LOCUS       NM_001105988           10201 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus plexin A2 (Plxna2), mRNA.
ACCESSION   NM_001105988 NM_001198564 XM_001070296 XM_223080
VERSION     NM_001105988.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10201)
  AUTHORS   Zhao,M., Li,J., Gao,Z., Guo,D., Yang,Y., Wang,F., Wang,L., Yang,Y.,
            He,X., Li,H. and Chang,S.
  TITLE     miR-145a-5p/Plexin-A2 promotes the migration of OECs and
            transplantation of miR-145a-5p engineered OECs enhances the
            functional recovery in rats with SCI
  JOURNAL   Neurobiol Dis 182, 106129 (2023)
   PUBMED   37068642
  REMARK    GeneRIF: miR-145a-5p/Plexin-A2 promotes the migration of OECs and
            transplantation of miR-145a-5p engineered OECs enhances the
            functional recovery in rats with SCI.
REFERENCE   2  (bases 1 to 10201)
  AUTHORS   Li,S., Hua,X., Zheng,M., Wu,J., Ma,Z., Xing,X., Ma,J., Zhang,J.,
            Shan,C. and Xu,J.
  TITLE     PLXNA2 knockdown promotes M2 microglia polarization through
            mTOR/STAT3 signaling to improve functional recovery in rats after
            cerebral ischemia/reperfusion injury
  JOURNAL   Exp Neurol 346, 113854 (2021)
   PUBMED   34474008
  REMARK    GeneRIF: PLXNA2 knockdown promotes M2 microglia polarization
            through mTOR/STAT3 signaling to improve functional recovery in rats
            after cerebral ischemia/reperfusion injury.
REFERENCE   3  (bases 1 to 10201)
  AUTHORS   Nogi,T., Yasui,N., Mihara,E., Matsunaga,Y., Noda,M., Yamashita,N.,
            Toyofuku,T., Uchiyama,S., Goshima,Y., Kumanogoh,A. and Takagi,J.
  TITLE     Structural basis for semaphorin signalling through the plexin
            receptor
  JOURNAL   Nature 467 (7319), 1123-1127 (2010)
   PUBMED   20881961
REFERENCE   4  (bases 1 to 10201)
  AUTHORS   Janssen,B.J., Robinson,R.A., Perez-Branguli,F., Bell,C.H.,
            Mitchell,K.J., Siebold,C. and Jones,E.Y.
  TITLE     Structural basis of semaphorin-plexin signalling
  JOURNAL   Nature 467 (7319), 1118-1122 (2010)
   PUBMED   20877282
REFERENCE   5  (bases 1 to 10201)
  AUTHORS   Kodo,K., Nishizawa,T., Furutani,M., Arai,S., Yamamura,E., Joo,K.,
            Takahashi,T., Matsuoka,R. and Yamagishi,H.
  TITLE     GATA6 mutations cause human cardiac outflow tract defects by
            disrupting semaphorin-plexin signaling
  JOURNAL   Proc Natl Acad Sci U S A 106 (33), 13933-13938 (2009)
   PUBMED   19666519
REFERENCE   6  (bases 1 to 10201)
  AUTHORS   Renaud,J., Kerjan,G., Sumita,I., Zagar,Y., Georget,V., Kim,D.,
            Fouquet,C., Suda,K., Sanbo,M., Suto,F., Ackerman,S.L.,
            Mitchell,K.J., Fujisawa,H. and Chedotal,A.
