004)
   PUBMED   15330859
REFERENCE   9  (bases 1 to 8414)
  AUTHORS   Oinuma,I., Ishikawa,Y., Katoh,H. and Negishi,M.
  TITLE     The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein
            for R-Ras
  JOURNAL   Science 305 (5685), 862-865 (2004)
   PUBMED   15297673
  REMARK    GeneRIF: Plexin-B1 mediates Sema4D-induced repulsive axon guidance
            signaling by acting as a GTPase activating protein for R-Ras.
REFERENCE   10 (bases 1 to 8414)
  AUTHORS   Artigiani,S., Conrotto,P., Fazzari,P., Gilestro,G.F., Barberis,D.,
            Giordano,S., Comoglio,P.M. and Tamagnone,L.
  TITLE     Plexin-B3 is a functional receptor for semaphorin 5A
  JOURNAL   EMBO Rep 5 (7), 710-714 (2004)
   PUBMED   15218527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1 and CA504175.1.
            
            On or before Aug 22, 2019 this sequence version replaced
            XM_006243882.2, XM_006226570.2, NM_001108188.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This transcript is based on
            transcript alignments from orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000008.1  118623161-118623229
            70-122              JAXUCZ010000008.1  118626924-118626976
            123-1235            JAXUCZ010000008.1  118627845-118628957
            1236-1418           JAXUCZ010000008.1  118629820-118630002
            1419-1547           JAXUCZ010000008.1  118630242-118630370
            1548-1648           JAXUCZ010000008.1  118630495-118630595
            1649-1781           JAXUCZ010000008.1  118630874-118631006
            1782-1938           JAXUCZ010000008.1  118631253-118631409
            1939-2047           JAXUCZ010000008.1  118631686-118631794
            2048-2156           JAXUCZ010000008.1  118631903-118632011
            2157-2831           JAXUCZ010000008.1  118632417-118633091
            2832-2954           JAXUCZ010000008.1  118633267-118633389
            2955-3077           JAXUCZ010000008.1  118633570-118633692
            3078-3171           JAXUCZ010000008.1  118633998-118634091
            3172-3344           JAXUCZ010000008.1  118634178-118634350
            3345-3496           JAXUCZ010000008.1  118634495-118634646
            3497-3602           JAXUCZ010000008.1  118635838-118635943
            3603-3739           JAXUCZ010000008.1  118636115-118636251
            3740-3916           JAXUCZ010000008.1  118636619-118636795
            3917-4052           JAXUCZ010000008.1  118636984-118637119
            4053-4295           JAXUCZ010000008.1  118637302-118637544
            4296-4472           JAXUCZ010000008.1  118638159-118638335
            4473-4621           JAXUCZ010000008.1  118638411-118638559
            4622-4722           JAXUCZ010000008.1  118639203-118639303
            4723-4940           JAXUCZ010000008.1  118639392-118639609
            4941-5119           JAXUCZ010000008.1  118639715-118639893
            5120-5186           JAXUCZ010000008.1  118640087-118640153
            5187-5333           JAXUCZ010000008.1  118640328-118640474
            5334-5502           JAXUCZ010000008.1  118641106-118641274
            5503-5606           JAXUCZ010000008.1  118641461-118641564
            5607-5691           JAXUCZ010000008.1  118641639-118641723
            5692-5864           JAXUCZ010000008.1  118641984-118642156
            5865-6025           JAXUCZ010000008.1  118642307-118642467
