LOCUS       NP_001101051            1872 aa            linear   ROD 28-APR-2025
DEFINITION  plexin-A3 precursor [Rattus norvegicus].
ACCESSION   NP_001101051 XP_001055498 XP_219723
VERSION     NP_001101051.2
DBSOURCE    REFSEQ: accession NM_001107581.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1872)
  AUTHORS   Xiang,X., Zhang,X. and Huang,Q.L.
  TITLE     Plexin A3 is involved in semaphorin 3F-mediated oligodendrocyte
            precursor cell migration
  JOURNAL   Neurosci Lett 530 (2), 127-132 (2012)
   PUBMED   23063687
  REMARK    GeneRIF: These results suggest that plexin A3 is expressed in OPCs
            and immature oligodendrocytes and is involved in OPC migration.
REFERENCE   2  (residues 1 to 1872)
  AUTHORS   Matsuoka,R.L., Chivatakarn,O., Badea,T.C., Samuels,I.S., Cahill,H.,
            Katayama,K., Kumar,S.R., Suto,F., Chedotal,A., Peachey,N.S.,
            Nathans,J., Yoshida,Y., Giger,R.J. and Kolodkin,A.L.
  TITLE     Class 5 transmembrane semaphorins control selective Mammalian
            retinal lamination and function
  JOURNAL   Neuron 71 (3), 460-473 (2011)
   PUBMED   21835343
REFERENCE   3  (residues 1 to 1872)
  AUTHORS   He,H., Yang,T., Terman,J.R. and Zhang,X.
  TITLE     Crystal structure of the plexin A3 intracellular region reveals an
            autoinhibited conformation through active site sequestration
  JOURNAL   Proc Natl Acad Sci U S A 106 (37), 15610-15615 (2009)
   PUBMED   19717441
REFERENCE   4  (residues 1 to 1872)
  AUTHORS   Schwarz,Q., Waimey,K.E., Golding,M., Takamatsu,H., Kumanogoh,A.,
            Fujisawa,H., Cheng,H.J. and Ruhrberg,C.
  TITLE     Plexin A3 and plexin A4 convey semaphorin signals during facial
            nerve development
  JOURNAL   Dev Biol 324 (1), 1-9 (2008)
   PUBMED   18804103
REFERENCE   5  (residues 1 to 1872)
  AUTHORS   Cheng,H.J., Bagri,A., Yaron,A., Stein,E., Pleasure,S.J. and
            Tessier-Lavigne,M.
  TITLE     Plexin-A3 mediates semaphorin signaling and regulates the
            development of hippocampal axonal projections
  JOURNAL   Neuron 32 (2), 249-263 (2001)
   PUBMED   11683995
REFERENCE   6  (residues 1 to 1872)
  AUTHORS   Strolin Benedetti,M., Goldaniga,G., Montesanti,L., Battaglia,R. and
            Vicario,G.
  TITLE     Disposition of 14C-labelled FCE 22101 in animals
  JOURNAL   J Antimicrob Chemother 23 Suppl C, 165-171 (1989)
   PUBMED   2732138
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC094668.10.
            
            On Jan 9, 2008 this sequence version replaced NP_001101051.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript was available for the full length
            of the gene. The extent of this transcript is supported by
            orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132270 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     Protein         1..1872
                     /product="plexin-A3 precursor"
                     /note="Plexin 4, SEX, homolog to the cMet/HGF receptors"
                     /calculated_mol_wt=205966
     sig_peptide     1..19
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZPX4.1)"
                     /calculated_mol_wt=2036
     mat_peptide     20..1872
                     /product="Plexin-A3. /id=PRO_0000411105"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZPX4.1)"
                     /calculated_mol_wt=205966
     Region          22..490
                     /region_name="Sema_plexin_A3"
                     /note="The Sema domain, a protein interacting module, of
                     Plexin A3; cd11273"
                     /db_xref="CDD:200534"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZPX4.1)"
     Site            order(77,79..80,139,176..178,204..206,213..215,369,372,
                     374,377..381,391..392,394)
                     /site_type="other"
                     /note="putative Semaphorin binding site [polypeptide
                     binding]"
                     /db_xref="CDD:200534"
     Region          491..>528
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          547..637
                     /region_name="TIG_plexin"
                     /note="TIG domain; pfam17960"
                     /db_xref="CDD:465588"
     Site            549
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZPX4.1)"
     Region          638..685
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          691..785
                     /region_name="TIG_2"
                     /note="TIG domain found in plexin; pfam18020"
                     /db_xref="CDD:465619"
     Region          789..838
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          841..935
                     /region_name="IPT_plexin_repeat1"
                     /note="First repeat of the IPT domain of Plexins and Cell
                     Surface Receptors (PCSR) . Plexins are involved in the
                     regulation of cell proliferation and of cellular adhesion
