LOCUS       NM_001395103            3451 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus polo-like kinase 4 (Plk4), mRNA.
ACCESSION   NM_001395103 XM_006232299
VERSION     NM_001395103.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3451)
  AUTHORS   Li,D., Chen,Y., Wang,Y., Liu,J., Chai,L., Zhang,Q., Qiu,Y.,
            Chen,H., Shen,N., Shi,X. and Li,M.
  TITLE     NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell
            proliferation by TLR4/NF-kappaB/PLK4 signaling pathway
  JOURNAL   Eur J Pharmacol 961, 176151 (2023)
   PUBMED   37914064
  REMARK    GeneRIF: NAMPT mediates PDGF-induced pulmonary arterial smooth
            muscle cell proliferation by TLR4/NF-kappaB/PLK4 signaling pathway.
REFERENCE   2  (bases 1 to 3451)
  AUTHORS   Zheng,Y., Liu,Y., Wang,L., Xu,H., Lu,Z., Xuan,Y., Meng,W., Ye,L.,
            Fang,D., Zhou,Y., Ke,K., Liu,Y. and An,M.
  TITLE     MicroRNA-126 suppresses the proliferation and migration of
            endothelial cells in experimental diabetic retinopathy by targeting
            polo-like kinase 4
  JOURNAL   Int J Mol Med 47 (1), 151-160 (2021)
   PUBMED   33416109
  REMARK    GeneRIF: MicroRNA126 suppresses the proliferation and migration of
            endothelial cells in experimental diabetic retinopathy by targeting
            pololike kinase 4.
REFERENCE   3  (bases 1 to 3451)
  AUTHORS   Fournier,M., Orpinell,M., Grauffel,C., Scheer,E., Garnier,J.M.,
            Ye,T., Chavant,V., Joint,M., Esashi,F., Dejaegere,A., Gonczy,P. and
            Tora,L.
  TITLE     KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation
            in preventing centrosome amplification
  JOURNAL   Nat Commun 7, 13227 (2016)
   PUBMED   27796307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3451)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3451)
  AUTHORS   Fan,G., Sun,L., Shan,P., Zhang,X., Huan,J., Zhang,X., Li,D.,
            Wang,T., Wei,T., Zhang,X., Gu,X., Yao,L., Xuan,Y., Hou,Z., Cui,Y.,
            Cao,L., Li,X., Zhang,S. and Wang,C.
  TITLE     Loss of KLF14 triggers centrosome amplification and tumorigenesis
  JOURNAL   Nat Commun 6, 8450 (2015)
   PUBMED   26439168
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3451)
  AUTHORS   Ward,A., Morettin,A., Shum,D. and Hudson,J.W.
  TITLE     Aberrant methylation of Polo-like kinase CpG islands in Plk4
            heterozygous mice
  JOURNAL   BMC Cancer 11, 71 (2011)
   PUBMED   21324136
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3451)
  AUTHORS   Martindill,D.M., Risebro,C.A., Smart,N., Franco-Viseras Mdel,M.,
            Rosario,C.O., Swallow,C.J., Dennis,J.W. and Riley,P.R.
  TITLE     Nucleolar release of Hand1 acts as a molecular switch to determine
            cell fate
  JOURNAL   Nat Cell Biol 9 (10), 1131-1141 (2007)
   PUBMED   17891141
REFERENCE   8  (bases 1 to 3451)
  AUTHORS   Kleylein-Sohn,J., Westendorf,J., Le Clech,M., Habedanck,R.,
            Stierhof,Y.D. and Nigg,E.A.
  TITLE     Plk4-induced centriole biogenesis in human cells
  JOURNAL   Dev Cell 13 (2), 190-202 (2007)
   PUBMED   17681131
REFERENCE   9  (bases 1 to 3451)
  AUTHORS   Leung,G.C., Ho,C.S., Blasutig,I.M., Murphy,J.M. and Sicheri,F.
  TITLE     Determination of the Plk4/Sak consensus phosphorylation motif using
            peptide spots arrays
  JOURNAL   FEBS Lett 581 (1), 77-83 (2007)
   PUBMED   17174311
REFERENCE   10 (bases 1 to 3451)
  AUTHORS   Habedanck,R., Stierhof,Y.D., Wilkinson,C.J. and Nigg,E.A.