            6026-6173           JAXUCZ010000008.1  118642556-118642703
            6174-6238           JAXUCZ010000008.1  118643178-118643242
            6239-6314           JAXUCZ010000008.1  118643340-118643415
            6315-6389           JAXUCZ010000008.1  118644267-118644341
            6390-8397           JAXUCZ010000008.1  118645483-118647490
            8398-8414           CA504175.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..8414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..8414
                     /gene="Plxnb1"
                     /note="plexin B1"
                     /db_xref="GeneID:316009"
                     /db_xref="RGD:1310564"
     exon            1..69
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..122
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..1235
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..6494
                     /gene="Plxnb1"
                     /codon_start=1
                     /product="plexin-B1 precursor"
                     /protein_id="NP_001101658.2"
                     /db_xref="GeneID:316009"
                     /db_xref="RGD:1310564"
                     /translation="MSVLGPVLLQVFWAGCVLTLQFPVPAAFTANGTHLQHLARDPTT
                     GTLYVGATNFLFQLSPGLQLEAVVSTGPVNDSRDCLPPVIPDECPQAQPTNNPNQLLL
                     VSPEALVVCGSVHQGICELRSLGQIRQLLLRPERPGDTQYVAANDPAVSTVGLVAQGL
                     AGEPLLFVGRGYTSRGVGGGIPPITTRALRPPDPQAAFSYEETAKLAVGRLSEYSHHF
                     VSAFVRGTSAYFLFLRRDLKAPSRAFRAYVSRVCLQDQHYYSYVELPLACQGGRYGLI
                     QAAAVATSKEAARGEILFAAFSSVAPPTVDWPLSASTGASGTSVLCAFPLDEVDQLAN
                     DTRDACYTREGRAENGTKVADIAYDVLSDCAQLPVDTPDAFPCGSDHTPSPMVSCVPL
                     EATPILELPGVQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGRSAAPYSKQSIQPG
                     SAVNRDLTFDGTFEHLYVATQTTLVKVPVAPCAQHLDCDSCLAHRDPYCGWCVLLGRC
                     SRRSECSRAQGPEQWLWSFQSELGCLRVVAVSPANISRGERREVFLSVPGLPSLWPEE
                     SYFCYFGDQQSPALLTSSGVMCPSPDPSEAPVLQRGADHISVNVELRFGAVVIANTSL
                     SFYDCMAVTEFFPSAPCRACVSSRWGCNWCVWQQLCTHKASCDSGPMVASQQSPLLPL
                     IPPARDVLTPFPLTVPRATATPTPNTFPAEPRAPSIASDVLPGAKPSRLSLWGPWAGP
                     GPILSPTSTESPLHEKPLPPEPPTTPGTTVPAPADLGPLTTPEDLLASYPFPSDAAAV
                     SPTEPGPETLPSMVALDQPPGTAPATLFPGATGSMKPVLDWLTKGGGELLEAEEWMGG
                     DTPAFSTSTLLSGDGDSAEHEGPSAPLILLSSLDYQYDTPGLWELGEVNQRVSSCPCV
                     ENVQGSLLIPVHVKREVQLRGRNLWLFQDGPRSSECVLVLEGLEVAVEAQVECEPPPD
                     TWCHIKCQQHQFSYEASKPELQVGLFLRWAGGLRVDSADGLHVVLYDCSVGHGDCSRC
                     QTAMPQYDCVWCEGEHPRCVAREACNEAETVATQCPAPLIHSVEPLTGPIDGGTRVTI
                     RGSNLGQHVQDVLGMVRVAGVPCAVDVGEYDVSSSLVCITGSSGEEVTGAVAVEVPGR
                     GHGVSEFSFAYQDPKVLSIFPVHGPRAGGTHLTLHGSKLLTGRLEDIRVVVGDQPCHL
                     LLEQQSEQLHCETSPNPVPAELPVMVWFGATERRLQHSQFKYTADPNITSVGPAKSFF
                     SGGREIWVRGQNLDVVQMPRIRVTVIPRVPQHGQGLGQKHHVVPEKIEEPCLVNSSHL
                     IMCRSPALPGPPQDPWVQVEFILDNMVFDFATLSPTPFSYEADPTLRSLNPEDPTTPF
                     RHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVEQPLPHHHA
                     LREAPDALPEFTVQMGNLRFSLGHVQYDGESPVAFPVAAQVGLGVGVSLLALGVIVIV
                     LIYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFL
                     DYKVYAERVFFPGHQESPLHRDLGVPDSRRPTVEQGLGQLSNLLNSKLFLTKFIHTLE
