LOCUS       NP_112252                277 aa            linear   ROD 30-APR-2025
DEFINITION  myelin proteolipid protein [Rattus norvegicus].
ACCESSION   NP_112252
VERSION     NP_112252.1
DBSOURCE    REFSEQ: accession NM_030990.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 277)
  AUTHORS   Zhang,Z., Wang,J., Song,Z., Wang,Y., Cheng,Z., Guo,Q., Wang,E.,
            Jian,Y. and Wu,L.
  TITLE     Downregulation of microRNA-199a-5p alleviated lidocaine-induced
            sensory dysfunction and spinal cord myelin lesions in a rat model
  JOURNAL   Toxicol Lett 336, 1-10 (2021)
   PUBMED   33166664
REFERENCE   2  (residues 1 to 277)
  AUTHORS   Oberoi,R., Chu,T., Mellen,N., Jagadapillai,R., Ouyang,H.,
            Devlin,L.A. and Cai,J.
  TITLE     Diverse changes in myelin protein expression in rat brain after
            perinatal methadone exposure
  JOURNAL   Acta Neurobiol Exp (Wars) 79 (4), 367-373 (2019)
   PUBMED   31885393
  REMARK    GeneRIF: All pups with exposure to methadone demonstrated decreased
            expression of PLP in the cerebral cortex and hippocampus.In the
            cerebellum, PLP expression was downregulated without apparent
            alteration of CNP and MBP expression. PLP and MBP expression, but
            not CNP expression, were significantly inhibited in the brainstem.
REFERENCE   3  (residues 1 to 277)
  AUTHORS   Shimizu,T., Wisessmith,W., Li,J., Abe,M., Sakimura,K.,
            Chetsawang,B., Sahara,Y., Tohyama,K., Tanaka,K.F. and Ikenaka,K.
  TITLE     The balance between cathepsin C and cystatin F controls
            remyelination in the brain of Plp1-overexpressing mouse, a chronic
            demyelinating disease model
  JOURNAL   Glia 65 (6), 917-930 (2017)
   PUBMED   28251676
REFERENCE   4  (residues 1 to 277)
  AUTHORS   Takeda,K., Dezawa,M. and Kitada,M.
  TITLE     The expression of PLP/DM-20 mRNA is restricted to the
            oligodendrocyte-lineage cells in the adult rat spinal cord
  JOURNAL   Histochem Cell Biol 145 (2), 147-161 (2016)
   PUBMED   26563642
  REMARK    GeneRIF: PLP and DM-20 mRNA expression is restricted to
            oligodendrocyte-lineage cells
REFERENCE   5  (residues 1 to 277)
  AUTHORS   Bayless,D.W. and Daniel,J.M.
  TITLE     Sex differences in myelin-associated protein levels within and
            density of projections between the orbital frontal cortex and
            dorsal striatum of adult rats: implications for inhibitory control
  JOURNAL   Neuroscience 300, 286-296 (2015)
   PUBMED   26002313
  REMARK    GeneRIF: Protein levels of PLP were significantly greater in
            orbital frontal cortex (OFC) but not dorsal striatum (dSTR) of
            females as compared to males, suggesting that myelination is
            increased in OFC but similar in dSTR of females as compared to
            males
REFERENCE   6  (residues 1 to 277)
  AUTHORS   Gordon,M.N., Kumar,S., Espinosa de los Monteros,A. and de Vellis,J.
  TITLE     Ontogeny of glycerol phosphate dehydrogenase-positive
            oligodendrocytes in rat brain. Impaired differentiation of
            oligodendrocytes in the myelin deficient mutant rat
  JOURNAL   Int J Dev Neurosci 10 (4), 243-253 (1992)
   PUBMED   1384273
REFERENCE   7  (residues 1 to 277)
  AUTHORS   Amiguet,P., Gardinier,M.V., Zanetta,J.P. and Matthieu,J.M.
  TITLE     Purification and partial structural and functional characterization
            of mouse myelin/oligodendrocyte glycoprotein
  JOURNAL   J Neurochem 58 (5), 1676-1682 (1992)
   PUBMED   1373175
REFERENCE   8  (residues 1 to 277)
  AUTHORS   Simons,R. and Riordan,J.R.
  TITLE     The myelin-deficient rat has a single base substitution in the
            third exon of the myelin proteolipid protein gene
  JOURNAL   J Neurochem 54 (3), 1079-1081 (1990)
   PUBMED   1689377
REFERENCE   9  (residues 1 to 277)
  AUTHORS   Csiza,C.K. and de Lahunta,A.
  TITLE     Myelin deficiency (md): a neurologic mutant in the Wistar rat
  JOURNAL   Am J Pathol 95 (1), 215-224 (1979)
   PUBMED   434110
REFERENCE   10 (residues 1 to 277)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J Biol Chem 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093596.1, M11185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     Protein         1..277
                     /product="myelin proteolipid protein"
                     /note="Proteolipid protein (Pelizaeus-Merzbacher disease,
                     spastic paraplegia 2, uncomplicated); lipophilin;
                     proteolipid protein (myelin) 1"
                     /calculated_mol_wt=29946
     Region          5..273
                     /region_name="Myelin_PLP"
                     /note="Myelin proteolipid protein (PLP or lipophilin);
                     pfam01275"
                     /db_xref="CDD:460144"
     Site            10..36
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60203.2)"
     Site            64..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60203.2)"
     Site            114
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60203.2)"
     Site            116
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60203.2)"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P60203.2)"
     Site            152..177
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60203.2)"
     Site            234..260
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P60203.2)"
     CDS             1..277
                     /gene="Plp1"
                     /gene_synonym="Plp"
                     /coded_by="NM_030990.3:148..981"
                     /db_xref="GeneID:24943"
                     /db_xref="RGD:3354"
ORIGIN      
        1 mglleccarc lvgapfaslv atglcffgva lfcgcgheal tgtekliety fsknyqdyey
       61 linvihafqy viygtasfff lygalllaeg fyttgavrqi fgdyktticg kglsatvtgg
      121 qkgrgsrgqh qahslervch clgkwlghpd kfvgityalt vvwllvfacs avpvyiyfnt
      181 wttcqsiafp sktsasigsl cadarmygvl pwnafpgkvc gsnllsickt aefqmtfhlf
      241 iaafvgaaat lvslltfmia atynfavlkl mgrgtkf
//