  TITLE     Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome
            coupling in migrating granule cells
  JOURNAL   Nat Neurosci 11 (4), 440-449 (2008)
   PUBMED   18327254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Oct 27, 2010 this sequence version replaced
            NM_001198564.1, NM_001105988.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.53624.1,
                                           SRR26360194.188781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               JAXUCZ010000013.1  108691530-108692100
            572-1833            JAXUCZ010000013.1  108715021-108716282
            1834-2016           JAXUCZ010000013.1  108721125-108721307
            2017-2151           JAXUCZ010000013.1  108783463-108783597
            2152-2252           JAXUCZ010000013.1  108817548-108817648
            2253-2376           JAXUCZ010000013.1  108820695-108820818
            2377-2530           JAXUCZ010000013.1  108822192-108822345
            2531-2627           JAXUCZ010000013.1  108822866-108822962
            2628-2742           JAXUCZ010000013.1  108825056-108825170
            2743-2943           JAXUCZ010000013.1  108833076-108833276
            2944-3040           JAXUCZ010000013.1  108835034-108835130
            3041-3231           JAXUCZ010000013.1  108837907-108838097
            3232-3383           JAXUCZ010000013.1  108852687-108852838
            3384-3501           JAXUCZ010000013.1  108858958-108859075
            3502-3638           JAXUCZ010000013.1  108860992-108861128
            3639-3806           JAXUCZ010000013.1  108861944-108862111
            3807-3900           JAXUCZ010000013.1  108862356-108862449
            3901-4140           JAXUCZ010000013.1  108865987-108866226
            4141-4284           JAXUCZ010000013.1  108866652-108866795
            4285-4519           JAXUCZ010000013.1  108867090-108867324
            4520-4662           JAXUCZ010000013.1  108868742-108868884
            4663-4931           JAXUCZ010000013.1  108869368-108869636
            4932-4998           JAXUCZ010000013.1  108871413-108871479
            4999-5145           JAXUCZ010000013.1  108871662-108871808
            5146-5305           JAXUCZ010000013.1  108872381-108872540
            5306-5409           JAXUCZ010000013.1  108872915-108873018
            5410-5509           JAXUCZ010000013.1  108876606-108876705
            5510-5700           JAXUCZ010000013.1  108877708-108877898
            5701-5870           JAXUCZ010000013.1  108878907-108879076
            5871-6083           JAXUCZ010000013.1  108881463-108881675
            6084-6234           JAXUCZ010000013.1  108882351-108882501
            6235-10201          JAXUCZ010000013.1  108883487-108887453
FEATURES             Location/Qualifiers
     source          1..10201
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..10201
                     /gene="Plxna2"
                     /note="plexin A2"
                     /db_xref="GeneID:289392"
                     /db_xref="RGD:1305325"
     exon            1..571
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1833
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     CDS             646..6330
                     /gene="Plxna2"
                     /codon_start=1
                     /product="plexin-A2 precursor"
                     /protein_id="NP_001099458.2"
                     /db_xref="GeneID:289392"
                     /db_xref="RGD:1305325"
