LOCUS       NM_001107852           12981 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus plexin A4 (Plxna4), mRNA.
ACCESSION   NM_001107852 XM_001063665 XM_001063723 XM_017592970 XM_017602771
            XM_231590
VERSION     NM_001107852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12981)
  AUTHORS   Gutekunst,C.A. and Gross,R.E.
  TITLE     Plexin a4 expression in adult rat cranial nerves
  JOURNAL   J Chem Neuroanat 61-62, 13-19 (2014)
   PUBMED   24970554
  REMARK    GeneRIF: This is the first detailed description of the cellular and
            subcellular distribution of PlexinA4 in the adult rat cranial
            nerves
REFERENCE   2  (bases 1 to 12981)
  AUTHORS   Yamashita,N., Usui,H., Nakamura,F., Chen,S., Sasaki,Y., Hida,T.,
            Suto,F., Taniguchi,M., Takei,K. and Goshima,Y.
  TITLE     Plexin-A4-dependent retrograde semaphorin 3A signalling regulates
            the dendritic localization of GluA2-containing AMPA receptors
  JOURNAL   Nat Commun 5, 3424 (2014)
   PUBMED   24599038
  REMARK    GeneRIF: Data suggest amechanism by which retrograde semaphorin 3A
            (Sema3A) signalling regulates the glutamate receptor localization
            through trafficking of cis-interacting PlexA4 with GluA2 along
            dendrites.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12981)
  AUTHORS   Gutekunst,C.A., Stewart,E.N., Franz,C.K., English,A.W. and
            Gross,R.E.
  TITLE     PlexinA4 distribution in the adult rat spinal cord and dorsal root
            ganglia
  JOURNAL   J Chem Neuroanat 44 (1), 1-13 (2012)
   PUBMED   22465808
  REMARK    GeneRIF: This is the first detailed description of the cellular and
            subcellular distribution of PlexinA4 in the adult spinal cord and
            dorsal root ganglia
REFERENCE   4  (bases 1 to 12981)
  AUTHORS   Schwarz,Q., Waimey,K.E., Golding,M., Takamatsu,H., Kumanogoh,A.,
            Fujisawa,H., Cheng,H.J. and Ruhrberg,C.
  TITLE     Plexin A3 and plexin A4 convey semaphorin signals during facial
            nerve development
  JOURNAL   Dev Biol 324 (1), 1-9 (2008)
   PUBMED   18804103
REFERENCE   5  (bases 1 to 12981)
  AUTHORS   Suto,F., Ito,K., Uemura,M., Shimizu,M., Shinkawa,Y., Sanbo,M.,
            Shinoda,T., Tsuboi,M., Takashima,S., Yagi,T. and Fujisawa,H.
  TITLE     Plexin-a4 mediates axon-repulsive activities of both secreted and
            transmembrane semaphorins and plays roles in nerve fiber guidance
  JOURNAL   J Neurosci 25 (14), 3628-3637 (2005)
   PUBMED   15814794
REFERENCE   6  (bases 1 to 12981)
  AUTHORS   Suto,F., Murakami,Y., Nakamura,F., Goshima,Y. and Fujisawa,H.
