LOCUS       NM_001012139            1781 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phospholipid scramblase 3 (Plscr3), mRNA.
ACCESSION   NM_001012139 XM_340827
VERSION     NM_001012139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Luevano-Martinez,L.A. and Kowaltowski,A.J.
  TITLE     Topological characterization of the mitochondrial phospholipid
            scramblase 3
  JOURNAL   FEBS Lett 591 (24), 4056-4066 (2017)
   PUBMED   29171872
  REMARK    GeneRIF: PLSCR3, via its C-terminal transmembrane domain,
            participates in the bidirectional movement of phospholipids within
            the inner membrane of mitochondria.
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Ren,M., Phoon,C.K. and Schlame,M.
  TITLE     Metabolism and function of mitochondrial cardiolipin
  JOURNAL   Prog Lipid Res 55, 1-16 (2014)
   PUBMED   24769127
  REMARK    Review article
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Kowalczyk,J.E., Beresewicz,M., Gajkowska,B. and Zablocka,B.
  TITLE     Association of protein kinase C delta and phospholipid scramblase 3
            in hippocampal mitochondria correlates with neuronal vulnerability
            to brain ischemia
  JOURNAL   Neurochem Int 55 (1-3), 157-163 (2009)
   PUBMED   19428821
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Py,B., Basmaciogullari,S., Bouchet,J., Zarka,M., Moura,I.C.,
            Benhamou,M., Monteiro,R.C., Hocini,H., Madrid,R. and Benichou,S.
  TITLE     The phospholipid scramblases 1 and 4 are cellular receptors for the
            secretory leukocyte protease inhibitor and interact with CD4 at the
            plasma membrane
  JOURNAL   PLoS One 4 (3), e5006 (2009)
   PUBMED   19333378
  REMARK    Erratum:[PLoS ONE. 2009;4(4). doi:
            10.1371/annotation/657cd713-aaac-4ebb-80ad-3ec8dfb12b42]
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Lu,B., Sims,P.J., Wiedmer,T., Moser,A.H., Shigenaga,J.K.,
            Grunfeld,C. and Feingold,K.R.
  TITLE     Expression of the phospholipid scramblase (PLSCR) gene family
            during the acute phase response
  JOURNAL   Biochim Biophys Acta 1771 (9), 1177-1185 (2007)
   PUBMED   17590392
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Wiedmer,T., Zhao,J., Li,L., Zhou,Q., Hevener,A., Olefsky,J.M.,
            Curtiss,L.K. and Sims,P.J.
  TITLE     Adiposity, dyslipidemia, and insulin resistance in mice with
            targeted deletion of phospholipid scramblase 3 (PLSCR3)
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13296-13301 (2004)
   PUBMED   15328404
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098055.1.
            
            On Jun 12, 2005 this sequence version replaced NM_001012139.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098055.1, SRR8487230.70012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1781
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /note="phospholipid scramblase 3"
                     /db_xref="GeneID:360549"
                     /db_xref="RGD:1307016"
     exon            1..62
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            63..231
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1115
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /note="PL scramblase 3; ca(2+)-dependent phospholipid
                     scramblase 3"
                     /codon_start=1
                     /product="phospholipid scramblase 3"
                     /protein_id="NP_001012139.1"
                     /db_xref="GeneID:360549"
                     /db_xref="RGD:1307016"
                     /translation="MAGYLPPKGYAPSPPPPYPVPAGYPEAAALHPGPGQAPVPTQGP
                     APAPGFSLFPSPGPVVPGPPGPFVPLPGVPSGLEFLVQIDQILIHQKAERVETFLGWE
                     TCNRYELRSGTGQQLGQAAEESNCCARLCCGARRPLRIRLADPGDREVLRLLRPLHCG
                     CSCCPCGLQEMEVQAPPGTTIGHVLQTWHPFIPKFSILDADRQPVLRVVGPCCTCGCG
                     TDTNFEVKTKDESRSVGRISKQWGGLLREALTDADDFGLQFPVDLDVRVKAVLLGATF
                     LIDYMFFEKRGGAGPSAITS"
     exon            232..470
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..513
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..734
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..896
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1058
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1746
                     /gene="Plscr3"
                     /gene_synonym="Pls3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcctgtga gcccgggagt gcgtggcccc cccccccggc tttcttattc tgggggcttc
       61 aggtgcctcc caagagaccc tgggccggtg ctgggcgcag ctgcctcttc gcctctgctt
      121 gtccgtcttt gtttctgtgc ctgtctggct gttcccaagc ttgtccccac tccagaacta
      181 agcctcccct acgccgacag cccaagacac ccttcccctt tcccatggca ggctacttgc
      241 cccccaaagg ttatgcccct tcgcccccac ctccctaccc cgtgccagct gggtatccag
      301 aggcggcggc gctgcatcct ggacccggac aggctccagt gcccacccag gggcctgccc
      361 ctgcgcctgg cttctctctc ttcccctcgc caggcccggt ggtcccaggg cctcctggtc
      421 ccttcgtgcc attgccaggg gtgccttctg gcctggaatt cctagtgcag attgatcaaa
      481 tcttgattca tcagaaggct gagcgagtgg aaacgttcct aggctgggag acctgtaata
      541 ggtatgaact tcgctccggg accggacagc aactgggtca ggcagctgag gagagcaact
      601 gctgtgcccg gctgtgctgt ggtgcccgcc ggccgcttcg tatccgccta gcggaccccg
      661 gggaccgcga ggtgctccgc ctcctccgcc cacttcactg cggctgcagc tgctgtcctt
      721 gtggtcttca ggagatggaa gtccaggccc cacctggcac caccattggc catgtgctac
      781 agacctggca ccccttcatt cccaagtttt ccatcctgga tgcagatcgc caacctgttc
      841 tacgagtcgt agggccttgc tgcacttgtg gctgtgggac ggacaccaac tttgaggtga
      901 agacaaagga tgaatctcga agtgtgggcc gcatcagcaa gcagtgggga gggctgctcc
      961 gagaagccct cacagatgcg gatgactttg gcctccagtt cccagtagat ctagatgtga
     1021 gagtgaaggc ggtgctgctg ggagccacgt tcctcattga ttatatgttc ttcgagaagc
     1081 gaggaggtgc tggaccctct gccatcacca gttagaagcc acctcaggat gaggagacca
     1141 tcagctgaac cagagtttaa gatggtcacc tgccctggac tttccctcct gaagcaaagc
     1201 cttccttggc atacactgca gtggacccac aagggtgact gagtggttgg gagccattgt
     1261 gtcccatccc ttccctcctt cacctgtggc cctgcagagg agcatgtatg agacccattc
     1321 ttccttgtgt ttaccatctc ccagcagtcc ctatgcacac attagctttt aaatttcctt
     1381 gcccactcct tccagccttc ctccagggcc tctgcacagg agggggcctc tggaatccag
     1441 gactcaagtt ttacagcagg gcttgtgggt aaaaggcaag cggcaccaaa gatggcagat
     1501 accaccctta ccttctagca ctttagccaa ttagtttagc ttcagacggt ggcactctga
     1561 ggggatccct gcctccccac taatagctgt agggttggga cccagtgcca acccctaacc
     1621 cctgggccct gctggtgctt tctgcagctt cctgtgcctt atttaactgt caaccccttc
     1681 cttcccctac tgtaggaagg aggctgtgtc tttgtatgtt gtactcatat aaactttgca
     1741 acttttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
