LOCUS       NM_001001508            5554 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phospholipid phosphatase related 4 (Plppr4),
            mRNA.
ACCESSION   NM_001001508 XM_227624
VERSION     NM_001001508.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5554)
  AUTHORS   Hashimoto,T., Yamada,M., Iwai,T., Saitoh,A., Hashimoto,E., Ukai,W.,
            Saito,T. and Yamada,M.
  TITLE     Plasticity-related gene 1 is important for survival of neurons
            derived from rat neural stem cells
  JOURNAL   J Neurosci Res 91 (11), 1402-1407 (2013)
   PUBMED   24038138
  REMARK    GeneRIF: These results suggest that Prg1 is important for survival
            of neurons through its dephosphorylation activity.
REFERENCE   2  (bases 1 to 5554)
  AUTHORS   Gaaya,A., Poirier,O., Mougenot,N., Hery,T., Atassi,F., Marchand,A.,
            Saulnier-Blache,J.S., Amour,J., Vogt,J., Lompre,A.M., Soubrier,F.
            and Nadaud,S.
  TITLE     Plasticity-related gene-1 inhibits lysophosphatidic acid-induced
            vascular smooth muscle cell migration and proliferation and
            prevents neointima formation
  JOURNAL   Am J Physiol Cell Physiol 303 (10), C1104-C1114 (2012)
   PUBMED   23015549
  REMARK    GeneRIF: Taken together, these findings provide the first evidence
            of a protective role of PRG-1 in the vascular media under
            pathophysiological conditions.
REFERENCE   3  (bases 1 to 5554)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   4  (bases 1 to 5554)
  AUTHORS   Ni,H., Jiang,Y.W., Xiao,Z.J., Tao,L.Y., Jin,M.F. and Wu,X.R.
  TITLE     Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat
            brain following flurothyl-induced recurrent neonatal seizures
  JOURNAL   Toxicol Lett 194 (3), 86-93 (2010)
   PUBMED   20167268
  REMARK    GeneRIF: These data are consistent with an important role for
            ZnT-1, ZnT-3 and PRG-1 in the pathophysiology of the long-term
            adverse effects of recurrent neonatal seizure-induced hippocampal
            mossy fiber sprouting and cognitive deficit.
REFERENCE   5  (bases 1 to 5554)
  AUTHORS   Trimbuch,T., Beed,P., Vogt,J., Schuchmann,S., Maier,N.,
            Kintscher,M., Breustedt,J., Schuelke,M., Streu,N., Kieselmann,O.,
            Brunk,I., Laube,G., Strauss,U., Battefeld,A., Wende,H.,
            Birchmeier,C., Wiese,S., Sendtner,M., Kawabe,H., Kishimoto-Suga,M.,
            Brose,N., Baumgart,J., Geist,B., Aoki,J., Savaskan,N.E.,
            Brauer,A.U., Chun,J., Ninnemann,O., Schmitz,D. and Nitsch,R.
  TITLE     Synaptic PRG-1 modulates excitatory transmission via lipid
            phosphate-mediated signaling
  JOURNAL   Cell 138 (6), 1222-1235 (2009)
   PUBMED   19766573
  REMARK    Erratum:[Cell. 2011 Sep 16;146(6):1043]
REFERENCE   6  (bases 1 to 5554)
  AUTHORS   Ni,H., Jiang,Y.W., Tao,L.Y., Jin,M.F. and Wu,X.R.
  TITLE     ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following
            neonatal seizure-induced cognitive deficit in rats
  JOURNAL   Toxicol Lett 184 (3), 145-150 (2009)
   PUBMED   19059322
  REMARK    GeneRIF: ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus
            following neonatal seizure-induced cognitive deficit in rats.
REFERENCE   7  (bases 1 to 5554)
  AUTHORS   Yamada,M., Shida,Y., Takahashi,K., Tanioka,T., Nakano,Y., Tobe,T.
            and Yamada,M.
  TITLE     Prg1 is regulated by the basic helix-loop-helix transcription
            factor Math2
  JOURNAL   J Neurochem 106 (6), 2375-2384 (2008)
   PUBMED   18643870
  REMARK    GeneRIF: Our results suggest that Math2 directly regulates Prg1
            expression and that the Math2-Prg1 cascade plays an important role
            in neurite outgrowth in PC12 cells.
