LOCUS       NM_017100               2193 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus polo-like kinase 1 (Plk1), mRNA.
ACCESSION   NM_017100
VERSION     NM_017100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Gao,Z., Zheng,C., Xing,Y., Zhang,X., Bai,Y., Chen,C., Zheng,Y.,
            Wang,W., Zhang,H. and Meng,Y.
  TITLE     Polo-like kinase 1 promotes sepsis-induced myocardial dysfunction
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111074 (2023)
   PUBMED   37879229
  REMARK    GeneRIF: Polo-like kinase 1 promotes sepsis-induced myocardial
            dysfunction.
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Mao,S., Tian,S., Luo,X., Zhou,M., Cao,Z. and Li,J.
  TITLE     Overexpression of PLK1 relieved the myocardial ischemia-reperfusion
            injury of rats through inducing the mitophagy and regulating the
            p-AMPK/FUNDC1 axis
  JOURNAL   Bioengineered 12 (1), 2676-2687 (2021)
   PUBMED   34115550
  REMARK    GeneRIF: Overexpression of PLK1 relieved the myocardial
            ischemia-reperfusion injury of rats through inducing the mitophagy
            and regulating the p-AMPK/FUNDC1 axis.
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Zhao,T.F., Wang,S.Y., Zou,X.Z. and Zhao,H.D.
  TITLE     MiR-593-5p promotes the development of hypoxic-induced pulmonary
            hypertension via targeting PLK1
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (8), 3495-3502 (2019)
   PUBMED   31081105
  REMARK    GeneRIF: MiR-593-5p promotes the development of hypoxic-induced
            pulmonary hypertension via targeting PLK1.
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Zhang,B., Wang,G., Xu,X., Yang,S., Zhuang,T., Wang,G., Ren,H.,
            Cheng,S.Y., Jiang,Q. and Zhang,C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Zurnic,I., Hutter,S., Rzeha,U., Stanke,N., Reh,J., Mullers,E.,
            Hamann,M.V., Kern,T., Gerresheim,G.K., Lindel,F., Serrao,E.,
            Lesbats,P., Engelman,A.N., Cherepanov,P. and Lindemann,D.
  TITLE     Interactions of Prototype Foamy Virus Capsids with Host Cell
            Polo-Like Kinases Are Important for Efficient Viral DNA Integration
  JOURNAL   PLoS Pathog 12 (8), e1005860 (2016)
   PUBMED   27579920
  REMARK    Erratum:[PLoS Pathog. 2016 Oct 10;12(10):e1005956. doi:
            10.1371/journal.ppat.1005956.. PMID: 27723818]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Neef,R., Preisinger,C., Sutcliffe,J., Kopajtich,R., Nigg,E.A.,
            Mayer,T.U. and Barr,F.A.
  TITLE     Phosphorylation of mitotic kinesin-like protein 2 by polo-like
            kinase 1 is required for cytokinesis
  JOURNAL   J Cell Biol 162 (5), 863-875 (2003)
   PUBMED   12939256
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Fan,H.Y., Tong,C., Teng,C.B., Lian,L., Li,S.W., Yang,Z.M.,
            Chen,D.Y., Schatten,H. and Sun,Q.Y.
  TITLE     Characterization of Polo-like kinase-1 in rat oocytes and early
            embryos implies its functional roles in the regulation of meiotic
            maturation, fertilization, and cleavage
  JOURNAL   Mol Reprod Dev 65 (3), 318-329 (2003)
   PUBMED   12784254
  REMARK    GeneRIF: may be a multifunctional kinase that plays pivotal
            regulatory roles in microtubule assembly during rat oocyte meiotic
            maturation, fertilization, and early embryonic mitosis
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Walter,S.A., Cutler,R.E. Jr., Martinez,R., Gishizky,M. and
            Hill,R.J.
  TITLE     Stk10, a new member of the polo-like kinase kinase family highly
            expressed in hematopoietic tissue
  JOURNAL   J Biol Chem 278 (20), 18221-18228 (2003)
   PUBMED   12639966
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Jackman,M., Lindon,C., Nigg,E.A. and Pines,J.
  TITLE     Active cyclin B1-Cdk1 first appears on centrosomes in prophase
  JOURNAL   Nat Cell Biol 5 (2), 143-148 (2003)
   PUBMED   12524548
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Lane,H.A. and Nigg,E.A.