                     /translation="MEQRRFQLRAMQADNLSVVLLSVAWLLLARGTTGMPQFSTFHSE
                     NRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQP
                     CSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLS
                     SVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELH
                     SDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGMAINSAGDLFY
                     TSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGEALAQAFNISSEEDV
                     LFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQ
                     CTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSVASYVYNGYSVVFVGT
                     KSGKLKKIRADGPPHGGVQYEMVSVFKDGSPILRDMAFSINQLYLYVMSERQVTRVPV
                     ESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEANRFAASISQCMSLEVHP
                     NSISVSDHSRLLSLVVNDAPNLSEGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVI
                     PLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCT
                     HDPTTCSFQEGRINVSEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECV
                     LNIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLK
                     VHLYKCAAQRESCGLCLKADHKFECGWCSGERRCTLRQHCPSTSSPWLDWSSHNVKCS
                     NPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPIPGEYIIAEQI
                     VCEMGHALMGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLSPIRGPESGGTMV
                     TITGHYLGAGSSVAVYLGNQTCEFYGRSMNEIVCVSPPSSNGLGPVPVSVSVDRARVD
                     SSLQFEYIDDPRVQRIEPEWSITSGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCT
                     VVNTTTLTCLAPSLTSDYRPGLDTVERPDEFGFLFNNVQSLLIYNDTKFIYYPNPTFE
                     LLSPTGILDQKPGSPIILKGKNLCPPASGGAKLNYTVMIGETPCTVTVSETQLLCEPP
                     NLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYKR
                     KSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTY
                     AMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSF
                     SMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEK
                     MLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQ
                     IEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMD
                     LEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPAS
                     ASISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGVKVWHLVKNHDHGDQKEGDR
                     GSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADR
                     HSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCST
                     SEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKLPAISDQDMNAYLAEQSRLHAT
                     EFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEHLINAMSIES"
     exon            1834..2016
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2151
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2252
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2376
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2530
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2627
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2742
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2943
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3040
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3231
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3383
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3501
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3638
