LOCUS       NM_053827               2912 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus procollagen-lysine, 2-oxoglutarate 5-dioxygenase
            1 (Plod1), mRNA.
ACCESSION   NM_053827
VERSION     NM_053827.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2912)
  AUTHORS   Cao,Z.R., Zheng,W.X., Jiang,Y.X., Chai,H., Gong,J.H., Zhao,M.J.,
            Yan,P., Liu,Y.Y., Liu,X.Y., Huang,Z.T., Yang,H., Peng,D.D.,
            Zong,K.Z. and Wu,Z.J.
  TITLE     miR-449a ameliorates acute rejection after liver transplantation
            via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in
            macrophages
  JOURNAL   Am J Transplant 23 (3), 336-352 (2023)
   PUBMED   36695693
  REMARK    GeneRIF: miR-449a ameliorates acute rejection after liver
            transplantation via targeting
            procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages.
REFERENCE   2  (bases 1 to 2912)
  AUTHORS   Heard,M.E., Besio,R., Weis,M., Rai,J., Hudson,D.M., Dimori,M.,
            Zimmerman,S.M., Kamykowski,J.A., Hogue,W.R., Swain,F.L.,
            Burdine,M.S., Mackintosh,S.G., Tackett,A.J., Suva,L.J., Eyre,D.R.
            and Morello,R.
  TITLE     Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum
            Complex Regulating Collagen Lysyl Hydroxylation
  JOURNAL   PLoS Genet 12 (4), e1006002 (2016)
   PUBMED   27119146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2912)
  AUTHORS   Flister,M.J., Tsaih,S.W., O'Meara,C.C., Endres,B., Hoffman,M.J.,
            Geurts,A.M., Dwinell,M.R., Lazar,J., Jacob,H.J. and Moreno,C.
  TITLE     Identifying multiple causative genes at a single GWAS locus
  JOURNAL   Genome Res 23 (12), 1996-2002 (2013)
   PUBMED   24006081
REFERENCE   4  (bases 1 to 2912)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2912)
  AUTHORS   Saha,S.K., Ghosh,P., Konar,A., Bhattacharya,S. and Roy,S.S.
  TITLE     Differential expression of procollagen lysine 2-oxoglutarate
            5-deoxygenase and matrix metalloproteinase isoforms in hypothyroid
            rat ovary and disintegration of extracellular matrix
  JOURNAL   Endocrinology 146 (7), 2963-2975 (2005)
   PUBMED   15817667
REFERENCE   6  (bases 1 to 2912)
  AUTHORS   Pirskanen,A., Kaimio,A.M., Myllyla,R. and Kivirikko,K.I.
  TITLE     Site-directed mutagenesis of human lysyl hydroxylase expressed in
            insect cells. Identification of histidine residues and an aspartic
            acid residue critical for catalytic activity
  JOURNAL   J Biol Chem 271 (16), 9398-9402 (1996)
   PUBMED   8621606
REFERENCE   7  (bases 1 to 2912)
  AUTHORS   Armstrong,L.C. and Last,J.A.
  TITLE     Rat lysyl hydroxylase: molecular cloning, mRNA distribution and
            expression in a baculovirus system
  JOURNAL   Biochim Biophys Acta 1264 (1), 93-102 (1995)
   PUBMED   7578263
REFERENCE   8  (bases 1 to 2912)
  AUTHORS   Hautala,T., Heikkinen,J., Kivirikko,K.I. and Myllyla,R.
  TITLE     A large duplication in the gene for lysyl hydroxylase accounts for
            the type VI variant of Ehlers-Danlos syndrome in two siblings
  JOURNAL   Genomics 15 (2), 399-404 (1993)
   PUBMED   8449506
REFERENCE   9  (bases 1 to 2912)
  AUTHORS   Croyle,M.L., Bhattacharya,A., Gordon,D.F. and Maurer,R.A.
  TITLE     Analysis of the organization and nucleotide sequence of the
            chromosomal gene for the beta-subunit of rat thyrotropin
  JOURNAL   DNA 5 (4), 299-304 (1986)
   PUBMED   3017658
REFERENCE   10 (bases 1 to 2912)
  AUTHORS   Croyle,M.L. and Maurer,R.A.
  TITLE     Thyroid hormone decreases thyrotropin subunit mRNA levels in rat
            anterior pituitary
  JOURNAL   DNA 3 (3), 231-236 (1984)
   PUBMED   6086256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ074486.1, FQ202794.1, CA513298.1, CB736258.1, CO397075.1,
            CV080837.1 and FQ107796.1.