  TITLE     Antibody microinjection reveals an essential role for human
            polo-like kinase 1 (Plk1) in the functional maturation of mitotic
            centrosomes
  JOURNAL   J Cell Biol 135 (6 Pt 2), 1701-1713 (1996)
   PUBMED   8991084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017100.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            28 bp suspected to be vector contamination from the 3' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10188.2, BC083926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               JAXUCZ010000001.1  186147658-186148149
            493-661             JAXUCZ010000001.1  186148698-186148866
            662-806             JAXUCZ010000001.1  186149612-186149756
            807-900             JAXUCZ010000001.1  186150398-186150491
            901-1120            JAXUCZ010000001.1  186151784-186152003
            1121-1276           JAXUCZ010000001.1  186155354-186155509
            1277-1354           JAXUCZ010000001.1  186156313-186156390
            1355-1509           JAXUCZ010000001.1  186156571-186156725
            1510-1692           JAXUCZ010000001.1  186156823-186157005
            1693-2193           JAXUCZ010000001.1  186157137-186157637
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2193
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /note="polo-like kinase 1"
                     /db_xref="GeneID:25515"
                     /db_xref="RGD:3352"
     exon            1..492
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1896
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /EC_number="2.7.11.21"
                     /note="PLK-1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PLK1"
                     /protein_id="NP_058796.2"
                     /db_xref="GeneID:25515"
                     /db_xref="RGD:3352"
                     /translation="MNAAAKAGKLARAPADLGKGGVPGDAAPGAPGAAPLAKEIPEVL
                     MDPRSRRQYVRGRFLGKGGFAKCFEISDSDTKEVFAGKIVPKSLLLKPHQKEKMSMEI
                     SIHRSLAHQHVVGFHGFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQI
                     VLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYI
                     APEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINP
                     VAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDP
                     SNRKPLTVLNKGVENPLPDRPREKEEPVVRETNEAIECHLSDLLQQLTSVNASKPSER
                     GLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDS
                     LQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARL
                     PYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFRTYRLSL
                     LEEYGCCKELASRLRYARTMVDKLLSSRSACNRLKAS"
     exon            493..661
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            662..806
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            807..900
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1120
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1276
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1354
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1509
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1692
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..2193
                     /gene="Plk1"
                     /gene_synonym="Plk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgtttg aattcgggga ggagcggagc agagcaggat cctctgcacc tacccggcca
       61 ggtccgtgga gcaacatcgg catcatgaat gcagcggcca aagctggaaa gctggctcga
      121 gcaccagccg acctagggaa aggtggggtc ccgggagacg cagctcccgg tgccccaggg
      181 gccgccccgc tggcgaaaga gattccggag gtcctgatgg atccacgcag ccggcggcag
      241 tatgtacggg gccgctttct gggtaaagga ggcttcgcca aatgcttcga aatctcagac
      301 tcagacacaa aagaggtgtt cgcaggcaag atcgtgccta agtctttgct gctcaagccc
      361 catcagaagg agaaaatgtc tatggagatc tccattcacc gcagcctcgc acaccagcac
      421 gtcgtaggct tccatggctt ttttgaggac agcgactttg tgttcgtggt tttggagctc
      481 tgtcgcagga ggtctctcct ggagctgcac aaaaggagga aggcgctgac cgagcccgag
      541 gcccgatact acctgcggca gatagtcctg ggttgccagt acctgcaccg caatcaagtc
      601 attcacaggg acctcaaact gggcaacctc tttctgaatg aggatctgga ggtgaaaata
      661 ggggattttg gcctggcaac aaaagtggaa tatgaagggg aacggaagaa gaccctgtgt
      721 ggcactccta actacatagc tcccgaggtg ctgagcaaga agggacacag ctttgaggtg
      781 gacgtgtggt ccattgggtg catcatgtat accttgctgg tgggcaagcc accttttgag
      841 acctcatgcc taaaagagac ctacctccgg atcaagaaaa atgaatacag tattcccaag
      901 cacatcaacc cagtggctgc ctccctcatc cagaaaatgc ttcagacaga ccccactgcc
      961 cgccccacca ttcacgagtt gctcaatgac gagttcttca cttccggcta catccccgcc
     1021 cgtctgccta ttacctgcct caccatccca ccaaggtttt caatagctcc cagcagccta
     1081 gaccccagca acaggaagcc tctcacagtc cttaataaag gtgtggagaa ccccctgcct
     1141 gaccgtcccc gagagaaaga ggaaccagtg gttcgggaga caaatgaggc catcgagtgc
     1201 caccttagtg acttgctaca gcagctgacc agtgtcaacg cctccaagcc ctcagagcga
     1261 gggctggtgc ggcaagagga ggccgaggat cctgcttgca tccctatctt ctgggtcagc
     1321 aaatgggtag actattcgga caagtatggc cttggttatc agctatgtga caacagtgtg
     1381 ggagtgctct ttaatgactc aacacgcctc atcctctaca atgacgggga cagcctgcag
     1441 tacatagagc gtgatggcac ggagtcctac ctcactgtga gctcccaccc caactccttg
     1501 atgaagaaga tcactctcct caactatttc cgcaattaca tgagtgaaca cctgttgaag
     1561 gcaggggcca acatcacgcc ccgggaaggc gacgagctgg cccggctgcc ctacctacga
     1621 acatggttcc gcacacgcag cgccatcatc ctgcacctca gcaatggcac agtacagatt
     1681 aatttcttcc aggaccacac caaacttatc ctgtgccccc tgatggcagc agtgacctac
     1741 atcaacgaga agagggactt ccggacatac cgcctgagcc ttctggagga atatggctgc
     1801 tgcaaggaac tggctagccg cctccgctat gcccgcacca tggtagacaa gctgctgagc
     1861 tcgcgttccg cctgcaaccg cctcaaggcc tcctaggtct ccgtccttcg gactggtgcc
     1921 ccttcattct gctagcgctc tgctagctct gggcctgcac tactgggctc ctggggccgc
     1981 tgttcagtgc ccctggccct gggggctggc agggagcagt gccccctgtg aaggggttgc
     2041 tgtgtgtaag ttattttgta catgattggg tgtgggtttg cagcctgttc cctgccctcg
     2101 gcccactgta tgaactgtat aaatatttct attgaatttg ggactgccct ttccttagct
     2161 ttatatatat taaatatttg tacatctctc tct
//
