LOCUS       NM_178101               2775 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus procollagen-lysine, 2-oxoglutarate 5-dioxygenase
            3 (Plod3), mRNA.
ACCESSION   NM_178101
VERSION     NM_178101.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Shen,Q., Eun,J.W., Lee,K., Kim,H.S., Yang,H.D., Kim,S.Y., Lee,E.K.,
            Kim,T., Kang,K., Kim,S., Min,D.H., Oh,S.N., Lee,Y.J., Moon,H.,
            Ro,S.W., Park,W.S., Lee,J.Y. and Nam,S.W.
  TITLE     Barrier to autointegration factor 1, procollagen-lysine,
            2-oxoglutarate 5-dioxygenase 3, and splicing factor 3b subunit 4 as
            early-stage cancer decision markers and drivers of hepatocellular
            carcinoma
  JOURNAL   Hepatology 67 (4), 1360-1377 (2018)
   PUBMED   29059470
  REMARK    Erratum:[Hepatology. 2018 Jul;68(1):391. doi: 10.1002/hep.30114..
            PMID: 29975814]
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Banushi,B., Forneris,F., Straatman-Iwanowska,A., Strange,A.,
            Lyne,A.M., Rogerson,C., Burden,J.J., Heywood,W.E., Hanley,J.,
            Doykov,I., Straatman,K.R., Smith,H., Bem,D., Kriston-Vizi,J.,
            Ariceta,G., Risteli,M., Wang,C., Ardill,R.E., Zaniew,M.,
            Latka-Grot,J., Waddington,S.N., Howe,S.J., Ferraro,F., Gjinovci,A.,
            Lawrence,S., Marsh,M., Girolami,M., Bozec,L., Mills,K. and
            Gissen,P.
  TITLE     Regulation of post-Golgi LH3 trafficking is essential for collagen
            homeostasis
  JOURNAL   Nat Commun 7, 12111 (2016)
   PUBMED   27435297
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Wang,C., Kovanen,V., Raudasoja,P., Eskelinen,S., Pospiech,H. and
            Myllyla,R.
  TITLE     The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in
            the extracellular space are important for cell growth and viability
  JOURNAL   J Cell Mol Med 13 (3), 508-521 (2009)
   PUBMED   18298658
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Mercer,D.K., Nicol,P.F., Kimbembe,C. and Robins,S.P.
  TITLE     Identification, expression, and tissue distribution of the three
            rat lysyl hydroxylase isoforms
  JOURNAL   Biochem Biophys Res Commun 307 (4), 803-809 (2003)
   PUBMED   12878181
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Heikkinen,J., Risteli,M., Wang,C., Latvala,J., Rossi,M.,
            Valtavaara,M. and Myllyla,R.
  TITLE     Lysyl hydroxylase 3 is a multifunctional protein possessing
            collagen glucosyltransferase activity
  JOURNAL   J Biol Chem 275 (46), 36158-36163 (2000)
   PUBMED   10934207
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Passoja,K., Rautavuoma,K., Ala-Kokko,L., Kosonen,T. and
            Kivirikko,K.I.
  TITLE     Cloning and characterization of a third human lysyl hydroxylase
            isoform
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10482-10486 (1998)
   PUBMED   9724729
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Valtavaara,M., Szpirer,C., Szpirer,J. and Myllyla,R.
  TITLE     Primary structure, tissue distribution, and chromosomal
            localization of a novel isoform of lysyl hydroxylase (lysyl
            hydroxylase 3)
  JOURNAL   J Biol Chem 273 (21), 12881-12886 (1998)
   PUBMED   9582318
  REMARK    Erratum:[J Biol Chem 2000 Jul 7;275(27):20956]
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Nutt,E., Dunwiddie,C., Jacobs,J.W. and Simpson,E.
  TITLE     Identification of novel proteins synthesized in bone cells by
            antibody screening of a cDNA expression library
  JOURNAL   Biochem Biophys Res Commun 151 (1), 382-387 (1988)
   PUBMED   3162363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO386873.1 and BC085683.1.
