LOCUS       NM_001308145            2025 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus perilipin 1 (Plin1), mRNA.
ACCESSION   NM_001308145
VERSION     NM_001308145.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Liu,L.R., Lin,S.P., Chen,C.C., Chen,Y.J., Tai,C.C., Chang,S.C.,
            Juang,R.H., Tseng,Y.W., Liu,B.H., Mersmann,H.J., Shen,T.L. and
            Ding,S.T.
  TITLE     Serum amyloid A induces lipolysis by downregulating perilipin
            through ERK1/2 and PKA signaling pathways
  JOURNAL   Obesity (Silver Spring) 19 (12), 2301-2309 (2011)
   PUBMED   21701568
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Gandolfi,G., Mazzoni,M., Zambonelli,P., Lalatta-Costerbosa,G.,
            Tronca,A., Russo,V. and Davoli,R.
  TITLE     Perilipin 1 and perilipin 2 protein localization and gene
            expression study in skeletal muscles of European cross-breed pigs
            with different intramuscular fat contents
  JOURNAL   Meat Sci 88 (4), 631-637 (2011)
   PUBMED   21420243
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Borg,J., Klint,C., Wierup,N., Strom,K., Larsson,S., Sundler,F.,
            Lupi,R., Marchetti,P., Xu,G., Kimmel,A., Londos,C. and Holm,C.
  TITLE     Perilipin is present in islets of Langerhans and protects against
            lipotoxicity when overexpressed in the beta-cell line INS-1
  JOURNAL   Endocrinology 150 (7), 3049-3057 (2009)
   PUBMED   19299455
  REMARK    GeneRIF: evidence is presented for perilipin expression in rat,
            mouse, and human islets of Langerhans
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Jiang,H., He,J., Pu,S., Tang,C. and Xu,G.
  TITLE     Heat shock protein 70 is translocated to lipid droplets in rat
            adipocytes upon heat stimulation
  JOURNAL   Biochim Biophys Acta 1771 (1), 66-74 (2007)
   PUBMED   17175194
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Yamaguchi,T., Matsushita,S., Motojima,K., Hirose,F. and Osumi,T.
  TITLE     MLDP, a novel PAT family protein localized to lipid droplets and
            enriched in the heart, is regulated by peroxisome
            proliferator-activated receptor alpha
  JOURNAL   J Biol Chem 281 (20), 14232-14240 (2006)
   PUBMED   16571721
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Forcheron,F., Legedz,L., Chinetti,G., Feugier,P., Letexier,D.,
            Bricca,G. and Beylot,M.
  TITLE     Genes of cholesterol metabolism in human atheroma: overexpression
            of perilipin and genes promoting cholesterol storage and repression
            of ABCA1 expression
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (8), 1711-1717 (2005)
   PUBMED   15961705
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Yamaguchi,T., Omatsu,N., Matsushita,S. and Osumi,T.
  TITLE     CGI-58 interacts with perilipin and is localized to lipid droplets.
            Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman
            syndrome
  JOURNAL   J Biol Chem 279 (29), 30490-30497 (2004)
   PUBMED   15136565
  REMARK    GeneRIF: perilipin interacts with CGI-58 and is localized to lipid
            droplets
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Tansey,J.T., Sztalryd,C., Gruia-Gray,J., Roush,D.L., Zee,J.V.,
            Gavrilova,O., Reitman,M.L., Deng,C.X., Li,C., Kimmel,A.R. and
            Londos,C.
  TITLE     Perilipin ablation results in a lean mouse with aberrant adipocyte
            lipolysis, enhanced leptin production, and resistance to
            diet-induced obesity
  JOURNAL   Proc Natl Acad Sci U S A 98 (11), 6494-6499 (2001)
   PUBMED   11371650
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Clifford,G.M., McCormick,D.K., Londos,C., Vernon,R.G. and
            Yeaman,S.J.
  TITLE     Dephosphorylation of perilipin by protein phosphatases present in
            rat adipocytes
  JOURNAL   FEBS Lett 435 (1), 125-129 (1998)
   PUBMED   9755872
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Greenberg,A.S., Egan,J.J., Wek,S.A., Moos,M.C. Jr., Londos,C. and
            Kimmel,A.R.
