LOCUS       NM_030990               3050 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus proteolipid protein 1 (Plp1), mRNA.
ACCESSION   NM_030990
VERSION     NM_030990.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Zhang,Z., Wang,J., Song,Z., Wang,Y., Cheng,Z., Guo,Q., Wang,E.,
            Jian,Y. and Wu,L.
  TITLE     Downregulation of microRNA-199a-5p alleviated lidocaine-induced
            sensory dysfunction and spinal cord myelin lesions in a rat model
  JOURNAL   Toxicol Lett 336, 1-10 (2021)
   PUBMED   33166664
REFERENCE   2  (bases 1 to 3050)
  AUTHORS   Oberoi,R., Chu,T., Mellen,N., Jagadapillai,R., Ouyang,H.,
            Devlin,L.A. and Cai,J.
  TITLE     Diverse changes in myelin protein expression in rat brain after
            perinatal methadone exposure
  JOURNAL   Acta Neurobiol Exp (Wars) 79 (4), 367-373 (2019)
   PUBMED   31885393
  REMARK    GeneRIF: All pups with exposure to methadone demonstrated decreased
            expression of PLP in the cerebral cortex and hippocampus.In the
            cerebellum, PLP expression was downregulated without apparent
            alteration of CNP and MBP expression. PLP and MBP expression, but
            not CNP expression, were significantly inhibited in the brainstem.
REFERENCE   3  (bases 1 to 3050)
  AUTHORS   Shimizu,T., Wisessmith,W., Li,J., Abe,M., Sakimura,K.,
            Chetsawang,B., Sahara,Y., Tohyama,K., Tanaka,K.F. and Ikenaka,K.
  TITLE     The balance between cathepsin C and cystatin F controls
            remyelination in the brain of Plp1-overexpressing mouse, a chronic
            demyelinating disease model
  JOURNAL   Glia 65 (6), 917-930 (2017)
   PUBMED   28251676
REFERENCE   4  (bases 1 to 3050)
  AUTHORS   Takeda,K., Dezawa,M. and Kitada,M.
  TITLE     The expression of PLP/DM-20 mRNA is restricted to the
            oligodendrocyte-lineage cells in the adult rat spinal cord
  JOURNAL   Histochem Cell Biol 145 (2), 147-161 (2016)
   PUBMED   26563642
  REMARK    GeneRIF: PLP and DM-20 mRNA expression is restricted to
            oligodendrocyte-lineage cells
REFERENCE   5  (bases 1 to 3050)
  AUTHORS   Bayless,D.W. and Daniel,J.M.
  TITLE     Sex differences in myelin-associated protein levels within and
            density of projections between the orbital frontal cortex and
            dorsal striatum of adult rats: implications for inhibitory control
  JOURNAL   Neuroscience 300, 286-296 (2015)
   PUBMED   26002313
  REMARK    GeneRIF: Protein levels of PLP were significantly greater in
            orbital frontal cortex (OFC) but not dorsal striatum (dSTR) of
            females as compared to males, suggesting that myelination is
            increased in OFC but similar in dSTR of females as compared to
            males
REFERENCE   6  (bases 1 to 3050)
  AUTHORS   Gordon,M.N., Kumar,S., Espinosa de los Monteros,A. and de Vellis,J.
  TITLE     Ontogeny of glycerol phosphate dehydrogenase-positive
            oligodendrocytes in rat brain. Impaired differentiation of
            oligodendrocytes in the myelin deficient mutant rat
  JOURNAL   Int J Dev Neurosci 10 (4), 243-253 (1992)
   PUBMED   1384273
REFERENCE   7  (bases 1 to 3050)
  AUTHORS   Amiguet,P., Gardinier,M.V., Zanetta,J.P. and Matthieu,J.M.
  TITLE     Purification and partial structural and functional characterization
            of mouse myelin/oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 58 (5), 1676-1682 (1992)
   PUBMED   1373175
REFERENCE   8  (bases 1 to 3050)
  AUTHORS   Simons,R. and Riordan,J.R.
