LOCUS       NM_001170557            2094 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus polo-like kinase 5 (Plk5), mRNA.
ACCESSION   NM_001170557
VERSION     NM_001170557.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   de Carcer,G., Escobar,B., Higuero,A.M., Garcia,L., Anson,A.,
            Perez,G., Mollejo,M., Manning,G., Melendez,B., Abad-Rodriguez,J.
            and Malumbres,M.
  TITLE     Plk5, a polo box domain-only protein with specific roles in neuron
            differentiation and glioblastoma suppression
  JOURNAL   Mol Cell Biol 31 (6), 1225-1239 (2011)
   PUBMED   21245385
REFERENCE   2  (bases 1 to 2094)
  AUTHORS   Andrysik,Z., Bernstein,W.Z., Deng,L., Myer,D.L., Li,Y.Q.,
            Tischfield,J.A., Stambrook,P.J. and Bahassi el,M.
  TITLE     The novel mouse Polo-like kinase 5 responds to DNA damage and
            localizes in the nucleolus
  JOURNAL   Nucleic Acids Res 38 (9), 2931-2943 (2010)
   PUBMED   20100802
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2094
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /note="polo-like kinase 5"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
     exon            1..212
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1895
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /EC_number="2.7.11.21"
                     /note="polo-like kinase 5 pseudogene;
                     serine/threonine-protein kinase PLK5"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase PLK5"
                     /protein_id="NP_001164028.1"
                     /db_xref="GeneID:314627"
                     /db_xref="RGD:1305038"
                     /translation="MEPRLRRRRSRQLVATFLRDPGSGRVYRRGKLIGKGAFSRCYKL
                     TDMSTSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLHHRNIVAFHAHFADRDHVYM
                     VLEYCSRQSLAHVLKVRRTLTEPEVRYYFRGLVSGLRYLHQQRIVHRDLKPSNFFLNK
                     NMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSAKSDIWALGCIMYTV
                     LTGTPPFAAAPLSEMYQNIRDGHYLEPTQLSPSARSLIARLLAPDPDERPSLDHLLQD
                     DFFSQGFTPERLPPHSCHSPPVFAFPPPLGRLFRKVGQLLLTQCRPPCPFTSKEASGP
                     GEESTEPDHMEASNEARAPLCTESRIHLLTLGTPRTDPADAKGTLALQLEVATRKLCL
                     CLDAGPVAGQDPPGEQRSVLWAPKWVDYSLKYGFGYQLSDGGSGVLFRDGSHMALRPP
                     GGHVSYQPDQGTLWIFALRDVPGPLRAKLAVLRLFACYMQRRLREEGTAPMTATPASP
                     DFCLLSFTADAQALAMLFSNGTVQVSSKTSPVQLVLSGEGEDFLLTIQEPGGPSMGTS
                     YTLDVLRSHGISLAVRHHLRLGLHLLQSV"
     exon            213..320
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            321..437
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            438..567
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            568..655
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            656..751
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            752..950
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1077
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1158
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1227
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1305
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1462
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1592
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1703
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..2094
                     /gene="Plk5"
                     /gene_synonym="Plk5p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taagacccgc tcctgctgct cgcgggctca cagcggcagc gctgcaggca gcactggctt
       61 gcccagttcc cgcgcgcgcg ctgcgcaccc aggcccaccc cgcgtcgatg gagccccggt
      121 tgaggcggcg gcgaagccgc cagctagtgg ccaccttcct gcgtgacccg ggctcagggc
      181 gcgtgtaccg gcgcgggaag ctgatcggca agggcgcctt cagccgctgc tacaagctca
      241 cggacatgtc caccagcgcg gtgtttgctc ttaaggtggt gccgaggggc ggagcggggc
      301 ggctgcgcct gcgcgggaag gtggagcgtg agatcgccct gcacagccgc ctgcaccacc
      361 gcaacatcgt ggccttccac gcacactttg ctgaccgcga ccacgtgtat atggtgctgg
      421 agtactgtag ccgccagtcc ttggctcatg tactgaaagt gcggcggacc ctgacggagc
      481 ctgaagtgcg ctactacttt cggggcctgg tcagtggcct ccgctacctg caccaacaac
      541 gcatcgtgca cagggacctg aaacccagta atttcttcct taacaagaac atggaagtta
      601 agataggtga cctggggctg gctgcccgtg tggggcccgc tggccgctgc cacagggtgc
      661 tctgtgggac tccgaacttc caggctcctg aagtggtgtc ccgaaatgga cactcggcca
      721 agtctgacat ctgggccctg gggtgcatta tgtacacggt gctgacgggc acgcccccct
      781 tcgctgccgc acccttgtcc gagatgtacc aaaacatccg agacggtcac taccttgagc
      841 ccactcagct gtcacccagc gcccgtagcc tcattgcacg acttctggca ccggaccctg
      901 atgagcggcc cagcctggac cacttactgc aagatgactt ttttagtcag ggctttaccc
      961 cagagcggct gcctccacat tcctgccaca gcccacccgt gtttgccttc cccccgccac
     1021 tgggcaggtt gttccggaag gtgggccaac tcctgctgac ccagtgccgg ccgccctgtc
     1081 cctttacctc aaaagaggcc tcaggcccgg gagaagagag tacagaacct gaccacatgg
     1141 aggccagcaa cgaggcaagg gctcctctct gcactgagag ccgaatccac ctcctcactc
     1201 ttggaacccc tcggactgac ccggccgatg cgaaggggac cttggccctg cagctggagg
     1261 tggcaaccag aaaactgtgc ctctgcttgg atgcaggacc tgtggctgga caggaccccc
     1321 ccggggagca gcgctctgtc ctctgggctc ccaagtgggt ggattattcc ctcaagtatg
     1381 gcttcggtta ccagctgtcg gatgggggca gtggcgtgct gtttcgggat ggctcccaca
     1441 tggccctgcg ccccccagga ggccatgtct cctaccaacc tgaccaaggg actctgtgga
     1501 tcttcgccct gagggacgtc cccggcccac tccgcgccaa gctggccgtc ctgaggctct
     1561 ttgcctgcta catgcagcgg cgtctgcggg aggaggggac agcacccatg acggccacac
     1621 ccgcctctcc tgacttctgt ctgctgagct tcaccgctga tgcccaagct ctggccatgc
     1681 tctttagcaa tgggacagtg caggtcagtt ccaaaacctc cccagtccag ctggtgctga
     1741 gtggggaagg cgaggacttt ctgctcacca tccaggagcc agggggaccc agcatgggca
     1801 cctcctacac gctggacgtc ctgcggagtc acggcatcag ccttgcggtc cgccaccacc
     1861 tgcgccttgg actgcatctg cttcagagtg tctaaggagc cggacggaga tctgggcgga
     1921 cctctgcgtg atggtgctgg tgtctgtttc tgtctgcgct cctccgccac agccagtgtc
     1981 tgtggagggt ggacacattg ggacctctga tgggtgggcg tctttgatta tttgactact
     2041 caaggtagac tttttttgga ttttcattaa agaaaacaga accctttaaa ctgc
//
