LOCUS       NM_053491               2752 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus plasminogen (Plg), mRNA.
ACCESSION   NM_053491 XM_001068594 XM_574314
VERSION     NM_053491.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2752)
  AUTHORS   Cramer,D.A.T., Yin,V., Caval,T., Franc,V., Yu,D., Wu,G., Lloyd,G.,
            Langendorf,C., Whisstock,J.C., Law,R.H.P. and Heck,A.J.R.
  TITLE     Proteoform-Resolved Profiling of Plasminogen Activation Reveals
            Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage
            Site
  JOURNAL   Mol Cell Proteomics 23 (1), 100696 (2024)
   PUBMED   38101751
  REMARK    GeneRIF: Proteoform-Resolved Profiling of Plasminogen Activation
            Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal
            Cleavage Site.
REFERENCE   2  (bases 1 to 2752)
  AUTHORS   Wu,Y., Wang,T., Guo,C., Zhang,D., Ge,X., Huang,Z., Zhou,X., Li,Y.,
            Peng,Q. and Li,J.
  TITLE     Plasminogen improves lung lesions and hypoxemia in patients with
            COVID-19
  JOURNAL   QJM 113 (8), 539-545 (2020)
   PUBMED   32275753
REFERENCE   3  (bases 1 to 2752)
  AUTHORS   Liu,C.M., Chen,J., Yang,S., Mao,L.G., Jiang,T.T., Tu,H.H.,
            Chen,Z.L., Hu,Y.T., Gan,L., Li,Z.J. and Li,J.C.
  TITLE     The Chinese herbal formula Zhibai Dihuang Granule treat
            Yin-deficiency-heat syndrome rats by regulating the immune
            responses
  JOURNAL   J Ethnopharmacol 225, 271-278 (2018)
   PUBMED   29729385
REFERENCE   4  (bases 1 to 2752)
  AUTHORS   Zachar,R., Al-Mashhadi,A., Dimke,H., Svenningsen,P., Jensen,B.L.
            and Carlstrom,M.
  TITLE     Hydronephrosis is associated with elevated plasmin in urine in
            pediatric patients and rats and changes in NCC and gamma-ENaC
            abundance in rat kidney
  JOURNAL   Am J Physiol Renal Physiol 315 (3), F547-F557 (2018)
   PUBMED   29767556
  REMARK    GeneRIF: The presence of active plasmin in urine in hydronephrosis
            could cause abnormal proteolytic activation of ENaC-gamma and
            impaired ability to excrete Na via NCC.
REFERENCE   5  (bases 1 to 2752)
  AUTHORS   Grundel,A., Pfeiffer,M., Jacobs,E. and Dumke,R.
  TITLE     Network of Surface-Displayed Glycolytic Enzymes in Mycoplasma
            pneumoniae and Their Interactions with Human Plasminogen
  JOURNAL   Infect Immun 84 (3), 666-676 (2015)
   PUBMED   26667841
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2752)
  AUTHORS   Kanalas,J.J. and Makker,S.P.
  TITLE     Identification of the rat Heymann nephritis autoantigen (GP330) as
            a receptor site for plasminogen
  JOURNAL   J Biol Chem 266 (17), 10825-10829 (1991)
   PUBMED   1645711
REFERENCE   7  (bases 1 to 2752)
  AUTHORS   Ichinose,A., Espling,E.S., Takamatsu,J., Saito,H., Shinmyozu,K.,
            Maruyama,I., Petersen,T.E. and Davie,E.W.
  TITLE     Two types of abnormal genes for plasminogen in families with a
            predisposition for thrombosis
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 115-119 (1991)
   PUBMED   1986355
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Apr 1;88(7):2967]
REFERENCE   8  (bases 1 to 2752)
  AUTHORS   Silverstein,R.L., Leung,L.L., Harpel,P.C. and Nachman,R.L.
  TITLE     Complex formation of platelet thrombospondin with plasminogen.