                     SQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQCVAKNPKLMLRRTETV
                     VEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLL
                     REDVEYRPLTLNALLAVGPGAGEAQSVPVKVLDCDTISQAKEKMLDQLYKGVPLAQRP
                     DSRTLDVEWRSGVAGHLILSDEDVTSELEGLWRRLNTLQHYKVPDGATVALVPCLTKH
                     ILRENQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAI
                     PEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDT
                     IHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRD
                     SPINKLLYARDIPRYKQMVERYYADIRQTVPASDQEMNSVLAELSRNCSADLGARVAL
                     HELYKYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL"
     exon            1236..1418
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1547
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1648
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1781
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1938
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2047
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2156
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2831
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2954
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3077
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3171
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3344
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3496
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3602
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3739
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3916
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4052
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4295
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..4472
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4473..4621
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4622..4722
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4940
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4941..5119
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5120..5186
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5333
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5334..5502
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5503..5606
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5691
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5692..5864
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5865..6025
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6026..6173
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6174..6238
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6239..6314
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6315..6389
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6390..8398
                     /gene="Plxnb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagatctga gctagcccgg agctgcgggc ggacgcctcg ccgcgcgcat cccgcaagag
       61 ggtcgggcgg tgactcctgc tcaggtcatg cccttatctg ctgatccagc cggccctgcc
      121 aggtgaccat gtctgtcctc ggcccagttc ttctccaggt gttctgggct ggctgtgtcc
      181 tcaccctgca gttccctgta ccagctgctt tcactgccaa tggcacacat ctacaacact
      241 tggcgagaga ccccaccaca ggtaccctct atgtaggggc caccaacttc ctgttccagt
      301 tgagccctgg gttgcagcta gaagctgtgg tgtccacggg ccctgtgaat gacagccggg
