LOCUS       NM_001168543            2025 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phospholipid transfer protein (Pltp), mRNA.
ACCESSION   NM_001168543 XM_001072197 XM_215939
VERSION     NM_001168543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Zhang,M., Zhai,X., Li,J., Albers,J.J., Vuletic,S. and Ren,G.
  TITLE     Structural basis of the lipid transfer mechanism of phospholipid
            transfer protein (PLTP)
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (9), 1082-1094
            (2018)
   PUBMED   29883800
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Li,Y., Yu,X., Fu,X., Wu,F., Zou,L., Chen,Y. and Chen,Y.
  TITLE     Effect of Phospholipid Transfer Protein on Cigarette Smoke
            Extract-Induced IL-8 Production in Human Pulmonary Epithelial Cells
  JOURNAL   Inflammation 39 (6), 1972-1980 (2016)
   PUBMED   27596005
  REMARK    GeneRIF: Lung injury was accompanied by the upregulation of PLTP
            and IL-8 in the CSE-exposed rat model
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Chirackal Manavalan,A.P., Kober,A., Metso,J., Lang,I., Becker,T.,
            Hasslitzer,K., Zandl,M., Fanaee-Danesh,E., Pippal,J.B., Sachdev,V.,
            Kratky,D., Stefulj,J., Jauhiainen,M. and Panzenboeck,U.
  TITLE     Phospholipid transfer protein is expressed in cerebrovascular
            endothelial cells and involved in high density lipoprotein
            biogenesis and remodeling at the blood-brain barrier
  JOURNAL   J Biol Chem 289 (8), 4683-4698 (2014)
   PUBMED   24369175
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Albers,J.J., Day,J.R., Wolfbauer,G., Kennedy,H., Vuletic,S. and
            Cheung,M.C.
  TITLE     Impact of site-specific N-glycosylation on cellular secretion,
            activity and specific activity of the plasma phospholipid transfer
            protein
  JOURNAL   Biochim Biophys Acta 1814 (7), 908-911 (2011)
   PUBMED   21515415
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Yatsuya,H., Tamakoshi,K., Hattori,H., Otsuka,R., Wada,K., Zhang,H.,
            Mabuchi,T., Ishikawa,M., Murata,C., Yoshida,T., Kondo,T. and
            Toyoshima,H.
  TITLE     Serum phospholipid transfer protein mass as a possible protective
            factor for coronary heart diseases
  JOURNAL   Circ J 68 (1), 11-16 (2004)
   PUBMED   14695459
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   O'Brien,K.D., Vuletic,S., McDonald,T.O., Wolfbauer,G., Lewis,K.,
            Tu,A.Y., Marcovina,S., Wight,T.N., Chait,A. and Albers,J.J.
  TITLE     Cell-associated and extracellular phospholipid transfer protein in
            human coronary atherosclerosis
  JOURNAL   Circulation 108 (3), 270-274 (2003)
   PUBMED   12835223
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Oka,T., Kujiraoka,T., Ito,M., Egashira,T., Takahashi,S.,
            Nanjee,M.N., Miller,N.E., Metso,J., Olkkonen,V.M., Ehnholm,C.,
            Jauhiainen,M. and Hattori,H.
  TITLE     Distribution of phospholipid transfer protein in human plasma:
            presence of two forms of phospholipid transfer protein, one
            catalytically active and the other inactive
  JOURNAL   J Lipid Res 41 (10), 1651-1657 (2000)
   PUBMED   11013307
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Rao,R., Albers,J.J., Wolfbauer,G. and Pownall,H.J.
  TITLE     Molecular and macromolecular specificity of human plasma
            phospholipid transfer protein
  JOURNAL   Biochemistry 36 (12), 3645-3653 (1997)
   PUBMED   9132017
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Albers,J.J., Wolfbauer,G., Cheung,M.C., Day,J.R., Ching,A.F.,
            Lok,S. and Tu,A.Y.
  TITLE     Functional expression of human and mouse plasma phospholipid
            transfer protein: effect of recombinant and plasma PLTP on HDL
            subspecies
  JOURNAL   Biochim Biophys Acta 1258 (1), 27-34 (1995)
   PUBMED   7654777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 12, 2009 this sequence version replaced
            XM_215939.4, XM_001072197.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.14189.1,
                                           SRR26643285.14348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000003.1  174011740-174011982 c
            244-354             JAXUCZ010000003.1  174011035-174011145 c
            355-454             JAXUCZ010000003.1  174010852-174010951 c
            455-583             JAXUCZ010000003.1  174009442-174009570 c
            584-739             JAXUCZ010000003.1  174008824-174008979 c
            740-803             JAXUCZ010000003.1  174007393-174007456 c
            804-867             JAXUCZ010000003.1  174007250-174007313 c
            868-959             JAXUCZ010000003.1  174006263-174006354 c
            960-1136            JAXUCZ010000003.1  174002046-174002222 c
            1137-1196           JAXUCZ010000003.1  174001891-174001950 c
            1197-1361           JAXUCZ010000003.1  173999629-173999793 c
            1362-1429           JAXUCZ010000003.1  173999469-173999536 c
            1430-1472           JAXUCZ010000003.1  173995196-173995238 c
            1473-1536           JAXUCZ010000003.1  173995034-173995097 c