  TITLE     The myelin-deficient rat has a single base substitution in the
            third exon of the myelin proteolipid protein gene
  JOURNAL   J Neurochem 54 (3), 1079-1081 (1990)
   PUBMED   1689377
REFERENCE   9  (bases 1 to 3050)
  AUTHORS   Csiza,C.K. and de Lahunta,A.
  TITLE     Myelin deficiency (md): a neurologic mutant in the Wistar rat
  JOURNAL   Am J Pathol 95 (1), 215-224 (1979)
   PUBMED   434110
REFERENCE   10 (bases 1 to 3050)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_030990.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093596.1, M11185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000021.1  104978053-104978203
            152-338             JAXUCZ010000021.1  104986426-104986612
            339-600             JAXUCZ010000021.1  104987303-104987564
            601-769             JAXUCZ010000021.1  104988624-104988792
            770-843             JAXUCZ010000021.1  104989401-104989474
            844-909             JAXUCZ010000021.1  104990223-104990288
            910-3050            JAXUCZ010000021.1  104991177-104993317
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..3050
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /note="proteolipid protein 1"
                     /db_xref="GeneID:24943"
                     /db_xref="RGD:3354"
     exon            1..151
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..981
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /note="Proteolipid protein (Pelizaeus-Merzbacher disease,
                     spastic paraplegia 2, uncomplicated); lipophilin;
                     proteolipid protein (myelin) 1"
                     /codon_start=1
                     /product="myelin proteolipid protein"
                     /protein_id="NP_112252.1"
                     /db_xref="GeneID:24943"
                     /db_xref="RGD:3354"
                     /translation="MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTE
                     KLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFG
                     DYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALT
                     VVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGK
                     VCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTK
                     F"
     exon            152..338
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            339..600
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            601..769
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            770..843
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            844..909
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /inference="alignment:Splign:2.1.0"
     exon            910..3050
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggagaag aggacaaaga tactcagaga gaaaaagtaa aggacagaag aaggagactg
       61 gagagaccag gatccttcca gctgaacaaa gtcagccgca aaacagacta gccagcaggc
      121 tgcaattgga gccagagtgc caaagacatg ggtttgttag agtgctgtgc tagatgtctg
      181 gtaggggccc cctttgcttc cctggtggcc actggattgt gtttctttgg agtggcactg
      241 ttctgtggat gtggacatga agctctcact ggtacagaaa agttaattga gacctatttc
      301 tccaaaaact accaggacta tgagtatctc attaatgtga ttcatgcttt ccagtatgtc
      361 atctatggaa ctgcctcttt cttcttcctt tatggggccc tcctgctggc cgagggcttc
