LOCUS       NM_001400556            1605 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus perilipin 2 (Plin2), transcript variant 8, mRNA.
ACCESSION   NM_001400556
VERSION     NM_001400556.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Zhang,Z., Li,Z., Peng,Y., Li,Z., Xv,N., Jin,L., Cao,Y., Jiang,C.
            and Chen,Z.
  TITLE     TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid
            droplet accumulation after acute spinal cord injury
  JOURNAL   Exp Neurol 381, 114916 (2024)
   PUBMED   39122166
  REMARK    GeneRIF: TRIM21-mediated ubiquitination of PLIN2 regulates neuronal
            lipid droplet accumulation after acute spinal cord injury.
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Liu,X.Y., Li,Q.S., Yang,W.H., Qiu,Y., Zhang,F.F., Mei,X.H.,
            Yuan,Q.W. and Sui,R.B.
  TITLE     Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion
            injury by blocking NLRP3 inflammasome activation both in vivo and
            in vitro
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (3), 204-213 (2023)
   PUBMED   37010675
  REMARK    GeneRIF: Inhibition of perilipin 2 attenuates cerebral
            ischemia/reperfusion injury by blocking NLRP3 inflammasome
            activation both in vivo and in vitro.
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Mishra,A., Liu,S., Promes,J., Harata,M., Sivitz,W., Fink,B.,
            Bhardwaj,G., O'Neill,B.T., Kang,C., Sah,R., Strack,S., Stephens,S.,
            King,T., Jackson,L., Greenberg,A.S., Anokye-Danso,F., Ahima,R.S.,
            Ankrum,J. and Imai,Y.
  TITLE     Perilipin 2 downregulation in beta cells impairs insulin secretion
            under nutritional stress and damages mitochondria
  JOURNAL   JCI Insight 6 (9), 144341 (2021)
   PUBMED   33784258
  REMARK    GeneRIF: Perilipin 2 downregulation in beta cells impairs insulin
            secretion under nutritional stress and damages mitochondria.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Angelini,G., Castagneto Gissey,L., Del Corpo,G., Giordano,C.,
            Cerbelli,B., Severino,A., Manco,M., Basso,N., Birkenfeld,A.L.,
            Bornstein,S.R., Genco,A., Mingrone,G. and Casella,G.
  TITLE     New insight into the mechanisms of ectopic fat deposition
            improvement after bariatric surgery
  JOURNAL   Sci Rep 9 (1), 17315 (2019)
   PUBMED   31754142
  REMARK    GeneRIF: New insight into the mechanisms of ectopic fat deposition
            improvement after bariatric surgery.
            Erratum:[Sci Rep. 2020 Feb 12;10(1):2786. doi:
            10.1038/s41598-020-58961-0. PMID: 32051424]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Akoumi,A., Haffar,T., Mousterji,M., Kiss,R.S. and Bousette,N.
  TITLE     Palmitate mediated diacylglycerol accumulation causes endoplasmic
            reticulum stress, Plin2 degradation, and cell death in H9C2
            cardiomyoblasts
  JOURNAL   Exp Cell Res 354 (2), 85-94 (2017)
   PUBMED   28336294
  REMARK    GeneRIF: Endoplasmic reticulum stress induced by either palmitate,
            tunicamycin, or thapsigargin led to the degradation of Plin2, an
            important lipid droplet binding protein.
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Nakamura,N. and Fujimoto,T.
  TITLE     Adipose differentiation-related protein has two independent domains
            for targeting to lipid droplets
  JOURNAL   Biochem Biophys Res Commun 306 (2), 333-338 (2003)
   PUBMED   12804567
  REMARK    GeneRIF: result indicates that ADRP has two independent domains
            related to its localization and lipid droplet biogenesis; the
            unique property found in the present study may be related to
            physiological function of ADRP [ADRP]
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   McManaman,J.L., Zabaronick,W., Schaack,J. and Orlicky,D.J.
  TITLE     Lipid droplet targeting domains of adipophilin
  JOURNAL   J Lipid Res 44 (4), 668-673 (2003)
   PUBMED   12562852
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Schultz,C.J., Torres,E., Londos,C. and Torday,J.S.
  TITLE     Role of adipocyte differentiation-related protein in surfactant
            phospholipid synthesis by type II cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (2), L288-L296 (2002)
   PUBMED   12114189
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Gao,J. and Serrero,G.
  TITLE     Adipose differentiation related protein (ADRP) expressed in
            transfected COS-7 cells selectively stimulates long chain fatty
            acid uptake
  JOURNAL   J Biol Chem 274 (24), 16825-16830 (1999)
   PUBMED   10358026
REFERENCE   10 (bases 1 to 1605)
  AUTHORS   Steiner,S., Wahl,D., Mangold,B.L., Robison,R., Raymackers,J.,
            Meheus,L., Anderson,N.L. and Cordier,A.