  TITLE     Identification and characterization of a novel mouse plexin,
            plexin-A4
  JOURNAL   Mech Dev 120 (3), 385-396 (2003)
   PUBMED   12591607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001107852.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-952               JAXUCZ010000004.1  62128494-62129445   c
            953-2222            JAXUCZ010000004.1  62055254-62056523   c
            2223-2405           JAXUCZ010000004.1  62038481-62038663   c
            2406-2537           JAXUCZ010000004.1  61852364-61852495   c
            2538-2638           JAXUCZ010000004.1  61792500-61792600   c
            2639-2762           JAXUCZ010000004.1  61781026-61781149   c
            2763-2916           JAXUCZ010000004.1  61779508-61779661   c
            2917-3016           JAXUCZ010000004.1  61778168-61778267   c
            3017-3131           JAXUCZ010000004.1  61775900-61776014   c
            3132-3332           JAXUCZ010000004.1  61764936-61765136   c
            3333-3429           JAXUCZ010000004.1  61757512-61757608   c
            3430-3620           JAXUCZ010000004.1  61756954-61757144   c
            3621-3772           JAXUCZ010000004.1  61752839-61752990   c
            3773-3890           JAXUCZ010000004.1  61747693-61747810   c
            3891-4027           JAXUCZ010000004.1  61744620-61744756   c
            4028-4192           JAXUCZ010000004.1  61743383-61743547   c
            4193-4286           JAXUCZ010000004.1  61740843-61740936   c
            4287-4526           JAXUCZ010000004.1  61740231-61740470   c
            4527-4673           JAXUCZ010000004.1  61739617-61739763   c
            4674-4908           JAXUCZ010000004.1  61738781-61739015   c
            4909-5051           JAXUCZ010000004.1  61734802-61734944   c
            5052-5320           JAXUCZ010000004.1  61728067-61728335   c
            5321-5387           JAXUCZ010000004.1  61725512-61725578   c
            5388-5534           JAXUCZ010000004.1  61724615-61724761   c
            5535-5694           JAXUCZ010000004.1  61721327-61721486   c
            5695-5798           JAXUCZ010000004.1  61708991-61709094   c
            5799-5898           JAXUCZ010000004.1  61708301-61708400   c
            5899-6089           JAXUCZ010000004.1  61706627-61706817   c
            6090-6259           JAXUCZ010000004.1  61705383-61705552   c
            6260-6472           JAXUCZ010000004.1  61701175-61701387   c
            6473-6623           JAXUCZ010000004.1  61696060-61696210   c
            6624-12981          JAXUCZ010000004.1  61687501-61693858   c
FEATURES             Location/Qualifiers
     source          1..12981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..12981
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /note="plexin A4"
                     /db_xref="GeneID:312213"
                     /db_xref="RGD:1308074"
     exon            1..952
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            953..2222
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             1038..6719
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /note="plexin A4, A"
                     /codon_start=1
                     /product="plexin-A4 precursor"
                     /protein_id="NP_001101322.2"
                     /db_xref="GeneID:312213"
                     /db_xref="RGD:1308074"
                     /translation="MKAMPWNWTCLLSHLLVVGMGSSTLLPRQPPQMSQKPSFVTFRG
                     EPTEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQT
