LOCUS       NM_001007144            1841 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus perilipin 2 (Plin2), transcript variant 1, mRNA.
ACCESSION   NM_001007144 XM_216438
VERSION     NM_001007144.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Zhang,Z., Li,Z., Peng,Y., Li,Z., Xv,N., Jin,L., Cao,Y., Jiang,C.
            and Chen,Z.
  TITLE     TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid
            droplet accumulation after acute spinal cord injury
  JOURNAL   Exp Neurol 381, 114916 (2024)
   PUBMED   39122166
  REMARK    GeneRIF: TRIM21-mediated ubiquitination of PLIN2 regulates neuronal
            lipid droplet accumulation after acute spinal cord injury.
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Liu,X.Y., Li,Q.S., Yang,W.H., Qiu,Y., Zhang,F.F., Mei,X.H.,
            Yuan,Q.W. and Sui,R.B.
  TITLE     Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion
            injury by blocking NLRP3 inflammasome activation both in vivo and
            in vitro
  JOURNAL   In Vitro Cell Dev Biol Anim 59 (3), 204-213 (2023)
   PUBMED   37010675
  REMARK    GeneRIF: Inhibition of perilipin 2 attenuates cerebral
            ischemia/reperfusion injury by blocking NLRP3 inflammasome
            activation both in vivo and in vitro.
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Mishra,A., Liu,S., Promes,J., Harata,M., Sivitz,W., Fink,B.,
            Bhardwaj,G., O'Neill,B.T., Kang,C., Sah,R., Strack,S., Stephens,S.,
            King,T., Jackson,L., Greenberg,A.S., Anokye-Danso,F., Ahima,R.S.,
            Ankrum,J. and Imai,Y.
  TITLE     Perilipin 2 downregulation in beta cells impairs insulin secretion
            under nutritional stress and damages mitochondria
  JOURNAL   JCI Insight 6 (9), 144341 (2021)
   PUBMED   33784258
  REMARK    GeneRIF: Perilipin 2 downregulation in beta cells impairs insulin
            secretion under nutritional stress and damages mitochondria.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Angelini,G., Castagneto Gissey,L., Del Corpo,G., Giordano,C.,
            Cerbelli,B., Severino,A., Manco,M., Basso,N., Birkenfeld,A.L.,
            Bornstein,S.R., Genco,A., Mingrone,G. and Casella,G.
  TITLE     New insight into the mechanisms of ectopic fat deposition
            improvement after bariatric surgery
  JOURNAL   Sci Rep 9 (1), 17315 (2019)
   PUBMED   31754142
  REMARK    GeneRIF: New insight into the mechanisms of ectopic fat deposition
            improvement after bariatric surgery.
            Erratum:[Sci Rep. 2020 Feb 12;10(1):2786. doi:
            10.1038/s41598-020-58961-0. PMID: 32051424]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Akoumi,A., Haffar,T., Mousterji,M., Kiss,R.S. and Bousette,N.
  TITLE     Palmitate mediated diacylglycerol accumulation causes endoplasmic
            reticulum stress, Plin2 degradation, and cell death in H9C2
            cardiomyoblasts
  JOURNAL   Exp Cell Res 354 (2), 85-94 (2017)
   PUBMED   28336294
  REMARK    GeneRIF: Endoplasmic reticulum stress induced by either palmitate,
            tunicamycin, or thapsigargin led to the degradation of Plin2, an
            important lipid droplet binding protein.
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Nakamura,N. and Fujimoto,T.
  TITLE     Adipose differentiation-related protein has two independent domains
            for targeting to lipid droplets
  JOURNAL   Biochem Biophys Res Commun 306 (2), 333-338 (2003)
   PUBMED   12804567
  REMARK    GeneRIF: result indicates that ADRP has two independent domains
            related to its localization and lipid droplet biogenesis; the
            unique property found in the present study may be related to
            physiological function of ADRP [ADRP]
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   McManaman,J.L., Zabaronick,W., Schaack,J. and Orlicky,D.J.
  TITLE     Lipid droplet targeting domains of adipophilin
  JOURNAL   J Lipid Res 44 (4), 668-673 (2003)
   PUBMED   12562852
REFERENCE   8  (bases 1 to 1841)
  AUTHORS   Schultz,C.J., Torres,E., Londos,C. and Torday,J.S.
  TITLE     Role of adipocyte differentiation-related protein in surfactant
            phospholipid synthesis by type II cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (2), L288-L296 (2002)
   PUBMED   12114189
REFERENCE   9  (bases 1 to 1841)
  AUTHORS   Gao,J. and Serrero,G.
  TITLE     Adipose differentiation related protein (ADRP) expressed in
            transfected COS-7 cells selectively stimulates long chain fatty
            acid uptake
  JOURNAL   J Biol Chem 274 (24), 16825-16830 (1999)
   PUBMED   10358026
REFERENCE   10 (bases 1 to 1841)
  AUTHORS   Steiner,S., Wahl,D., Mangold,B.L., Robison,R., Raymackers,J.,
            Meheus,L., Anderson,N.L. and Cordier,A.