  TITLE     The Polo kinase Plk4 functions in centriole duplication
  JOURNAL   Nat Cell Biol 7 (11), 1140-1146 (2005)
   PUBMED   16244668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006232299.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166450.1, SRR26643293.11887.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               JAXUCZ010000002.1  125730480-125730724
            246-341             JAXUCZ010000002.1  125731429-125731524
            342-437             JAXUCZ010000002.1  125732208-125732303
            438-552             JAXUCZ010000002.1  125732380-125732494
            553-1471            JAXUCZ010000002.1  125735617-125736535
            1472-1572           JAXUCZ010000002.1  125737513-125737613
            1573-1925           JAXUCZ010000002.1  125739465-125739817
            1926-2030           JAXUCZ010000002.1  125741353-125741457
            2031-2133           JAXUCZ010000002.1  125741750-125741852
            2134-2283           JAXUCZ010000002.1  125742611-125742760
            2284-2417           JAXUCZ010000002.1  125743277-125743410
            2418-2509           JAXUCZ010000002.1  125743493-125743584
            2510-2654           JAXUCZ010000002.1  125744195-125744339
            2655-2780           JAXUCZ010000002.1  125745344-125745469
            2781-2887           JAXUCZ010000002.1  125747013-125747119
            2888-3451           JAXUCZ010000002.1  125748331-125748894
FEATURES             Location/Qualifiers
     source          1..3451
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..3451
                     /gene="Plk4"
                     /note="polo-like kinase 4"
                     /db_xref="GeneID:310344"
                     /db_xref="RGD:1305390"
     exon            1..245
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..2990
                     /gene="Plk4"
                     /EC_number="2.7.11.21"
                     /note="PLK-4; serine/threonine-protein kinase Sak"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK4"
                     /protein_id="NP_001382032.1"
                     /db_xref="GeneID:310344"
                     /db_xref="RGD:1305390"
                     /translation="MAACIGERIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
                     KKAMYKAGMVQRVQNEVKIHCQLKHPSVLELYNYFEDNNYVYLVLEMCHNGEMNRYLK
                     NRMKPFSESEARHFMHQIITGMLYLHSHGILHRDLTLSNILLTRNMNIKIADFGLATQ
                     LKMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKN
                     TLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMSRNPSTKSKDL
                     GTVEDSMDSGHATLSTTITASSGTSLSGSLLDRRRLLVGQPLPNKITVFQKNKNSSDF
                     SSGDGSNFCTQWGNPEQEANNRGRGRVIEDAEERPHSRYLRRAHSSDRSNPSNQSRAK
                     TYSIERCHSVEMLSKPRRSSLDETKHSSNHHCLGKTPFPFADQTPQMEIVQQWFGNLQ
                     MNGETSEHNTISPNRDFQDYPDVQDTLRNTWTDTRASKNSDNSANVHPAKQLSTMKYM
                     TAHHHKPEIMQQELAIHPHSEQNKSRSMESTLGYRKPTLRSITSPLVAHRLKPIRQKT
                     KKAVVSILDSEEVCVELLKECTSEGHVKEVLQISSDGTTITVYYPNDGRGFPLADRPP
                     LPTDNISRYSFDSLPEKYWRKYQYASRFIQLVRSKTPKITYFTRYAKCILMENSPGAD
                     FEVWFYDGAKIHKTEDVIHIIEKTGLSYTLKNENDFTSLKEEVKIYMDHANEGHRTCL
                     ALESVISEEEKRSRGSSFFPIIVGRKPGTTSSPKALSPPPVDPGYSKGEQASSSRLSA
                     NSAAFPTQTPVLSPSAVTVEGPGQTAATTGTSISSSLPKSAQLLKSVFVKNVGWATQL
                     TSGAVWVQFNDGSQLVVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILL
                     MFSNPTPSFQ"
     exon            246..341
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            342..437
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            438..552
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1471
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1572
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1925
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2030
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2133
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2283
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2417
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2509
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2654
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2780
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2887
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3451