                     CNEPLASTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPFHKKEHYLS
                     GVNESGSVFGVIVSYSNFDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFH
                     DEFVASMIKIPSDTFTVIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYT
                     SKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVRPDDDLL
                     FTVFSKGQKRKMKSLDESALCVFILKQINDRIKDRLQSCYRGEGTLDLAWLKVKDIPC
                     SSALLTIDDNFCGLDMNAPLGVSEMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTK
                     SGKLKKIRVDGPKGNALQYETVQVVDSGPVLRDMAFSKDHEQLYIMSERQLTRVPVES
                     CGQYRSCGECLGSGDPHCGWCVLHNTCTRKERCERSREPRRFASEMKQCVRLTVHPNN
                     ISVSQYNVLLVLETYNVPELSAGVNCTFEDLSEMDGLVIGNQIQCYSPAAKEVPRIIT
                     ENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTH
                     DPKTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECIL
                     NIQGMEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKV
                     YLYKCGAMRESCGLCLKADPDFECGWCQSPGQCTLRQHCPAHESRWLELSGANSKCTN
                     PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECIPLVDGYIPAEQIV
                     CEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLADLKPNRGPMSGGTQVT
                     ITGTNLNAGSNVVVMFGSQPCLFHRRSPSYIICNTTSSEEVLDMKVTVQVDRARIRQD
                     LVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVL
                     NATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAF
                     SPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPN
                     LIGRHKVMARVGGMEYSPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRK
                     SRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYT
                     MRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFS
                     MRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKM
                     LTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQI
                     EYKTLVLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDL
                     EWRQGSGARMILQDEDITTKIENDWKRLNTVAHYQVPDGSLVALVSKQVTAYNAVNNS
                     TVSRTSASKYENMIRYTGSPDSLRSRTPMITPDLESGVKLWHLVKNHEHGDQKEGDRG
                     SKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKH
                     GIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTS
                     EHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNE
                     FNTMSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMSLDS"
     exon            2223..2405
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2537
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2638
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2762
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2916
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3016
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3131
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3332
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3429
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3620
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3772
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3890
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4027
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..4192
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            4193..4286
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4526
