LOCUS       NM_022707               2254 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Rattus norvegicus phospholamban (Pln), mRNA.
ACCESSION   NM_022707 XM_346603
VERSION     NM_022707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Gregolin,C.S., do Nascimento,M., Borges de Souza,S.L., Ferreira
            Mota,G.A., Bomfim,G.F., de Azevedo Melo Luvizotto,R.,
            Sugizaki,M.M., Zanati Bazan,S.G., Salome de Campos,D.H., Dias,M.C.,
            Correa,C.R., Cicogna,A.C. and Ferreira do Nascimento,A.
  TITLE     Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated
            with Alterations of Phospholamban Phosphorylation and IL-6 Levels
  JOURNAL   Arch Med Res 52 (3), 284-293 (2021)
   PUBMED   33220932
  REMARK    GeneRIF: Myocardial Dysfunction in Cirrhotic Cardiomyopathy is
            Associated with Alterations of Phospholamban Phosphorylation and
            IL-6 Levels.
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Makarewich,C.A., Munir,A.Z., Schiattarella,G.G., Bezprozvannaya,S.,
            Raguimova,O.N., Cho,E.E., Vidal,A.H., Robia,S.L., Bassel-Duby,R.
            and Olson,E.N.
  TITLE     The DWORF micropeptide enhances contractility and prevents heart
            failure in a mouse model of dilated cardiomyopathy
  JOURNAL   Elife 7, e38319 (2018)
   PUBMED   30299255
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Francois,A.A., Obasanjo-Blackshire,K., Clark,J.E., Boguslavskyi,A.,
            Holt,M.R., Parker,P.J., Marber,M.S. and Heads,R.J.
  TITLE     Loss of Protein Kinase Novel 1 (PKN1) is associated with mild
            systolic and diastolic contractile dysfunction, increased
            phospholamban Thr17 phosphorylation, and exacerbated
            ischaemia-reperfusion injury
  JOURNAL   Cardiovasc Res 114 (1), 138-157 (2018)
   PUBMED   29045568
  REMARK    GeneRIF: Cardioprotection by PKN1 is associated with reduced
            CamKIIdelta-dependent phospholamban Thr17 phosphorylation at the SR
            and therefore may stabilize the coupling of SR Ca2+ handling and
            contractile function, independent of its kinase activity.
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Bocchi,L., Savi,M., Naponelli,V., Vilella,R., Sgarbi,G.,
            Baracca,A., Solaini,G., Bettuzzi,S., Rizzi,F. and Stilli,D.
  TITLE     Long-Term Oral Administration of Theaphenon-E Improves
            Cardiomyocyte Mechanics and Calcium Dynamics by Affecting
            Phospholamban Phosphorylation and ATP Production
  JOURNAL   Cell Physiol Biochem 47 (3), 1230-1243 (2018)
   PUBMED   29913456
  REMARK    GeneRIF: Long-term in vivo administration of GTE improves cell
            mechanical properties and intracellular calcium dynamics in normal
            cardiomyocytes, by increasing energy availability and removing the
            inhibitory effect of PLB on SERCA2.
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Luo,W., Grupp,I.L., Harrer,J., Ponniah,S., Grupp,G., Duffy,J.J.,
            Doetschman,T. and Kranias,E.G.
  TITLE     Targeted ablation of the phospholamban gene is associated with
            markedly enhanced myocardial contractility and loss of beta-agonist
            stimulation
  JOURNAL   Circ Res 75 (3), 401-409 (1994)
   PUBMED   8062415
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Cantilina,T., Sagara,Y., Inesi,G. and Jones,L.R.
  TITLE     Comparative studies of cardiac and skeletal sarcoplasmic reticulum
            ATPases. Effect of a phospholamban antibody on enzyme activation by
            Ca2+
  JOURNAL   J Biol Chem 268 (23), 17018-17025 (1993)
   PUBMED   8349590
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   Shanahan,C.M., Weissberg,P.L. and Metcalfe,J.C.
  TITLE     Isolation of gene markers of differentiated and proliferating
            vascular smooth muscle cells
  JOURNAL   Circ Res 73 (1), 193-204 (1993)
   PUBMED   8508530
REFERENCE   9  (bases 1 to 2254)
  AUTHORS   Johns,D.C. and Feldman,A.M.
  TITLE     Identification of a highly conserved region at the 5' flank of the
            phospholamban gene
  JOURNAL   Biochem Biophys Res Commun 188 (2), 927-933 (1992)
   PUBMED   1445334
REFERENCE   10 (bases 1 to 2254)
  AUTHORS   Hwang,K.S. and Nadal-Ginard,B.
  TITLE     Cloning phospholamban cDNA from rat aortic smooth muscle
  JOURNAL   Adv Exp Med Biol 304, 387-395 (1991)
   PUBMED   1725098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM050525.1, CK356371.1, FM056997.1, FM111426.1 and FM055105.1.