            
            On Mar 10, 2007 this sequence version replaced NM_178101.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085683.1, AJ430859.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               CO386873.1         7-226
            221-2775            BC085683.1         1-2555
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2775
                     /gene="Plod3"
                     /note="procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3"
                     /db_xref="GeneID:288583"
                     /db_xref="RGD:631339"
     exon            1..403
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2511
                     /gene="Plod3"
                     /EC_number="1.14.11.4"
                     /EC_number="2.4.1.50"
                     /EC_number="2.4.1.66"
                     /note="bone protein I (BP-I); LH3; lysyl hydroxylase 3;
                     multifunctional procollagen lysine hydroxylase and
                     glycosyltransferase LH3"
                     /codon_start=1
                     /product="multifunctional procollagen lysine hydroxylase
                     and glycosyltransferase LH3 precursor"
                     /protein_id="NP_835202.2"
                     /db_xref="GeneID:288583"
                     /db_xref="RGD:631339"
                     /translation="MAASVPEPRLLLLLLLLLPPLPPVTSASDRPRGANPVNPDKLLV
                     ITVATAETEGYRRFLQSAEFFNYTVRTLGLGQEWRGGDVARTVGGGQKVRWLKKEMEK
                     YASQEDMIIMFVDSYDVILASSPTELLKKFVQSGSHLLFSAESFCWPDWGLAEQYPEV
                     GVGKRFLNSGGFIGFAPTIHRIVRQWKYKDDDDDQLFYTQLYLDPGLREKLKLSLDHK
                     SRIFQNLNGALDEVVLKFDQNRVRIRNVAYDTLPVVVHGNGPTKLQLNYLGNYVPNGW
                     TPQGGCGFCNLNRRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDYPPDRISLF
                     LHNNEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSSGEARDMAMDSCRQNPECEFYF
                     SLDADAVLTNPETLRILIEQNRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVEL
                     VQRKRVGLWNVPYISQAYVIRGETLRTELPEKEVFSSSDTDPDMAFCRSVRDKGIFLH
                     LSNQHEFGRLLSTSHYDTDHLHPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPC
                     PDVYWFPLLTEQMCDELVEEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYED
                     QWLQLLRTYVGPMTEHLFPGYHTKTRAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVAL
                     NHKGVDYEGGGCRFLRYDCRVSSPRKGWALLHPGRLTHYHEGLPTTRGTRYIMVSFVD
                     P"
     exon            404..495
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..632
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            633..796
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..909
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..973
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1071
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1173
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1299
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1421
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1526
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1652
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1794
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1908
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1977
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2082
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2229
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2355
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2752