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4673
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4908
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            4909..5051
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            5052..5320
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            5321..5387
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            5388..5534
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            5535..5694
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            5695..5798
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            5799..5898
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            5899..6089
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            6090..6259
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6472
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            6473..6623
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
     exon            6624..12981
                     /gene="Plxna4"
                     /gene_synonym="Plxna4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagagagc gccaggcagc tggagttttg cagcgcttgg ccgggcttca atgcacagca
       61 gcagcgagcc gcggcggcag caggcagccc gggagctccg gcggcggccg agccagaggc
      121 ggccccgctc cctgccccct gcaaactttg ctagcagtcc gcccgggggg ccggggacgc
      181 gcctgggagg ctcggcttgg accacggccg cactcttggc cgccgcagcg ctagccgccg
      241 ccgtcgctgc taccaccgca gctccgcgcc tccccaggga gctgctggcg gcttccgagg
      301 ccccccagcc ccggcccctg ggcactgccc ggctagtccc cggccagggg tgggagcaac
      361 agcggcgcag tcagccctgg gctgccaggg ggtggccgtc actgcccagg gagacgcgca
      421 gaggctcgca gagcgctccc cggcgggtcc ccaacgtact cgccgccgcg cccgggcagc
      481 ggcccgaccc ggctagcatg ggcggcgcgg agtgacgccg ccgtgcccgc ttggcatcaa
      541 ggacattcag cccgcggggg tggggacgaa ggggggcagc cccgcgtcgc cgccgcagcc
      601 cctgagagcc accgctgtcg ttgcttgggc tccggggctg gatggaggat aggggtgctt
      661 ggaattgatc tacattttct gacctttttg ttggacatta cgcccacctt ggacgctgca
      721 agaggagctg tcaagcccgg caggctctga tttggccccc tccgtttttc tctgctgctc
      781 gtggcttccc cgtgccttgg tggagtattt gcgttcgggg ctggggctgg aggaggcagc
      841 cacacgcgcg cacacgcaca cgttcagagg agggcgagag gcagcggtac aggcaccatc
      901 tgcagtgtca atgcggcgct ggggctgaag gagggaaacg ccgcgcttcc aggggagaca
      961 gccctgctga gtcctggcct cccgaaaggg acggttgtgc tggagtgccg ctgtgtctga
     1021 taggacctgt gtctgaaatg aaagccatgc cctggaactg gacttgcctg ctctcccacc
     1081 tgctggtggt agggatgggt tcctctaccc tgcttccgcg ccagccaccc cagatgtctc
     1141 agaagccctc ttttgtcaca ttccgagggg agcccaccga gggcttcaat caccttgtgg
     1201 tggatgagag gacagggcac atttatttgg gggctgtcaa caggatctac aaactctcta
     1261 gtgacctcaa ggtcttggtg actcatcaga cagggccaga cgaggacaac cccaagtgtt
     1321 acccacctcg gattgttcag acctgcaatg agcccctggc cagcaccaat aacgtcaaca
     1381 agatgctgct tatagactac aaagaaaaca ggctgattgc atgtgggagc ctataccagg
     1441 gtatctgcaa gctcctgagg cttgaggacc tcttcaagtt gggagagccc tttcacaaga
     1501 aggaacacta cctctcgggg gttaatgaga gtggttcagt ctttggggtg atcgtttcct
     1561 acagcaactt cgatgataaa ctatttattg ccacagcagt agatggcaaa cctgaatatt
     1621 ttcctaccat ctccagcagg aagctgacta agaactctga ggcggatggc atgtttgctt
     1681 atgttttcca tgatgaattt gtggcctcta tgattaagat cccttcagac accttcacgg
     1741 ttatccccga ctttgacatt tactatgtct atggtttcag cagtggcaac tttgtctact
     1801 ttttgaccct tcagccagag atggtgtccc ccccaggttc cacgaccaag gagcaggtgt