            
            On Aug 1, 2012 this sequence version replaced NM_022707.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK357824.1, CK477878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132271, SAMD00132273
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               FM050525.1         1-583
            584-748             CK356371.1         581-745
            749-1273            FM056997.1         30-554
            1274-1702           FM111426.1         192-620
            1703-2254           FM055105.1         1-552               c
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2254
                     /gene="Pln"
                     /gene_synonym="Plm"
                     /note="phospholamban"
                     /db_xref="GeneID:64672"
                     /db_xref="RGD:619894"
     exon            1..72
                     /gene="Pln"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     exon            73..2254
                     /gene="Pln"
                     /gene_synonym="Plm"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..339
                     /gene="Pln"
                     /gene_synonym="Plm"
                     /note="cardiac phospholamban; PLB"
                     /codon_start=1
                     /product="phospholamban"
                     /protein_id="NP_073198.1"
                     /db_xref="GeneID:64672"
                     /db_xref="RGD:619894"
                     /translation="MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLL
                     ICIIVMLL"
     regulatory      686..691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pln"
                     /gene_synonym="Plm"
     polyA_site      709
                     /gene="Pln"
                     /gene_synonym="Plm"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pln"
                     /gene_synonym="Plm"
     polyA_site      1893
                     /gene="Pln"
                     /gene_synonym="Plm"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pln"
                     /gene_synonym="Plm"
ORIGIN      
        1 aaagctgcgc agctgagctc ccagacttca cacaactaaa cagtctgcat tgtgacgatc
       61 acagaagcca aggcctccta aaaggagaca gctcgcgttt ggctgcctgc tgtcaacttt
      121 ttatctttct cttgactact taaaaaagac ttgtcttcct acttttgtct tcctggcatc
      181 atggaaaaag tccaatacct tactcgctcg gctatcagga gagcctcgac tattgaaatg
      241 ccccagcaag cgcgtcagaa cctccagaac ctctttatca atttctgtct catcttgata
      301 tgtctgctgc tgatctgcat cattgtgatg cttctgtgac aagctgtcgc caccgcagac
      361 ctgcaccatg ccaacgcagc ttacaacctg gccctccacc acgagggagg cagtgccgcc
      421 gccttcctgc tggacatcgt cgtgaaggtc acgattaaga gtgagactga tggcagccag
      481 tgtgatcatc ggctggatct tgtaaacttt accacgacta agtgtgcaca atgtagctgc
      541 ccgtttcctc agtgtggctc ataaatgtct ttcctaaata cttctgacat tgtagtatga
      601 gttttaattt tgaaacagca ctacaaaaaa agttcacttt ctatatccag cactagaaag
      661 ttcaacttat agcttcagtt tggggaataa atgaaattta aactgcgttg ccaccacttt
      721 ttttttatag gaactaaata ttcttcaggt ctgcacaaag tagaaaataa taatttaaat
      781 gaagtgttct tattcaaaat agctcactgg gtcctcatat agacgacgat gacgatgacc
      841 atgacgatga caatgattca gaagtcatgg tcattactgt cagaacacat accttgaaaa
      901 aaggttgtgc cctttttcta aacactaatt atttttaagc ttatgagagt caaataggga
      961 aatgtaaaag catattctca tataaaaatc ttcactaatt tttccactaa ttgtggaatt
     1021 caagcacatt tacattaacc acaaatgtgc tctctctagg gtttgaccag caagcaagaa
     1081 catcttactg tgtggttgcg ataatcacta aaacatcaga acctcacccg aaggttggct
     1141 tggcacagat ctcctgggtt gtgccgggct tctccagata ataaatgata acaacaaacc
     1201 agacagctgt gctggggtac agctctcttc ctgcatcccc cagagaggag aggcttgctc
     1261 tcctaactta aaaactagag attctatttt acaatcctta ctaatcacgg tttcaatttc
     1321 cctttctaaa ttcctaatat ctctcaataa atactaaaag attaggagct aaaaactgta
     1381 ttggaaaaca ttcaccaaaa tttagttaac ttaagttatc caatacaaaa cagttcacac
     1441 ctctcctgtg cactcccaca gttcacacct ctcctgtgca ctcccacagt gttaagtcca
     1501 gctcaaggca ttctaccaac acagcagcta ttaggagagt tataattaga tatattttcc
     1561 ataatgatta ctacgaagat acggcgcatc agtattcacc ttggtcccta acagagcagc
     1621 tgaaggcatg ctgattcgaa ctgtttgaat ccctgataga aaggaagatg tctggtttca
     1681 gaaattatcc aaagagtagc ccacaaagga gtcccacgtt aataggcgtc tcttcagaaa
     1741 aggctggggg tgagggtgcc catcacagaa actataaaac atggatgaca taatctctaa
     1801 atcaatgttc cctttgtgat gctatgaccc tttcatatag ttcctcatgt tgtggtgaaa
     1861 cccaacaata aaattatttt tgttgctatt ccataactgt aattttgcct ccactatgaa
     1921 ttgcgaatat ttgtgtagac aaaggtttgc gtgaggggtt gcaacgcaca ggttgagaag
     1981 cactggtgaa tggtctgcgg aattatgtac aagtgcataa gttcgtagtt gccatgctga
     2041 gaggaaaagg aaggtgaaaa gcgcctggcc ctttacattc tcactaccac accaactgtc
     2101 aactcataag ttcttctcat caaacattta atgtttaatg ccttttacat ttcagtagtt
     2161 aaatgtttat ctataaaatg caataagaat ggcctatatt cagatgggat tatgattttg
     2221 gtgcaattgc tatacaatta aatgctatta ctat
//