REFERENCE   8  (bases 1 to 5554)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 4, 2011 this sequence version replaced NM_001001508.1.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2399099.1,
                                           SRR26360186.1992495.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-815               JAXUCZ010000002.1  208096377-208097191 c
            816-1001            JAXUCZ010000002.1  208074624-208074809 c
            1002-1131           JAXUCZ010000002.1  208069277-208069406 c
            1132-1327           JAXUCZ010000002.1  208065877-208066072 c
            1328-1385           JAXUCZ010000002.1  208064339-208064396 c
            1386-1559           JAXUCZ010000002.1  208063453-208063626 c
            1560-5554           JAXUCZ010000002.1  208056206-208060200 c
FEATURES             Location/Qualifiers
     source          1..5554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..5554
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /note="phospholipid phosphatase related 4"
                     /db_xref="GeneID:295401"
                     /db_xref="RGD:727806"
     exon            1..815
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..2891
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /EC_number="3.1.3.106"
                     /note="plasticity-related gene 1 protein; brain-specific
                     phosphatidic acid phosphatase-like protein 1; plasticity
                     related gene 1; lipid phosphate phosphatase-related
                     protein type 4; 2-lysophosphatidate phosphatase PLPPR4;
                     inactive 2-lysophosphatidate phosphatase PLPPR4"
                     /codon_start=1
                     /product="phospholipid phosphatase-related protein type 4"
                     /protein_id="NP_001001508.2"
                     /db_xref="GeneID:295401"
                     /db_xref="RGD:727806"
                     /translation="MQRAGSSGARGECDISGTGRLRLEQAARLGGRAVHTSPTGGLGA
                     RQVAGMSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGF
                     SCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGAGLEP
                     NINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTS
                     LNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSS
                     KLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPS
                     EDSMLQHRDALRSLTDLNQDPSRVLSAKNGSSGDGIAHTEGILNRNHRDASSLTNLKR
                     ANADVEIITPRSPMGKESMVTFSNTLPRANTPSVEDPVRRNASIHASMDSARSKQLLT
                     QWKSKNESRKMSLQVMDSEPEGQSPPRSIEMRSSSEPSRVGVNGDHHVPGNQYLKIQP
                     GTVPGCNNSMPAGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAKWLKAAEKT
                     VACNRGNNQPRIMQVIAMSKQQGVLQSSPKNAEGSTVTCTGSIRYKTLTDHEPSGIVR
                     VEAHPENNRPIIQIPSSTEGEGSGSWKWKAPEKSSLRQTYELNDLNRDSESCESLKDS
                     FGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSVSSSRDSTLRRKGNIILI
                     PERSNSPENTRNIFYKGTSPTRAYKD"
     exon            816..1001
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1131
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1327
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1385
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1559
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..5554
                     /gene="Plppr4"
                     /gene_synonym="Lppr4; Prg-1; Prg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccccaat tcaccctctc tcttcagatg caggcaaaaa attctcactt tgttcctcgg
