LOCUS       NM_031821               2781 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus polo-like kinase 2 (Plk2), mRNA.
ACCESSION   NM_031821
VERSION     NM_031821.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Abdel-Ghani,M., Lee,Y., Akli,L.A., Moran,M., Schneeweis,A.,
            Djemil,S., El Choueiry,R., Murtadha,R. and Pak,D.T.S.
  TITLE     Plk2 promotes synaptic destabilization through disruption of
            N-cadherin adhesion complexes during homeostatic adaptation to
            hyperexcitation
  JOURNAL   J Neurochem 167 (3), 362-375 (2023)
   PUBMED   37654026
  REMARK    GeneRIF: Plk2 promotes synaptic destabilization through disruption
            of N-cadherin adhesion complexes during homeostatic adaptation to
            hyperexcitation.
REFERENCE   2  (bases 1 to 2781)
  AUTHORS   Fan,Y., Wang,J., He,N. and Feng,H.
  TITLE     PLK2 protects retinal ganglion cells from oxidative stress by
            potentiating Nrf2 signaling via GSK-3beta
  JOURNAL   J Biochem Mol Toxicol 35 (8), e22815 (2021)
   PUBMED   34047419
  REMARK    GeneRIF: PLK2 protects retinal ganglion cells from oxidative stress
            by potentiating Nrf2 signaling via GSK-3beta.
REFERENCE   3  (bases 1 to 2781)
  AUTHORS   Liu,W., Zha,Z. and Wang,H.
  TITLE     Upregulation of microRNA-27a inhibits synovial angiogenesis and
            chondrocyte apoptosis in knee osteoarthritis rats through the
            inhibition of PLK2
  JOURNAL   J Cell Physiol 234 (12), 22972-22984 (2019)
   PUBMED   31134620
  REMARK    GeneRIF: Overexpression of PLK2 reverses the effect of upregulation
            of miR-27a on synovial angiogenesis and chondrocyte injury in KOA
            rats. Our study suggests that upregulation of miR-27a inhibits
            synovial angiogenesis and chondrocyte apoptosis in KOA rats through
            the inhibition of PLK2.
REFERENCE   4  (bases 1 to 2781)
  AUTHORS   Mochizuki,M., Lorenz,V., Ivanek,R., Della Verde,G., Gaudiello,E.,
            Marsano,A., Pfister,O. and Kuster,G.M.
  TITLE     Polo-Like Kinase 2 is Dynamically Regulated to Coordinate
            Proliferation and Early Lineage Specification Downstream of
            Yes-Associated Protein 1 in Cardiac Progenitor Cells
  JOURNAL   J Am Heart Assoc 6 (10), e005920 (2017)
   PUBMED   29066438
  REMARK    GeneRIF: Plk2 acts as coordinator of cell proliferation and early
            lineage commitment in cardiac progenitor cells downstream of
            Yes-associated protein 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2781)
  AUTHORS   Deng,S., Wang,H., Jia,C., Zhu,S., Chu,X., Ma,Q., Wei,J., Chen,E.,
            Zhu,W., Macon,C.J., Jayaweera,D.T., Dykxhoorn,D.M. and Dong,C.
  TITLE     MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis
            and Senescence by Targeting Polo-Like Kinase 2 Expression
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (2), 280-290 (2017)
   PUBMED   27908889
REFERENCE   6  (bases 1 to 2781)
  AUTHORS   Ma,S., Charron,J. and Erikson,R.L.
  TITLE     Role of Plk2 (Snk) in mouse development and cell proliferation
  JOURNAL   Mol Cell Biol 23 (19), 6936-6943 (2003)
   PUBMED   12972611
REFERENCE   7  (bases 1 to 2781)
  AUTHORS   Burns,T.F., Fei,P., Scata,K.A., Dicker,D.T. and El-Deiry,W.S.
  TITLE     Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic
            catastrophe in paclitaxel (taxol)-exposed cells
  JOURNAL   Mol Cell Biol 23 (16), 5556-5571 (2003)
   PUBMED   12897130
REFERENCE   8  (bases 1 to 2781)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   9  (bases 1 to 2781)
  AUTHORS   Shan,L., He,M., Yu,M., Qiu,C., Lee,N.H., Liu,E.T. and
            Snyderwine,E.G.