      361 attgcctgcc acctgtgata cctgatgaat gtccccaagc ccagcctact aacaacccta
      421 accagctgct cctggtgagc ccagaggctc tggtggtgtg tgggagcgta caccagggca
      481 tctgtgagct acggagcctg ggacagatca ggcaattgct gctacggcca gagcgacctg
      541 gggacaccca gtatgtggct gcaaatgacc ctgcggtcag cacagtgggg ctggtggccc
      601 agggattagc aggggaaccc ctcctgtttg tgggacgggg atataccagc aggggcgtag
      661 gtggtggaat tcctcccatt acaacccgag ccttgcgacc accggacccc caagctgctt
      721 tctcttacga agaaacagcc aagctggcag tgggccgcct ctctgagtac agccaccact
      781 tcgtgagtgc cttcgtacgt gggaccagcg catacttcct gttcttgagg cgagacctga
      841 aggccccttc tcgagctttc cgtgcctacg tgtcccgagt gtgccttcag gaccagcatt
      901 actactctta tgtggaattg cccttggcct gccagggtgg ccgctatggt cttatccagg
      961 ctgcagctgt agccacatcc aaggaggcgg cccgtgggga aatactcttc gcagctttct
     1021 cctcagtagc tcctcctact gtggattggc ccctgtcagc atctactggg gcatctggaa
     1081 cctctgtgct ctgtgccttc cccctggatg aggtagacca gcttgctaat gatactcgag
     1141 atgcctgtta cacccgggaa ggccgtgctg agaatgggac caaggtggct gacattgcct
     1201 atgatgtcct ttccgactgt gcacagctac cagtggacac cccggatgct tttccatgtg
     1261 gctcggacca cacacccagt cccatggtca gctgcgtccc tttggaagcc acaccaattc
     1321 tggagctgcc aggggttcag ctaactgctg tggcagtcac catggaggat ggacatacta
     1381 ttgctttcct gggtgacagt caaggacagt tgcatagggt ctacttaggc cctgggagaa
     1441 gtgctgcccc atattccaaa cagagcatcc agccggggtc tgccgtgaac agagatctta
     1501 cctttgatgg tacctttgag catctgtatg tagcaactca gactacactt gtgaaagttc
     1561 ctgtggcccc ttgtgctcag cacctggatt gcgactcttg ccttgctcac agggaccctt
     1621 attgcggatg gtgtgtgctc ctgggcaggt gtagtcgccg gtcggagtgc tcaagggccc
     1681 agggcccaga gcagtggctg tggagcttcc agtcggaact aggctgtctt cgagtggtgg
     1741 ccgtgagccc tgccaacatt agtcggggag agaggaggga ggttttcctg tcggtgccag
     1801 gcctgccatc tctctggcca gaggagtcat atttctgcta ctttggggac caacagagtc
     1861 ctgctctact gaccagttct ggtgtgatgt gtccctcccc agaccctagt gaggctccag
     1921 tgctgcagag aggagccgac catatctccg tgaatgtgga gctcaggttt ggtgctgtgg
     1981 tgatcgccaa cacctccctc tcgttctatg actgcatggc ggttaccgag tttttcccgt
     2041 ctgcaccgtg ccgggcctgt gtgagcagcc gctggggctg taactggtgt gtgtggcagc
     2101 agctgtgtac gcacaaggcc tcgtgtgact ctgggcctat ggtggcaagc caacagagcc
     2161 cacttctccc cctaatccct cctgcaaggg acgtactcac ccctttccca ctcacagtcc
     2221 ccagagccac agccactcca actcccaaca ccttcccagc agagcctagg gctccctcca
     2281 tagcctcaga tgtcctaccc ggggccaagc cttcccggct cagcctctgg ggcccatggg
     2341 caggccctgg ccccatactt tcccctacct ccacagagtc acctctccat gagaagcccc
     2401 tccctcctga gccccctacc acacctggaa ccactgtccc tgcccccgct gacctgggac
     2461 ccttgaccac gcctgaggac ctcttggcct cctacccatt cccctcagat gcagctgcag
     2521 tatcccccac agagcctggc cctgagactc tgccttccat ggtagctctg gatcagcccc
     2581 ctggcactgc tccagccacc cttttcccag gggccactgg ctccatgaag ccagttctgg
     2641 attggctcac caaaggaggc ggcgagctgc tcgaggcgga ggagtggatg gggggtgaca
     2701 cgcccgcctt ctccacttcc acactcctct caggtgatgg cgactcagca gagcacgagg
     2761 gcccttctgc tcccctcatc ctcctgtcca gcctcgacta ccagtacgac acccccgggc
     2821 tctgggagct gggagaggtg aatcagaggg tgagctcctg cccctgtgtg gagaacgtcc
     2881 aaggctcctt gctgataccg gtccacgtga agcgggaagt ccagcttcga ggcaggaacc
     2941 tgtggctctt ccaggacggc ccaaggagca gtgagtgtgt gctggtgctg gagggcctcg
     3001 aggtggcagt ggaggctcag gtggagtgtg agccacctcc agacacatgg tgccacatca