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3806
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3900
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4140
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4141..4284
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4519
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4520..4662
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4663..4931
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4932..4998
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5145
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5146..5305
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5409
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5410..5509
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5510..5700
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5701..5870
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5871..6083
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6084..6234
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6235..10201
                     /gene="Plxna2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccgagct gagtcgcgct gcgcgcagca ctgtccgcgc agagccaagc gggggcggcg
       61 ggagcagctg ccgggatcct tcagctgaag acgagcgatc agatctggtg gacccgtgag
      121 ccgcggagcc gcggggagct tacgggcccg gtcgcagaca gagctggcag cggttcccgg
      181 aggaaatagg gccgagcggg ccaggaacag aggggaagga agcgcaggat cgctgatgtc
      241 agagcagccc ggaaagtcgt gccggagaaa cctgaagaca cccggctttg agccgccccg
      301 gagagaccct gcgggacccc acgccccttc gcaaccaggt ccctgcgcgc aggcgaccag
      361 gacgaatacg cgaagaccca atccggggct accccaggaa tacaggcaag cagccggcgc
      421 gggccgagga ttttaatgac cctgggttcc atgtggacca ggctgttcct gtgactcggg
      481 tcaggcagga ctgggcgcac gctgccctgg gcaatcgcca gacgagcgga cgaagcggcg
      541 acgcagggac agacagacag cgccgagctg gaaccatgtg agagctcatc ttgaaaagtg
      601 gagaaacaca cagaggagct gtcccccagc ctcacccctt tagggatgga gcagaggagg
      661 ttccagttgc gggccatgca ggctgacaac ctgtctgtgg tactgctctc tgtggcctgg
      721 ctcctgctag cccgtgggac cacaggtatg cctcagttca gtactttcca ctctgagaat
      781 cgtgactgga cttttaacca tttgactgta caccgaagaa caggggctgt gtacgtgggg
      841 gccatcaatc gtgtctacaa gttgactggg aacctcacca tccaggtggc tcacaagacg
      901 gggccagaag aggacaataa ggcttgctac ccacccctca ttgtacagcc ctgtagcgaa
      961 gtgctcacac ttaccaataa tgtcaacaaa ctactgatca tcgactactc tgagaatcgc
     1021 ctgcttgcct gtggaagcct ctaccagggt gtttgcaagc tcctgcggct agatgacctc
     1081 ttcatcctgg tggagccatc ccacaagaag gagcactact tgtccagtgt caataagaca
     1141 ggaaccatgt atggtgtgat tgtgcgctct gagggggaag atggcaagct ttttatcggc
     1201 actgctgtgg atggcaagca ggattacttc cctaccctgt ccagccgcaa gctgccccgt
     1261 gaccccgagt cttcggcaat gctggactat gagctccaca gtgattttgt ctcttccctc
     1321 atcaagatcc cctctgacac cctagccctg gtctcccact ttgacatttt ctacatctat
     1381 ggctttgcca gtggagggtt tgtctacttt ctcactgtcc agccagagac cccagagggc
     1441 atggccatca attcagctgg agacctcttc tatacctcga gaatcgtgcg tctctgcaag
     1501 gatgacccca agttccattc ctatgtgtcc ctgccctttg gctgcacacg agctggggtg
     1561 gaataccgcc ttctgcaggc agcttacctc gcaaagccag gggaagctct agctcaggcc
     1621 ttcaacatca gcagtgaaga agatgtgctg tttgccatct tctccaaggg gcagaagcag
     1681 taccaccatc cccctgatga ctctgcccta tgtgccttcc ccatccgggc catcaacttg
     1741 caaatcaagg agcggttgca gtcttgctac catggagagg gcaacttgga gctcaactgg
     1801 ctgctgggaa aggatgtaca gtgcaccaag gcgccagtcc ccatcgatga taacttctgt
