LOCUS       NM_138905               3105 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phospholipid phosphatase 3 (Plpp3), mRNA.
ACCESSION   NM_138905
VERSION     NM_138905.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3105)
  AUTHORS   Gutierrez-Martinez,E., Fernandez-Ulibarri,I., Lazaro-Dieguez,F.,
            Johannes,L., Pyne,S., Sarri,E. and Egea,G.
  TITLE     Lipid phosphate phosphatase 3 participates in transport carrier
            formation and protein trafficking in the early secretory pathway
  JOURNAL   J Cell Sci 126 (Pt 12), 2641-2655 (2013)
   PUBMED   23591818
REFERENCE   2  (bases 1 to 3105)
  AUTHORS   Lopez-Juarez,A., Morales-Lazaro,S., Sanchez-Sanchez,R., Sunkara,M.,
            Lomeli,H., Velasco,I., Morris,A.J. and Escalante-Alcalde,D.
  TITLE     Expression of LPP3 in Bergmann glia is required for proper
            cerebellar sphingosine-1-phosphate metabolism/signaling and
            development
  JOURNAL   Glia 59 (4), 577-589 (2011)
   PUBMED   21319224
REFERENCE   3  (bases 1 to 3105)
  AUTHORS   Humtsoe,J.O., Liu,M., Malik,A.B. and Wary,K.K.
  TITLE     Lipid phosphate phosphatase 3 stabilization of beta-catenin induces
            endothelial cell migration and formation of branching point
            structures
  JOURNAL   Mol Cell Biol 30 (7), 1593-1606 (2010)
   PUBMED   20123964
REFERENCE   4  (bases 1 to 3105)
  AUTHORS   Kai,M., Sakane,F., Jia,Y.J., Imai,S., Yasuda,S. and Kanoh,H.
  TITLE     Lipid phosphate phosphatases 1 and 3 are localized in distinct
            lipid rafts
  JOURNAL   J Biochem 140 (5), 677-686 (2006)
   PUBMED   17005594
REFERENCE   5  (bases 1 to 3105)
  AUTHORS   Humtsoe,J.O., Bowling,R.A. Jr., Feng,S. and Wary,K.K.
  TITLE     Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated
            integrin ligand
  JOURNAL   Biochem Biophys Res Commun 335 (3), 906-919 (2005)
   PUBMED   16099422
REFERENCE   6  (bases 1 to 3105)
  AUTHORS   Humtsoe,J.O., Feng,S., Thakker,G.D., Yang,J., Hong,J. and Wary,K.K.
  TITLE     Regulation of cell-cell interactions by phosphatidic acid
            phosphatase 2b/VCIP
  JOURNAL   EMBO J 22 (7), 1539-1554 (2003)
   PUBMED   12660161
REFERENCE   7  (bases 1 to 3105)
  AUTHORS   Roberts,R., Sciorra,V.A. and Morris,A.J.
  TITLE     Human type 2 phosphatidic acid phosphohydrolases. Substrate
            specificity of the type 2a, 2b, and 2c enzymes and cell surface
            activity of the 2a isoform
  JOURNAL   J Biol Chem 273 (34), 22059-22067 (1998)
   PUBMED   9705349
REFERENCE   8  (bases 1 to 3105)
  AUTHORS   Kai,M., Wada,I., Imai,Si., Sakane,F. and Kanoh,H.
  TITLE     Cloning and characterization of two human isozymes of
            Mg2+-independent phosphatidic acid phosphatase
  JOURNAL   J Biol Chem 272 (39), 24572-24578 (1997)
   PUBMED   9305923
REFERENCE   9  (bases 1 to 3105)
  AUTHORS   Barila,D., Plateroti,M., Nobili,F., Muda,A.O., Xie,Y., Morimoto,T.
            and Perozzi,G.
  TITLE     The Dri 42 gene, whose expression is up-regulated during epithelial
            differentiation, encodes a novel endoplasmic reticulum resident
            transmembrane protein
  JOURNAL   J Biol Chem 271 (47), 29928-29936 (1996)
   PUBMED   8939937
REFERENCE   10 (bases 1 to 3105)
  AUTHORS   Barila,D., Murgia,C., Nobili,F., Gaetani,S. and Perozzi,G.