     1861 acacctcaaa gcttgtgagg ctctgcaaag aggacacagc cttcaattcc tatgtagagg
     1921 tgcccattgg ctgtgagcgc agtggggtgg agtatcgctt actacaggct gcctacctgt
     1981 ctaaggctgg tgcagtgctc ggccggaccc tgggtgtccg cccagatgat gacctcctct
     2041 tcaccgtctt ctccaagggc cagaagagga agatgaaatc tctggatgag tctgccctgt
     2101 gcgtcttcat cttgaagcag atcaatgatc gcattaagga ccgcctacag tcctgttata
     2161 ggggcgaggg aacgcttgac ctggcctggc tcaaggtgaa ggacatccct tgcagcagcg
     2221 cgctccttac cattgatgac aacttctgtg gcctggatat gaatgctcct ctgggagtgt
     2281 ctgaaatggt acgtggcatt ccagtcttca cagaagacag ggaccgcatg acctccgtca
     2341 tcgcatacgt ctacaagaat cactctctgg ccttcgtggg caccaaaagt ggcaagctaa
     2401 aaaagatccg ggttgatggg cccaagggca atgccctcca gtatgagact gtacaggtgg
     2461 tggactcagg accagtcctc cgggacatgg ccttttccaa ggaccacgag caactctaca
     2521 tcatgtcaga aaggcagctt actagagttc ctgtggagtc ctgtgggcaa tatcggagct
     2581 gtggcgagtg tcttggctca ggtgaccccc attgtggctg gtgtgtgctc cacaacacgt
     2641 gcacccggaa agaacggtgt gaacgctcca gggagccccg aagatttgcc tcagagatga
     2701 agcagtgtgt ccggctgacg gtccatccca acaacatctc tgtctctcag tacaacgtgc
     2761 tgctggtcct agagacatac aatgtcccgg aactgtcagc aggtgtcaac tgtacctttg
     2821 aggatctgtc agagatggat gggctggtaa taggcaatca gatccagtgc tactcccctg
     2881 cagccaagga ggtgccccgg atcatcacag aaaatgggga ccatcatgtt gtccagctgc
     2941 aactcaagtc aaaggagact gggatgacct tcgccagcac cagctttgtc ttctacaact
     3001 gcagtgtcca caattcatgt ctgtcctgtg tggagagccc ataccgctgc cactggtgta
     3061 aataccggca tgtttgtacc catgacccca agacatgctc cttccaggaa ggccgagtga
     3121 agctccctga ggactgcccc cagctgctgc gagtggacaa gatcctggtt ccagtagagg
     3181 tgatcaagcc catcactctg aaggctaaga acctcccaca gcctcagtcg ggacagagag
     3241 gctacgagtg catcttgaac atccaaggca tggagcagag ggtacctgcc ctgcgcttca
     3301 acagctccag tgtgcagtgt cagaacacct cctattccta tgaagggatg gagatcaaca
     3361 acctgccagt ggagctgaca gtcgtgtgga atggacactt caacatcgac aacccagctc
     3421 agaataaagt ttacctctac aagtgtgggg ccatgcgtga gagctgtggg ctgtgcctca
     3481 aggctgaccc ggatttcgag tgtggctggt gtcagagccc tggacagtgt actctacgcc
     3541 agcattgccc tgcccatgag agccggtggc tagaactgtc aggtgccaat agcaaatgca
     3601 ccaaccctcg gatcacagag atcatcccag tgacaggccc tcgggagggg ggcaccaaag
     3661 tcaccatccg aggggagaac ttgggcctgg aattccgtga cattgcttca catgtcaagg
     3721 tggctggtgt ggaatgcatc cccttggtgg atggctacat cccggcagaa cagattgtgt
     3781 gtgagatggg agaggccaag cctagccagc acgcgggctt tgtggagatc tgtgtggctg
     3841 tgtgtcggcc tgagttcatg gcccgctcct cacagctcta ttacttcatg actctgactc
     3901 tagcagatct gaagcccaac cgaggaccca tgtctggggg tacccaggtc accatcacag
     3961 gcaccaacct gaatgcaggc agcaatgtgg tggtgatgtt tgggagccag ccctgcctct
     4021 tccacaggcg ctcaccatcc tacattatct gtaacactac gtcctcagag gaagtgttgg
     4081 acatgaaggt gactgtacag gtggacaggg ccaggatccg ccaggacctg gtctttcagt
     4141 atgtggagga ccccaccatc gtgcgtattg agcctgaatg gagcattgtc agtgggaaca
     4201 cacctattgc cgtctgggga actcatctgg acctcataca gaacccacag atccgtgcca
     4261 agcacggagg gaaagagcac atcaacatct gtgaggtcct aaatgctact gagatgacct
     4321 gccaggctcc agcccttgcc ctgggtcctg accaccagtc agatctcact gagaggcctg
     4381 aagaatttgg tttcatcctg gacaacgtcc agtctctgct aattctgaac aagaccaact
     4441 tcacctacta tcctaaccct gtgtttgagg ctttcagtcc ctcaggaatc ctggagctca
     4501 agcctggcac ccccattatc ctaaagggca agaacctgat cccacctgtg gctggaggca
     4561 atgtgaagct gaactatact gtgctggttg gggagaaacc atgcaccgtg acagtgtcag
     4621 atgtgcagct gctctgcgag tctcccaacc tcatcggcag gcacaaagtg atggcacggg