     1861 ggcttggaca tcaaccagcc tctgggaggc tccactcctg tggagggact gaccttgtac
     1921 accaccagca gggaccgcct gacctctgtg gcctcctatg tttacaatgg ctacagtgtg
     1981 gtgtttgtgg ggactaagag tggcaagcta aagaagattc gagctgatgg tcccccccat
     2041 ggtggggtcc aatatgagat ggtctctgtg ttcaaagatg ggagccccat cctccgggac
     2101 atggccttct ccatcaatca gctgtaccta tatgtcatgt ctgagagaca ggtcaccagg
     2161 gtccctgtgg aatcatgtga acaatataca acttgtggag agtgtctaag ctcaggggat
     2221 cctcattgtg gctggtgtgc cctgcacaac atgtgctcta gaagagacaa atgccaacgg
     2281 gcctgggaag caaatcgatt cgctgccagt atcagccagt gtatgagcct tgaggtgcac
     2341 cccaacagca tctctgtgtc agatcacagc cggctgctca gcctggttgt gaatgatgct
     2401 cccaacctct ctgagggtat cgcctgtgcc tttgggaacc tgactgaggt ggaggggcag
     2461 gtgtctggga gtcaagtcat atgcatctca cctggaccca aggatgtccc tgtcattcct
     2521 ctggatcaag actggtttgg cctggagctg cagctgagat ccaaagagac aggaaagatc
     2581 tttgtcagca ccgaattcaa gttctataac tgcagtgccc accaactgtg cctgtcctgt
     2641 gttaacagcg ccttccgctg ccattggtgc aagtaccgga acctctgtac acatgatccc
     2701 accacctgtt ccttccagga aggcaggatc aatgtttcag aggactgtcc acagctcgtg
     2761 cccacagaag agattctgat cccagttggg gaagtaaaac caatcactct taaagcccga
     2821 aacctgcccc aaccccagtc tggccagcga ggctacgaat gtgtgctcaa cattcaaggg
     2881 gctgtccacc gggtccctgc cctacgtttc aacagttcca gtgtgcagtg ccaaaacagc
     2941 tcgtaccagt atgacgggat ggacatcagc aacctagcag tggactttgc tgtggtgtgg
     3001 aatggcaact tcattattga caaccctcag gacctgaaag tacacctcta caagtgtgca
     3061 gcccagcggg aaagctgtgg tctctgcctc aaggctgatc acaagttcga gtgtggctgg
     3121 tgcagtgggg agcgcagatg taccctccgc cagcattgcc ccagcacttc tagcccctgg
     3181 ctcgactggt ccagccacaa tgtcaagtgc tccaaccccc aaatcacaga gattttgaca
     3241 gtatcaggac cacctgaagg agggactcgt gtgaccatcc atggagtgaa cctgggcttg
     3301 gacttctctg agatcgctca ccacgtgcag gtggctggag tgccctgcac acccatccca
     3361 ggggaataca tcatcgctga gcagatcgtc tgtgagatgg gccatgccct tatgggtacc
     3421 acatctgggc ctgtgcgcct gtgcattggg gaatgcaagc cagagttcat gaccaagtcc
     3481 caccagcagt atacatttgt gaatccttct gtgctgtcac tcagcccaat ccggggacca
     3541 gagtcaggag gtaccatggt gaccatcaca ggccattacc ttggtgctgg gagcagcgtg
     3601 gcagtgtacc tgggcaatca gacctgcgaa ttctatggga ggtcaatgaa tgagattgtc
     3661 tgtgtttcac ccccatcatc caatggacta ggaccagtcc ctgtctccgt gagtgtcgac
     3721 agagcccggg tagacagcag tctacagttc gagtacatag atgacccacg ggtccaacgt
     3781 attgagccag agtggagcat cactagtgga cacacacccc taaccatcac aggcttcaac
     3841 ttggatgtaa ttcaggagcc aaggatccga gtcaagttca atgggaaaga atcagtcaat
     3901 gtatgcacag tggtaaacac aaccaccctc acctgtctgg caccctctct gaccagtgat
     3961 taccgtccag gtctggacac tgtggagcgg ccagatgagt ttggatttct ctttaacaat
     4021 gtccaatcct tacttatcta taatgacacc aagttcatct actaccccaa cccaactttt
     4081 gaactgctca gccccactgg aatcttggat cagaagccag gttcacccat catcctgaag
     4141 ggcaaaaatc tctgtcctcc tgcctccgga ggggccaaac tcaactacac agtaatgatt
     4201 ggagagacac cttgtacagt cactgtgtct gagacacaac tgctctgtga acctcccaac
     4261 ctcacaggac agcacaaggt catggttcac gtgggcggga tggtgttctc ccctggctct
     4321 gtgagtgtca tctccgacag cttgttgacc ctgccagcca tcatcagcat tgcagctggt
     4381 ggaagcctcc ttcttatcat cgtcatcatt gtcctcatcg cttacaagcg caagtctagg
     4441 gaaaatgacc tcacactcaa acggctccaa atgcagatgg acaacctgga gtccagggtg
     4501 gcgctggaat gcaaggaagc ttttgcggag cttcagacag acatcaatga gctaaccagt
     4561 gacttggacc gatcaggaat cccttacctg gactaccgta cctatgccat gagagtactg
     4621 ttcccaggca tcgaggacca ccctgttctt cgggagctgg aggtacaagg aaatggacag
