LOCUS       NM_057194               1569 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus phospholipid scramblase 1 (Plscr1), mRNA.
ACCESSION   NM_057194
VERSION     NM_057194.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Kassas A, Moura IC, Yamashita Y, Scheffel J, Guerin-Marchand C,
            Blank U, Sims PJ, Wiedmer T, Monteiro RC, Rivera J, Charles N and
            Benhamou M.
  TITLE     Regulation of the tyrosine phosphorylation of Phospholipid
            Scramblase 1 in mast cells that are stimulated through the
            high-affinity IgE receptor
  JOURNAL   PLoS One 9 (10), e109800 (2014)
   PUBMED   25289695
  REMARK    GeneRIF: This study reveals a complex regulation for PLSCR1
            tyrosine phosphorylation in FcepsilonRI-activated mast cells, and
            that PLSCR1 sits at a crossroads between Lyn and Fyn pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Zhu J, Sheng J, Dong H, Kang L, Ang J and Xu Z.
  TITLE     Phospholipid scramblase 1 functionally interacts with angiogenin
            and regulates angiogenin-enhanced rRNA transcription
  JOURNAL   Cell Physiol Biochem 32 (6), 1695-1706 (2013)
   PUBMED   24356419
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Cusick JK, Mustian A, Jacobs AT and Reyland ME.
  TITLE     Identification of PLSCR1 as a protein that interacts with RELT
            family members
  JOURNAL   Mol Cell Biochem 362 (1-2), 55-63 (2012)
   PUBMED   22052202
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Merregaert J, Van Langen J, Hansen U, Ponsaerts P, El Ghalbzouri A,
            Steenackers E, Van Ostade X and Sercu S.
  TITLE     Phospholipid scramblase 1 is secreted by a lipid raft-dependent
            pathway and interacts with the extracellular matrix protein 1 in
            the dermal epidermal junction zone of human skin
  JOURNAL   J Biol Chem 285 (48), 37823-37837 (2010)
   PUBMED   20870722
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   Sun J, Nanjundan M, Pike LJ, Wiedmer T and Sims PJ.
  TITLE     Plasma membrane phospholipid scramblase 1 is enriched in lipid
            rafts and interacts with the epidermal growth factor receptor
  JOURNAL   Biochemistry 41 (20), 6338-6345 (2002)
   PUBMED   12009895
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T and Sims PJ.
  TITLE     c-Abl tyrosine kinase binds and phosphorylates phospholipid
            scramblase 1
  JOURNAL   J Biol Chem 276 (31), 28984-28990 (2001)
   PUBMED   11390389
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Pastorelli C, Veiga J, Charles N, Voignier E, Moussu H, Monteiro RC
            and Benhamou M.
  TITLE     IgE receptor type I-dependent tyrosine phosphorylation of
            phospholipid scramblase
  JOURNAL   J Biol Chem 276 (23), 20407-20412 (2001)
   PUBMED   11259432
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Frasch SC, Henson PM, Kailey JM, Richter DA, Janes MS, Fadok VA and
            Bratton DL.
  TITLE     Regulation of phospholipid scramblase activity during apoptosis and
            cell activation by protein kinase Cdelta
  JOURNAL   J Biol Chem 275 (30), 23065-23073 (2000)
   PUBMED   10770950
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T and Sims PJ.
  TITLE     Molecular cloning of human plasma membrane phospholipid scramblase.
            A protein mediating transbilayer movement of plasma membrane
            phospholipids
  JOURNAL   J Biol Chem 272 (29), 18240-18244 (1997)
   PUBMED   9218461
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY024347.1.