       61 cggattggag ctttttctag gtgcttccct tggagttacc tccctagaga tcagtagtca
      121 gggctgtcac gcttgggtag cggccagctc ccagtgaatt ccttctatgg cctacttgtc
      181 agtatgaaat ctgagtttta attttgcaca ggtggaggtc tcttttgcta tgggtaaggt
      241 ggatagcggt gcccagcaag ctcctgctct ctagaaaggc aacaagaacc ccaggtagga
      301 gaccaggtgc cttggctcct cagccttgct tctgcagaaa ccaggagtgc ctccccccac
      361 tatttttgac gtcaagctca gacaaccagc agaggagcct cacagcttgg gcggtggaga
      421 gcccagggag agtggcaggg aggggaagcc atcacagcaa cagcttggag ggggagctgg
      481 ctatcacttt ccctcaaaat acggactaaa acccggctga agaagacctg cgggatcagg
      541 gaagcgccgg gttactgcaa agaagggcgg ggaaaaggag ggggcgctgc atgcagcgcg
      601 ctggctccag cggtgcccgc ggggaatgtg acatcagcgg caccgggcgc ttgcggctgg
      661 agcaggcagc tcgcctcggt ggccgcgcag tgcacacctc acccacggga ggactcggag
      721 cccggcaggt ggccgggatg tcggcgaagg agaggccaaa gggcaaagtg atcaaggaca
      781 gcgtcaccct cctgccctgt ttctatttcg ttgagttgcc tatattggcg tcatcggtgg
      841 ttagtctcta cttcctggaa ctcacagatg tcttcaaacc tgtgcactcc ggattcagtt
      901 gctatgacag gagtcttagc atgccgtaca ttgagccaac ccaagaggcc attccattcc
      961 tcatgttgct tagcttggct tttgctggac ctgcaattac gatcatggtg ggtgaaggga
     1021 ttctgtactg ctgcctctct aaaagaagaa atggagctgg attggagccc aacatcaacg
     1081 ccgggggctg caacttcaat tcctttctca gaagagccgt cagatttgtt ggtgtccacg
     1141 tgtttggact gtgctccaca gctctcatta cggatatcat acagctgtcc acaggatatc
     1201 aggcaccata ctttctgact gtgtgcaagc ccaattacac ctctctgaat gtatcctgca
     1261 aagaaaattc ctacatcgtg gaagacattt gttcgggatc tgaccttaca gttatcaaca
     1321 gtggcagaaa gtcattcccg tcccagcatg cgaccctcgc tgcctttgct gctgtgtatg
     1381 tgtccatgta cttcaattcc acattaactg actcctccaa gctcctgaaa cctctcttgg
     1441 tcttcacatt tatcatctgt ggaatcatct gcgggctaac acggatcact cagtataaga
     1501 accatcccgt cgatgtttat tgtggctttt taattggagg aggaatcgcg ctgtatttgg
     1561 gcctgtatgc tgtagggaat tttctgccta gtgaagacag catgcttcag cacagagatg
     1621 ccctcaggtc actgacagac ctcaatcaag accccagcag ggttttgtca gctaaaaatg
     1681 gtagcagcgg tgatggaatt gctcacacag agggtattct caaccgaaat cacagggatg
     1741 caagctcctt aacaaatctg aagagggcca acgctgacgt agagatcatc actcctagga
     1801 gccccatggg gaaggagagc atggtgacct tcagtaacac gctgcccagg gccaacaccc
     1861 cgtccgtgga agacccggtg agaagaaacg cgagcattca cgcctctatg gattctgccc
     1921 ggtccaagca gctccttacc cagtggaaga gcaagaacga gagtcgcaag atgtccctgc
     1981 aggttatgga ctctgaacca gaagggcagt caccacccag gtccatagaa atgaggtcca
     2041 gctcagagcc ctcgagggtg ggggtgaatg gagatcacca tgtcccgggc aatcagtacc
     2101 tcaagatcca gcctggcaca gttcccgggt gcaacaatag tatgcctgca gggccacgtg
     2161 tgtccatcca gtcccgccct ggctcttccc aattggtgca catccccgag gagacccagg
     2221 aaaacataag cacctcgccc aagagcagtt ccgcacgggc caagtggctg aaagcagcag
     2281 agaagaccgt ggcctgtaac cggggcaaca accagccacg catcatgcag gtcatcgcca
     2341 tgtccaagca gcagggcgtg ctgcagagca gccccaagaa tgccgaaggt agcacggtca
     2401 cctgcacagg ctccatccgc tacaaaaccc tgactgacca cgagccgagt ggcattgtgc
     2461 gagtggaggc tcatcccgag aacaacaggc ccatcatcca gattccatcg tccaccgagg
     2521 gcgaaggcag tggctcctgg aagtggaaag ctccggagaa gagtagcctg cgccaaacct
     2581 atgagctcaa cgacctcaac agggactcgg aaagctgcga gtccctcaaa gacagctttg
     2641 gttctggaga tcgcaagaga agcaacatcg acagcaatga gcaccaccac cacggcatca
     2701 caaccatccg cgtgacccca gtggagggca gcgagatagg ctcagagacg ctgtctgtat