                     /gene="Plk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaccggc gggaattttt caaaatggga gcatcgatgc gccgcccagg cctctggagg
       61 taccgagata aactttcggt ggcgttggcg gcgtcgccag cggcggcggc atagagaaag
      121 catcctgatg ggcgccaaga cctgctggct tctcggagcg ctgcctcgga gggactgcga
      181 gacggccgaa cccggggcac cggcggctcg ggaacatggc ggcgtgcatc ggagagagga
      241 tcgaggactt taaggttgga aatctacttg gtaaaggatc atttgctggt gtctacagag
      301 ctgagtccat acacactggt ttggaagttg caatcaaaat gatagataag aaagccatgt
      361 acaaagctgg aatggtacag agagtccaaa atgaggtgaa aatacattgc cagttgaaac
      421 acccctctgt cttggagctc tataattact ttgaagataa caattacgta tacctggtat
      481 tagaaatgtg ccacaacgga gaaatgaaca ggtacctaaa gaacagaatg aagcctttct
      541 ccgaaagcga agccaggcac ttcatgcacc agatcatcac aggaatgctg tatcttcatt
      601 ctcacggcat actacaccgc gacctcacac tctctaacat cttacttaca cggaatatga
      661 acataaaaat tgctgacttt ggactagcaa cacaattgaa aatgccacat gagaagcatt
      721 acaccctgtg tggaacccct aattatattt caccagaaat tgcaactcga agtgcacatg
      781 gacttgaatc tgatatttgg tcattgggct gtatgtttta tacattactt attggaagac
      841 caccttttga cactgataca gtcaaaaaca cattgaacaa agtagtattg gcagattatg
      901 aaatgccagc ctttttgtca cgagaggccc aggaccttat ccaccaatta cttcgtagaa
      961 accctgcaga tcggttaagt ctgtcttctg tgttggacca tccttttatg tcacgaaatc
     1021 cttcaacaaa gagtaaagac ttagggactg tagaggactc aatggatagt gggcatgcca
     1081 cactttccac aacaattaca gcttcttccg gaaccagttt gagtggtagc ctacttgaca
     1141 gaagaagact tttggttggt caaccacttc caaataaaat tactgtattt caaaaaaata
     1201 aaaattcaag tgacttttct tcaggagatg gaagtaattt ttgtactcaa tggggaaatc
     1261 cagaacaaga agctaataat agggggcggg gaagagtaat tgaagatgca gaagaaaggc
     1321 cacattctcg ataccttcgc agagctcatt cctctgatag atccaaccct tctaatcagt
     1381 ctcgagcaaa aacatactca atagagcggt gtcactcagt agaaatgctt tcaaagccca
     1441 gaagatcatc actggatgaa actaaacaca gttccaatca tcattgtcta gggaaaactc
     1501 cttttccatt tgcagaccag acacctcaga tggagatagt acaacagtgg tttgggaatc
     1561 tgcaaatgaa tggagaaact agtgagcaca acaccattag cccaaacaga gatttccagg
     1621 actatcctga tgtgcaggac acattaagaa atacttggac tgacacaaga gccagcaaga
     1681 attccgataa ttctgctaac gttcatcctg caaagcagct gagtaccatg aaatacatga
     1741 ctgcacatca ccataaacct gagatcatgc agcaagagct ggccatacat cctcattctg
     1801 aacaaaacaa gagtagaagt atggagtcaa cattgggtta caggaaacct accttaagaa
     1861 gcattacctc tcctttggtt gctcacagac taaaaccaat cagacagaaa accaaaaagg
     1921 ctgtggtgag catccttgat tcagaggagg tgtgtgtgga gcttctaaaa gagtgtacat
     1981 ctgaaggaca tgtgaaagaa gttcttcaga tatctagtga tgggactacg atcaccgttt
     2041 attacccaaa tgatggaaga ggctttcctc ttgctgatag accacccttg cctactgaca
     2101 acatcagcag gtacagcttt gacagtttac cagaaaaata ctggcggaaa tatcagtatg
     2161 cttccagatt cattcagctt gtaaggtcca aaactcccaa aatcacttac tttacaagat
     2221 atgctaaatg tattttgatg gaaaattctc ctggtgctga ttttgaagtt tggttttatg
     2281 atggagccaa aatacataaa acagaagatg taattcacat aattgaaaaa actgggttat
     2341 cttacacttt aaaaaatgag aatgacttta ccagcttgaa agaggaagta aaaatctata
     2401 tggaccatgc caatgagggt caccgtactt gcttggcact ggaatctgta atctctgaag
     2461 aggaaaaaag aagcaggggc tcttcattct tcccaataat tgtaggaaga aaacctggta
     2521 ctactagttc acctaaagcc ttatcaccac ctcctgtgga cccaggctac tcaaagggag
     2581 agcaagcatc atcaagcaga ttgagcgcga atagtgcggc tttcccaaca cagacaccag
     2641 tactcagtcc ttctgctgtg acagtggaag gacctggcca aacagcagct actacaggaa
     2701 caagcatctc ttcaagtctt cctaaatcag cacagctttt gaaatctgtt tttgtgaaaa
     2761 atgttggttg ggctacacag ctaactagtg gagctgtgtg ggttcagttt aatgatgggt
     2821 cacagttggt tgtccaggca ggagtatctt ccatcagtta tacatcacca gacggtcaga
     2881 caactaggta tggagaaaat gaaaaattgc ctgaatacat caaacagaaa ttgcaatgtc
     2941 tttcttccat ccttctgatg ttttctaatc caactcctag ttttcagtaa tttaagtctt
     3001 ggatgtctat atttaataaa tgattttttg cttggctttc aagtaagtga ttttttttaa
     3061 atttacttta acttcagaaa gcctttctat taaacagaat tttaatctac accattaaaa
     3121 aatatactaa gaaaacaata aaattatagt taccaaatac agtggtcata aagctaattt
     3181 tgctccaagc atgtaatcct tcagactttt gtgctcctat acttgtattg aactaagttg
     3241 tgtgtggcgt gtttttttat tttctttttt aataagacat tgagaatcat ggacaaaaca
     3301 tgctagtttt accattttga atatgtaaat attgtatgta taagcaatat gtaaacgtgt
     3361 atattttata tttattttta tagcacttgt gtctgataag atttctgtaa acacatttta
     3421 taaaataaac acagttgtaa gttttcctta a
//