                     and repulsion receptors. In general, there are three
                     copies of the IPT domain present...; cd01180"
                     /db_xref="CDD:238585"
     Region          936..1022
                     /region_name="IPT_plexin_repeat2"
                     /note="Second repeat of the IPT domain of Plexins and Cell
                     Surface Receptors (PCSR) . Plexins are involved in the
                     regulation of cell proliferation and of cellular adhesion
                     and repulsion receptors. In general, there are three
                     copies of the IPT domain present...; cd01179"
                     /db_xref="CDD:238584"
     Region          1024..1124
                     /region_name="IPT_plexin_repeat3"
                     /note="Third repeat of the IPT domain of Plexins and Cell
                     Surface Receptors (PCSR) . Plexins are involved in the
                     regulation of cell proliferation and of cellular adhesion
                     and repulsion receptors. In general, there are three
                     copies of the IPT domain present...; cd01181"
                     /db_xref="CDD:238586"
     Region          1126..1209
                     /region_name="IPT_PCSR"
                     /note="IPT domain of Plexins and Cell Surface Receptors
                     (PCSR) and related proteins . This subgroup contains IPT
                     domains of plexins, receptors, like the
                     plasminogen-related growth factor receptors, the
                     hepatocyte growth factor-scatter factors, and the...;
                     cd00603"
                     /db_xref="CDD:238337"
     Site            1163
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D3ZPX4.1)"
     Site            1221..1241
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZPX4.1)"
     Region          1294..1837
                     /region_name="Plexin_cytopl"
                     /note="Plexin cytoplasmic RasGAP domain; pfam08337"
                     /db_xref="CDD:462434"
     Site            1597
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51805; propagated from
                     UniProtKB/Swiss-Prot (D3ZPX4.1)"
     CDS             1..1872
                     /gene="Plxna3"
                     /gene_synonym="Plxn4; SEX"
                     /coded_by="NM_001107581.2:174..5792"
                     /db_xref="GeneID:309280"
                     /db_xref="RGD:1584973"
ORIGIN      
        1 mhtvcllpll fftiggclgs srpfrtfvvt dttlthlavh rvtgevfvga vnrvfklasn
       61 ltelrahvtg piednarcyp ppsmrvcshr lvpvdnvnkl llidyaarrl vacgsiwqgi
      121 cqflrlddlf klgephhrke hylsgaqepd smagviveqg qgpsklfvgt avdgkseyfp
      181 tlssrklidd edsgdmfslv yqdefvssqi kipsdtlsly pafdiyyiyg fvsasfvyfl
      241 tlqldtqqtl ldtagekfft skivrmcagd sefysyvefp igcswrgvey rlvqsahlak
      301 pglllaqalg vpadedvlft ifsqgqknra npprqtilcl ftlssinahi rrriqscyrg
      361 egtlalpwll nkelpcintp mqingnfcgl vlnqplgglh vieglpllad stdgmasvaa
      421 ytyhqhsvvf igtrsgnlkk vrvdgsqdaq lyetvsvvqg tpilrdllfs pdhrhiylls
      481 ekqvsqlpve tceqylscaa clgsgdphcg wcvlqhrccr egacpgasap hgfaeelnkc
      541 iqvrvrpnnv svtssgvqlt vamrnvpdls lgvscsfeev teseaillps gelrcpspsl
      601 qelqtltrgh gathtvrlql lsmetgvrfa gvdfvfyncs alqscmscvg spypchwcky
      661 rhvctshphe csfqegrvhs pegcpeilpr gdllipvgvm qpltlraknl pqpqsgqkny
      721 ecvvrvqgrq hrvpavrfns ssvqcqnasy fyegdefgdt eldfsvvwdg dfpidkppsf
      781 rallykcwaq rpscglclka dprfncgwci sehrcqlrvh cpapksnwmh psqkgarcsh
      841 pritqihplt gpkeggtrvt ivgenlglts revglrvagv rcnsipteyv saerivceme
      901 eslvpspppg paelcvgdcs adfrtqsqql ysfvtptldr vsptrgpasg gtrltisgts
      961 ldagsrvtvi irdgecqfvr rdaeaivcis pistlgpsqa piilaidhan isstgviyty
     1021 tqdptvthle ptwsiingst sitvsgthll tvqeprvrak yrgiettntc qvindtamlc
     1081 kapgiflghp qpraqgehpd efgflldhvq aarslnrssf tyypdpsfep lgpsgvldvk
     1141 pgshvvlkgk nlipaaagss rlnytvligg qpcaltvsdt qllcdspsqt grqpvmvlvg
     1201 glefwlgtlh itadraltlp amvglaaggg llllaitvvl vaykrktqda drtlkrlqlq
     1261 mdnlesrval eckeafaelq tdineltnhm dgvqipfldy rtyavrvlfp gieahpvlke
     1321 ldtppnveka lrlfgqllhs raflltfiht leaqssfsmr drgtvasltm valqsrldya
     1381 tgllkqllad lieknleskn hpklllrrte svaekmltnw ftfllhkflk ecageplfll
     1441 ycaikqqmek gpidaitgea ryslsedkli rqqidyktlt lhcvcpeseg saqvpvkvln
     1501 cdsitqakdk lldtvykgip ysqrpkaedm dlewrqgrma riilqdedit tkiecdwkri
     1561 nslahyqvtd gslvalvpkq vsaynmansf tftrslsrye sllraasspd slrsrapmlt
     1621 pdqeagtklw hlvknhdhad hregdrgskm vseiyltrll atkgtlqkfv ddlfetvfst
     1681 ahrgsalpla ikymfdflde qadqrqisdp dvrhtwksnc lplrfwvnvi knpqfvfdih
     1741 knsitdacls vvaqtfmdsc stsehrlgkd spsnkllyak dipnykswve ryyrdiakma
     1801 sisdqdmday lveqsrlhan dfnvlsalse lyfyvtkyrq eiltsldrda scrkhklrqk
     1861 leqiitlvss ss
//