                     /gene="Plod3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggttcctca ggcgtgagtc gggctgtgtc ggggaccaga ccctcggctc ctccccaccc
       61 tccagcccgc gcccgcgcga caatccttgc cttgtctcgc cgtctgcatc tcgggtttta
      121 ggtggcctcg ggttacgcct tttttccagg gcggagtccg gagcacagct cctcctctca
      181 gcgggctcgg cttccctttc ccagaatctt cctggggact cggaatctag gcgctaagct
      241 cagccctggt gcgggcctgg gtgtagccta agcgtgctgc tagccatggc agcgtcagtc
      301 ccggaacccc ggcttttgct cctgctcctg ctgctgctgc cgccgctgcc cccggtaact
      361 tctgcctccg atcgaccccg gggcgccaat cctgtcaacc ctgacaaact gctggtgatc
      421 accgtggcta cagcagagac agaggggtac cggcgttttc tgcagtctgc cgagttcttt
      481 aactacactg tacggaccct gggactggga caggagtggc gagggggtga tgtcgcccga
      541 acagtcggtg gaggccagaa ggtcaggtgg ctcaagaagg aaatggagaa atatgcgagt
      601 caggaggaca tgatcatcat gtttgtggac agctacgatg tgattctggc gagcagccca
      661 acagagctgc tgaagaagtt tgttcagagt ggcagtcatc tgctgttctc cgctgagagc
      721 ttctgctggc ctgactgggg gctggcagag cagtaccctg aggtgggcgt ggggaagcgc
      781 ttcctcaact ctggtggatt cattggcttc gctcccacca tccatcggat tgtccgccag
      841 tggaagtaca aggacgacga cgatgatcag ttgttctata ctcaactcta cctggaccca
      901 gggctgcggg agaaactcaa acttagcctg gaccataaat cccggatctt ccagaacctc
      961 aatggagcct tagatgaagt ggtcttaaag ttcgaccaga accgtgtgcg catccgaaat
     1021 gtggcctacg acacgcttcc tgttgtggtc catggcaacg gtcccactaa gctccagctt
     1081 aactacctgg ggaactatgt ccccaatggc tggactcccc agggaggctg tggattctgc
     1141 aacttgaacc ggaggacact cccggggggg cagcctcccc cccgggtgct tctggccgtg
     1201 tttgtggagc agcccactcc cttcctacct cggttcctgc agcgcctact gctcctggat
     1261 tacccgccgg acaggatctc tcttttcctt cacaacaacg aggtgtacca cgagcctcac
     1321 attgcagatg cctggccaca gctccaggac cacttctcag ctgtaaagct agtggggcca
     1381 gaggaggccc tgagctcagg ggaggccagg gacatggcca tggatagctg tcggcagaac
     1441 cccgagtgtg agttctactt tagcctggat gccgatgctg tcctcacgaa cccggagacc
     1501 ttgcgtatct tgattgaaca aaacaggaag gtaatagctc ccatgctttc tcgccacggc
     1561 aagctctggt ccaacttctg gggggccctg agccccgatg agtactatgc ccgctccgaa
     1621 gactacgtgg aattggtgca gcggaagcga gtgggcttgt ggaatgtacc ctacatatcc
     1681 caggcatatg tgatccgagg agagaccctg aggacagagc tccccgaaaa ggaagtattc
     1741 tccagcagcg acacagaccc agatatggct ttctgcagga gtgtccggga caagggcatc
     1801 ttcctgcacc tcagcaatca gcacgagttt ggccggctgc tgtctacttc ccactatgac
     1861 actgaccact tacacccgga cctctggcag atctttgaca accctgtgga ctggagagaa
     1921 cagtacatcc atgagaacta cagccgggcc ctggatgggg aggggctggt agaacagcca
     1981 tgcccagatg tgtactggtt cccactgctg accgagcaga tgtgtgatga gctggtggag
     2041 gaaatggaac actatggcca gtggtctgga ggccggcatg aggactccag gttggctgga
     2101 gggtatgaga atgttcccac cgtggacatc cacatgaagc aggtggggta cgaggaccag
     2161 tggcttcagc tgctgaggac atatgtgggg cccatgacgg agcacctgtt tcctggctac
     2221 cacaccaaga cacgggcagt gatgaacttt gtggtccgct accggccaga tgagcagccc
     2281 tcacttcggc cacaccatga ctcgtccacc ttcacgctca acgttgccct caatcacaag
     2341 ggtgtagatt atgagggagg tggctgccgc ttcctgaggt acgactgcag agtctcatcc
     2401 ccgaggaagg gctgggctct cctgcaccct ggtcgcctca cacactacca cgaggggctg
     2461 cccaccacca ggggaactcg atacatcatg gtgtccttcg ttgacccctg acactcaatc
     2521 agtctgccaa accttctctg ccactgtgcc ttgttgggcc acctgggttg tcattctcat
     2581 ctcctgagtg tgtctatgtg cctgggacag aatgtgctgg ccccaacagc cctcccagga
     2641 ggtccctaga gtcttctatt ttcccattga cccttctgag ggtcccctgc ctgataaatt
     2701 attaagcttc ctcagcctca ctttcaataa aaggatgttt gtaactgttg aaaaaaaaaa
     2761 aaaaaaaaaa aaaaa
//