            Modulation of activation by tissue activator
  JOURNAL   J Clin Invest 74 (5), 1625-1633 (1984)
   PUBMED   6438154
REFERENCE   9  (bases 1 to 2752)
  AUTHORS   Miyata,T., Iwanaga,S., Sakata,Y. and Aoki,N.
  TITLE     Plasminogen Tochigi: inactive plasmin resulting from replacement of
            alanine-600 by threonine in the active site
  JOURNAL   Proc Natl Acad Sci U S A 79 (20), 6132-6136 (1982)
   PUBMED   6216475
REFERENCE   10 (bases 1 to 2752)
  AUTHORS   Brower,M.S. and Harpel,P.C.
  TITLE     Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor
            and C1 inactivator by human polymorphonuclear leukocyte elastase
  JOURNAL   J Biol Chem 257 (16), 9849-9854 (1982)
   PUBMED   6980881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091135.1.
            
            On or before Feb 14, 2007 this sequence version replaced
            XM_574314.2, XM_001068594.1, NM_053491.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091135.1, FQ210878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2752
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2752
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /note="plasminogen"
                     /db_xref="GeneID:85253"
                     /db_xref="RGD:619893"
     exon            1..86
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..2476
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /EC_number="3.4.21.7"
                     /codon_start=1
                     /product="plasminogen precursor"
                     /protein_id="NP_445943.1"
                     /db_xref="GeneID:85253"
                     /db_xref="RGD:619893"
                     /translation="MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAG
                     SIADCLAKCEGETDFICRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSE
                     CKTGIGKGYRGTMSKTKTGVTCQKWSDTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQ
                     GPWCYTTDPDQRYEYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQSWDSQSPHAHG
                     YIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEYCDIPRCTTPPPPPGPTYQCL
                     KGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPW
                     CYTTDSQLRWEYCEIPSCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTN
                     TGKKCQSWVSMTPHSHSKTPANFPDAGLEMNYCRNPDNDQRGPWCFTTDPSVRWEYCN
                     LKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQ
                     EPHSHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSF
                     ECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAH
                     CLEKSSRPEFYKVILGAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDN
                     VIPACLPSPNYVVADRTLCYITGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNR
                     VKSTELCAGHLAGGIDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRV
                     SRYVNWIEREMRND"
     exon            87..222
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            223..329
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            330..444
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            445..584
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            585..705
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            706..824
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            825..987
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1130
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1290
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1475
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1624
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1718
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1842
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1920