            1537-1613           JAXUCZ010000003.1  173994815-173994891 c
            1614-2025           JAXUCZ010000003.1  173994162-173994573 c
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2025
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /note="phospholipid transfer protein"
                     /db_xref="GeneID:296371"
                     /db_xref="RGD:1306695"
     exon            1..243
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            244..354
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1745
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /note="BPI fold containing family E"
                     /codon_start=1
                     /product="phospholipid transfer protein precursor"
                     /protein_id="NP_001162015.1"
                     /db_xref="GeneID:296371"
                     /db_xref="RGD:1306695"
                     /translation="MALLPALFLALLAGAHAELPGCKIRVTSAALELVKQEGLRFLEQ
                     ELEDINIPDVYGAKGHFYYNISDVKVTQLQLISSELHFQPDQDLLLNISNASLGLHFR
                     RQLLYWFFYDGGYINASAEGVSIRTGLQLSRDPTGRIKVSNVSCEASVSKINMAFGGT
                     FRRMYNFFSTFITSGMRFLLNQQICPVLHHAGTVLLNSLLDTVPVRSSVDELVGIDYS
                     LLKDPVVSNGNLDMEFRGAFFPLKEGNWSLLNKAVEPQLDDDERMVYVAFSEFFFDSA
                     MESYFQAGALQLTLVGDKVPNDLDMLLRATYFGSIVLQSPTVINSPLKLKLQAISSPR
                     CTIKPSGTTISVTASVTISLAPPTMPEVELSKMIMEGRLSAKLTLKGKALRAKLDLRR
                     FQIYSNQSALESLALIPLQAPLKTLLQIGVMPLLNERIWRGVQIPLPEGINFVHEVVT
                     NHAGFVTVGADLHFAKGLREVIDKNRSAGGADTVDSSVPPPSAAAA"
     exon            355..454
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            455..583
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            584..739
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            740..803
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            804..867
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            868..959
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1136
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1196
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1361
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1429
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1472
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1536
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1613
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..2025
                     /gene="Pltp"
                     /gene_synonym="Bpife"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccccctctt gtccagacag cagtcgggct tgtcacaggc tccgtactgc cctctcctcc
       61 accctcccga ctgccagcgt cccgcccctt ccccttccag cccccaggga ggaggggaga
      121 acagcggcga ggaggggggt cggaggccca gacttataaa ggcggctgga cccgcgctac
      181 ccgccagacc tcgccgcttg gatcccccgc gctgcctgtc gctccacgtg atcgcgccac
      241 taagcttggt taccatggcc ctgctcccgg ccctcttcct agcgcttctg gcaggtgccc
      301 acgccgagct cccgggctgc aagatccgag tcacctctgc ggctctggag ctggtgaagc
      361 aggaggggct gcgctttctg gagcaagagc tggaggacat caacatccca gatgtgtatg
      421 gcgcaaaggg ccacttctac tacaatatct cggacgtgaa ggtcacacag ctgcagttga
      481 tatcctccga gctccacttc cagccggacc aggacctgtt gctgaacatc tccaatgcgt
      541 ccttggggct gcacttccgg agacagctcc tctactggtt cttctatgat gggggctaca
      601 tcaatgcctc ggccgagggt gtgtccatcc gaacaggtct gcagctctcc cgggatccca
      661 ctggtcggat taaagtgtcc aatgtctcct gcgaggcctc tgtgtctaaa ataaatatgg
      721 ccttcggggg aaccttcagg aggatgtata actttttttc cacgttcatc acttctggga
      781 tgcgattcct cctcaaccag cagatctgcc ctgtgctcca ccatgctggg acagtgctgc
      841 ttaactccct cctggacaca gtgcccgtgc gtagttctgt ggatgaactt gtgggcatcg
      901 attattccct tctgaaggat cctgtggtct ccaacggcaa tctggatatg gaattccggg
      961 gagcattctt ccctctcaag gagggcaact ggagccttct caacaaagcg gtggagcctc
     1021 agctggatga cgacgagagg atggtgtacg tggccttctc tgagttcttc tttgactctg
     1081 ccatggagag ctacttccaa gctggagcgc tgcagctgac gcttgttggg gacaaggtgc
     1141 caaatgatct ggacatgctt ctgagggcca cttactttgg gagcattgtt ctccagagcc
     1201 cgacagtgat taactccccg ctgaagctga agctacaggc cataagctct ccgcgttgta
     1261 ccatcaagcc gtcaggcacc accatctctg tcaccgccag cgtcaccatc tccttggccc
     1321 cacctacaat gcctgaagtc gagctgtcca agatgatcat ggaaggtcgt ctcagtgcta
     1381 agttgacact caagggcaag gcgctgcgag cgaagctgga ccttcgaagg tttcaaattt
     1441 actccaatca gtctgcgctg gagtctctgg cactgatccc actgcaggcc ccactgaaga
     1501 cgctgctgca aatcggagtg atgcctttgt tgaatgagcg tatctggcgt ggggtgcaga
     1561 tccccctccc tgagggtatc aacttcgtgc atgaggtggt gaccaaccat gcaggcttcg
     1621 tcactgttgg ggctgacctc cactttgcca aaggacttcg agaagtgatt gacaagaacc
     1681 gttctgccgg cggcgctgac actgtggact ccagtgtccc tccaccctct gctgcagctg
     1741 cctgagccct tcgcccgccc ctcctgggca gctggcattc aggaactgaa ctgaggcttc
     1801 tcagcacctc ctgcccaccc cttgccatca gcctagtggt cccagtgcca cagagaagag
     1861 cccagctgga agctataccc gatttaattc cataatcagt caaccatcaa ttacaatcca
     1921 tccaaccctc tccttgggct tctctagagc tctgttgggg tcctgggatg gggcattttt
     1981 tatgcagacc agggaaagcc atcctatcaa agccagaaca aagtg
//
