LOCUS       NM_175869               3672 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus procollagen lysine, 2-oxoglutarate 5-dioxygenase
            2 (Plod2), transcript variant 1, mRNA.
ACCESSION   NM_175869 XM_236485
VERSION     NM_175869.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3672)
  AUTHORS   Yao,Y., Cai,X., Zhang,M., Zheng,Y., Fei,W., Zhao,M. and Zheng,C.
  TITLE     Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote
            osteogenic differentiation of bone marrow mesenchymal stem cells
  JOURNAL   Eur J Pharmacol 961, 176192 (2023)
   PUBMED   37981258
  REMARK    GeneRIF: Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to
            promote osteogenic differentiation of bone marrow mesenchymal stem
            cells.
REFERENCE   2  (bases 1 to 3672)
  AUTHORS   Li,H., Zhao,J., Deng,H., Zhong,Y., Chen,M., Chi,L., Luo,G., Cao,C.,
            Yu,C., Liu,H. and Zhang,X.
  TITLE     N6-methyladenosine modification of PLOD2 causes spermatocyte damage
            in rats with varicocele
  JOURNAL   Cell Mol Biol Lett 28 (1), 72 (2023)
   PUBMED   37670228
  REMARK    GeneRIF: N6-methyladenosine modification of PLOD2 causes
            spermatocyte damage in rats with varicocele.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3672)
  AUTHORS   Du,H., Chen,Y., Hou,X., Huang,Y., Wei,X., Yu,X., Feng,S., Wu,Y.,
            Zhan,M., Shi,X., Lin,S., Lu,L., Yuan,S. and Sun,L.
  TITLE     PLOD2 regulated by transcription factor FOXA1 promotes metastasis
            in NSCLC
  JOURNAL   Cell Death Dis 8 (10), e3143 (2017)
   PUBMED   29072684
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3672)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 3672)
  AUTHORS   Saha,S.K., Ghosh,P., Konar,A., Bhattacharya,S. and Roy,S.S.
  TITLE     Differential expression of procollagen lysine 2-oxoglutarate
            5-deoxygenase and matrix metalloproteinase isoforms in hypothyroid
            rat ovary and disintegration of extracellular matrix
  JOURNAL   Endocrinology 146 (7), 2963-2975 (2005)
   PUBMED   15817667
REFERENCE   6  (bases 1 to 3672)
  AUTHORS   Scheurer,S.B., Rybak,J.N., Rosli,C., Neri,D. and Elia,G.
  TITLE     Modulation of gene expression by hypoxia in human umbilical cord
            vein endothelial cells: A transcriptomic and proteomic study
  JOURNAL   Proteomics 4 (6), 1737-1760 (2004)
   PUBMED   15174142
  REMARK    Erratum:[Proteomics. 2004 Sep;4(9):2822]
REFERENCE   7  (bases 1 to 3672)
  AUTHORS   Hofbauer,K.H., Gess,B., Lohaus,C., Meyer,H.E., Katschinski,D. and
            Kurtz,A.
  TITLE     Oxygen tension regulates the expression of a group of procollagen
            hydroxylases
  JOURNAL   Eur J Biochem 270 (22), 4515-4522 (2003)
   PUBMED   14622280
REFERENCE   8  (bases 1 to 3672)
  AUTHORS   Heikkinen,J., Risteli,M., Wang,C., Latvala,J., Rossi,M.,
            Valtavaara,M. and Myllyla,R.
  TITLE     Lysyl hydroxylase 3 is a multifunctional protein possessing
            collagen glucosyltransferase activity
  JOURNAL   J Biol Chem 275 (46), 36158-36163 (2000)
   PUBMED   10934207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 30, 2008 this sequence version replaced NM_175869.2.
