LOCUS       NM_031084               3101 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus plastin 3 (Pls3), mRNA.
ACCESSION   NM_031084 XM_001057425 XM_001057538 XM_343776
VERSION     NM_031084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3101)
  AUTHORS   van Dijk,F.S., Zillikens,M.C., Micha,D., Riessland,M.,
            Marcelis,C.L., de Die-Smulders,C.E., Milbradt,J., Franken,A.A.,
            Harsevoort,A.J., Lichtenbelt,K.D., Pruijs,H.E., Rubio-Gozalbo,M.E.,
            Zwertbroek,R., Moutaouakil,Y., Egthuijsen,J., Hammerschmidt,M.,
            Bijman,R., Semeins,C.M., Bakker,A.D., Everts,V., Klein-Nulend,J.,
            Campos-Obando,N., Hofman,A., te Meerman,G.J., Verkerk,A.J.,
            Uitterlinden,A.G., Maugeri,A., Sistermans,E.A., Waisfisz,Q.,
            Meijers-Heijboer,H., Wirth,B., Simon,M.E. and Pals,G.
  TITLE     PLS3 mutations in X-linked osteoporosis with fractures
  JOURNAL   N Engl J Med 369 (16), 1529-1536 (2013)
   PUBMED   24088043
REFERENCE   2  (bases 1 to 3101)
  AUTHORS   Ackermann,B., Krober,S., Torres-Benito,L., Borgmann,A., Peters,M.,
            Hosseini Barkooie,S.M., Tejero,R., Jakubik,M., Schreml,J.,
            Milbradt,J., Wunderlich,T.F., Riessland,M., Tabares,L. and Wirth,B.
  TITLE     Plastin 3 ameliorates spinal muscular atrophy via delayed axon
            pruning and improves neuromuscular junction functionality
  JOURNAL   Hum Mol Genet 22 (7), 1328-1347 (2013)
   PUBMED   23263861
REFERENCE   3  (bases 1 to 3101)
  AUTHORS   Schwander,M., Kachar,B. and Muller,U.
  TITLE     Review series: The cell biology of hearing
  JOURNAL   J Cell Biol 190 (1), 9-20 (2010)
   PUBMED   20624897
  REMARK    Review article
REFERENCE   4  (bases 1 to 3101)
  AUTHORS   Daudet,N. and Lebart,M.C.
  TITLE     Transient expression of the t-isoform of plastins/fimbrin in the
            stereocilia of developing auditory hair cells
  JOURNAL   Cell Motil Cytoskeleton 53 (4), 326-336 (2002)
   PUBMED   12378542
REFERENCE   5  (bases 1 to 3101)
  AUTHORS   Chafel,M.M., Shen,W. and Matsudaira,P.
  TITLE     Sequential expression and differential localization of I-, L-, and
            T-fimbrin during differentiation of the mouse intestine and yolk
            sac
  JOURNAL   Dev Dyn 203 (2), 141-151 (1995)
   PUBMED   7655078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB798973.1, CB557206.1 and BC092611.1.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_001057425.1, XM_001057538.1, XM_343776.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               CB798973.1         44-383
            341-679             CB557206.1         324-662
            680-3101            BC092611.1         147-2568
FEATURES             Location/Qualifiers
     source          1..3101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..3101
                     /gene="Pls3"
                     /note="plastin 3"
                     /db_xref="GeneID:81748"
                     /db_xref="RGD:621409"
     exon            1..76
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            77..157
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1977
                     /gene="Pls3"
                     /note="T-plastin; plastin 3 (T-isoform)"
                     /codon_start=1
                     /product="plastin-3"
                     /protein_id="NP_112346.1"
                     /db_xref="GeneID:81748"
                     /db_xref="RGD:621409"
                     /translation="MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEA
                     NMPLPGYKVREIIQKLMLDGDRNKDGKISFNEFVYIFQEVKSSDIAKTFRKAINRKEG
                     ICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAV
                     GDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAED
                     LRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRW
                     ANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDL
                     KRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTL
                     LEGETREERTFRNWMNSLGVNPHVNHLYVDLQDALVILQLYERIKVPVDWSKVNKPPY
                     PKLGANMKKLENCNYAVELGKNQAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLN
                     VMEDLGEGQKATDDIIVNWVNGTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGC
                     INYDLVKTGNLTEEDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMG
                     RGMKRV"
     exon            158..321
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..451
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..584
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            585..666