  TITLE     Subtractive hybridization cloning of novel genes differentially
            expressed during intestinal development
  JOURNAL   Eur J Biochem 223 (2), 701-709 (1994)
   PUBMED   8055940
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072544.1.
            
            On Jun 13, 2004 this sequence version replaced NM_138905.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072544.1, Y07783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3105
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /note="phospholipid phosphatase 3"
                     /db_xref="GeneID:192270"
                     /db_xref="RGD:620454"
     exon            1..556
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..1356
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /EC_number="3.1.3.4"
                     /note="lipid phosphate phosphohydrolase 3; PAP2b; PAP-2b;
                     PAP2-beta; phosphatidic acid phosphatase 2b; phosphatidate
                     phosphohydrolase type 2b; phosphatidic acid phosphatase
                     type 2B; differentially expressed in rat intestine 42; ER
                     transmembrane protein Dri 42"
                     /codon_start=1
                     /product="phospholipid phosphatase 3"
                     /protein_id="NP_620260.2"
                     /db_xref="GeneID:192270"
                     /db_xref="RGD:620454"
                     /translation="MQSYKYDKAIVPESKNGGSPALNNNPRKGGSKRVLLICLDLFCL
                     FMAALPFLIIETSTIKPYRRGFYCNDESIKYPLKVSETINDAVLCAVGIVIAILAIIT
                     GEFYRIYYLKEKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFL
                     SVCDPDFSQINCSEGYIQNYRCRGEDSKVQEARKSFFSGHASFSMFTMLYLVLYLQAR
                     FTWRGARLLRPLLQFTLLMMAFYTGLSRVSDYKHHPSDVLAGFAQGALVACCIVFFVS
                     DLFKTKTTLSLPAPAIRREILSPVDIMDRSNHHNMV"
     exon            557..714
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            715..995
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1053
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1230
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..3081
                     /gene="Plpp3"
                     /gene_synonym="Dri42; Ppap2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaggagg aggcagagtt ggagttgggc agacgctgtg gagagctagc tgcaggacgc
       61 tgcggagttg cagggctccg cgctgctcca ttcattaagt agctgcggag gatcgtggcc
      121 ggacgccgac gctgcccact cgcaaacttc agcacgcaga cgcacgccag cccggcgcgt
      181 ccgggacagc acagttttgc aaaagttcct gctcgggatt tggctctctt ccctttggac
      241 tagcgaacag tttggggttg agaggaaagc agaggcgctc agggggaaac ctacccgcgt
      301 ctgcagttgg agctactcgg ccgggctgta cactcgccgc cgcgtcccga gcccgcagat
      361 ccgctcctga gcagcggcgg cccgcagcgc cccgggaggc tccccgcagc cagcgccatg
      421 caaagctaca agtacgacaa ggcgatcgtc cctgagagta agaacggcgg tagcccggcg
      481 ctcaacaaca acccgaggaa aggcggcagc aagcgggtgc tgctcatctg cctcgacctc
      541 ttctgcctct tcatggcggc tctgcccttc ctcatcatcg agacaagcac cattaagcct
      601 tatcgtcgag ggttttactg caacgacgag agcatcaagt accccctgaa agtcagcgag