     3061 agtgccagca gcaccagttc agctatgaag cttcaaagcc agaactccaa gtgggactgt
     3121 tcctgcgctg ggcgggtggt ctgcgtgtgg acagtgccga tgggctacat gtggtattgt
     3181 atgactgctc tgtgggacat ggggactgca gccgctgcca aacggccatg cctcagtacg
     3241 actgtgtgtg gtgcgagggg gagcacccgc gctgtgtagc ccgagaagcc tgtaatgaag
     3301 ccgagaccgt ggctacccag tgccctgcac ctctaattca ctcggtggag ccgctgactg
     3361 gacctataga cggaggcacc cgtgtcacca tcaggggctc caacctgggc cagcatgtcc
     3421 aggacgtcct gggcatggtc agagtagcag gagtgccctg tgcggtcgat gttggcgagt
     3481 acgacgtctc cagtagtctt gtgtgcatca ctggaagcag cggggaggag gtgacaggcg
     3541 cagtggcagt ggaggtacct ggaagaggac acggtgtctc agagttcagc tttgcctatc
     3601 aggacccaaa agtactttcc atcttcccag tccatggccc tagagcagga ggtacccacc
     3661 tcaccctgca tggttctaag ctcctgactg gacggctaga ggacatccgt gtcgtggttg
     3721 gagaccagcc ttgccacttg ctcctggagc agcagtctga gcagctacac tgtgagacca
     3781 gcccaaaccc tgtgcctgcc gaactcccag tgatggtctg gttcggagcc actgaacgga
     3841 ggcttcagca cagccaattc aagtacacag cagaccccaa catcacctct gtgggccccg
     3901 ccaagagctt cttcagtgga ggacgagaga tatgggtccg aggccagaat ctggatgtag
     3961 tacagatgcc aagaatccga gtgactgtga tcccaagagt accacagcat ggccaggggc
     4021 ttgggcagaa gcaccacgtg gtccctgaga aaatcgaaga gccatgtctc gtgaactcct
     4081 cccacctcat catgtgccgc tcgcctgccc tccctggccc gccccaggac ccttgggtcc
     4141 aggtggagtt tatccttgac aacatggtct ttgactttgc tacactgagc cccacaccct
     4201 tctcctatga ggctgatccc accctgcgtt ccctcaaccc cgaggatccc accacgccat
     4261 tccggcacaa gccagggagt gtgttctctg tggaggggga gaatctggac cttgccatgt
     4321 ctaaggaaga ggtggtggcc atgatcggag atggcccctg cgtggtgaag acactgaccc
     4381 ggcaccacct gtactgcgag ccccctgtgg agcagcccct gccacatcac catgccctcc
     4441 gtgaggcccc cgacgctctg ccggagttca cggtacagat ggggaacctg cgcttctccc
     4501 tgggtcatgt gcagtacgat ggcgagagcc ctgtggcttt tcctgtggca gcccaagtgg
     4561 gcttgggagt gggcgtgtct ctcctggctc tgggggtcat cgtcattgtc ctcatctaca
     4621 ggaggaagag caagcaggcc ctgagggact ataaaaaggt gcagatccag ctggagaatc
     4681 tggagagcag tgtgcgggac cgctgtaaga aggagtttac agacctcatg acggagatga
     4741 ctgatctcac cagtgacctc cttggcagcg gcatcccctt ccttgactac aaagtgtatg
     4801 ctgagagggt cttcttccct gggcaccagg agtcaccctt gcacagggac ctcggtgtgc
     4861 ctgacagcag gcgacccact gtggaacagg ggctggggca gctctccaac ctgctaaaca
     4921 gcaagctctt ccttaccaag ttcatccaca cactggagag tcagcgtacc ttctctgctc
     4981 gagaccgtgc ctacgtggca tctctgctca ctgttgccct tcacgggaag cttgagtact
     5041 tcacggacat cctccgtact ctgctcagtg acctggtagc ccagtgtgta gccaagaacc
     5101 ccaagctgat gctgcgcagg acagagactg tggtggaaaa gctgctcacc aactggatgt
     5161 ccatctgcct ctacaccttc gtgagggact ctgtaggaga gcccctgtac atgctcttca
     5221 gagggattaa acatcaagtg gacaagggtc ctgtggacag tgtgactggc aaagccaaat
     5281 acactctgaa tgacaaccgc ctgctcagag aggacgtgga gtaccgtccc ctgaccttga
     5341 atgctctcct ggctgtgggg cccggagcag gagaagccca gagtgtgcca gtgaaagtcc
     5401 tggactgcga caccatctcc caggccaagg agaagatgct agaccagctt tataaggggg
     5461 tgcctctcgc ccagcgcccc gactctcgca ccttggatgt tgaatggcgg tctggagtgg
     5521 ctgggcacct tatcctttct gacgaggatg tcacttctga acttgagggt ctgtggaggc
     5581 gtctgaacac actgcagcat tacaaggtcc cagatggagc aacggtggcc cttgtcccct
     5641 gcctcaccaa gcatattctt agggaaaacc aggattatgt ccctggagaa cggactccga
     5701 tgctggagga tgtagatgaa gggggcatcc ggccctggca cctggtaaag ccgagtgatg
