LOCUS       NM_001025119            1477 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus pleckstrin homology domain containing O1
            (Plekho1), mRNA.
ACCESSION   NM_001025119
VERSION     NM_001025119.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1477)
  AUTHORS   Ren,J., Li,J., Hu,J., Yu,H., Yang,Q. and Mu,J.
  TITLE     Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte
            injury by up-regulating Nrf2 antioxidant signaling via Keap1
            inhibition
  JOURNAL   Biochimie 163, 163-170 (2019)
   PUBMED   31201843
  REMARK    GeneRIF: CKIP-1 alleviates hypoxia-induced cardiomyocyte injury
            through the up-regulation of Nrf2 antioxidant signaling via the
            down-regulation of Keap1, suggesting a potential role for CKIP-1 in
            myocardial infarction.
REFERENCE   2  (bases 1 to 1477)
  AUTHORS   Liu,J., Liang,C., Guo,B., Wu,X., Li,D., Zhang,Z., Zheng,K.,
            Dang,L., He,X., Lu,C., Peng,S., Pan,X., Zhang,B.T., Lu,A. and
            Zhang,G.
  TITLE     Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP
            signaling to inhibit bone formation during aging
  JOURNAL   Aging Cell 16 (2), 360-376 (2017)
   PUBMED   28083909
  REMARK    GeneRIF: the increased PLEKHO1 could suppress Smad-dependent BMP
            signaling to inhibit bone formation during aging.
REFERENCE   3  (bases 1 to 1477)
  AUTHORS   Baas,D., Caussanel-Boude,S., Guiraud,A., Calhabeu,F., Delaune,E.,
            Pilot,F., Chopin,E., Machuca-Gayet,I., Vernay,A., Bertrand,S.,
            Rual,J.F., Jurdic,P., Hill,D.E., Vidal,M., Schaeffer,L. and
            Goillot,E.
  TITLE     CKIP-1 regulates mammalian and zebrafish myoblast fusion
  JOURNAL   J Cell Sci 125 (Pt 16), 3790-3800 (2012)
   PUBMED   22553210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091420.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091420.1, EV773056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1477
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1477
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /note="pleckstrin homology domain containing O1"
                     /db_xref="GeneID:310674"
                     /db_xref="RGD:1311487"
     exon            1..166
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1366
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /note="CK2 interacting protein 1; PH domain-containing
                     family O member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family O
                     member 1"
                     /protein_id="NP_001020290.1"
                     /db_xref="GeneID:310674"
                     /db_xref="RGD:1311487"
                     /translation="MKKSGSGKRGPPDGNHQSVAPEKVGWVRKFCGKGIFREIWKNRY
                     VVLKGDQLYVSEKEVKDEKNSQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLARCRQP
                     GTTAPNLIFLAVSPEEKESWINALSSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQ
                     HSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPASCAESFRVDLDKSVAQLA
                     GSRRRADSDRIRPSSHRASSLSRPWERPDKGAPYTPQALKKLPSTEKSRCASLEEILS
                     QRDTAPAHPLHLQAEESPAPVPSQPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKWK
                     AKDPPRSPPDSQSEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDS
                     HLRQTSQHSQYRKSLM"
     exon            167..313
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /inference="alignment:Splign:2.1.0"
     exon            314..454
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /inference="alignment:Splign:2.1.0"
     exon            455..559
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /inference="alignment:Splign:2.1.0"
     exon            560..661
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1469
                     /gene="Plekho1"
                     /gene_synonym="Ckip1; RGD1311487"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgacgtca gcggcggtgg ccggggcccg tgcagcgggg gcgggcatgg gcggcggggg
       61 cggcgggggc agcgggggcc tggcctgcgg ctagcgcgag ccgccgagcg agcagcgggc
      121 gcggtcgccc gatcccgcca tgaagaagag cggctccggc aagcgggggc ctccggatgg
      181 aaaccatcag tctgtggctc ccgagaaggt cggctgggtc cggaaattct gcgggaaagg
      241 gattttcagg gagatttgga aaaaccgcta tgtggtgctg aaaggcgacc agctctacgt
      301 ctccgagaag gaggtaaaag atgagaaaaa tagtcaagag gtgtttgacc tgagtgacta
      361 tgagaagtgc gaagagctcc ggaaatccaa gagtaggagc aagaaaaacc acagcaagtt
      421 cacactggcc cgatgcagac agccgggcac cacggccccc aacctcatct tcctggcagt
      481 aagtcctgag gaaaaggaat catggatcaa cgccctgagt tctgccatta ctagagctaa
      541 aaaccgcatc ctggatgagg tcaccgttga ggaggacagc tatcttgccc accctacccg
      601 agacagagca aaaatccaac actcccgccg tcctccaacc cggggacacc tcatggctgt
      661 ggcttccacc tctacctcag atgggatgct aacattagac ctaatccaag aagaagaccc
      721 ttcccctgag gagccagcct cttgtgctga gagctttcgg gtcgatctgg acaagtctgt
      781 ggcccagctg gctggcagtc gacggagagc ggactcagac aggatccgtc cctcttcaca
      841 ccgggcaagc agcctttctc ggccttggga aagaccagac aagggagccc cctacacccc
      901 acaagcactg aagaagttac ccagtacaga gaagagccga tgtgcctccc tggaggagat
      961 cctatcccag agggacactg ccccagccca ccctctccac cttcaagctg aggaatcccc
     1021 agcccctgtc ccctcccagc cggggcagct gtcccggatc caggacttgg tagcaaggaa
     1081 actggagaag actcaggagc tgctggcaga ggttcaggga ctgggagatg gcaaatggaa
     1141 ggccaaggac cccccacggt ctccacccga ctcccagtca gagcagctgc tgctggagac
     1201 agagaggctg ctgggagagg cttcgtctaa ctggagccag gcgaagagag tgctgcagga
     1261 agtcagggag ctgagagacc tgtacagaca gatggacctg cagaccccgg actcccacct
     1321 cagacagacc tctcagcaca gtcaataccg gaagagtctg atgtgaagga tgggctgggc
     1381 tgggattttg aggggcacag actctttatc tccaaatgtt gcaggataaa gcttttttat
     1441 ttacctcaat ccaaaaaaaa aaaaaaaaaa aaaaaaa
//