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..832
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..975
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1071
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1267
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1346
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1461
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1595
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1719
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1844
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..3078
                     /gene="Pls3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattcctagg ggcagaagtt gtctgagagc ttggtcggaa gcagtagggc cagatcagcg
       61 actctgcgac ttttacatct tcacatggac gagatggcaa ccactcagat ttccaaagat
      121 gagcttgatg aactcaaaga ggcctttgca aaagttgatc tcaacagcaa tggattcatt
      181 tgcgactatg aacttcatga gcttttcaag gaagcgaata tgccattgcc cggatataaa
      241 gtgagagaaa ttattcaaaa actcatgctg gatggcgaca gaaataaaga tgggaagata
      301 agctttaatg aatttgttta tattttccaa gaggtaaaga gcagtgacat tgctaaaacc
      361 ttccgcaaag ccatcaacag gaaagaaggg atttgtgctc tgggaggaac ttcagagttg
      421 tccagtgaag gaacccagca ttcctactca gaggaagaaa aatatgcttt cgttaattgg
      481 ataaataaag ctttggaaaa tgatcccgat tgcagacatg tcatacccat gaacccaaat
      541 actgatgacc tattcaaagc agttggtgat ggaattgtgc tctgcaaaat gatcaacctt
      601 tctgttcccg atacaattga tgagagagca atcaataaga agaagcttac acccttcatc
      661 attcaggaaa acttgaactt ggccctgaat tctgcttctg ccattgggtg tcacgttgtg
      721 aacattggtg ccgaagatct gcgtgccggg aaacctcatc tggtcttggg actgctctgg
      781 cagattatta agattggctt atttgctgac attgaattaa gcaggaatga agcactggcg
      841 gctttgcttc gagatggtga gactctggag gagcttatga aattgtctcc agaagagctt
      901 ctgctgagat gggccaactt ccatctggaa aactcaggct ggcaaaagat caacaacttc
      961 agtgctgaca tcaaggattc caaagcctat ttccatctac tcaatcaaat tgcaccgaaa
     1021 ggacagaagg aaggggaacc acggatagat attaacatgt caggtttcaa cgaaacagat
     1081 gatttaaaga gagccgaaag tatgcttcag caagcagata aattaggctg cagacagttc
     1141 gttaccccgg ctgatgttgt gagcggaaac cccaaactga acttggcctt tgtagccaac
     1201 ctctttaata aatatccagc actaactaaa cctgagaacc aggatattga ttggactctt
     1261 ctagaaggag aaactcgtga agaaagaacc tttcgtaact ggatgaactc tcttggtgtg
     1321 aatccccatg tcaaccatct ctatgttgac ctgcaggatg ccctggtgat cttacagctg
     1381 tatgagagaa ttaaagttcc tgtggactgg agtaaagtta acaagcctcc atacccaaag
     1441 ctgggtgcca acatgaaaaa gttagaaaac tgcaactatg cagttgaatt agggaagaat
     1501 caagctaaat tctccttggt tggcattgga ggacaagact tgaatgatgg gaacccaacc
     1561 ttgaccttgg ctgtagtctg gcagctgatg agaagatata cccttaatgt tatggaagat
     1621 cttggagagg gtcagaaagc aactgatgac atcattgtaa actgggtcaa tggaacattg
     1681 agtgaagctg gaaagtcaac ttctattcag agttttaagg acaagacgat cagctccagt
     1741 ttggcagttg tggatttaat tgatgccatc cagccaggct gcattaacta tgaccttgtg
     1801 aagactggaa atctaacaga agaagacaag cacaataacg ccaagtatgc agtgtcgatg
     1861 gctagaagaa taggagccag agtgtatgct ctccctgaag accttgtgga agtaaaaccg
     1921 aagatggtca tgaccgtgtt tgcctgtttg atgggcagag ggatgaagag agtgtgaaat
     1981 agctaattag aacattacca accttactcg caggtgcatg attagcaagt cagctagtct
     2041 caggtgaagt gcacatggct tcagaagtct tggtcattta aaggactttt agttttgatt
     2101 agcaagacta gttaatcatg acggccttca gagaaagcat tttaataaac aagcagttcc
     2161 tctttcctgt agacctggat ctgttcagca cacctgaaca agctcacagc caaccttttt
     2221 gctctctcct cctagaatgc tgcccttgac attccggctt gctttgtatt atctatgtat
     2281 cttttccctc ctgggatatc catctcttga gacttgcata gatgtgtaga taggaatatt
     2341 attagctcgt cattttgctt tccaagtgct agcgattctt tctgaagaac tgtgctctga
     2401 ggctatatgg agatgagtgt tctttgctta ccttgtagtg ctgaaaatct gctgaagtaa
     2461 ctggctgtgc agaatgtact agaagctttt ctcattcttt tattcttaaa atcagtatct
     2521 ttttacagta ttctttctac atgattattt ttttgtacat ttaagaatat tttgattaca
     2581 tccaacacgt ctgctgattt gctacttttt taaaaggggt cttcatgtaa gtaaaacata
     2641 caaaggcata aattataggt ggaggaaagt ggacccgaag gttgcatttc cccctcatac
     2701 ccaggctcaa atggaatgaa atattttgtc ttcaataagt cagtctgata catacttctt
     2761 tgtttggaaa tctttatcac aaaactcttt ttggtctaca atgctgttga atatgacact
     2821 ttgaggggag agtgggctca gaatttagat gggaatttga taagcaaaga atgctaaagt
     2881 gtacaatata tgtttaagtt tcacacctgt aacaaggaga tgtggtcaca aaaatgagaa
     2941 agtatgtcgg acttgatgtc ctcttgctct gtcaagctat ttgctatagt tttcaagatc
     3001 attatgttac tctaactctg aaaagtgatg taatctggta gcaacatagt agtccaaata
     3061 aaggcatttg cataataaaa aaaaaaaaaa aaaaaaaaaa a
//