     5761 aaccagagcc tcccaggccg aggaggggca gccttcgggg tggggagcga gagcgagcca
     5821 aggctatccc tgagatctac ctgacacgcc tgctatccat gaagggcaca ctgcagaagt
     5881 ttgtggatga cctgttccag gtgatcctca gcacaagccg ccccgtgcct ctggctgtga
     5941 agtacttctt tgacctgctg gatgaacaag cccagcagca tggcatctct gatcaggaca
     6001 ccatccacat ctggaagacc aacagcctgc ctctgaggtt ctggatcaac atcatcaaga
     6061 acccacagtt tgtgttcgat gtgcagactt cggataacat ggacgcggtg ctgctggtca
     6121 tcgcacagac cttcatggat gcctgcaccc tggccgacca caagctgggc cgggattctc
     6181 ccatcaacaa gcttctgtat gctcgagata ttccccgtta caaacagatg gtggaaaggt
     6241 actatgcaga catccgacag actgtcccag ccagtgacca agagatgaac tcagtcttgg
     6301 cagagctgtc ccggaactgc tctgccgacc ttggtgctcg agtagctctg catgaactct
     6361 acaagtatat caacaagtac tatgaccaga tcatcactgc cctggaggag gatggcactg
     6421 cccagaagat gcagctggga taccggctcc agcagatcgc ggctgctgtg gaaaacaagg
     6481 tcacggatct atagggacca gggagccttg gcctgctatt gtctcagctc ctcctgggca
     6541 gccctggaat ctcaagggag aggccacctt cgtagatgcc tgtagtgact gacaagcaga
     6601 ggttaatgaa aggtggctcc cagtctcctg tggtaccagc tcacagcctc agcccctttg
     6661 gacctgcctt ataggcctgg gacctagtgg ttcagtgggt agtgccaggc ctgcccgaag
     6721 cctggtgact ctctgaccac ttcctgggtg acgccagcct gcaggaagct ggggacttaa
     6781 ggtttccaga gaatgtctag taggccctcc aggcccctgg ggagactgta ctgttcttga
     6841 gcactgacct atgtcccatt gggaatcaca gaggaaggaa gagaacccgc ccacttcctg
     6901 tcctcttcat ccatcctcct tgaccttgag tttagcttcc tctgtccttg ttcgctgttg
     6961 ccaattccaa ggcctaagag agagaaaaat gcctttctag gctgctgctg cctcagcagg
     7021 attggcgcct caggaccaca ctgtcttcca ggtggcctat ggggagggac aactgcttca
     7081 ggggagcctt ggggagagca gtggtccagt gatggcacag ctcttcatta aaggatagca
     7141 catggtgcgg acttaccagc ccctctgcta agatataact agcagctgtt gggggacatg
     7201 ggcctcacgc tctaaagggt ctcctgaccc ccatgaaagg ccacagtgag agcttacaag
     7261 ctctctccgg ctcctaggaa gggcctgcca gaggcaacac ttcccagaaa ggagaacttg
     7321 aagcacaata tggctcaggg agagttgggg cctgatgtgg ggttctgtcc tccattttta
     7381 agaggtccac cttgcttgta ggttgtggta acttctccat tcatgttcca tgaattttga
     7441 aaggaattga ggaagcatgg tgttattaaa ggtgactcca ggcagcatgg ctttcacggg
     7501 tccatgactc accctgtttc tggattccag tttccatatt gctgtccacg ttgaggaacc
     7561 tatgccaggg gctcagagcc attccacctg cctgtgtagt ggtcaccttg tggtattttc
     7621 ctatctgaag ctgtagatga gcttcaagaa cgtggttccg tagtgccctt ggctgctggg
     7681 tgagaagagc tggaggttga gaatgctgtt ggcttcccca ggcaagggtc aggtatcctc
     7741 agagagctcc cccttggctc gtgtgtatag ccagtaccct ggcttccctg agggtttgaa
     7801 gagataggct gatacacttc caagagtcct ttcttgctgt cttttagaat ctttgtcttc
     7861 aagatagcag gagccaagat gttggttttc atgccagggg taatcacagc tgctatttct
     7921 gtcagatcct gtcttgccca tgcctgccag atgtggggaa ccacaatcac agacggtcag
     7981 cagtgaggcc ctcatttggg agcatgtgaa ctttagtact aatgatagtt gtcctagttc
     8041 agattttacc ctcactcaga atgtttttgg ctctcccagt ggctgctctg accaactatg
     8101 gtgttgacag tcttagagaa cagggctgac agggggaatg tggtcttggc tagacttcag
     8161 acaggtacag ggagggaggc accttaagtc aacatggcag ggatggtgac agacacacct
     8221 ctgctctagg cttgggcttc tgcagtcttt aggagtcctg tgaggaggtg aggctttctg
     8281 cgtgcttggg cgtgtgctca tgggatgggc gagtagagaa cgctctgagt cactcatgtc
     8341 tcacctcaca gaacattgtg atagaagatg tcatgaaaat aaaaacgtta ccatgtaaaa
     8401 aaaaaaaaaa aaaa
//
