LOCUS       NM_001134637            1937 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Rattus norvegicus perilipin 5 (Plin5), mRNA.
ACCESSION   NM_001134637 XM_001061544 XM_576698
VERSION     NM_001134637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1937)
  AUTHORS   Yin,X., Dong,L., Wang,X., Qin,Z., Ma,Y., Ke,X., Li,Y., Wang,Q.,
            Mi,Y., Lyu,Q., Xu,X., Zheng,P. and Tang,Y.
  TITLE     Perilipin 5 regulates hepatic stellate cell activation and high-fat
            diet-induced non-alcoholic fatty liver disease
  JOURNAL   Animal Model Exp Med 7 (2), 166-178 (2024)
   PUBMED   37202925
  REMARK    GeneRIF: Perilipin 5 regulates hepatic stellate cell activation and
            high-fat diet-induced non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 1937)
  AUTHORS   Zhu,Y., Ren,C., Zhang,M. and Zhong,Y.
  TITLE     Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity
            by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in
            INS-1 Pancreatic beta-Cells
  JOURNAL   Front Endocrinol (Lausanne) 11, 166 (2020)
   PUBMED   32296390
  REMARK    GeneRIF: Perilipin 5 Reduces Oxidative Damage Associated With
            Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling
            Pathway in INS-1 Pancreatic beta-Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1937)
  AUTHORS   Billecke,N., Bosma,M., Rock,W., Fleissner,F., Best,G.,
            Schrauwen,P., Kersten,S., Bonn,M., Hesselink,M.K. and Parekh,S.H.
  TITLE     Perilipin 5 mediated lipid droplet remodelling revealed by coherent
            Raman imaging
  JOURNAL   Integr Biol (Camb) 7 (4), 467-476 (2015)
   PUBMED   25804837
  REMARK    GeneRIF: These results suggest that lipotoxic protection afforded
            by natural PLIN5 upregulation in muscle involves molecular changes
            in lipid composition within LDs.
REFERENCE   4  (bases 1 to 1937)
  AUTHORS   MacPherson,R.E., Castelli,L.M., Miotto,P.M., Frendo-Cumbo,S.,
            Milburn,A., Roy,B.D., LeBlanc,P.J., Ward,W.E. and Peters,S.J.
  TITLE     A maternal high fat diet has long-lasting effects on skeletal
            muscle lipid and PLIN protein content in rat offspring at young
            adulthood
  JOURNAL   Lipids 50 (2), 205-217 (2015)
   PUBMED   25552350
  REMARK    GeneRIF: Exposure to a maternal high fat diet resulted in higher
            skeletal muscle lipid and PLIN5 content in plantaris of offspring
            through to young adulthood.
REFERENCE   5  (bases 1 to 1937)
  AUTHORS   Macpherson,R.E., Vandenboom,R., Roy,B.D. and Peters,S.J.
  TITLE     Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest
            and following lipolysis during adrenergic or contractile
            stimulation
  JOURNAL   Physiol Rep 1 (4), e00084 (2013)
   PUBMED   24303154
REFERENCE   6  (bases 1 to 1937)
  AUTHORS   Granneman,J.G., Moore,H.P., Mottillo,E.P., Zhu,Z. and Zhou,L.
  TITLE     Interactions of perilipin-5 (Plin5) with adipose triglyceride
            lipase
  JOURNAL   J Biol Chem 286 (7), 5126-5135 (2011)
   PUBMED   21148142
REFERENCE   7  (bases 1 to 1937)
  AUTHORS   Grasselli,E., Voci,A., Pesce,C., Canesi,L., Fugassa,E., Gallo,G.
            and Vergani,L.
  TITLE     PAT protein mRNA expression in primary rat hepatocytes: Effects of
            exposure to fatty acids
  JOURNAL   Int J Mol Med 25 (4), 505-512 (2010)
   PUBMED   20198297
  REMARK    GeneRIF: This study demonstrates, for the first time, the presence
            of OXPAT and TIP47 transcripts in rat hepatocytes, as well as their
            up-regulation with lipid accumulation.
REFERENCE   8  (bases 1 to 1937)
  AUTHORS   Wang,H., Hu,L., Dalen,K., Dorward,H., Marcinkiewicz,A., Russell,D.,
            Gong,D., Londos,C., Yamaguchi,T., Holm,C., Rizzo,M.A., Brasaemle,D.
            and Sztalryd,C.
  TITLE     Activation of hormone-sensitive lipase requires two steps, protein
            phosphorylation and binding to the PAT-1 domain of lipid droplet
            coat proteins
  JOURNAL   J Biol Chem 284 (46), 32116-32125 (2009)
   PUBMED   19717842
REFERENCE   9  (bases 1 to 1937)
  AUTHORS   Wolins,N.E., Quaynor,B.K., Skinner,J.R., Tzekov,A., Croce,M.A.,
            Gropler,M.C., Varma,V., Yao-Borengasser,A., Rasouli,N., Kern,P.A.,
            Finck,B.N. and Bickel,P.E.
  TITLE     OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes
            fatty acid utilization
  JOURNAL   Diabetes 55 (12), 3418-3428 (2006)
   PUBMED   17130488
REFERENCE   10 (bases 1 to 1937)
  AUTHORS   Yamaguchi,T., Matsushita,S., Motojima,K., Hirose,F. and Osumi,T.