      421 tacaccaccg gcgctgtcag gcagatcttt ggcgactaca agaccaccat ctgcggcaag
      481 ggcctgagcg caacggtaac agggggccag aaggggaggg gttccagagg ccaacatcaa
      541 gctcattctt tggagcgggt gtgtcattgt ttgggaaaat ggctaggaca tcccgacaag
      601 tttgtgggca tcacctatgc cctgactgtt gtatggctcc tggtgtttgc ctgctctgct
      661 gtgcctgtgt acatttactt caatacctgg accacctgcc agtctattgc cttccctagc
      721 aagacctctg ccagtatagg cagtctctgc gctgatgcca gaatgtatgg tgttctccca
      781 tggaatgctt ttcctggcaa ggtttgtggc tccaaccttc tgtccatctg caaaacagcc
      841 gagttccaaa tgaccttcca cctgtttatt gctgcatttg tgggtgctgc agccacacta
      901 gtttccctgc tcaccttcat gattgctgcc acttacaact ttgccgtcct taaactcatg
      961 ggccgaggca ccaagttctg atctcccata gaaatccccc tttgtctaat agcgaggctc
     1021 taaccacaca gcctatagtg ttgtgtctcc tgtcttaact ctgcctttgc cactgattgg
     1081 ccctcttctt acttgatgag tataacaaga aaggagagta ttgcagtgat taatctctct
     1141 ctgtggactc tccctcttat gtacctcttt cagtcatttt gctccacagt gggctcctgc
     1201 tagaaatggg gaatacctga gaaggtgatt cccccgctgc aagtcgcaga ggaatgaaag
     1261 ctctaattga gtttgcaagc atctcctgaa ggccaggatg tgcttccttc tcaaagggca
     1321 cttccattga ggaaaacaaa gtggaaagaa agattctcag gtagaaagca ggaatgtcct
     1381 tggtctcctt gccatcagta ggagtcaaat atattctctt tgatgcacaa aaccaagaac
     1441 tcactctttt cttcctagtt ccactgaaga cagaaggaaa taagcaatag catttgccca
     1501 aatctgcctc ctgcagctag gagaaggggg tcaaagcaag gatctttcac ccttagaaag
     1561 agagctctga cgccagtggc aatggactat ttaagcccta actcagccaa ccttccttac
     1621 agcattaggg agcacagtgt ctatttagac aaagtggggc ctggaggagg ggggcctcat
     1681 ctgtccttac agctcattag gaagagaaac agagtgttgt caggatcgac tcactccctt
     1741 ctccctgata acagctacca tgacaacctt gtggtttcca aggagctgag aatagaaggg
     1801 aactagctta tataaaataa gactgtgacc taaggagcat cagttggggg atgctaaagg
     1861 tgtaaattga gatgccctct ggcagatgca aaacacttaa ctctttggat agcatctccc
     1921 cccaccccat cagttgtgtc ctcttggcct ctggcacaat atcttcacaa tggtgctctt
     1981 ttccttgggt tttatccatt cacttacagc aggtgattag aggattttga ttagtttcag
     2041 aatgattcct gtttcatatt tcccagttgt ttatctcttg tttggagctg taccagaaag
     2101 aactggagaa tgattctttg agcttagttc tttttcaaaa gaaaaaagaa aaactggaca
     2161 gtaagcatca caaaaatatt tgaaattgtg tagtcccatg aaatgattgg gattttcccc
     2221 aagtattcta ccttttgtag aactaggctt ggtaaatttg aacctccatt tgaataacct
     2281 gtccaatatt ttcttttcta ataaatgaca gatgattttg cttgctaata ttatctcagc
     2341 attttgaaag tttaggctta gcatagaggt tattgtgtct tggtatatat aggtcacata
     2401 atagatttca gcaactgcca gctgtttagt tggtgagctt ccagagagct ctggagacat
     2461 ggtgaggaca gacagaattg gaaacctgaa gaactcccag atttcaggct tatcctgtac
     2521 ttgttaactt tgggtgaaag aaagaaaagc aaagaaagaa aggaaaagcc tctgatctgt
     2581 ttttactgaa ggaaaagtta ctgtagattt ttttttttgt agatttgtgc tgtcattccc
     2641 caaagtgctt ttgtcatgtt gaaagagata taaggattta gaagaagata cttgagactt
     2701 gttcttgggc cagtatataa ggtaaactag caggatgcac agtagtgagg agagcttaaa
     2761 ggacctggaa gaaaccaatc aagataaagg aaggtgaaat aatctatatc ttttatttgg
     2821 tttgatttta atatcataac agataaccaa ccactccctg aaaacctcac acgtatatat
     2881 acacacacgc atgcacatac aaagagagtt aatcaactgc aagtgtttcc ttcatttctg
     2941 atatagaatt ttgattttaa caacataaag gataaactct tagaaactca tcttacaaaa
     3001 tgtattttat aaaattaaag aaaataaaat taagaatgtt ctcaatcaaa
//