            
            On Aug 10, 2012 this sequence version replaced NM_053827.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               FQ074486.1         1-155
            156-768             FQ202794.1         138-750
            769-1021            CA513298.1         488-740
            1022-1239           CB736258.1         126-343
            1240-1661           CO397075.1         208-629
            1662-2242           CV080837.1         165-745
            2243-2912           FQ107796.1         1-670               c
FEATURES             Location/Qualifiers
     source          1..2912
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2912
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /note="procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1"
                     /db_xref="GeneID:116552"
                     /db_xref="RGD:621382"
     exon            1..124
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2235
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /EC_number="1.14.11.4"
                     /note="LH1; lysyl hydroxylase 1; procollagen-lysine,
                     2-oxoglutarate 5-dioxygenase (lysine hydroxylase,
                     Ehlers-Danlos syndrome type VI); procollagen-lysine 1,
                     2-oxoglutarate 5-dioxygenase 1"
                     /codon_start=1
                     /product="procollagen-lysine,2-oxoglutarate 5-dioxygenase
                     1 precursor"
                     /protein_id="NP_446279.2"
                     /db_xref="GeneID:116552"
                     /db_xref="RGD:621382"
                     /translation="MRSLLLLASLAWLLLAQAKDDAKLEDNLLVLTVATKETEGFRRF
                     KRSAQFFNYKIQSLGLGEDWSAAGGPSAAGGGQKVRLLKKALKKYADKEDLVILFVDS
                     YDVVFASGPRELLKKFQQAKSRVVFSAEELIYPDRRLEAKYPTVPDGKRFLGSGGFIG
                     YAPSLSKLVAEWEGQDNDSDQLFYTKIFLDPEKREQINISLDHRCRIFQNLDGALDEV
                     VLKFEMGHVRARNLAYDTLPVVIHGNGPTKLQVNYLGNYIPRFWTFETGCTVCDEGLR
                     SLKGIGDEALPTVLVGVFIEQPTPFLSLFFRRLLHLRYPQKQMRLFIHNQEQHHKLQV
                     EQFLAEHGGEYQSVKLVGPEVRMANADARNMGADLCRQDQTCTYYFSVDADVALTEPN
                     SLRLLIEQNKNVIAPLMTRHGRLWSNFWGALSADGYYARSEDYVDIVQGRRVGVWNVP
                     YISNIYLIKGSALRAELRHVDLFHYSKLDPDMSFCANVRQQEVFMFLTNRHTFGHLLS
                     LDNYQTTHLHNDLWEVFSNPEDWKEKYIHENYTKALAGKLVETPCPDVYWFPIFTEVA
                     CDELVEEMEHYGQWSLGDNKDNRIQGGYENVPTIDIHMNQITFEREWHKFLVEYIAPL
                     TEKLYPGYYTKAQFDLAFVVRYKPDEQPSLMPHHDASTFTINIALNRVGEDYEGGGCR
                     FLRYNCSVRAPRKGWALMHPGRLTHYHEGLPTTKGTRYIAVSFVDP"
     exon            125..216
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            217..353
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            354..517
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            518..630
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            631..694
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            695..792
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            793..894
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1026
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1148
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1253
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1379
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1521
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1635
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1701
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1806
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1953
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2079
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2895
                     /gene="Plod1"