  TITLE     MLDP, a novel PAT family protein localized to lipid droplets and
            enriched in the heart, is regulated by peroxisome
            proliferator-activated receptor alpha
  JOURNAL   J Biol Chem 281 (20), 14232-14240 (2006)
   PUBMED   16571721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474092.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_001061544.1, XM_576698.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132269, SAMD00132272
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1937
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /note="perilipin 5"
                     /db_xref="GeneID:501283"
                     /db_xref="RGD:1589602"
     exon            1..42
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     exon            43..157
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1541
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /note="lipid storage droplet protein 5"
                     /codon_start=1
                     /product="perilipin-5"
                     /protein_id="NP_001128109.1"
                     /db_xref="GeneID:501283"
                     /db_xref="RGD:1589602"
                     /translation="MDQRGKDTTLALHSRMSGDQTAQDPGSSLGELDQHNVVKRVVAL
                     PLVRATCTAVSGAYNSAKDRHPLLGSACRFAEHCVCSVATCALDHAQPLLEHLQPKLA
                     TVNDLACRGLDKLEEKLPFLQQPSDTVVTSAKDAVAKSVTGVVDLAQRGRRWSGELRR
                     SVSQAMDTVLRRSVSQAMDTVLGKSEELVDHFLPMTEAELVALATESQGPEVGSVEEQ
                     RQKQGYFVRLGSLSARLRHLAYQHSLGKLRESKHRTQEMLAQLQKTLELIQHMQSRAS
                     PTPTFHHPKVQELCGDWSPCLENGYRHSQVELETLALSRSLTLELQSAVDALAGCVRG
                     LPPSAQAKVAEVQRSVDALQATFADAHCLGDVAPTALAEGQDSVAQAHACVDEFLDLV
                     LRAMPLAWLVGPFAPILVERSEPLINLATCVDEVVGDPDPRWAHMDWPAQQRAWEAEP
                     ADPGGQEAEPPLGQVKHTMMPELDF"
     exon            158..218
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     exon            219..414
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     exon            415..497
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     exon            498..714
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     exon            715..914
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1028
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1937
                     /gene="Plin5"
                     /gene_synonym="Oxpat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatcgcccg aaatacccgc agagtctgag ctctgcactc agggatctga ttttccggct
       61 gctgcctcca cctctgtaag tggggctggt gttcctgtct gtccctactg gaaatggacc
      121 agagaggcaa agacaccacc ctagctctac acagcaggat gtccggtgat cagacagctc
      181 aggaccctgg atccagcctg ggggaactgg accagcacaa cgtggtgaag cgagtggtgg
      241 ccttgcccct ggtcagggcc acgtgcactg ctgtgtctgg tgcctacaac tcagccaagg
      301 acaggcaccc gctgctgggc tctgcctgcc gctttgctga acactgtgtg tgtagtgtgg
      361 ctacctgtgc cctggaccac gcacagccac tgctggagca cctgcagccc aagttggcca
      421 cagtgaatga tcttgcctgc aggggactag acaaattgga agagaagctg cccttcctgc
      481 agcagccatc ggacacggtg gtcacctcag ccaaggatgc agtggccaaa agtgtcacag
      541 gcgtggtgga cctggcccaa aggggccggc gttggagcgg ggagctgagg cgctccgtga
      601 gccaagccat ggacactgtg ctgaggcgct ccgtgagcca agccatggac actgtgctgg
      661 gcaaatcaga ggagctggtg gaccatttcc tgcccatgac tgaagctgag ctagtggccc
      721 tggcgactga gtcccagggc ccagaagtgg gctcagtgga ggagcagagg cagaaacagg
      781 gctactttgt gcgtctggga tccctatcgg cacgcctccg ccatcttgcc tatcaacact
      841 ctttggggaa actgagggag agcaaacacc gcacccagga gatgctggcc cagctgcaga
      901 aaactctgga gctgatccag catatgcaga gtagggcaag ccccacccct actttccatc
      961 acccaaaggt ccaggagctt tgcggggact ggagcccatg tctggagaat ggctaccgcc
     1021 acagccaggt ggagctggag acactggctc tgtcgagaag tctgaccctg gagctgcaga
     1081 gtgcagtgga tgcccttgca ggctgtgttc ggggcctgcc ccctagtgcc caggccaagg
     1141 tggctgaagt gcagcgcagt gtggatgctc tacaggccac ctttgctgat gcacactgcc
     1201 ttggtgacgt ggcacccact gctctggctg agggccagga cagcgtggcc caggcacatg
     1261 cctgtgtgga tgagttcctg gatttggtcc ttcgagccat gccactggcc tggcttgtgg
     1321 ggccctttgc gcccatcttg gtggagcggt cagagcccct gatcaacctg gccacctgtg
     1381 tggatgaggt ggtgggtgac cctgaccccc gctgggcaca catggactgg ccagcccagc
     1441 agagggcctg ggaggctgag cctgcagacc ctgggggaca agaggctgag cccccactgg
     1501 gccaggtcaa gcacacaatg atgccagagc tagacttctg accatcgagg tccctactgc
     1561 cccctggtgg tcctatgaca gcactcaagc tagtcagggc ttctgctccc ttccctagat
     1621 tttgaggtct aagtggactt cagcagacaa atttcaaccc ctcacaggag acccttcctt
     1681 atgatcatgt ccttaccccc aaagttgacg gccagcttga gctgccttat caagaatgtc
     1741 tcaaaaaaaa aaaaaaaaaa aaaaaaaaag aaagacaaag gtggctggga ggaagacctg
     1801 gtacccacag tacctggggg cttgggactc ctcaaatcaa atgattttgg ttagtgccca
     1861 gccacccttg ctgggccaga gagactcaat tgctttgctg tttgtggtcc agaataaaca
     1921 tgtttggtgt ggtctaa
//