            
            Transcript Variant: This variant (1), also known as the long
            variant, represents the longer transcript and encodes the longer
            isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ430860.1, SRR26360190.757329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000008.1  101964318-101964623
            307-398             JAXUCZ010000008.1  101993672-101993763
            399-535             JAXUCZ010000008.1  101995866-101996002
            536-699             JAXUCZ010000008.1  102005088-102005251
            700-812             JAXUCZ010000008.1  102007281-102007393
            813-876             JAXUCZ010000008.1  102009628-102009691
            877-974             JAXUCZ010000008.1  102011207-102011304
            975-1076            JAXUCZ010000008.1  102013755-102013856
            1077-1202           JAXUCZ010000008.1  102016194-102016319
            1203-1324           JAXUCZ010000008.1  102017700-102017821
            1325-1429           JAXUCZ010000008.1  102019691-102019795
            1430-1555           JAXUCZ010000008.1  102023526-102023651
            1556-1697           JAXUCZ010000008.1  102025845-102025986
            1698-1760           JAXUCZ010000008.1  102027189-102027251
            1761-1874           JAXUCZ010000008.1  102028271-102028384
            1875-1940           JAXUCZ010000008.1  102030088-102030153
            1941-2045           JAXUCZ010000008.1  102030734-102030838
            2046-2192           JAXUCZ010000008.1  102045142-102045288
            2193-2318           JAXUCZ010000008.1  102045398-102045523
            2319-3672           JAXUCZ010000008.1  102045669-102047022
FEATURES             Location/Qualifiers
     source          1..3672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..3672
                     /gene="Plod2"
                     /note="procollagen lysine, 2-oxoglutarate 5-dioxygenase 2"
                     /db_xref="GeneID:300901"
                     /db_xref="RGD:3353"
     exon            1..306
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..2474
                     /gene="Plod2"
                     /EC_number="1.14.11.4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Procollagen-lysine, 2-oxoglutarate
                     5-dioxygenase (Lysine hydroxylase) 2; LH2; lysyl
                     hydroxylase 2"
                     /codon_start=1
                     /product="procollagen-lysine,2-oxoglutarate 5-dioxygenase
                     2 isoform 1 precursor"
                     /protein_id="NP_787065.2"
                     /db_xref="GeneID:300901"
                     /db_xref="RGD:3353"
                     /translation="MGDRGVRLGLLMPMLALLSWAASLGVAEETPSRIPADKLLVITV
                     ATKENDGFHRFMNSAKYFNYTVKVLGQGQEWRGGDGMNSIGGGQKVRLMKEAMEHYAG
                     QDDLVILFTECFDVIFAGGPEELLKKFQKTNHKIVFAADALLWPDKRLADKYPGVHIG
                     KRYLNSGGFIGYAPYISRLVQQWDLQDNDDDQLFYTKVYIDPLKREALNITLDHRCKI
                     FQALNGATDEVVLKFENGKSRVKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQE
                     NGCALCDFDTIDLSTVDVYPKVTLGVFIEQPTPFLPRFLDLLLTLDYPKEALRLFVHN
                     KEVYHEKDIKAFVDKAKHDISSIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVD
                     ADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQG
                     NRVGIWNVPYMANVYLIQGKTLRSEMSERNYFVRDKLDPDMSLCRNARDMTLQREKDS
                     PTPETFQMLSPPKGVFMYISNRHEFGRLISTANYNTSHLNNDLWQIFENPVDWKEKYI
                     NRDYSKIFTENIVEQPCPDVFWFPIFSERACDELVEEMEHYGKWSGGKHHDSRISGGY
                     ENVPTDDIHMKQIDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQR
                     SLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHE
                     GLPVKNGTRYIAVSFIDP"
     exon            307..398
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..535
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..699
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..812
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            813..876
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..974
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1076
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1202
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1324
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1429
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1555
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1697
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1760
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1874
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1940
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2045
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2192
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2318
