LOCUS       NM_022538               1290 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phospholipid phosphatase 1 (Plpp1), mRNA.
ACCESSION   NM_022538
VERSION     NM_022538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   denDekker,A.D., Xu,X., Vaughn,M.D., Puckett,A.H., Gardner,L.L.,
            Lambring,C.J., Deschenes,L. and Samuelson,D.J.
  TITLE     Rat Mcs1b is concordant to the genome-wide association-identified
            breast cancer risk locus at human 5q11.2 and MIER3 is a candidate
            cancer susceptibility gene
  JOURNAL   Cancer Res 72 (22), 6002-6012 (2012)
   PUBMED   22993404
REFERENCE   2  (bases 1 to 1290)
  AUTHORS   Tomsig,J.L., Snyder,A.H., Berdyshev,E.V., Skobeleva,A., Mataya,C.,
            Natarajan,V., Brindley,D.N. and Lynch,K.R.
  TITLE     Lipid phosphate phosphohydrolase type 1 (LPP1) degrades
            extracellular lysophosphatidic acid in vivo
  JOURNAL   Biochem J 419 (3), 611-618 (2009)
   PUBMED   19215222
REFERENCE   3  (bases 1 to 1290)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1290)
  AUTHORS   Kai,M., Sakane,F., Jia,Y.J., Imai,S., Yasuda,S. and Kanoh,H.
  TITLE     Lipid phosphate phosphatases 1 and 3 are localized in distinct
            lipid rafts
  JOURNAL   J Biochem 140 (5), 677-686 (2006)
   PUBMED   17005594
REFERENCE   5  (bases 1 to 1290)
  AUTHORS   Fukunaga,K., Arita,M., Takahashi,M., Morris,A.J., Pfeffer,M. and
            Levy,B.D.
  TITLE     Identification and functional characterization of a presqualene
            diphosphate phosphatase
  JOURNAL   J Biol Chem 281 (14), 9490-9497 (2006)
   PUBMED   16464866
REFERENCE   6  (bases 1 to 1290)
  AUTHORS   Ulrix,W., Swinnen,J.V., Heyns,W. and Verhoeven,G.
  TITLE     Identification of the phosphatidic acid phosphatase type 2a isozyme
            as an androgen-regulated gene in the human prostatic adenocarcinoma
            cell line LNCaP
  JOURNAL   J Biol Chem 273 (8), 4660-4665 (1998)
   PUBMED   9468526
REFERENCE   7  (bases 1 to 1290)
  AUTHORS   Kai,M., Wada,I., Imai,Si., Sakane,F. and Kanoh,H.
  TITLE     Cloning and characterization of two human isozymes of
            Mg2+-independent phosphatidic acid phosphatase
  JOURNAL   J Biol Chem 272 (39), 24572-24578 (1997)
   PUBMED   9305923
REFERENCE   8  (bases 1 to 1290)
  AUTHORS   Kai,M., Wada,I., Imai,S., Sakane,F. and Kanoh,H.
  TITLE     Identification and cDNA cloning of 35-kDa phosphatidic acid
            phosphatase (type 2) bound to plasma membranes. Polymerase chain
            reaction amplification of mouse H2O2-inducible hic53 clone yielded
            the cDNA encoding phosphatidic acid phosphatase
  JOURNAL   J Biol Chem 271 (31), 18931-18938 (1996)
   PUBMED   8702556
REFERENCE   9  (bases 1 to 1290)
  AUTHORS   Waggoner,D.W., Gomez-Munoz,A., Dewald,J. and Brindley,D.N.
  TITLE     Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide
            1-phosphate, lysophosphatidate, and sphingosine 1-phosphate
  JOURNAL   J Biol Chem 271 (28), 16506-16509 (1996)
   PUBMED   8663293
REFERENCE   10 (bases 1 to 1290)
  AUTHORS   Kanoh,H., Imai,S., Yamada,K. and Sakane,F.
  TITLE     Purification and properties of phosphatidic acid phosphatase from
            porcine thymus membranes
  JOURNAL   J Biol Chem 267 (35), 25309-25314 (1992)
   PUBMED   1334090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061815.1.
