LOCUS       NM_001191770            4467 bp    mRNA    linear   ROD 03-OCT-2017
DEFINITION  Rattus norvegicus pleckstrin homology, MyTH4 and FERM domain
            containing H2 (Plekhh2), mRNA.
ACCESSION   NM_001191770 XM_233830
VERSION     NM_001191770.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4467)
  AUTHORS   Perisic L, Lal M, Hulkko J, Hultenby K, Onfelt B, Sun Y, Duner F,
            Patrakka J, Betsholtz C, Uhlen M, Brismar H, Tryggvason K,
            Wernerson A and Pikkarainen T.
  TITLE     Plekhh2, a novel podocyte protein downregulated in human focal
            segmental glomerulosclerosis, is involved in matrix adhesion and
            actin dynamics
  JOURNAL   Kidney Int. 82 (10), 1071-1083 (2012)
   PUBMED   22832517
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AABR07073203.1
            and AC120701.5.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by
            NM_001191770.3.
            
            On Jun 30, 2017 this sequence version replaced NM_001191770.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00052296,
                              SAMD00052297 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AABR07073203.1     54991-55113
            124-186             AABR07073203.1     78846-78908
            187-336             AABR07073203.1     89198-89347
            337-420             AABR07073203.1     91428-91511
            421-502             AABR07073203.1     92140-92221
            503-688             AABR07073203.1     96589-96774
            689-1644            AABR07073203.1     98537-99492
            1645-1720           AABR07073203.1     102417-102492
            1721-1815           AC120701.5         1373-1467
            1816-1963           AC120701.5         2014-2161
            1964-2091           AC120701.5         5183-5310
            2092-2202           AC120701.5         5410-5520
            2203-2289           AC120701.5         5953-6039
            2290-2448           AC120701.5         7398-7556
            2449-2529           AC120701.5         14809-14889
            2530-2709           AC120701.5         17428-17607
            2710-2818           AC120701.5         20221-20329
            2819-2931           AC120701.5         21855-21967
            2932-3111           AC120701.5         22619-22798
            3112-3209           AC120701.5         24477-24574
            3210-3387           AC120701.5         26335-26512
            3388-3543           AC120701.5         27335-27490
            3544-3641           AC120701.5         28888-28985
            3642-3783           AC120701.5         34454-34595
            3784-3929           AC120701.5         40394-40539
            3930-4059           AC120701.5         41380-41509
            4060-4146           AC120701.5         45041-45127
            4147-4281           AC120701.5         47177-47311
            4282-4467           AC120701.5         51867-52052
FEATURES             Location/Qualifiers
     source          1..4467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="mixed"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..4467
                     /gene="Plekhh2"
                     /gene_synonym="RGD1304935"
                     /note="pleckstrin homology, MyTH4 and FERM domain
                     containing H2"
                     /db_xref="GeneID:313866"
                     /db_xref="RGD:1304935"
     CDS             1..4467
                     /gene="Plekhh2"
                     /gene_synonym="RGD1304935"
                     /note="pleckstrin homology domain containing, family H
                     (with MyTH4 domain) member 2"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family H
                     member 2"
                     /protein_id="NP_001178699.2"
                     /db_xref="GeneID:313866"
                     /db_xref="RGD:1304935"
                     /translation="MEESSDPERPIDWKERCVALEAQLMKFRVQASKIRELLADKMQQ
                     LERQVIDAERQAERAFQEVQVMEEKLKAANIQTSESETRLYKKCQDLESVMQEKDDLI
                     QNLALRLEEQKQVRIKEAKTIEEKAAKIKEWVTVKLNELEVENQNLRFINQTQTEELR
                     AIQSKLQELQEKKVSCVSSPKPSEGQRLSSLTFGCFLSRAKSPPCAVRSEEASKMASS