     2761 cctcctcacg cgactccacc ctgcgcagga agggcaacat tatcttgatc cctgaaagaa
     2821 gcaacagccc tgaaaacaca agaaacatct tctacaaagg aacctccccc acgagggctt
     2881 ataaggattg agtgaccgcc cttcttgtca tcattttggt gacatcccca cccccacccc
     2941 aagaccacac atttattata gtaccttgtg ctcttttggg tattttgttg ttgttttggt
     3001 tttggttttt tgttttcttt tctagtggat atggagagcc ttcttgccca actagattgt
     3061 tcaccatcag cctggaactc tcactgaccc accacagaaa ccgtggtgat tttccaccaa
     3121 gggaaaggaa aagcacaaag caagacccga actaatctca tcatctgaat agttcttaag
     3181 gcctgtcact gagacttcgc agagggcagt attaggataa agtggtctcc tccgatgtat
     3241 agtatttaac tttctgaatg tgccaacttt gaagtttctt tttttttttt ttcattataa
     3301 ttagcggtgg gaacccaaaa cactacaggt ttccccggca gcagaggcca cgcagtatta
     3361 tatagtattt atttttgcag actctgcacc agaagagcag actgggcggt gctgattacc
     3421 acagtacatc taccatttca actctcagac tctgtgtagc tgtgagagag tggtgtacaa
     3481 cccccttgtc agagaaatgc tacttcattc agaagacgcc agtgactttg tggtagcata
     3541 ggccattctt ggcttccctg tagtggctct ctcacagtca aaaagaaaaa agaaagaaaa
     3601 aactggacag ggttctgagc atttctttga aagattcttt gttttcaaca tttgaaagtc
     3661 tgtagggatg ttttcggtga gacggaacaa ctagttctcc gcatcgtttt tctgcttttt
     3721 atttaagtat tggtaatgct ggtttctggt atcttttttt tttagtgagt gcatttgcat
     3781 atttaaaata cattgtttta gagaatattt tgaaattatt ataatcacat tttccatttt
     3841 gtggcttcat cttagtttat taagtttttt gaggttatgc acaccattct tctattttaa
     3901 gaaagcaaca gtgaccattt acattccttg tgcaaaatac actgcttcga ggtcctacgc
     3961 aagaaatatg agccaacggt tgaaactgtg cgttccattg ccagatacat tggtcacatt
     4021 caagatgtct ccaatccgat ggcataggtt atcacatcag taagcgatcc ccaaacttca
     4081 ttttcttcca gagcatttca tttttgtgtt atcctgataa tcaccatatc ggagccacca
     4141 tgggggtgag cttgactccc ttccctgaca cacttttaac tggacaccaa cagtaaggac
     4201 ctaggcaaag gctaattgat agatagaagt gtatcacagc atacatttag aaagtgtatc
     4261 ttcaaaacag cagaccaggc aaagcttttg tgcttagagt actattgaca gttttggctg
     4321 cctgtcttga atctagaacc ttgagccaaa atcaaaggaa accatactgt tgatagcaag
     4381 aagattacca caagatattt ttgaagtgtt ttcccaggtt agatgtttaa agagtggaga
     4441 catatatttg gtccttgaaa tttgttataa aacctttctc atgccatgtc ttaagaatta
     4501 taatggacac ttgatgattg ccaagagggg gagcaaaaac agcgaacagc agagctggtt
     4561 ggtctgaact cagtgcagct ttcagtgaga acaaaagctg tccagcaaag agtcacatca
     4621 ttcattctct agcctctcca ttcaaagggc agagcttttt ttttttttta agaaaactca
     4681 acctcttaag gcattaggaa tttagctgag accagcagaa ttgaaaactc tggcaataaa
     4741 atataggctc aaccataacc cttctggcaa gttccttctc agagaaggaa gtgggagtaa
     4801 aatgtggcct tccccacttc tcttacatca ccactgtcac aatgtccccg ctggcccggc
     4861 cagttcctag agggaagggt ggactggttt tagtactctg gagaaaaaaa aaaccaagct
     4921 gcagtatttg aggtgcagta tgatatttcc taatctttcc tatttcttaa caaaaaagat
     4981 tttaaagcac ttctctagtc attgaacttt tgttctttac atactattga tatattcttt
     5041 ttctactcaa agtgccaaag gctacagttt ttaaacgact taacaaattg taccacactg
     5101 ttaaggaact ataacgatag acactagaat tcagacctct gcatgtatat ttgataacac
     5161 atcttttgta aaaaataaat aattacaaaa aatttgttta cattccactg gtaccttaat
     5221 ttaaaagaaa tcagactaac aggtggtatc tcttcttagt gttctattta tcttacttgc
     5281 taacgagagc aattcttctt ttgttaggct gtgctttatt gatgaaaccg agtattgaat
     5341 aaagagagtt aattatcttt ttaaagtaaa taaaactatg aatatataat atatatgaag
     5401 tatcgtgttt aataaaaatg ttatgcaatg ttttccaaac tgataaagtt tgtaaagtgc
     5461 tataaatgta ttttgttaag tacagatcaa agctatcgtg tgagtatatt gtgctggcat
     5521 catagaaata aagattagat ttcttcatca aaaa
//
