LOCUS       NM_021757               1830 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus pleiotropic regulator 1 (Plrg1), mRNA.
ACCESSION   NM_021757
VERSION     NM_021757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Marechal,A., Li,J.M., Ji,X.Y., Wu,C.S., Yazinski,S.A., Nguyen,H.D.,
            Liu,S., Jimenez,A.E., Jin,J. and Zou,L.
  TITLE     PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and
            drives ATR activation via a ubiquitin-mediated circuitry
  JOURNAL   Mol Cell 53 (2), 235-246 (2014)
   PUBMED   24332808
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Kleinridders,A., Pogoda,H.M., Irlenbusch,S., Smyth,N., Koncz,C.,
            Hammerschmidt,M. and Bruning,J.C.
  TITLE     PLRG1 is an essential regulator of cell proliferation and apoptosis
            during vertebrate development and tissue homeostasis
  JOURNAL   Mol Cell Biol 29 (11), 3173-3185 (2009)
   PUBMED   19307306
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087742.1.
            
            On Dec 26, 2004 this sequence version replaced NM_021757.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087742.1, FQ215141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1830
                     /gene="Plrg1"
                     /note="pleiotropic regulator 1"
                     /db_xref="GeneID:60376"
                     /db_xref="RGD:621047"
     exon            1..102
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1638
                     /gene="Plrg1"
                     /note="pleiotropic regulator 1 homolog"
                     /codon_start=1
                     /product="pleiotropic regulator 1"
                     /protein_id="NP_068525.1"
                     /db_xref="GeneID:60376"
                     /db_xref="RGD:621047"
                     /translation="MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKM
                     AIKLRNEYGPVLHMPTSKENLKEKGPQNAPDSYPHKQYPANQGQDVEYLVTGTHPYPP
                     GPGVALTADTKIQRMPSESAAQSLAVALPSQTRVDANRTAPAGSEYRHPGASDRSQPT
                     AMNSMIMETSNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQW
                     FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLE
                     YNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVA
                     TVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLHYTFASGSP
                     DNIKQWKFPDGGFIQNLSGHNAIINTLAVNTDGVLVSGADNGTMHLWDWRTGYNFQRV
                     HAAVQPGSLDSESGIFACAFDRSESRLLTAEADKTIKVYREDETATEETHPVSWKPEI
                     IKRKRF"
     exon            103..209
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..352
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..406
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..497
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..585
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..687
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..780
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..930
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1032
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1135
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1244
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1384
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1578
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1758
                     /gene="Plrg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccggaagg agcggcagaa tagtggcggc gatttctgcg tcgagcattt ggagtttctt
       61 cgctgctgaa cgggtagact aaacggcggc gacatggtgg aggaggtaca gaagcattct
      121 gtgcacacac tagtgttcag gtcattgaag aggacccatg acatgtttgt ggctgataat
      181 ggaaaacctg tgcctttgga tgaagagagt cacaagcgga aaatggcaat caagcttcgt
      241 aatgagtatg gccctgtgct gcatatgcct acttcaaaag agaatcttaa ggagaaggga
      301 cctcaaaacg caccagattc atatcctcat aagcagtatc ctgccaatca aggacaagat
      361 gttgaatatt tggtgacagg tacacatcca tatccaccag gacctggtgt tgccttgact
      421 gctgatacta agatccaaag aatgccaagc gagtcagccg cacagtcctt agctgtggcg
      481 ttaccgtctc agaccagagt tgatgcaaat cggactgcgc ctgctggaag tgaataccga
      541 cacccagggg cttctgaccg ttcccagccc acagcaatga attctatgat tatggagacc
      601 agcaatacca agaactctgc attaatggct aaaaaagccc ctacaatgcc caaaccccag
      661 tggcacccac cgtggaaact ctacagggtt atcagtgggc atcttggctg ggttcggtgt
      721 attgctgtgg aacctggaaa tcagtggttc gttactggat ctgctgacag aactataaag
      781 atttgggact tggccagtgg caaattaaag ctgtcattga ctggccacat cagcacagta
      841 cgcggtgtga ttgtgagcac gaggagccct tacttgttct cttgtggaga agacaaacaa
      901 gtgaagtgtt gggatcttga atataacaag gttatacggc actatcatgg ccatctaagt
      961 gcagtgtatg gtctggattt gcatccaaca atcgatgtcc tggtcacttg tagtcgagat
     1021 tctactgctc ggatctggga tgtgagaact aaagccagtg tgcacacttt gtctggacac
     1081 acaaatgcag ttgctaccgt gagatgccaa gctgcagagc cacaaattat tactggaagt
     1141 cacgatacca caatacgatt atgggatctg gtggctggaa agacacgagt cacattgacg
     1201 aatcataaga agtcagtcag ggctgtggtc ttacatccgc tacattacac atttgcatct
     1261 ggttctccag ataacataaa gcagtggaaa ttccctgacg gaggcttcat tcagaatctc
     1321 tctgggcaca atgcaattat taacacgctg gcagtcaata cggatggagt acttgtatct
     1381 ggagctgaca atggcactat gcacctttgg gactggagaa ctggctataa ttttcagcgc
     1441 gttcatgctg ctgtacagcc tgggtctttg gacagtgaat caggaatatt cgcttgtgct
     1501 tttgatcggt cagaaagtcg gttactaaca gctgaagctg ataaaaccat taaagtttac
     1561 agagaggatg agactgcgac agaagaaact cacccagtca gctggaaacc agaaattatc
     1621 aagagaaaga gattttagtg tcctcatggc tgtcctgttc atagcttggt gttgctgagg
     1681 atgtccagtc attcatggat gctcacttgc agaaaacatg gctgctttgt attttacaat
     1741 aaactgctcc ccatgtccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
