LOCUS       NM_020086               1968 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus plasmalemma vesicle associated protein (Plvap),
            mRNA.
ACCESSION   NM_020086
VERSION     NM_020086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Herrnberger,L., Seitz,R., Kuespert,S., Bosl,M.R., Fuchshofer,R. and
            Tamm,E.R.
  TITLE     Lack of endothelial diaphragms in fenestrae and caveolae of mutant
            Plvap-deficient mice
  JOURNAL   Histochem Cell Biol 138 (5), 709-724 (2012)
   PUBMED   22782339
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Ciofi,P., Garret,M., Lapirot,O., Lafon,P., Loyens,A., Prevot,V. and
            Levine,J.E.
  TITLE     Brain-endocrine interactions: a microvascular route in the
            mediobasal hypothalamus
  JOURNAL   Endocrinology 150 (12), 5509-5519 (2009)
   PUBMED   19837874
  REMARK    GeneRIF: Data show that PV-1 was detected exclusively over highly
            permeable regions of the brain by in situ hybridization.
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Keuschnigg,J., Henttinen,T., Auvinen,K., Karikoski,M., Salmi,M. and
            Jalkanen,S.
  TITLE     The prototype endothelial marker PAL-E is a leukocyte trafficking
            molecule
  JOURNAL   Blood 114 (2), 478-484 (2009)
   PUBMED   19420356
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Hnasko,R. and Ben-Jonathan,N.
  TITLE     Developmental regulation of PV-1 in rat lung: association with the
            nuclear envelope and limited colocalization with Cav-1
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 288 (2), L275-L284 (2005)
   PUBMED   15640522
  REMARK    GeneRIF: PV-1 is developmentally regulated in the rat lung and
            shows a divergent intracellular localization, with a limited
            caveolae/Cav-1 colocalization in cultured endothelial cells.
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Stan,R.V.
  TITLE     Multiple PV1 dimers reside in the same stomatal or fenestral
            diaphragm
  JOURNAL   Am J Physiol Heart Circ Physiol 286 (4), H1347-H1353 (2004)
   PUBMED   14630628
  REMARK    GeneRIF: tested the role of PV1 in the structure of the diaphragms
            and demonstrated that multiple PV1 homodimers reside in close
            proximity within the same diaphragm.
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Hnasko,R., McFarland,M. and Ben-Jonathan,N.
  TITLE     Distribution and characterization of plasmalemma vesicle protein-1
            in rat endocrine glands
  JOURNAL   J Endocrinol 175 (3), 649-661 (2002)
   PUBMED   12475376
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Stan,R.V., Arden,K.C. and Palade,G.E.
  TITLE     cDNA and protein sequence, genomic organization, and analysis of
            cis regulatory elements of mouse and human PLVAP genes
  JOURNAL   Genomics 72 (3), 304-313 (2001)
   PUBMED   11401446
REFERENCE   9  (bases 1 to 1968)
  AUTHORS   Stan,R.V., Kubitza,M. and Palade,G.E.
  TITLE     PV-1 is a component of the fenestral and stomatal diaphragms in
            fenestrated endothelia
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13203-13207 (1999)
   PUBMED   10557298
REFERENCE   10 (bases 1 to 1968)
  AUTHORS   Stan,R.V., Ghitescu,L., Jacobson,B.S. and Palade,G.E.