     4681 tgggtggtat ggaatattcc cctgggatgg tgtacatcgc cccagacagc cctctcagcc
     4741 tgcccgccat cgtcagcatc gcagtggctg gtggtctcct catcatcttt attgtggctg
     4801 tgctcattgc ttacaaacgc aagtcccgag aaagtgacct cactctgaag aggctgcaga
     4861 tgcagatgga caaccttgaa tcccgtgtgg ccctggagtg caaggaagct tttgcagagc
     4921 tgcagacaga tattcatgag cttaccagtg acctggatgg agctgggatt ccttttctgg
     4981 actacaggac ctataccatg cgggtgctgt tcccagggat tgaagaccac cctgtgctac
     5041 gagaccttga ggtcccaggc taccgtcagg agcgtgtgga gaaaggattg aagctcttcg
     5101 cccagctcat caacaacaag gtgttcctac tctctttcat ccgcactctt gagtctcagc
     5161 gcagtttttc catgcgcgac cgaggcaacg tggcctcgct catcatgact gtacttcaga
     5221 gcaagctaga gtatgccact gatgtgctga agcagctcct ggctgacctc attgataaga
     5281 acctggagag caagaaccat cccaagctgc tactcaggag gacggagtcg gtggccgaga
     5341 agatgttgac taattggttc actttcctcc tctacaagtt cctcaaggag tgtgctgggg
     5401 agcccctctt ctccctgttc tgtgccatca agcagcagat ggagaaaggt cctatcgatg
     5461 ccatcacagg agaggctcgc tactcactaa gtgaggacaa gctcatccgg cagcagattg
     5521 aatataagac cctggtcctg agctgtgtca gtccagataa cgctaacagc ccagaggtcc
     5581 cagtgaagat cctcaactgt gacacaatca ctcaggtcaa ggagaagatc ctagacgcca
     5641 tcttcaagaa tgttccatgc tcccatcggc ccaaagctgc agacatggac ctggagtggc
     5701 gacaaggaag tggggcgaga atgattctgc aggacgaaga tatcaccacc aagattgaga
     5761 atgattggaa gagactcaac acagtagccc actaccaggt gccggatggt tccttggtgg
     5821 ctttagtgtc caagcaagtg acagcctata atgcagtgaa taactccact gtctccagga
     5881 cctcagcgag taaatatgaa aacatgatcc ggtacacagg cagccctgac agcctccgtt
     5941 cccgaacacc catgatcacc cctgacctgg aaagtggggt caagctgtgg catctggtga
     6001 agaaccatga acatggagac cagaaagagg gggatcgggg gagcaagatg gtgtctgaga
     6061 tctatctgac acgactgctg gccacaaagg gcacactgca gaagtttgtg gatgacctgt
     6121 tcgagaccat cttcagcaca gcccaccgtg gttccgctct gcccctagcc atcaagtaca
     6181 tgtttgactt ccttgatgag caggctgata agcatggcat ccatgacccg catgtccgcc
     6241 atacctggaa gagcaactgc ctgcccctac ggttttgggt gaatatgatc aagaaccctc
     6301 agtttgtgtt tgacatccat aagaacagca tcacagatgc ctgcctctct gtggtggccc
     6361 agactttcat ggactcctgc tccacctcgg agcaccgact gggcaaggat tccccctcga
     6421 acaagctgct ctacgccaag gacattccca gctacaagaa ctgggtagag aggtattatt
     6481 cagacattgg gaagatgccg gcgataagtg accaggacat gaacgcgtac ctggctgagc
     6541 aatcgcggat gcacatgaat gagttcaaca caatgagtgc gctctcggag atcttctcct
     6601 atgtgggcaa atacagtgag gagatccttg gacccctgga ccatgatgac cagtgtggaa
     6661 agcagaaact ggcttacaaa ctagaacaag tcataaccct catgagctta gacagctgag
     6721 aactgtcctt ccagggccat cctggaggga gggacacacc aagccgtgcc tcagtctaga
     6781 ttatcatctt taccaagtgc aagttccgac aggcatcagc agcaatcccc aagcagcgcc
     6841 gtctctcctt tcatttctct gcctcttctg tctctccctc cttccggagt cccatctctt
     6901 tcagttgctc tgccagtgga attggaccac atcgctgacc ctccatcaat ttagggatgg
     6961 ccaggccata gtgagggacc tgaccagatc tcagagtcag gctccctccc agctgctcct
     7021 ggccccatgc atcagtggca gggctcagaa aggatgagga gctgaggaca gaacattcct
     7081 atgctgctac ttcaccgtct gctttggcaa tccccactgt ggtccaaaac ctggcttcgg
     7141 gaagcaactg tgagctcagt attatctgaa gtaggagaca tcactcagat ctccctttcc
     7201 aacacactca acaataagag gccaggcagt gggcctgggt gctttgtaac tgtgagataa
     7261 aggccttgcc tcctactgat gttggattgg ggaccagtgg aagtttaaag atgctctctc
     7321 agcagctgct gcctatctat ttgatgtcca gcagccttct gtccccttct aatatccttg
     7381 gaggccttcc gaatgacctt cctccccttc ctgtggaaag tcagacagga aaaggtaaca