  TITLE     Isolation of cDNAs for perilipins A and B: sequence and expression
            of lipid droplet-associated proteins of adipocytes
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 12035-12039 (1993)
   PUBMED   7505452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM044716.1, JAXUCZ010000001.1, FM042626.1 and BU671441.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.2371.1,
                                           SRR26643295.2765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               FM044716.1         1-405
            406-628             JAXUCZ010000001.1  143079704-143079926 c
            629-982             FM042626.1         213-566
            983-1539            BU671441.1         87-643
            1540-2025           JAXUCZ010000001.1  143074214-143074699 c
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2025
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /note="perilipin 1"
                     /db_xref="GeneID:25629"
                     /db_xref="RGD:3351"
     exon            1..16
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            17..75
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1587
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /note="PERI; lipid droplet-associated protein"
                     /codon_start=1
                     /product="perilipin-1"
                     /protein_id="NP_001295074.1"
                     /db_xref="GeneID:25629"
                     /db_xref="RGD:3351"
                     /translation="MSMNKGPTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYNST
                     KEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKI
                     PALQYPPEKIASELKGTISTRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKET
                     AEYAANTRVGRLASGGADLALGSIEKVVEYLLPPDKVESAPSSGRQKMQKAPKAKPSL
                     LRRVSTLANTLSRHTMQTTARALKRGHSLAMWIPGVAPLSSLAQWGASAAMQVVSRRQ
                     SEVRVPWLHNLAASKDENHEDQTDTEGEETDEEEEEEESEAEENVLREVTALPTPLGF
                     LGGVVHTVQKTLQNTISAVTWAPAAVLGTVGRILHLTPAQAVSSTKGRAMSLSDALKG
                     VTDNVVDTVVHYVPLPRLSLMEPESEFQDIDNPPAEVERKGSGSRPASPESTARPGQP
                     RGSLRSVRGLSAPSCPDLDDKTETSARPGFLAMPREKPARRVSDSFFRPSVMEPILGR
                     TQYSQLRKKS"
     exon            76..280
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            281..363
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            364..628
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            629..801
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1002
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1248
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..2025
                     /gene="Plin1"
                     /gene_synonym="PERIA; Plin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggctctca gctgcatgtg aagagtaagg atgtccatga acaagggccc gaccctgctg
       61 gatggagacc tccctgaaca ggagaatgtg ctccagagag tcctgcagct gcctgtggtg
      121 agcgggacct gtgagtgctt ccagaagacc tataacagca ccaaagaagc ccaccccctg
      181 gtggcctctg tgtgcaatgc ctatgagaag ggtgtacagg gtgccagcaa cctggctgcc
      241 tggagcatgg agccggtggt ccgccggctc tccacccagt tcacagctgc taatgagttg
      301 gcctgcagag gcctggacca cctggaggaa aagatcccgg ctcttcaata ccctccggaa
      361 aagatcgcct ctgaactgaa gggcaccatc tctacccgcc tccgaagcgc caggaacagc
      421 atcagcgtgc ccattgcaag cacttctgac aaggttctgg gggccactct ggccggctgt
      481 gagcttgcct tggggatggc caaggagaca gcggaatatg ctgccaacac ccgagttggc
      541 cgactggcct ctggaggggc tgatctggct ttgggaagca tcgagaaggt ggtagaatat
      601 ctcctgccac cagacaaggt ggagtcagcc ccttcttcag gacggcaaaa gatgcagaag
      661 gctcccaagg ccaaaccaag ccttttgagg agggtcagca ccctggccaa cactctttct
      721 cgacacacca tgcagaccac agcacgggcc ctgaagcggg gtcactctct ggccatgtgg
      781 atcccgggtg tggcacccct gagcagcctg gcccagtggg gtgcatcggc agccatgcag
      841 gtggtgtccc ggcggcagag tgaggtacgg gtgccctggt tgcacaacct ggcagcctcc
      901 aaggatgaga accatgaaga ccagacagac acagagggag aggagacaga tgaggaggaa
      961 gaagaagaag agtcagaggc cgaggagaac gtgctcagag aggtaacagc cctgcccacc
     1021 cctctcggct tcctgggtgg tgtggtacac accgtgcaga agactctgca gaacaccatc
     1081 tcggcggtga catgggcacc tgcggctgtg ctgggcacgg tgggaaggat cctacacctc
     1141 acaccagccc aggctgtctc ctccaccaaa gggagggcca tgtccctatc cgatgccctg
     1201 aagggtgtta cggataacgt ggtagacact gtggtacact atgtcccgct tcccaggctg
     1261 tccctgatgg agcccgagag cgaattccaa gacatcgata atcctccagc agaggtggag
     1321 cgcaaagggt cggggtcgcg gcccgccagc ccagagtcca cggcgcgccc gggccagccc
     1381 cgcggcagct tgcgcagcgt gcggggtctc agcgcgccct cttgccccga tctggatgac
     1441 aaaaccgaga catcagcgcg tcctggcttc ctggctatgc ccagagagaa gcctgcgcgc
     1501 agggtcagcg acagcttctt ccggcccagc gtcatggagc ccatcctggg ccgcacgcag
     1561 tacagccagc tgcgcaagaa gagctgagta gcctgcgccc ctaaccgccc tggcgccacc
     1621 ctcaccggaa ggtcgcttct ctccccaagg aaacagaaac cacacttcca agtgggccac
     1681 tccttcaggg tggcctcttg ggagcccgag tcacaacccc acgatgttct cgagacccac
     1741 atcatttcta aggcatcctt ggggcttgac catcacagtc aggttttaag gggcacccga
     1801 gcggctgtcg actctttcct ctctcgtggg ctgaatctct catggctttt tttttttttt
     1861 aactataaaa gcaattgctt aattggattt ctcacttctt taacaaaact tggcctgact
     1921 agttctaaaa atgtagatcc cttctctgtg gacacgtatt tattgccaaa aagtagtgcg
     1981 tcagttgact gttttctctt ctttcttttc tcttgttttt ctcct
//