  TITLE     cDNA microarray profiling of rat mammary gland carcinomas induced
            by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and
            7,12-dimethylbenz[a]anthracene
  JOURNAL   Carcinogenesis 23 (10), 1561-1568 (2002)
   PUBMED   12376462
REFERENCE   10 (bases 1 to 2781)
  AUTHORS   Kauselmann,G., Weiler,M., Wulff,P., Jessberger,S., Konietzko,U.,
            Scafidi,J., Staubli,U., Bereiter-Hahn,J., Strebhardt,K. and Kuhl,D.
  TITLE     The polo-like protein kinases Fnk and Snk associate with a Ca(2+)-
            and integrin-binding protein and are regulated dynamically with
            synaptic plasticity
  JOURNAL   EMBO J 18 (20), 5528-5539 (1999)
   PUBMED   10523297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031821.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070878.1, AF136583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               JAXUCZ010000002.1  43702536-43702924
            390-497             JAXUCZ010000002.1  43703518-43703625
            498-614             JAXUCZ010000002.1  43703772-43703888
            615-744             JAXUCZ010000002.1  43704093-43704222
            745-832             JAXUCZ010000002.1  43704388-43704475
            833-928             JAXUCZ010000002.1  43704922-43705017
            929-1127            JAXUCZ010000002.1  43705129-43705327
            1128-1275           JAXUCZ010000002.1  43705417-43705564
            1276-1373           JAXUCZ010000002.1  43705864-43705961
            1374-1503           JAXUCZ010000002.1  43706206-43706335
            1504-1744           JAXUCZ010000002.1  43706570-43706810
            1745-1874           JAXUCZ010000002.1  43706924-43707053
            1875-1985           JAXUCZ010000002.1  43707266-43707376
            1986-2781           JAXUCZ010000002.1  43707510-43708305
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..2781
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /note="polo-like kinase 2"
                     /db_xref="GeneID:83722"
                     /db_xref="RGD:620760"
     exon            1..389
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2177
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /EC_number="2.7.11.21"
                     /note="PLK-2; polo-like kinase 1; serine/threonine-protein
                     kinase SNK; serum-inducible kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK2"
                     /protein_id="NP_114009.1"
                     /db_xref="GeneID:83722"
                     /db_xref="RGD:620760"
                     /translation="MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQS
                     QAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNN
                     KVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCS
                     RRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKV
                     GDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPP
                     FETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQG
                     FTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDI
                     YKLRHDLKKTSITQQPSKHRTDEELQPPPTTFAKSGTSAVENKQQIGDAIRMIVRGTL
                     GSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYS
                     NKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQV
                     TVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYH
                     DHTKIIICNQNEEYLLTYINEDRISTTFRLTTLLMSGCSLELKHRMEYALNMLLQRCN
                     "
     exon            390..497
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            498..614
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            615..744
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            745..832
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            833..928
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1127
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1275