  TITLE     Induction of the adipose differentiation-related protein in liver
            of etomoxir-treated rats
  JOURNAL   Biochem Biophys Res Commun 218 (3), 777-782 (1996)
   PUBMED   8579590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 25, 2022 this sequence version replaced NM_001007144.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085861.1, SRR26643295.21700.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000005.1  106228968-106229018 c
            52-106              JAXUCZ010000005.1  106227823-106227877 c
            107-302             JAXUCZ010000005.1  106227548-106227743 c
            303-385             JAXUCZ010000005.1  106224193-106224275 c
            386-665             JAXUCZ010000005.1  106220846-106221125 c
            666-847             JAXUCZ010000005.1  106218677-106218858 c
            848-973             JAXUCZ010000005.1  106217073-106217198 c
            974-1841            JAXUCZ010000005.1  106215211-106216078 c
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..1841
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /note="perilipin 2"
                     /db_xref="GeneID:298199"
                     /db_xref="RGD:728889"
     exon            1..51
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            52..106
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1345
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adipose differentiation related protein"
                     /codon_start=1
                     /product="perilipin-2 isoform 1"
                     /protein_id="NP_001007145.1"
                     /db_xref="GeneID:298199"
                     /db_xref="RGD:728889"
                     /translation="MASVAVDPQPSVVTRVANLPLVSSTYDLVSSAYVSTKDQHPYLR
                     SVCEMAEKGVRTVTSVAVTGALPIIQKLEPQIAVANTYACKGLDRMEARLPILNQPTS
                     EIVANARGAVTGAKDVVTTTMAGAKDSVASTVSGVVDKTKGAVTGSVERTKSVVNGGI
                     DTVLGMVQLMSSGVENAISKSELLVDQYLPLTQKELEMEAKKVEGFDMVQKQRYYERL
                     ESLSTKICTRAYHQALGRIKDAKQKGQETISQLHSTVHLIEFARKNVHSANQKIQDKL
                     SVSWVEWKRIVGYDDTDESHCAEHIESHTLSMARNLTQQLHTTCQTLLFNVQGLPQNI
                     QDQAKHLGVMAGDIYSAFRNVTSFKEVSDGVLTSSKGQLQKMKESLDEVMDYLVNNTP
                     LNWLVGPFYPQSTEVDKASLKVQQSELTTQ"
     exon            107..302
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            303..385
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            386..665
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            666..847
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            848..973
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1841
                     /gene="Plin2"
                     /gene_synonym="Adfp; Adrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtgattc tggaccgtgc cgatttgctc gtctctcagc tctcctgttc ggcatctctt
       61 tactccagga ggaaaaatgg catcagtagc agtggatcca caaccgagcg tggtgacgag
      121 ggtggccaac ctgcccttgg tgagctccac ctacgacctg gtgtcctccg cttatgtcag
      181 tacaaaggat cagcacccgt atttgaggtc agtgtgtgag atggcagaga agggagtgag
      241 gaccgtgacc tcagtggctg tgacaggcgc actgcccatc atccagaagc tggagccaca
      301 gattgcggtc gccaatacct atgcctgcaa ggggctagac aggatggagg caaggctgcc
      361 tattctgaac cagccaacat ctgagattgt tgccaatgcc cgaggtgccg taactggggc
      421 aaaggatgta gtgacgacta ccatggctgg agccaaggat tctgtagcca gcacagtctc
      481 aggggtggtg gataagacca aaggagcagt tactggcagc gtggaaagga ccaagtctgt
      541 ggtcaatggc ggcatcgata cggttttggg gatggtgcag ctcatgagca gtggagtgga
      601 aaatgcaatt agcaagtcgg agctgctggt agaccagtac ttgccgctca ctcagaagga
      661 gctcgagatg gaagcaaaaa aggtggaagg atttgatatg gttcagaagc aaagatacta
      721 tgaacggctg gagtccctgt ctaccaagat ctgcacccgg gcctatcatc aggctctcgg
      781 caggatcaaa gacgccaaac aaaagggcca ggagaccatt tcccagctcc actccactgt
      841 ccatctgatt gaattcgcca ggaagaatgt gcacagtgct aaccagaaaa ttcaggacaa
      901 gctctctgtc tcatgggtgg agtggaagag aatcgtcggc tacgacgaca cggacgagtc
      961 ccattgtgct gagcacatcg agtcacatac tctgtctatg gcccgcaacc tgacccagca
     1021 gctccacact acatgccaga cgctcctgtt caacgtccaa gggttaccac agaacattca
     1081 agaccaggcc aaacacttgg gggtgatggc aggtgacatc tactcggcgt tccgcaatgt
     1141 tacctccttc aaggaagtgt ctgatggcgt cctcacttct agcaaggggc agctgcagaa
     1201 aatgaaggag tccttagatg aagttatgga ttaccttgtt aacaacacgc ctctcaactg
     1261 gctggtaggt cccttttatc ctcagtctac cgaggtggac aaggccagcc tgaaggtcca
     1321 gcagtctgag ctcacaactc agtaaacctg ctcttgtcac cagtgtatga tgttgctgac
     1381 caggtggcac cttttatttt ttatttttta tttttttgta ttgaaattaa cctgattaga
     1441 ttagaaaagc agctagtttg aacaaaggtc ctcattatgg tcattcacag ctcacttatg
     1501 gtcgtgcccc cgctggccct gacacatgag ttcttcttac ccggctggta tgtggagtgt
     1561 gttagttttg tgaggacctc accagaacct taaagctcag gtgcgcttac agtcttgtcc
     1621 atggcctttg tgttcttatt ggctgtaaac gtctgtctgt tccgaataaa gatttgttca
     1681 tgcggcctct gctctgaatg ggcatctgct cctgtgtggt ccgagcaggc ttcatcactg
     1741 tttccctcaa ggcatgttct tgtgtggctt gaatttagtt ttttccatgt gaagaaatat
     1801 cacctttgga cccaataaaa ttcataacag ggtagagcgt t
//