            
            [WARNING] On Aug 8, 2023 this sequence was replaced by NM_057194.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY024347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1569
                     /gene="Plscr1"
                     /note="phospholipid scramblase 1"
                     /db_xref="GeneID:117540"
                     /db_xref="RGD:620521"
     exon            1..149
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            150..170
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1165
                     /gene="Plscr1"
                     /note="PL scramblase 1; ca(2+)-dependent phospholipid
                     scramblase 1; phospholipid scramblase 2; mg(2+)-dependent
                     nuclease"
                     /codon_start=1
                     /product="phospholipid scramblase 1"
                     /protein_id="NP_476542.1"
                     /db_xref="GeneID:117540"
                     /db_xref="RGD:620521"
                     /translation="MEKHGPPEHAAYPIPQADYQGSQGPYPGPQGPYPGPQGPYAGPQ
                     GPYPGPQGPYAGPQGPYPGPQPGYPVPPGSYAGGDPSGFPVQHQPAYNHPGGPGGTPW
                     MQAPPPPLDCPPGLEYLTQIDQILVHQQIELLEVLTGFETNNKYEIKNSLGQRVYFAV
                     EDTDCCTRNCCGASRPFTLRILDNMGREVMTLERPLRCSSCCFPCCLQEIEIQAPPGV
                     PVGYVIQTWHPCLPKFTLQNEKRQDVLKVVGPCVVCSCCSDIDFELKSLDEESVVGKI
                     SKQWSGFVREAFTDADNFGIQFPLDLDVKMKAVMLGACFLIDFMFFERTGNEEQRSGV
                     W"
     exon            171..520
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..563
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..784
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..946
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1108
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1552
                     /gene="Plscr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctggct cgcgtcatcc agagtgagtc cctctgcgag gctttaggga gagctgtgcg
       61 acagctgcac cactagcaag gggttgggac tcacgactgc caggagccag ctgtccacct
      121 tgcagacctc agagcagaag gagcctcagt ttaaatcatg gagaagcacg gaccaccaga
      181 acatgctgct taccccattc ctcaggctga ctaccaaggg tcccagggtc cctatccagg
      241 accgcagggt ccatatccag ggccccaggg tccctatgca gggcctcaag gtccctatcc
      301 agggccccag ggtccctatg cagggcccca aggtccctat ccagggcccc aacctggcta
      361 cccagttcca ccaggcagtt atgcaggtgg tgacccaagt ggctttcctg tccaacatca
      421 gccggcgtat aatcacccag gtggacctgg gggcacccca tggatgcaag caccacctcc
      481 acccctggac tgtccgcctg ggctggaata cttaacgcag atagatcaga ttctggttca
      541 tcagcagatt gaacttctgg aagtcttaac aggctttgaa acaaataaca aatatgaaat
      601 caagaacagc cttgggcaga gggtttactt tgcggtggaa gatacggact gctgcactcg
      661 aaactgctgt ggggcgtcta gaccgttcac cttgaggatc ctggataaca tgggccgaga
      721 agtcatgact ctggagagac ccctgagatg cagtagctgc tgcttcccct gctgcctcca
      781 ggagatagaa atccaggctc ctcctggggt gccagtaggt tatgtgattc agacctggca
      841 cccatgtctg ccaaagttca ctctccaaaa tgagaagagg caggacgttc taaaggtcgt
      901 tggtccgtgt gttgtgtgta gctgctgttc agacattgac tttgagctca aatctctaga
      961 tgaggaatcc gttgttggca aaatttccaa gcagtggtct ggttttgtga gagaggcctt
     1021 cacggatgca gataacttcg ggatccagtt cccgctggac ctggatgtga agatgaaagc
     1081 tgtgatgctt ggcgcttgtt tcctcataga tttcatgttt tttgaaagaa ctggaaatga
     1141 ggaacaaagg tcaggagtat ggtagtagtt tcccaagatt cctcggctgt aaggactgca
     1201 tgccgataga cgctgagagg agatcaagga atcaaaggaa cgcaccatgg cttcttttcc
     1261 tttactgaaa taactttata tcaattaacc tgtgatggct gtaggccctt ttgtacaatt
     1321 gtgctctcaa attagagttt attttctgta actctgtcat gtatttgttt ttatacattc
     1381 ttaaggttgt cactgtgaat ttgtgaaaaa aatatatgaa tttatcaaca tagaaatgat
     1441 cttgtctatg aaaagaggct ttgacttagt ctttcattca ttttcatttt tatgaaaact
     1501 taaatatatt gttatttaat ataaagctac atattaaatg taatttaatt taaaaaaaaa
     1561 aaaaaaaaa
//
