LOCUS       NM_022187               2389 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus polo-like kinase 3 (Plk3), mRNA.
ACCESSION   NM_022187 XM_001071757 XM_342888
VERSION     NM_022187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Wang,H., Tian,C., Sun,J., Chen,L.N., Lv,Y., Yang,X.D., Xiao,K.,
            Wang,J., Chen,C., Shi,Q., Shao,Q.X. and Dong,X.P.
  TITLE     Overexpression of PLK3 Mediates the Degradation of Abnormal Prion
            Proteins Dependent on Chaperone-Mediated Autophagy
  JOURNAL   Mol Neurobiol 54 (6), 4401-4413 (2017)
   PUBMED   27344333
REFERENCE   3  (bases 1 to 2389)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   4  (bases 1 to 2389)
  AUTHORS   Li,F., Jo,M., Curry,T.E. Jr. and Liu,J.
  TITLE     Hormonal induction of polo-like kinases (Plks) and impact of Plk2
            on cell cycle progression in the rat ovary
  JOURNAL   PLoS One 7 (8), e41844 (2012)
   PUBMED   22870256
  REMARK    GeneRIF: the increase in Plk2 and Plk3 expression contributes to
            the cell cycle arrest of granulosa cells which is important for the
            luteinization of granulosa cells during the periovulatory period.
            Erratum:[PLoS One. 2012;7(8):
            doi/10.1371/annotation/1a9779fe-f0ab-4937-a3ce-1bc7fb0268df]
REFERENCE   5  (bases 1 to 2389)
  AUTHORS   Wang,J., Beauchemin,M. and Bertrand,R.
  TITLE     Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle
            progression and checkpoints
  JOURNAL   Cell Signal 23 (12), 2030-2038 (2011)
   PUBMED   21840391
REFERENCE   6  (bases 1 to 2389)
  AUTHORS   Bahassi el,M., Hennigan,R.F., Myer,D.L. and Stambrook,P.J.
  TITLE     Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear
            translocation
  JOURNAL   Oncogene 23 (15), 2658-2663 (2004)
   PUBMED   14968113
REFERENCE   7  (bases 1 to 2389)
  AUTHORS   Weichert,W., Denkert,C., Schmidt,M., Gekeler,V., Wolf,G., Kobel,M.,
            Dietel,M. and Hauptmann,S.
  TITLE     Polo-like kinase isoform expression is a prognostic factor in
            ovarian carcinoma
  JOURNAL   Br J Cancer 90 (4), 815-821 (2004)
   PUBMED   14970859
REFERENCE   8  (bases 1 to 2389)
  AUTHORS   Pak,D.T. and Sheng,M.
  TITLE     Targeted protein degradation and synapse remodeling by an inducible
            protein kinase
  JOURNAL   Science 302 (5649), 1368-1373 (2003)
   PUBMED   14576440
REFERENCE   9  (bases 1 to 2389)
  AUTHORS   Xie,S., Wang,Q., Wu,H., Cogswell,J., Lu,L., Jhanwar-Uniyal,M. and
            Dai,W.
  TITLE     Reactive oxygen species-induced phosphorylation of p53 on serine 20
            is mediated in part by polo-like kinase-3
  JOURNAL   J Biol Chem 276 (39), 36194-36199 (2001)
   PUBMED   11447225
REFERENCE   10 (bases 1 to 2389)
  AUTHORS   Kauselmann,G., Weiler,M., Wulff,P., Jessberger,S., Konietzko,U.,
            Scafidi,J., Staubli,U., Bereiter-Hahn,J., Strebhardt,K. and Kuhl,D.
  TITLE     The polo-like protein kinases Fnk and Snk associate with a Ca(2+)-
            and integrin-binding protein and are regulated dynamically with
            synaptic plasticity
  JOURNAL   EMBO J 18 (20), 5528-5539 (1999)
   PUBMED   10523297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_342888.3, XM_001071757.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136584.1, SRR26643292.22646.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               JAXUCZ010000005.1  135848578-135848900 c
            324-431             JAXUCZ010000005.1  135848362-135848469 c
            432-548             JAXUCZ010000005.1  135848158-135848274 c
            549-678             JAXUCZ010000005.1  135847872-135848001 c
            679-766             JAXUCZ010000005.1  135847693-135847780 c
            767-862             JAXUCZ010000005.1  135846780-135846875 c
            863-1061            JAXUCZ010000005.1  135846490-135846688 c
            1062-1188           JAXUCZ010000005.1  135846254-135846380 c
            1189-1280           JAXUCZ010000005.1  135845921-135846012 c
            1281-1374           JAXUCZ010000005.1  135845586-135845679 c
            1375-1458           JAXUCZ010000005.1  135845366-135845449 c
            1459-1621           JAXUCZ010000005.1  135845108-135845270 c
            1622-1751           JAXUCZ010000005.1  135844837-135844966 c
            1752-1865           JAXUCZ010000005.1  135844359-135844472 c
            1866-2389           JAXUCZ010000005.1  135843725-135844248 c
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2389
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /note="polo-like kinase 3"
                     /db_xref="GeneID:58936"
                     /db_xref="RGD:62039"
     exon            1..323
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2057
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /EC_number="2.7.11.21"
                     /note="serine-threonine kinase; PLK-3; FGF-inducible
                     kinase; cytokine-inducible serine/threonine-protein
                     kinase; cytokine inducible kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK3"