     4681 cagcacgtgg agaaagccct gaaactcttc gcccagctta tcaacaacaa ggtgttcttg
     4741 ctgaccttca tccgcacact ggaactacag cgcagcttct ccatgcgaga ccgtgggaat
     4801 gtggcctctc tcatcatgac aggtcttcag ggtcgcctgg aatatgccac cgatgttctc
     4861 aagcagctgc tctctgacct cattgacaag aacctggaga acaagaacca ccccaagctg
     4921 cttctccgca ggactgagtc tgtggcggag aagatgctga ccaactggtt tgctttcctt
     4981 ttacacaagt tcctaaagga gtgtgctggg gaaccactct tcatgctata ctgtgcaatc
     5041 aagcagcaga tggagaaagg ccccattgat gctatcactg gtgaggcccg gtactccctg
     5101 agtgaagaca agctcatccg gcagcagatc gagtacaaga ctctgatcct gaactgtgtc
     5161 aaccctgaca atgagaatag cccagagatc cccgtgaagg tactaaactg tgacaccatc
     5221 actcaagtca aggagaagat cctcgatgct gtatataaga atgttcccta ctcccagcgg
     5281 ccaagggctg tggacatgga cctggagtgg cgccaaggcc ggattgccag agtggtatta
     5341 caggatgagg acattaccac caagatagag ggtgactgga agcggcttaa cacactgatg
     5401 cattaccagg tgtcagacag atcagtggtg gctctggtcc ctaagcagac ctcctcctac
     5461 aacatccctg cctctgccag catctctcgg acatccatca gcagatacga ctcttccttc
     5521 aggtacacag gcagcccaga cagcctccgg tcccgggttc ccatgatcac cccagacctg
     5581 gagagtggtg tcaaggtttg gcatctggta aagaaccatg accatggtga ccagaaggag
     5641 ggcgaccggg gcagcaaaat ggtgtctgag atctacttga cccggcttct agccaccaag
     5701 ggcaccctgc agaaatttgt ggacgacttg tttgagacct tgttcagcac tgtgcacagg
     5761 ggtagtgctc tccccctagc catcaagtac atgtttgatt tcctggatga gcaggcagac
     5821 agacacagta tccacgacac agatgtgcgg cacacctgga aaagcaactg ccttccactt
     5881 cgtttctggg tgaatgtcat caagaaccct caatttgtat ttgacatcca caagggcagc
     5941 atcacagatg cttgcctctc tgtggtagcc cagaccttca tggactcctg ctccacatca
     6001 gagcaccgac tgggcaagga ctcaccttcc aataagttgc tctatgccaa ggatatcccc
     6061 agttacaaga actgggtaga aagatactat gcagatattg ccaagctccc agccattagt
     6121 gaccaagata tgaacgccta cctcgcggag cagtctcgcc tgcatgccac ggagttcaat
     6181 atgctgagcg ccctcaacga gatctactcc tatgtcagca agtacagtga ggagctcatc
     6241 ggggcactag agcaggatga gcaggccaga cggcaacgac tggcctacaa ggtggaacat
     6301 ctcatcaatg ccatgtccat agagagctga aaggaagaca ttctgttcct ggaagaaaga
     6361 ctcatacaag ctatcacact ggtgtctcaa aaggaagatg ggatgagtga agggtatcag
     6421 gccccagagc tggctgtcct ctaaaaatct caccgaggaa agaaggaaag gctcctctgt
     6481 caatggcagc catgtttctt catagccggt tccttccaga aggacagtga acaccaccca
     6541 tcacagtgtg agctcagtac actacgggca aggagaaggt ggccctttaa gctgagaggc
     6601 ttgagccaaa tggttctgcc tctgtgactg ctgctttgca tgaaaactca tttgatgtat
     6661 attgggaaat aatgagaact ttatttaatt ttttaagaaa aagggaaaaa acagaaataa
     6721 aacaaaacat aaatcccccc tgtccatccc gtccaacttt tgtttaattt gatttctgtt
     6781 cccttctcag taatatttct tcttctgtaa cacctctttc tcaatgtcag aaaaatgcct
     6841 gagagatgcc gagtagaacc agtttggaaa tgctctcctc tcctttgaac tgagaggaag
     6901 aaggagaggc aggaaggagt agaagttctt actaaacatt tggcaaatta gccaggaaga
     6961 cctggatccc accacagcca gatgcacctg agaactgcag gcttttgtgg gacttttgga
     7021 agctgatcgg atccacctgc taataggaaa ctgccttcca tgctgtgccc ttgtgtatcc
     7081 tcatctccta agaggaggaa gtacccaaca aggacctgtg ggaacacctt ttctttgttt
     7141 tacttaatcc cgagcctcag caagtgagga gttgggcttt ggtacttttc cttttggttt
     7201 ccttagaatt gataacagaa aaggaagagg tgagactcac agaacagcca cctcctcccc
     7261 aaggactctg aacagagccc tacaagccag gcaccttggg actgtgcaga ccaggtctcc
     7321 tagacctgag ctgaatgggg agcatgggtg tttgactttg gattctactc aaccatccac
     7381 tagtttacgg caattaaaaa gaaaacaaac tcaaacactg tttacagtaa gcaatacttg