     7441 gttacattcc accatggaga tgctcctaca ttatctaatc tggttcctaa tagcagaaat
     7501 gtaacatgga gagagagaga agaggaaaaa gaatgccatg tatgccagaa gcaccaatga
     7561 attattctct attcacccca agttcaaatg catcatgacc atagtcaagg atctattgcc
     7621 agagccttgt gtgttgtcta gagaaggcat ctccatgctc ctttgtcacc atcaccaatg
     7681 ctcaccgtga aatgcagatg catccaggag agtctacctc cagccgtctc cgaggctcca
     7741 tccctactgt ctaagagaac tccatagatg gccaggccag aaggcctagc ccttgtccct
     7801 cctgcagaat ccggtgccat tgctatgcag atgactttgt cactgaaatg tccagacctc
     7861 tgtgggaatt gtttcatcaa catctcagct gtctcttcag tggttcttcc tcttaccctt
     7921 cctgaagtca cctaccactg aagaaacata cttacgcaca ccaagacaaa acaagacgcc
     7981 agcagcctca gccaacagct tgtgcctgga agggactaga gagctaagtg agggacctgg
     8041 ctggatatgg agaacagtac ataccactaa acagtggcct tggcatttgc gtctccattg
     8101 tgtctttcca tctttggata tgccattttg ctttagcaaa tgtgtgttcg gaaatgtacc
     8161 aagtggctat gccaagaggt ggtcttttgg tgggtcctgg gaacatacag tcttgaaaac
     8221 atcatagata cttagtgaac cagtctccac cataagcaag aatctcttta ggcagctctg
     8281 gcttcttgtt gtccaacact catggaggca agagaggcac tggagaaggt gttaatagca
     8341 tcccacagtc tcgccttcct tcattcgcca tgcatcacat accattactt tccgtcacta
     8401 agcttcatat ggagcaaagt ccatgtgtct gtcatcctgc ccctgtaagg acaccgagtc
     8461 cctctgcatg tgagagaaca gggttggggg aggcacccag gaacccgcag gaaatatgca
     8521 aggatttctt atccatgtac gaggatgctg aggcagtccc cttctctgtc ccctggttca
     8581 tctgtccagt cttcagtgtc agtgtacttc actgagtggt agtgtatgtg gtaagaacat
     8641 tcttctaatc acaggaaatc aaaatgctac ctaccaaggc tgacctgtgg cgactcagag
     8701 cagaaggccc cacgtggcat tgctgtagac aaacagcaaa gacacaccga tgtagcaaac
     8761 aggaaaagga ggctggggag agatgcattg gagtctggga agggtaatga gaaacaataa
     8821 caagaaaacc aaaggttttg gcaaatcaac tgccgggtgg agacatgcag aatttctgtc
     8881 accacatatc gttttcttcc atgaagccac aggacctggc aggctttagg gtgcatgtgg
     8941 gggttcggct ggaagagtac ctcagctgca aaggtctttt tacacatatg aagggttagg
     9001 gagaagagag acaggaacct atttaatgca gacttgtgga cagaaggaag gtgtgtgtgt
     9061 gtgtgtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtttaga tgcatgagcg
     9121 agagatattt gagttttaag ttttgcacag ttagaaaaat atgaacaagc agcaaaagag
     9181 ttcgtgacct tgctgacttt ttttttttac tggatgattt tattgttatt attttgtcgg
     9241 tacagaattt tttttttttg tcatttttgt tacaagcaaa acttcaaaca cctcagagaa
     9301 acacacatat caggaagaaa gaggccagga cagtcacatt tcctgggtat cctcatttct
     9361 cttgggaggg aggggcttta gttattttac tttacttggt aatgtaggca gtcccagtgg
     9421 cttgcttgag gaactcagaa gttgaggtcc atcttgcctg taaaaaactc tcctttttgc
     9481 tgcttgtttg tttgtttgtt tgtttgtttg tttgtttact ttccatttct tccatttgaa
     9541 tttttggtgc aagtgtgata catttaaaag caagtatagg caatgttatc caaaatctgt
     9601 caaatcctcc catatattcc tacccaactc ctccttgggg ttctctagtt cctcttagca
     9661 gccaaagacc ctggtggtct gtgaacttcc agagaactaa ctcagagaag cttggccatg
     9721 cagtgcagtg gtgccttgcc ctctttccag agttcatttg cagggtgttg cagatctgtt
     9781 aaaggagaaa ctttcattta tctgctagag tttgttccaa aggtatgtgt ggagggggca
     9841 gaggggaagt agtctctctc acctcccact cacctctata tcctcctgtt cataacacca
     9901 ctggtcaaaa tggtactgat cacacatcca aaatatcagg ccaagtgagg atttgaatct
     9961 tgaagggaga ttagcaagga atttgatagg gtcctgcatg caaaagaatt tgtggaagaa
    10021 accaaggaag gtatctgcgg gttggttatg tctctgtggc atatgtctct ttaggtgtgg
    10081 gcatggtccg gtcatgtctt cctccttctg tgaaaggaga cgccctaatg tttcttagtg
    10141 ccatgaagtc aagttagcct ttgagtcagt tacttcctca ggaaaatact ttcttgcctt