                     /gene_synonym="Plod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcagctt gtgtttcagt gccggcggat cgtctccaag actcgactat gcggtccctg
       61 ctgctcctgg cctcgctggc ctggcttctt ctggcccagg cgaaggacga cgccaagctg
      121 gaggacaacc ttttggtcct caccgtggcc acaaaagaga cagagggctt ccgccgattc
      181 aagcgctcag cccagttctt caactacaag atccagtcac tgggcctggg ggaggactgg
      241 agcgcggccg ggggaccatc ggcagcaggt ggaggacaga aggttcggct gctgaagaag
      301 gcactgaaaa agtatgcaga caaggaagac ctggttattc tcttcgttga cagctatgac
      361 gtggtgtttg cctcgggacc ccgggaactc ttaaagaagt tccagcaggc caagagccgg
      421 gtggtcttct cagcagagga gcttatctac cctgaccgga ggctggaggc caagtatccc
      481 acagtccccg atggcaaacg attcttgggc tctggaggct tcattggtta tgctcccagc
      541 ctcagcaaac tggtggccga gtgggagggc caggacaatg acagcgacca gctcttttat
      601 accaagatct tcttggaccc ggagaagagg gagcaaatca atatcagcct ggaccatcgc
      661 tgccgaatct tccagaacct ggatggagcc ttggatgaag tcgtactcaa gtttgaaatg
      721 ggccacgtga gagcccggaa tctggcctat gacaccctcc cagtggtcat ccacggcaac
      781 gggcccacca agctgcaggt gaactacctg ggcaactaca ttcctcgatt ctggaccttc
      841 gaaacgggct gcaccgtgtg cgacgagggc ctgcgaagcc tcaagggcat tggggatgaa
      901 gctctcccta ccgtcctggt cggtgtgttc attgagcagc ccacaccatt cctatccttg
      961 ttctttcggc ggctgctgca cctacgatac cctcagaaac agatgcggct cttcattcac
     1021 aaccaagaac agcaccacaa gcttcaggta gagcagttcc tggcagagca cggcggtgag
     1081 taccagtctg tgaagctagt gggtcccgag gtacgcatgg ccaacgcaga cgccaggaac
     1141 atgggcgccg acctgtgccg ccaggatcaa acatgcacct actacttcag tgtggatgct
     1201 gacgtggccc tgaccgagcc gaacagccta cggctcctga ttgagcaaaa caagaatgtc
     1261 attgctccac tcatgacccg tcacgggagg ctctggtcca acttctgggg ggcactgagt
     1321 gcggatgggt actacgcccg ctcggaggac tacgtggaca tcgtgcaggg ccgtcgtgtt
     1381 ggcgtctgga atgtgcctta catctcaaac atctacctga tcaagggcag tgccctgcgg
     1441 gccgagctgc ggcacgtaga cctgttccac tacagcaagc tggatcctga catgagtttc
     1501 tgcgccaatg tccgacagca ggaggtgttc atgttcctga ccaaccggca tacctttggc
     1561 cacctgctgt cgctggataa ttaccagacc acccacctac ataatgatct ctgggaggtg
     1621 ttcagcaacc ctgaggattg gaaagagaag tacatccacg agaattacac caaggccctg
     1681 gcagggaagc tggtggagac gccttgtccg gatgtctact ggttccccat cttcacggag
     1741 gtggcctgtg atgagctggt ggaggaaatg gaacactacg gccaatggtc tctgggtgac
     1801 aataaggaca accgtatcca gggtggctat gaaaacgtgc ccactattga catccacatg
     1861 aaccagatca ccttcgagcg ggagtggcac aagttcctgg tggagtacat cgcccccctg
     1921 acagagaagc tgtaccccgg ctactacacc aaggcccagt ttgatctagc cttcgtcgtc
     1981 cgctataagc ctgatgagca gccttccttg atgcctcacc atgacgcctc tactttcacc
     2041 atcaacatag ccctgaacag ggttggggaa gattatgagg gtggaggttg ccgatttcta
     2101 cgctacaact gctccgtgag agccccaagg aagggctggg ccctcatgca ccccgggcgg
     2161 ctcacacact accacgaggg gcttcccact accaagggta cccgctacat tgccgtgtcc
     2221 ttcgtcgatc cctaactgct tgcccagtgc ctgcttccat tcgacctatc tcttcattga
     2281 caaccactgc ctagcagcct ctggggccaa ggaacccaat ccgacctctg attcctgaat
     2341 tcctgttgct cttgaagctg ccagttggaa ggattgggtg caggccagaa atggggcacc
     2401 ccctccaaga ctggggctgc ccgtggtgct cccaccagtc tccggagatg gtagcaatgt
     2461 ttatcttcct ggagttccta acctcccttc ttctctgact ttccctgggg ccagacttct
     2521 gctggagagt tcctggagag tcagaagctt tgcctagagg acttctagaa gagctagccc
     2581 ccgggatcct gtttcaagat tcagtgccac caagatctgg gtcaaccaac ttaccccaac
     2641 ttcacccctg cctggactgt tgatacgctc tcttccaggt ttttatcacc ggagcaaata
     2701 gttgtctcta ttgagactat aactcgaaat cctcccggag gggcaggaaa gacatctgtg
     2761 acaatgcttg gctcgctgct gaccctgctt gagggagggg cacatgttca cactgtacta
     2821 ggtcaccctg ccccgatgcc tgtggggaca gggacagaga tgagagttct attaaatttt
     2881 gttcaaacca ctgtaaaaaa aaaaaaaaaa aa
//