            
            On Mar 27, 2005 this sequence version replaced NM_022538.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061815.1, JQ013728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..1290
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /note="phospholipid phosphatase 1"
                     /db_xref="GeneID:64369"
                     /db_xref="RGD:621832"
     exon            1..155
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..946
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /EC_number="3.1.3.4"
                     /EC_number="3.1.3.106"
                     /EC_number="3.6.1.75"
                     /note="lipid phosphate phosphohydrolase 1; PAP2a; PAP-2a;
                     PAP2-alpha; phosphatidate phosphohydrolase type 2a;
                     phosphatidic acid phosphatase 2a; phosphatidic acid
                     phosphatase type 2A"
                     /codon_start=1
                     /product="phospholipid phosphatase 1"
                     /protein_id="NP_071983.2"
                     /db_xref="GeneID:64369"
                     /db_xref="RGD:621832"
                     /translation="MFDKTRLPYVVLDVICVLLAGLPFIILTSRHTPFQRGVFCTDES
                     IKYPYREDTIPYALLGGIVIPFCIIVMITGETLSVYFNVLHSNSFVSNHYIATIYKAV
                     GAFLFGASASQSLTDIAKYSIGRLRPHFLAVCNPDWSKINCSDGYIENFVCQGNEQKV
                     REGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPMLQFGLVALSIYVGLSRV
                     SDYKHHWSDVLIGLIQGAVVAILVVLYVTDFFKTTESNKERKEDSHTTLHETTNRQSY
                     ARNHEP"
     exon            156..307
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            308..588
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            589..646
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            647..823
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1275
                     /gene="Plpp1"
                     /gene_synonym="Ppap2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgagggcg gggctcctgg gaattgggta tctggaccgc cgcggtctct tccaaccgcc
       61 gcccgcacct ggtagtgaca tcgtccagcc cgtgaccatg ttcgacaaga cgcggctgcc
      121 gtacgtggtc ctcgatgtga tttgcgtgtt gctggctgga ttgcctttta taattcttac
      181 ttcaaggcat acccccttcc aacgaggagt gttctgtact gatgagtcca tcaagtaccc
      241 ttacagagaa gacaccatcc cttatgcgtt attaggtgga atagtcattc cattctgtat
      301 tatcgttatg attactggag aaactctgtc tgtttacttt aatgtcttgc attcaaattc
      361 ctttgtcagc aatcactata tagccaccat ttacaaagcc gttggagcct ttttgtttgg
      421 agcctcagcc agtcagtccc tgactgacat tgctaagtac tctataggca gactgcggcc
      481 tcacttcctg gctgtctgta acccagactg gtcaaaaatc aactgcagcg atggctacat
      541 tgagaacttc gtatgtcaag ggaatgaaca gaaggtcagg gaaggcaggt tgtccttcta
      601 ctcggggcac tcctcattct ctatgtactg catgctgttt gtcgcacttt atcttcaagc
      661 caggatgaag ggagattggg caagactctt acgacccatg ctacagtttg ggcttgttgc
      721 tttatccata tatgtgggcc tgtctcgagt ttctgattac aaacaccact ggagcgacgt
      781 gttaattggc ctcattcaag gagctgttgt ggcaatatta gtggttttgt atgtaactga
      841 tttcttcaag accacagagt ctaacaaaga aagaaaagag gactcacata cgactctaca
      901 cgaaaccacc aacagacaga gctacgcaag gaatcatgag ccctgaaggg tgcagaggaa
      961 caggccagct tcgaagggaa ctgctggagg cagagggcag gaagatgcat atcactccct
     1021 ggtgtataca ttaaagggct gctgctatac ctcttggatg cccactttat ctatgtatat
     1081 agttacttta acacaatgag ttttttgagt ttttaattga actagtagtt caattaaaaa
     1141 aaatttaagc ctttcactaa aacactgccc cacctgtaca tttttttatt gaaagatgct
     1201 atgtacaaat gtgtatgtta catgccttct cagaatgata tttgatttaa atataataaa
     1261 aatgcttgcg aacaaaaaaa aaaaaaaaaa
//