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2061
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2168
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2314
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2717
                     /gene="Plg"
                     /gene_synonym="Ab1-346"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacacagtt gtccaggtgc tgttggccag tcccaacatg gaccataagg aaataatcct
       61 tctgtttctc ttgtttctga aaccaggaca aggggactca ctggatggct atgtaagcac
      121 acagggggct tcactgcata gcctcaccaa gaagcagcta gcggcaggaa gcatagcaga
      181 ctgtttggcc aaatgtgaag gggaaacaga cttcatctgc aggtcattcc agtaccacag
      241 caaagagcag cagtgcgtga tcatggccga gaacagcaag acttcctcca tcatccggat
      301 gagagatgtc atcttattcg aaaagagagt gtatctgtca gagtgtaaga ctggcatcgg
      361 caagggctac agaggaacca tgtccaagac aaagactggt gttacctgtc aaaagtggag
      421 tgacacgtcc ccccacgtac ccaaatactc ccccagcaca caccccagcg agggactaga
      481 ggagaactac tgtaggaacc cagacaatga tgaacaaggg ccctggtgct acacaacaga
      541 cccggaccag agatatgagt actgcaacat ccccgaatgc gaagaggaat gcatgtactg
      601 cagtggagaa aagtacgagg gcaaaatctc caagaccatg tctggactcg actgccagtc
      661 ctgggattct cagagcccac atgctcacgg atacatccct gccaaatttc caagcaagaa
      721 cttgaagatg aattactgtc gcaaccctga cggggagccg cggccctggt gcttcaccac
      781 agaccccaac aaacgctggg aatactgtga catcccccgc tgcacaacac ccccaccccc
      841 accgggccca acctaccaat gtctgaaggg gagaggtgaa aattaccgag ggaccgtgtc
      901 tgtcactgcg tctgggaaaa cctgtcagcg ctggagtgag caaacacctc ataggcacaa
      961 caggacgcca gaaaacttcc cctgcaaaaa tctggaagag aactactgcc ggaacccaga
     1021 tggagaaact gctccctggt gctataccac tgacagccag ctgaggtggg agtactgtga
     1081 gattccgtcc tgcgggtcct cggtatcacc agaccagtca gattcctcag ttcttccgga
     1141 gcaaacacct gtggtccagg agtgctacca gggcaatgga aagagctatc ggggcacatc
     1201 gtccactacc aacacaggga agaagtgcca gtcctgggta tctatgactc cacatagtca
     1261 ctcgaagacc ccagcgaact tcccagatgc tggcttggag atgaactact gcaggaaccc
     1321 agataatgac cagaggggcc cttggtgctt caccactgac ccgagcgtca ggtgggaata
     1381 ctgcaacctg aagcggtgct cggagacagg agggggtgtt gcggaatcag ccatagtccc
     1441 ccaagttccc agtgcgccag gcacctctga gacagactgc atgtatggga atggcaaaga
     1501 atatcggggc aaaacggccg tcactgcagc tggaaccccc tgccaggaat gggctgccca
     1561 ggagccccac agtcacagaa tcttcacccc acagacaaac ccacgggcag gtctggaaaa
     1621 gaattactgc cgaaacccgg atggggatgt caatgggccc tggtgctata caatgaaccc
     1681 cagaaaactt tacgactatt gtaacattcc cctttgtgca tcattatcgt cctttgaatg
     1741 tgggaagcct caggtggagc cgaagaaatg ccctgggagg gtggtgggtg gctgtgtggc
     1801 caaccctcac tcctggccct ggcaaatcag ccttagaaca agattttctg gacagcactt
     1861 ctgtggcggt actttaatat ccccagagtg ggtgctgact gccgctcact gcttggagaa
     1921 atcttcgaga cctgaattct acaaggttat cctgggagca cacgaagaac gaatccttgg
     1981 gtcagatgtt cagcaaatag cagtaaccaa actggtcttg gaacccaacg acgctgacat
     2041 tgccctgctg aagctaagcc gcccagccac catcacagat aatgtcatcc cagcttgtct
     2101 gccatctcca aattatgtgg ttgccgaccg gacactgtgt tacatcaccg gctggggaga
     2161 aacgaaaggg actccaggtg ccggccgtct caaggaggcc cagctgcccg tgatcgagaa
     2221 caaggtgtgc aaccgcgctg agtatctaaa caacagagtc aaatccaccg agctctgtgc
     2281 cgggcatctg gctggtggca tcgacagttg ccagggcgac agtggaggac ctctggtttg
     2341 cttcgagaag gacaagtata ttttacaagg agtcacttct tggggtcttg gctgtgctcg
     2401 ccccaataag cctggtgtct atgttcgtgt ttcccggtac gttaattgga ttgaaaggga
     2461 gatgaggaat gactaattgg gtgggaggca gaacaaaact actaaatatg gggaggggat
     2521 tagggcgctt gaaaaaaaac ctgacagcaa tcaaaccaaa gacactacac tggaccacta
     2581 cttcctgtca cccctcagct cctccctctt tttgtattat tgtgggtaaa attttcctgt
     2641 ccctggactt ctggattttg tgacaataga ccatcacttc tgtgaccttt gttgaaaata
     2701 aactcgatac ttactttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