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1373
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1503
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1744
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1874
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1985
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2781
                     /gene="Plk2"
                     /gene_synonym="Snk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaagagg agccggacgt cggactagag agtagggaga gcgattgggg ctcgagggac
       61 agggctagac cggacgcgtg tccgcgcctc ggaggtggca gtaggtagtg tcgggtagcg
      121 aggcaacgat ggagctcctg cggactatca cctaccagcc ggccgccggc accaagatgt
      181 gcgagcaggc gctgggcaaa gcttgcggcg gggactcaaa gaagaagcga ccgcagcagc
      241 cttctgaaga cgggcagtcc caagcccagg tgaccccggc ggccccacac caccatcatc
      301 accattctca ctccggaccc gagatctcgc ggattatagt cgaccccacg acggggaagc
      361 gctactgccg gggcaaagtg ctgggcaagg gtggatttgc aaagtgttac gaaatgacag
      421 atctgacaaa caacaaagtc tacgctgcaa aaattatccc tcacagcaga gtagctaaac
      481 ctcatcaaag ggaaaagatc gacaaagaaa ttgagcttca cagaatcctg caccataagc
      541 atgtagtgca gttttaccac tactttgaag acaaagaaaa catttacatc ctcttggagt
      601 actgcagtag aaggtccatg gctcatatct tgaaagcaag aaaggtgttg acagagccag
      661 aagtccgata ctacctcagg cagattgtgt cgggactcaa gtatcttcac gaacaagaaa
      721 tcttgcatag ggatctcaag ctagggaact tttttattaa tgaggccatg gagctgaagg
      781 ttggagactt cggcttggct gccagactgg aacctttgga acacagaagg agaacaatat
      841 gtggaacccc aaattatctc tcccctgaag tcctcaacaa acaaggacat ggctgtgaat
      901 cagacatctg ggccttaggc tgtgtaatgt atacaatgct gctaggaaga cctccattcg
      961 aaacaacaaa tctgaaagaa acgtacaggt gcataagaga agcaagatat acaatgccgt
     1021 cttcattact ggcccccgcc aagcacttga tagccagcat gctgtccaaa aacccagagg
     1081 accgccccag tttggatgac atcattcggc atgacttctt tctgcagggc ttcactccag
     1141 acagactctc ttctagctgt tgccacacag ttccagactt ccacttgtca agcccagcta
     1201 agaatttctt taagaaagct gctgccgctc tttttggtgg caaaaaggac aaagcaagat
     1261 ataatgacac acacaataaa gtgtctaagg aagatgaaga catctacaag cttcggcatg
     1321 atttgaagaa aacatcgata acccagcaac ccagcaaaca cagaacagat gaggagctcc
     1381 agcctcctcc aactaccttt gccaaatctg ggacatccgc agtggaaaac aaacagcaga
     1441 ttggagatgc aatccggatg atagttagag ggacgctggg cagctgcagc agcagcagtg
     1501 aatgccttga ggatagcacc atgggaagtg ttgcagacac agtggcaaga gtccttcgag
     1561 ggtgtctaga aaacatgcct gaagctgact gtattcccaa agagcagttg agcacgtcct
     1621 ttcagtgggt caccaaatgg gtcgactact ccaacaaata cggctttgga taccagctct
     1681 cagaccacac tgttggagtc cttttcaaca acggcgctca catgagcctc cttccagaca
     1741 aaaagacagt tcactattat gcggaacttg gccaatgctc tgttttccca gcaacagatg
     1801 cccccgaaca atttattagt caagtgacgg tgctgaaata cttttcccac tacatggagg
     1861 agaacctcat ggatggtggc gatctcccta gtgttactga cattcgaaga cctcggctct
     1921 acctccttca gtggttaaag tctgataaag ccttaatgat gctcttcaat gacggcacat
     1981 ttcaggtgaa tttctaccac gatcatacaa agataattat ctgtaaccaa aatgaagaat
     2041 accttctcac atacatcaac gaagacagga tatctacaac tttcagactg acgaccctgt
     2101 tgatgtctgg ctgttcgcta gaattgaaac atcgaatgga atacgccctg aacatgctct
     2161 tgcagagatg taactgaaaa acctctttta gagcggacct cgtgggggct cttttccact
     2221 gtgagatcaa cagggaagcc agtggaggga taacggagca tgctagagaa atcggacagg
     2281 tgctggtacg aatacgagtc gtctgtggcc tgctggactg ctggaaccag accagcctaa
     2341 ggtggacagt tgactttggg caatcttaag tgtggagcca agtacagttt tccttgagat
     2401 acctgtcttt acaaagttta tcggacaatt ttgcagacag acgcattgac tctgaagttc
     2461 tctctgtgga gagtgttttc agttggaaga cttggaactg tgaataaact tcctgaaggg
     2521 gagggagaag ggaggaagct ccctcgctgt tgaaaggcta caatcagagc agcttttgtt
     2581 tggctgctta actgtgaact atggccatac atattttttt tttttggtta tttttgaata
     2641 cacttgtggc tggaaaagtg cattccttgt taataaactt tttatttatt acagccccaa
     2701 gagcagtatt tattatcaag atgtcttttt ttttatgttg accattttga actcttggca
     2761 ataaagagta tgaaatagaa a
//