  TITLE     Isolation, cloning, and localization of rat PV-1, a novel
            endothelial caveolar protein
  JOURNAL   J Cell Biol 145 (6), 1189-1198 (1999)
   PUBMED   10366592
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF154831.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070900.1, AF154831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1968
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /note="plasmalemma vesicle associated protein"
                     /db_xref="GeneID:56765"
                     /db_xref="RGD:619971"
     exon            1..390
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1341
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /function="component of the stomatal diaphragms of
                     caveolae and transendothelial channels and of the
                     fenestral diaphragms"
                     /note="gp68; plasmalemma vesicle protein 1; PV-1"
                     /codon_start=1
                     /product="plasmalemma vesicle-associated protein"
                     /protein_id="NP_064471.1"
                     /db_xref="GeneID:56765"
                     /db_xref="RGD:619971"
                     /translation="MGLSMDRSPYSRTGDRDRGCWYYLRYFFLFVSLIQFLIILGLVL
                     FMIYGNVHATTESSLRATEIRADNLYSQVVGLSAAQANLSKQLNISTLVKDTVMQQLL
                     TTRREVERINASFRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEGNKTCEALLFKL
                     GEKVKTLEMEVVKEKAVCSKDKDSLLAGKRQAEMQQEACGKAREQQKQDQQVTEEQLR
                     KVQSLCLPLDQEKFQADVLNVWRDSLVYRSLDNIGYHYSLMPEFSSLRRTCESLPGIM
                     TTKVEELARGLRAGIERVTRENGELRRQKLELERAIQGEREARTRAGTEAQARETQLR
                     TECARQTQLALEEKAALRTQRDDLERQLEARKRELEQLRTEVDVRISALDTCVKAKSL
                     PAIQPRLPGPPPNPPPIDPASLEEFKKRILESQRPPLVNPAVPPSG"
     exon            391..487
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..1194
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1252
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1334
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1946
                     /gene="Plvap"
                     /gene_synonym="Pv1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgccctg cggacactgc gcaaatgggg ctctccatgg accgcagccc gtactcccgc
       61 acgggggacc gggatcgcgg ctgctggtac tacctgcgct atttcttcct cttcgtgtcg
      121 ctcatccagt tcctcatcat cctgggcctg gtcctcttca tgatctatgg taatgtgcac
      181 gccaccaccg agtccagtct gcgggccacg gagatccgcg ccgacaacct atacagccag
      241 gtggtgggac tgtcggccgc acaggctaac ctgagcaaac agctgaacat cagcaccctc
      301 gtcaaggaca ccgtcatgca gcagctgctg accacgcggc gcgaggtgga gcgcatcaac
      361 gccagcttcc gccagtgcca aggcgacctg atcacctaca taaactataa tcggttcatc
      421 gccgctatca tcctgagcga gaagcagtgc caggaacagc tgaaggaggg caacaagacc
      481 tgcgaagcct tgctcttcaa gctgggagag aaggttaaga cactggagat ggaggtggtc
      541 aaggagaagg cggtgtgctc caaagacaag gacagcctgc tggcaggaaa gcggcaggcg
      601 gaaatgcagc aggaggcctg tggcaaagcg cgagagcagc aaaagcagga ccagcaggtg
      661 accgaggagc aactgcgcaa ggtgcagtcc ctgtgcctcc cactggacca ggagaagttc
      721 caggcggacg tgctgaacgt gtggcgggat tcgctggtct accgttccct ggataatata
      781 ggctaccact actcgctgat gccggagttc tcgtccctcc gccgaacatg cgagagcctg
      841 cccgggatca tgaccaccaa ggtagaagag ctggcgcgcg ggttgcgcgc gggcattgag
      901 cgcgtgaccc gtgaaaatgg agagctgcga cgccagaagc tggagctgga gcgcgcgata
      961 cagggcgagc gggaggcgcg gacgcgcgcc gggaccgagg cgcaggctcg agagacccag
     1021 ctacggacgg agtgcgcgcg ccagacacag ctggctctgg aggagaaggc agcgctgcgg
     1081 acacagcggg acgacctgga gcgccagctg gaggcgcgga agcgggagct ggagcaactg
     1141 cgcaccgagg tggatgtgcg cattagcgct ctggacacct gcgtcaaggc caagtcgctg
     1201 ccagccatcc agccgagact cccaggtcca ccccccaacc ctccacccat tgatccagct
     1261 agcctggagg aattcaagaa aaggatccta gagtcgcagc ggccccctct agtcaaccct
     1321 gctgtcccac ccagtggctg aggatgaagc tgctgccgga cactgggcac cagaatcgcc
     1381 cacccgtgga tgggggcagc cagatgccca cagtgctgga cacccgctgt gccccgccag
     1441 ggacctccac ccccacacct cttctagcac cccttcactg tcccctgcac cccactgtcc
     1501 tcccagacac tggatttaag gcacaggcag ctgtgaggtg acgtcacatc gcccccttcg
     1561 cacatgaagt gcccacagct cagctgccta ggcacctcct ccggtttcct atcactctgc
     1621 tcctgacccg ggaggtgaga acaggaagcc cggccttcag ctcccttggg agtgtccagc
     1681 ctctctctta aaggtttcca ggttctcctt gagagtttcc aggcctctcc tgaagggttc
     1741 ttgcccccat tcccgcagaa ttttcattgg gttctagaac cctttctaga gtctgcaggt
     1801 tcccctcctc ctcacaagga aggacctcaa ctgtagatga gtcccctgtg gatctcaggc
     1861 cctggagggc tgcctcccgc ctcagtctgc ttgtagccct taaagacatc actggcacgt
     1921 aataaatatc atgaaagtcc tttggaaaaa aaaaaaaaaa aaaaaaaa
//