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..3672
                     /gene="Plod2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgtcgtc tgctcggtgc gctcgggctc cgcgctagtc cgctcagtgt tctccaatcg
       61 ctttggtacc cacgcagtcc tctcatccgt cctccgctgc cgtcccgggc cccacgtcta
      121 acccggtgct cttcggggtc tccgcgtctc gcgagaagtc ctcgccgcag gcctcgggct
      181 ttcgggctta ggggcggatg ggggaccgcg gagtgaggct ggggctgctg atgcccatgc
      241 tcgccctgct ctcctgggcg gctagcctgg gcgtagcgga ggagactccc tcgcgcatcc
      301 cagcagataa gttattagtc ataactgtag caaccaaaga aaacgatgga ttccacagat
      361 ttatgaattc agccaagtat ttcaattata ctgtgaaggt tcttggtcaa gggcaagagt
      421 ggagaggtgg tgatgggatg aacagtattg gagggggcca gaaggtgaga ttaatgaaag
      481 aagccatgga gcactacgcc ggtcaggacg atctggtcat cttgtttact gaatgttttg
      541 atgttatatt tgctggtggg cctgaagaac ttcttaaaaa gttccaaaag acaaatcata
      601 aaatcgtctt tgcagcggat gcgctgttgt ggccagataa gcggctggca gacaagtatc
      661 ctggtgtgca cattgggaaa cgctacctga attctggagg ctttattggc tatgctccct
      721 acatcagccg tctggtccag cagtgggatc tgcaggataa tgatgacgac cagctctttt
      781 acactaaagt ttacatcgac ccgctgaaaa gggaagctct taacatcaca ttggatcaca
      841 gatgcaaaat tttccaggcc ttgaatggag ctacagacga agttgtttta aagtttgaaa
      901 atggtaaaag cagagtgaag aatacatttt atgaaacact gccagtggcc atcaatggga
      961 atgggcccac caaaattctc ttgaattact ttggaaacta tgttccaaat tcatggacac
     1021 aggaaaatgg ctgtgctctt tgtgactttg acacaattga cctgtctaca gtagatgtct
     1081 atccgaaggt aacactaggt gtttttattg aacaaccaac cccctttcta cctcggttcc
     1141 tggacttact gttaacactg gattacccta aagaagcact tcgactcttt gtccataata
     1201 aagaagttta tcatgaaaag gacatcaaag cgtttgttga taaagctaaa cacgacatca
     1261 gctctataaa aatagtagga ccagaggaaa atctaagtca agcggaagcc agaaacatgg
     1321 gaatggattt ctgccgtcag gatgaaaagt gtgattacta ctttagtgtg gatgcagatg
     1381 ttgttttgac aaacccaaga actttaaaaa ttttgattga acaaaacagg aagatcattg
     1441 cccctcttgt gacacgtcat ggaaagttgt ggtccaactt ctggggagcc ctgagtcctg
     1501 atggatacta tgctcgttct gaagattacg tagatatcgt tcagggaaac agagtaggaa
     1561 tatggaatgt cccatacatg gctaatgtgt acttaattca agggaagacg ctgcgatcag
     1621 agatgagtga aaggaactat tttgtgcgtg ataagttgga tcccgacatg tctctctgcc
     1681 gcaatgctcg agacatgacc ttacaaaggg aaaaagactc ccccactccg gaaacattcc
     1741 aaatgctcag ccccccaaag ggtgtgttta tgtacatttc taacagacat gaatttggac
     1801 gactgatatc aactgctaat tacaacactt cccatctcaa caatgacctc tggcagattt
     1861 ttgaaaatcc cgtggattgg aaggaaaaat atataaaccg tgactattca aagattttca
     1921 ctgaaaatat agtcgagcag ccctgtccag atgtcttctg gtttcccata ttttctgaac
     1981 gagcctgtga cgagttggta gaagaaatgg aacattacgg caagtggtcc gggggaaagc
     2041 atcatgacag ccgtatatct ggtggctatg aaaatgtccc aacggatgac attcatatga
     2101 agcagattga cctggagaac gtctggcttc actttatccg agagtttatc gctccagtta
     2161 ccctgaaggt cttcgcggga tattacacca agggatttgc cctgctgaac ttcgtagtga
     2221 agtactcgcc cgaaagacag cgctcgctcc ggcctcacca cgatgcgtca accttcacca
     2281 tcaacattgc tctaaataat gtaggagagg attttcaggg aggtggatgc aaattcctaa
     2341 ggtataattg ctccatcgaa tccccccgaa aaggctggag cttcatgcat cctgggaggc
     2401 ttactcatct acacgaaggg cttcctgtca aaaatggaac aagatacatt gcagtctcat
     2461 ttatcgatcc ctaagttatt gacagaactt aaactgagtg gctctttgag atggatgact
     2521 ggcgggaaca tgtctctgaa gttgtacttg agaagacgag aggaatattt aaataatgtc
     2581 accagaacaa cgtcactttg ggccaagcat ttgaaaactt tttatataaa tttgttttat
     2641 gtttcttaac gtctgctctg agccttaaaa cacaggttga agaagaagag agaggaaaaa
     2701 agtgaaagtt ggtatttatt tctgtgcttt aattgtctat gaaaatgatg acattttata
     2761 aaatgtttag gtacaaaggc atgaatgata atcagtaagc ctaataatat tttcttattt
     2821 aaggagaacc tgagaagatt ttatttttca gtgggagaaa tatggaaaat ggttctaaat
     2881 gagggtcggc acgtctggaa gcccgggatt ctgacgcgta ctgaatttat gtgtaacttt
     2941 taagccatgc tgacctccgg gtagattcgc ttttcagtga taaggaagaa aacccaaaga
     3001 aaatattgca cagaggcttt cctcaagcag cctgggcaga tggccagtgg aagcccatcc
     3061 actggagatt ctcagcttgt gaggcaggtg ctcctgtccg ttggaaactg ggcccctgtg
     3121 tgtctccagg gcaagctctc aggggaagct cacatctgcc tgctttacag agtgcttcag
     3181 gcgtcagctc caagtcaaac aggatgtgtt tccttctgtt tttcccctct aattatagaa
     3241 aatagtaagg aaaaatatca gtttcattga gattagtagt acattttact atcttctttt
     3301 ttaacgatta agtacttgaa ttttatatca ggaaaatagt ttttgagcct gttcttacct
     3361 ttggccgtag ttggtagttg gtctctttgt ttttcctgga ggaggggcat ttcttttcct
     3421 catcataaac tactttctca ttcttagtct tgttattact tttcctctac cccacttttt
     3481 aaaaattccc acagcaaaat ttttatttga atttttaata tttctctgaa tgaggtttaa
     3541 atatctttat tagagctact gtctttaatt taaaggttaa acttgaagaa agtctttatt
     3601 catggtgcca aaatgcattt ttctaactct gtgtgttaga aaataatgaa aaataaaata
     3661 acttaacata aa
//