  TITLE     Induction of the adipose differentiation-related protein in liver
            of etomoxir-treated rats
  JOURNAL   Biochem Biophys Res Commun 218 (3), 777-782 (1996)
   PUBMED   8579590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.19611.1,
                                           SRR26643289.15490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000005.1  106228968-106229018 c
            52-106              JAXUCZ010000005.1  106227823-106227877 c
            107-189             JAXUCZ010000005.1  106224193-106224275 c
            190-469             JAXUCZ010000005.1  106220846-106221125 c
            470-651             JAXUCZ010000005.1  106218677-106218858 c
            652-777             JAXUCZ010000005.1  106217073-106217198 c
            778-1068            JAXUCZ010000005.1  106215788-106216078 c
            1069-1605           JAXUCZ010000005.1  106202634-106203170 c
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..1605
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /note="perilipin 2"
                     /db_xref="GeneID:298199"
                     /db_xref="RGD:728889"
     exon            1..51
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            52..106
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            107..189
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1146
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /note="isoform 6 is encoded by transcript variant 8;
                     adipose differentiation related protein"
                     /codon_start=1
                     /product="perilipin-2 isoform 6"
                     /protein_id="NP_001387485.1"
                     /db_xref="GeneID:298199"
                     /db_xref="RGD:728889"
                     /translation="MEARLPILNQPTSEIVANARGAVTGAKDVVTTTMAGAKDSVAST
                     VSGVVDKTKGAVTGSVERTKSVVNGGIDTVLGMVQLMSSGVENAISKSELLVDQYLPL
                     TQKELEMEAKKVEGFDMVQKQRYYERLESLSTKICTRAYHQALGRIKDAKQKGQETIS
                     QLHSTVHLIEFARKNVHSANQKIQDKLSVSWVEWKRIVGYDDTDESHCAEHIESHTLS
                     MARNLTQQLHTTCQTLLFNVQGLPQNIQDQAKHLGVMAGDIYSAFRNVTSFKEVSDGV
                     LTSSKGQLQKMKESLDEVMDYLVNNTPLNWLMLDFSAFDSTSDTDEVPDIIPLEED"
     exon            190..469
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            470..651
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            652..777
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1068
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1605
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtgattc tggaccgtgc cgatttgctc gtctctcagc tctcctgttc ggcatctctt
       61 tactccagga ggaaaaatgg catcagtagc agtggatcca caaccgttgc ggtcgccaat
      121 acctatgcct gcaaggggct agacaggatg gaggcaaggc tgcctattct gaaccagcca
      181 acatctgaga ttgttgccaa tgcccgaggt gccgtaactg gggcaaagga tgtagtgacg
      241 actaccatgg ctggagccaa ggattctgta gccagcacag tctcaggggt ggtggataag
      301 accaaaggag cagttactgg cagcgtggaa aggaccaagt ctgtggtcaa tggcggcatc
      361 gatacggttt tggggatggt gcagctcatg agcagtggag tggaaaatgc aattagcaag
      421 tcggagctgc tggtagacca gtacttgccg ctcactcaga aggagctcga gatggaagca
      481 aaaaaggtgg aaggatttga tatggttcag aagcaaagat actatgaacg gctggagtcc
      541 ctgtctacca agatctgcac ccgggcctat catcaggctc tcggcaggat caaagacgcc
      601 aaacaaaagg gccaggagac catttcccag ctccactcca ctgtccatct gattgaattc
      661 gccaggaaga atgtgcacag tgctaaccag aaaattcagg acaagctctc tgtctcatgg
      721 gtggagtgga agagaatcgt cggctacgac gacacggacg agtcccattg tgctgagcac
      781 atcgagtcac atactctgtc tatggcccgc aacctgaccc agcagctcca cactacatgc
      841 cagacgctcc tgttcaacgt ccaagggtta ccacagaaca ttcaagacca ggccaaacac
      901 ttgggggtga tggcaggtga catctactcg gcgttccgca atgttacctc cttcaaggaa
      961 gtgtctgatg gcgtcctcac ttctagcaag gggcagctgc agaaaatgaa ggagtcctta
     1021 gatgaagtta tggattacct tgttaacaac acgcctctca actggctgat gcttgatttc
     1081 tctgcttttg actcgacatc tgacactgat gaagttcctg atattattcc tttggaagaa
     1141 gactgaaccc aatgatcaca cacagctttg tcctcttaag gcaaaagact acccaaccaa
     1201 cacaaggaaa gactttattt tattcaacac ataatacgta tctttttttt taaatatttg
     1261 catctgtttt attcctgtgg ctttattaat ctactccttt ttggctgctt gatcttagtt
     1321 gtaaatgacg tgaacatttg taagagaact tgttctgcgt catgtatcat tttatacaat
     1381 tctttaatgt ttaactgctg aaatcccttt gtaataatat ttagctgtag gccagtgaga
     1441 tggcttaatg ggtaaaggtg ccaagcctga cgatctgagt ttgactcttt aggacccatg
     1501 tgatgaagtg actttctcaa actgttctct ctctacacac acacacacac acacacacac
     1561 acacacaaac gtgtaataaa aatacaaaaa ttgggtagca taaaa
//