                     /protein_id="NP_071523.1"
                     /db_xref="GeneID:58936"
                     /db_xref="RGD:62039"
                     /translation="MEPAAGFLSPRPFPRAAAPSSPPAGPGPPASASPRSEPGVLAGP
                     QTPDASRLITDPRSGRTYIKGRLLGKGGFARCYEATDTETSIAYAVKVIPQSRVAKPH
                     QREKIINEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEP
                     EVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKK
                     TICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVH
                     YTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDL
                     TPPNPARSLFAKVTKSLFGRRKSKNKNHSEEQDNVSCLVSGLMRTSIGHPDVRPEAPA
                     ASALAPVSLVETAAEDSSPRGTLASSGDGFEEGLTVTTVVESALCALRNCVAFMPPAE
                     QNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYN
                     PTSTKHFSFSVGSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQ
                     WVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQL
                     GCSPDLRQRLRYALRLLRDRSPA"
     exon            324..431
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            432..548
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            549..678
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            679..766
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            767..862
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1061
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1188
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1280
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1374
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1458
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1621
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1751
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1865
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2389
                     /gene="Plk3"
                     /gene_synonym="Cnk; Fnk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcggcgcg atcgcagcgt agagaaacca ggcagcgcca cccgcggccg gggccgggcg
       61 gaaccgagaa caagctcggc aggcgctgcg ccgcgccgcg ccgcgccgtc cgcatggagc
      121 ccgccgccgg cttcttgtcc ccgcgcccct tcccgcgcgc ggctgctccg tcctcgcccc
      181 ccgccggtcc ggggccgccc gccagtgcct ccccacggtc ggaacctggg gtgctggccg
      241 ggccacagac gccggatgcc agtcgcctca tcaccgaccc tcgcagcggc cgtacctaca
      301 tcaagggtcg cttgttgggc aaggggggct tcgctcgctg ctatgaagcc actgacactg
      361 agactagtat agcctacgcg gtcaaagtca tcccgcagag tcgcgtcgcc aagccgcatc
      421 agcgcgagaa gatcataaac gagatagagt tgcaccgaga cctacagcac cgccatatcg
      481 ttcgattttc gcatcatttc gaggatgctg acaacatata tattttcctg gagctctgta
      541 gccgaaagtc cctggcccac atctggaagg cccgtcacac cctactggaa ccagaggttc
      601 gctactacct gcgccagatt ctttctggtc tcaagtactt gcaccagagg ggtatcttgc
      661 acagagatct caagctggga aattttttca tcactgataa catggaactg aaggtgggag
      721 attttgggct ggcagctcgg ctagagcctc cagagcagag gaaaaagacc atctgtggta
      781 ctcccaacta tgtggcccca gaagtgctgc tgaggcaggg ccatggcccc gaggcagatg
      841 tgtggtccct tggttgtgtc atgtacacac tcctgtgtgg gagccccccg tttgagacag
      901 ctgacctaaa ggagacctat cgctgcatca agcaggttca ttacacactg cctgccagcc
      961 tctcactgcc tgcccgccag ctcctggctg ccatccttcg agcttcaccc cgagaccgcc
     1021 cttccattga gcagatcctg cgccatgact tctttacaaa gggctacacc cctgatcggc
     1081 tccctgtcag cagctgtgtg acagtcccag atctgacacc ccccaaccct gcgaggagtc
     1141 tgtttgctaa agttaccaag agcctgtttg gcaggagaaa gagcaagaat aagaaccatt
     1201 ctgaggaaca ggataatgtc tcctgcttgg tgagcggcct catgcgcaca tccatcggtc
     1261 atccagatgt caggccggag gctccagcag cctcagctct ggcccctgtc agcttggtag
     1321 agacagctgc tgaggacagc tcaccccgtg ggacactggc aagcagtgga gatggatttg
     1381 aagaaggttt gactgtgacc acggtggtgg agtctgccct ctgtgcactg agaaactgtg
     1441 tggccttcat gcccccagct gaacagaacc cagccccgtt ggcacagcca gagcctctgg
     1501 tgtgggtcag caagtgggtt gactactcca acaagtttgg ctttggctat cagctgtcca
     1561 gccgccgtgt agccgtgctc ttcaatgacg gcacacacat ggccctgtca gccaatagga
     1621 agactgtgca ctacaacccc accagcacga agcacttctc tttctctgtg ggttctgtgc
     1681 cccgtgctct gcagcctcag ctgggcatcc tccggtattt cgcctcctac atggagcagc
     1741 acctcatgaa gggtggagat ctgcccagtg tggaggaggt agaggtccct gccccaccct
     1801 tgctgctgca gtgggtcaag acggaccagg cccttctcat gctgttcagt gacggcactg
     1861 tccaggtgaa cttctacggg gaccatacga agctgatcct cagtggctgg gagcctctcc
     1921 tcgtgacctt cgtggcccga aatcgcagtg cttgtactta cctcgcctcc cacctccggc
     1981 agctgggctg ctccccagac ttgcggcagc gactgcgcta tgctctgcgc ctgctcaggg
     2041 accgaagccc tgcttaggtt ccaacttgca gagagcaggc tggaatccag accctgggcc
     2101 tgggcccgag aggctctggg cctcaccttt gtggcccttc gtgtcccttt ggtgcctcac
     2161 tgggggctcc tggctgaatc cccccaggga atcagggacc agctttatga aagttgggga
     2221 cggtctgccc tccctgaacc tcacccttct ctcggagata aacctgagcc ttagctccca
     2281 gctagggggc attatttatg gaccactttt atttattaac agacatttat ttattgggat
     2341 gtgagcccca ggggggcctc ctccagggat aataaaccgt ttttcagaa
//