    10201 cttctttcag tataatttta aacttgggga cagagaataa atagaagatt ccccagacca
    10261 aggtactttg caaccctgtg caacatgcat ggccagaccc aacccctgga gtctccatgc
    10321 tggaagccca tagccctgga gtaagcttgt ggtacccgaa tggcagcaca tttggaaaga
    10381 gaaatacttt taatgaatct tgcagctcaa ggtagagcat ccaggacaat tgcaagaaag
    10441 catgagctgc taacagacaa agcctttcta tgctcccagg ttcaactcct gttcccactg
    10501 ggttaatatt gatatagtgc ccagcttgtc cacctcctta tgactctgag gtgtttattt
    10561 accaccccac actcccaccc ccagttgcat gtctgtctac tgactatacc ccaccctggc
    10621 agctagcttc ctccctgttc ttccttgaac ctcctgtaca aggagcctcc ctgaggccaa
    10681 gtactgattc tgatacagga attgctcagt accttagtct attagtagta agtgctgtcc
    10741 caacccagct ttggctgctt tgttgagtga aagggtcacc ctcctccagc caacaccctg
    10801 tgggtcctcc cctagggaaa ccacaagcaa tggcatcccc agtgatctcc aagatgtgag
    10861 actctgacac actttccagg accatgggtg atgctgccgt ggtctatctt ggcctaagca
    10921 cctctcattt tgatagaaat aagacagcct ccatcctgct atctctccta ggactcgctg
    10981 ccattgactt cactagacag caagtaaatg cttcatcttg agaaaggcca atactcctgt
    11041 catcaggaac aaattttcct gatgtcatag aatcaactcg agcttcatgc tgacaagtga
    11101 gcagctgagg gatcattgca ggtggaggta aaggggcagc tcctgagaaa gaggctggag
    11161 ccttgcgagc ttcccctgag gttctgatga gggccacacc cctctcccat ttagaaagca
    11221 atcactgaag gaaacatttc aaatcttagg agagacattt tgttgttgtt gttttgctac
    11281 agatcattgc tcttcaataa tattgctttt tattagaggg agcatccaag tttaaaaaaa
    11341 aaaaaaacta tgtctttcgg ttgtaaagac agaatgcctt tgtgagcacc tggatggaat
    11401 cccttgagta gactgatagc tatcagaagc tgagcagagc aagcagttcc caaggagtga
    11461 agagaaggtc atgttctacc tcctggcaaa gatccccggt gagggctcta agtagttggt
    11521 tggggaaact cacatccctc ctccctcctc ccttctcctt gggctcctat ctagtcctcc
    11581 ctctctgagc tgcccctgga actgctgagt ccttcaaatt ttttctcagc ctccttcaaa
    11641 ctgcacctaa gctcattttg ggggacccaa gctccctgtc cccaataaga caaatacaag
    11701 tggccactca attagccagt ttcttcctct tctgcccatt tattttgtct atatatttaa
    11761 agttaagact caagcacatg ttggaagggc tcccttatga gattggagtt caaaacagag
    11821 ggtacagtta agcagcaccg caaaaacact ttgaagcaga gacctctcca gcaaacagaa
    11881 tcaaggaaca ctcctgtgca gaaatcagtt cagttctatc caagcaagag aggaagatgg
    11941 catatgtcct ctcatttctg tgcagagatc agttctatct aaacaagggg aagatgtctc
    12001 ccttgtccct tccctggcat tcttgtcagc ttgttggctt attaaacctt ccgttcttta
    12061 aaaacaaaag ctagtttacc tcaaagaatt ttgcttccat ttagaaacca gtaacagggc
    12121 tggagaatag atgacactcc tcatatctct ccctacctgg gcctggtgtc tttgggacac
    12181 gtggtcttac cttagtcctg agtcctgagt gctctaagcg ggaaccaggt ccccagacct
    12241 gcgatgggaa ggaaggattg tatgcagcct ttctccctgc ttagcatgta gggaacagcc
    12301 tctgtctctt ccatcagggt cttgtcaagt taccatagca accagcaact ccaggtacca
    12361 caaaagacaa tgcctccaag agctgaggtg tgagagagag cacagggttc tggcctggtc
    12421 agaggaccca gaattaagcc ccagatgcta agagagtaaa ggaaggaggg atggaactgg
    12481 atacatgagt gggttaagta gctgcagcgg ccttgcgagt ctgagaaagg ccactggcag
    12541 agctagaaca gatcccttct gttttcctca ccacttaccc ttctccagcc tgccccacct
    12601 ctattccaaa actctcccct tgaattccga ccctttgaaa gaagaaagca aaatatacct
    12661 ttagacaaca gtgttaccct gagccgcaag gacaggtgga tgggaatctc tgaaagaaaa
    12721 aaaaaaagga gggtcttctg gttttgattt ttaaaaagag tatcctagta agaataaaaa
    12781 caaaaagatt taaaaaaagt ttttaaaaga aaacctatgc tatttaaatt ggagcccagt
    12841 tgtaacttgg taaaggtaag cctcggtacc tttgttataa ttaattgtat acctgtgtat
    12901 gtaaatataa ggcattccta ttttgcagtt cagaacaaaa aaaactattt gtaatataga
    12961 ataaagttta ttaaaaaata a
//