     7441 aagagtgtag gtttaaaaag cagcagtatt tattattata ttttcttttc tcttgtgcct
     7501 ggagagggga ggccaacctt cgctcatacc cagaagcccc tgaccatctg ggcatactgc
     7561 atttgcctca gtagaaatga ccgtggtagc ccatcatctc tatctgtcat ggaatcatgg
     7621 atgtgaaagt ctattacttc tgagaaggca cttgtccttc cctgtgtctc ctgatacctg
     7681 atgccataga tagccagcct tcctgagtat agcttccaag caaagatcaa ggctccatcc
     7741 ttgggcccag aggcaagctc tgtggtagca ggacaagaaa ttcaactggt aagccctcag
     7801 ggaatttagt tctcctgcct tggcatggcc cctagcagcc aattctcaac agctttgcaa
     7861 ttagcatccg tctcaaggta gggtagcaag aggaagacaa aaggtgggca taagggaaca
     7921 gtgaacgtat gtcccctaag aaggcatgag ccttctgctt tttaaggggt caggaatgcc
     7981 aggctgtagg gctgggaaat ggggcttact atcccaacag agttggccct gggttatttc
     8041 cttcacaatt aactcaggcc tcagcttatt tctccagttg attccagttt ctgagactct
     8101 gctgaccaga tgtgactgcc tgcacagggc aaagaagaaa gtcaagaagg tggcttccat
     8161 gcaatgtatg tgtccttgga tggctgtctc acacacagct gatgctgtct gggctgttca
     8221 gcttgtttct tgcctgaatg caactgacaa gtggagagag aaaagcattc agcaaaatac
     8281 tcaggaaact tgctgatttt atgatgattc acaaccagcc atgccaaggc cacttttctt
     8341 ctgataattt actcatgtta aagtttttct gggccatacc aatagcctgg aaagaaacta
     8401 atgactggcc ttccacacca agccaaagtg tttgctcctc atagcaccca aagcttatca
     8461 tcttagagcc tgtaatttat gaaaatgaaa gaagtgatgt agtcaaaaca agaataggaa
     8521 cagaagacag gataaactct ggcctgccta tttctccatc ccagcactgt tgaagacttt
     8581 ctgagcagct gctactgctt gagctgatgt ccagagtgcc gtttcatcaa gaagtaaaaa
     8641 agaaaatgtt ttacatctct ttcaatagca tcttacccac acccttctca gtgtgcctac
     8701 ctggtatatc ccagcagcca cttatggtac ctgctcactg cctctggctt gcttcactaa
     8761 agatgtttgg agagtatgga gagaatgatg gggcgagagc aaatctaaga atgtagatga
     8821 agggagcagg gccaaccatg gaaggtggtc tagtcacttt gccaaggatt ccatgagttg
     8881 gacaacttgg actgaaaaag aagagtggcc aagggacaca attaaagaag aagtgaggaa
     8941 atttcagcta gagacaggcc atgccatgcc aggagggtga gttattgtag agtcttgctc
     9001 tcattttagc tttctaccta tcattccacc agctctttgc tttcgtttac tagtcactga
     9061 tagtctactc cctaggagat ggagaggaga ggaagttgat tggtcactct tcttgccgtt
     9121 atccaattta aggatagttt ggccttttgt ttaaaaagaa aaaataaatt gttaaagcta
     9181 ccacccttcc ccacaaaaag ccatctatct ttggggaggc atgaagtctc tcttaaactt
     9241 acctagcttt actttatttc attgatctac acaaaagcca attctctagg aaaagaatag
     9301 gactgcagag ggtttggcaa aacagagttc tagaggactg tattaagact tatccctcaa
     9361 ctggatttga caacacctcc tgccttctgt gtgtcaggca cttctgtgtc tgatgttcta
     9421 cctctttctg tggtttgaat ctcaaaacca cttctgatcc ctctttcttt atagagtgca
     9481 gtcattcaac tcatgggcac actgtgatct tacagaagga gggaactgcg tccttcattc
     9541 attcacttgg agagcattcc taagtagtaa tcatctgcca agttcttaga ggttctgcag
     9601 agcagggtga ataagaccat gaaggtcctt ctttcagcaa ctgcagattc tccaagctgc
     9661 taggcctgcc agcaatacag caagatggct cctcccaccc tccccagcag aaagcactag
     9721 gtgcatagaa aatggggtgt cattaaggaa gagggctgac ccccccacac acacacacac
     9781 gctctgctac catgtgctgc tctttagtca gcacaacctt gctgattatg ctcctgacct
     9841 tccttcagtt ccaccaggat gaaaatagaa attagttgtt aaggcccctg ggcctgctgc
     9901 acgtgaggta aaagcagtgg tggctgctag cagtcgtctg atacaacaag cagagactgc
     9961 tggaagcctt ctcagatact acacaactgc caaatctgta atctcaccta ctgcctggca
    10021 atactaagct ggcagttact ctaaaagggc cctttccaac cacattgtgt cacagctaag
    10081 agccctgcat ccttcacaca gacagttaag aattgagaca cagagggcca ggagggtgag
    10141 gaaatgcaaa gtggccactt agcacatggt gcagatctta tggtgggagg gaggccagaa
    10201 g
//