      661 actataaacg acgccgtgct ctgtgcggtg gggatcgtca tcgccatcct ggcgatcatc
      721 acgggggaat tctaccggat ctattacctc aaggagaagt cccgatccac cattcagaac
      781 ccttatgtgg ccgctctcta taagcaagtg ggatgcttcc ttttcggctg tgccatcagc
      841 cagtccttca cagacatcgc caaagtgtcc attgggcgcc tgaggcctca cttcctcagc
      901 gtctgtgacc ctgatttcag tcagatcaat tgctccgagg gctacattca gaactacagg
      961 tgccgaggag aagacagcaa agtacaggag gccaggaaat ccttcttctc gggccacgcc
     1021 tccttctcca tgttcacaat gctgtatctg gtgctttatc tacaggcccg cttcacctgg
     1081 cgtggggccc ggctcctccg ccccctcctg cagttcactt tgctcatgat ggccttctac
     1141 acgggattgt cacgtgtatc tgactacaaa caccatccta gcgatgtcct ggcaggattt
     1201 gcccaaggag ctctggtggc ctgctgcata gtgttcttcg tgtctgacct cttcaagact
     1261 aagacgaccc tctcactgcc tgcccccgcg atcaggagag agatcctgtc tcctgtagac
     1321 atcatggaca ggagcaatca ccacaacatg gtgtaggtgc tgcggcctcc agagcacttt
     1381 ctctgaagcg actgcttgac agcatgtccc tgctgctctc caatctcatc agacagtaga
     1441 atgtagggaa aagctttttg cccgatggat tttgaaaaca tttaaagaaa aaaaaaaagc
     1501 cttaccttgt ggccttccaa aataggttgt ttgcctgtgt ggagacaaca gtgccggagt
     1561 cctgagtgct ggctgcacag ctggctaagt gttcatgttc tagtgagcac gggcttgtca
     1621 ggagcaaaac actaggataa ttgagcagag gctgtggtca ccttttgtga cccgagaaat
     1681 cccaggccag aatagcgggg gcgcttatgt agcatgcaag gcctgaacca gcaccgaatc
     1741 agcccctctg cctgccccac tctactgtga ctttgattca aggaagtttt tgcgctttga
     1801 aataccggga atgaacacac agtttttcag tcgagggatc agatcctgaa tccaaacccc
     1861 atgtcctgag gcctctgtca tctctccatc cccaggctaa caaccacagt cccctcactt
     1921 ttagagatta ggagaccctt tgtggaagag tgaacttcac aaatagcaca agttcagaag
     1981 acatgtaggg tgtcttctca cacaccacac tgtgacgcac gcggaactgc cattgcgggg
     2041 tcaatcacca ggcacttgca cgtgtagaaa cccgtagact ttggttactg ctatatcccc
     2101 cttgagatcc ttgctgggtg cctaccagga tttcatgtga gggccaggga tgcataggca
     2161 tggccaacct ttggtggatc aaaagagcct cagtagagag acagggaggg agggagaggg
     2221 cagaatgaaa aaaaagtgaa ccaattcttt tggctccttg ggtttagaga gagccagggt
     2281 agcagacagt cttatgccca aaaggtaccc ttccagataa gggagcccca agggtcttcg
     2341 caggagttga tcttgctgtg taaagcactg ttgtcgcagg gttgacccct gggacagttc
     2401 ttggtgggtt ctgctgggca gaacacatag gttaaatctg tgtcgagagt tttcctcata
     2461 ctctatccac aagtgtcctt ccaagcaagg tcccactcta gccagtagac aaggtccctt
     2521 ctactgaacc tccaaggaaa agaagaagga gaagaaaaag tgcttttcaa atctttcaaa
     2581 gggctacatg taaccatatg gatcaaccac atgcatatcc tcccagactc cgtcctttca
     2641 tttcaacata tagcaagcta tgattttata tataaaatta tataaataat gtataaaaca
     2701 gtaaaagtta actatgtaag atattatttc tgaaacaatg ttagtcacac ccactatgat
     2761 tataaactgt gtcttgacct gtgttattta ctttagctgc ttaaaggagc attgagtttt
     2821 tttggtttgt tttttttttt tttttaatct caactaaaga tatcatagtt ctgtggtagc
     2881 cattgtttta caatgaaata actgcgacta gagggaaaaa gaactgtata aaaacattaa
     2941 attgtcagta tttttgtaag gttccgtttt gtaaagagaa taatattcaa acacttctgt
     3001 ggcatacaaa gtgaaaaatg tgtatctgag aaactaaaca tgtattaaat gtgcttttta
     3061 aaataaaagc tcataacatg aaaaaaaaaa aaaaaaaaaa aaaaa
//