                     EPEFAEARCVEEMEIAEKPADNQVQENSRSQRKLLETSCGSEHNRKTGASFVADGGTP
                     EHSGLPVSDWSSDDDDGSKGRSKSRCTSTLSSHTSEEGGQCGRPGSEAYLTASDDSSS
                     IFEEETFDANRPQHKKLYSWQQKAPWKAPSNLAKGSSQSEVKQRDSSSDELNKKFQSQ
                     RLDYSSSSSEANTPSPILTPALTPKHPNSLPGKGTPLVPPPFLPPPKLRIPNVFSISV
                     ALTKRHLSQPQLCSDRMFGMNRNAISMIRPLRPQETDLDMVDGDRAEAVDIMDTGCGD
                     LFSYDSQDPPSAEDPENSEATKKASCSKPPTPPLHRFPSWESRIYAVAKSGIRVSEAF
                     NMENANKNAASLLSHSVAGPYMSLIYKNVTTPVYTTLKGKATQISTSPFLDDSSGSDE
                     EDGSRASSRSQSESETRSRSGPNSPRAMKRGVSDSSEGDYAIPPDAYSIDTECSQPEQ
                     KLLKTCSTSSDNGKSELLEKSGYLLKMSGRLKTWRRRWFVLKGGELLYYRSPSDVIRK
                     PQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVFQNVLRVQAAN
                     PLCLQPEGKPTVKGLLTKVKHGYSKRVWCTLVGKCLYYFRSQEDKFPLGQIKLWEAKV
                     EEVDRSCDSDEDYETSGRCLLSTHYTIIVHPKDQGPTYLLIGSKHEKEAWLYHLTVAA
                     GSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPMLCHSKEGILCPLTSLPSEALQTEA
                     IKLFKTCQLFINAVVDSPAIDYHISLAQSALQVCLTHPELQSEICCQLIKQTRRRQQQ
                     NQAGPLQGWQLLALCVGLFLPHHPFLWLLQVHLQRSADSRTEFGKYAIYCQRCVERTL
                     QNGDREARPSRMEILSTLLRNPYHHSRPFSIPVHFMNGIYQVVGFDASTTVEEFLNTL
                     NQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKELQPGKCEGS
                     RTVRLTYKNRLYFSMQARGETDREKLLLLYQTNEQIINGLFPLNKDLALEMAALLAQV
                     DIGDFERPFSTPAGHVTNQCKANQTLKQVVEKFYPKRYREGCSEEQLRQLYQRLSTRW
                     MALRGHSTTDCIRIYLTVARKWPFFGAKLFLAKPITPSSLGNNFIWLAVHENGLSILE
                     YTSMRLVTGYVYKSVMTFGGYQEDFMVVISTQAKDRPTEKLLFAMAKPKILEITLLIA
                     SYINNFYQQKAAFHHLSAPALLSAKVQEPQAKAMGSQPLLSNNRPTKGPTLL"
ORIGIN      
        1 atggaggagt cctctgaccc ggaaagaccc atagattgga aagaacgctg tgtagctctg
       61 gaggctcaac taatgaaatt ccgagttcaa gcaagcaaga tccgagagct cctagcagac
      121 aaaatgcaac aattggagag acaagtcatc gatgcagaac gccaagcaga aagggctttt
      181 caagaggtac aagttatgga agagaaacta aaagcagcta acattcaaac cagtgagtca
      241 gagacacggc tatacaagaa gtgtcaagat ctggagtctg tgatgcagga gaaggatgac
      301 ctcattcaga acttggctct gcggcttgaa gagcagaaac aagtgaggat aaaagaagct
      361 aaaacaatag aagaaaaagc agctaagatc aaagaatggg taacagttaa attaaacgag
      421 ctagaagtag agaatcagaa tcttcgtttc atcaaccaaa cccagaccga agagctaaga
      481 gcaatacagt caaaattgca agaactccaa gagaagaaag tatcctgtgt ctccagccca
      541 aagccctcag aagggcagcg tctgagcagt ttgacgtttg gatgcttctt gtcccgagca
      601 aagagtccgc cttgtgcagt aaggtccgag gaagcgagca agatggcctc aagcgaacct
      661 gagttcgccg aagcaagatg cgtagaagag atggaaattg cagagaagcc tgctgacaac
      721 caagtgcaag agaacagcag gagccagaga aagttgctcg agacctcttg tggctcagaa
      781 cacaaccgga aaacgggagc aagctttgta gcggatggtg ggacccccga gcattctggg
      841 cttccagtga gtgactggag ttcagacgat gacgacggaa gcaagggcag atctaagtcc
      901 aggtgcacgt ccactctttc cagccacacg tctgaggagg gtggccagtg tggcaggccg
      961 ggcagcgaag cttatctcac agcatccgat gacagtagtt ctatattcga ggaagagact
     1021 tttgatgcta acagaccaca gcacaagaag ctgtattctt ggcagcagaa ggcaccatgg
     1081 aaagctccca gtaaccttgc aaagggaagt tctcagtcag aagttaagca gcgagatagt
     1141 tcctcagatg aactgaataa gaaatttcag tcccagagac tggattattc atcctcatca
     1201 agcgaggcca acaccccaag ccctatttta accccagctt taacccccaa gcaccctaac
     1261 tcactccctg gaaaaggaac accattagtg cctccaccat tcctgccacc cccaaagctg
     1321 aggatcccca acgtcttcag tataagtgtg gcactgacca aaaggcacct gagccaacca
     1381 cagttatgtt cggaccggat gtttggcatg aaccggaatg ccatcagcat gatccggcct
     1441 ctgaggcctc aggaaacgga ccttgatatg gttgatggtg atagggcgga agccgtggac
     1501 atcatggaca cgggctgcgg tgacttattt tcctatgact cccaggatcc tccttctgca
     1561 gaagacccgg aaaacagcga ggccacaaag aaggcctcgt gcagcaaacc ccccactcct
     1621 cctttgcacc gcttcccctc ttgggagagc aggatttatg cagtagccaa atcaggcatc
     1681 cgagtgtctg aggccttcaa tatggagaat gctaataaaa atgctgcaag cttactttcc
     1741 cactctgtag caggccctta catgtctctc atatacaaga atgtgacgac ccctgtgtac
     1801 acaacgttga aggggaaggc gacacaaata agtaccagcc ctttcctgga tgattcttct
     1861 ggctcagatg aagaggacgg ttctagggcc agctcccgga gtcagtcgga gtcagaaacg
     1921 cgcagccgca gtggaccgaa cagtcccaga gccatgaagc gaggcgtgtc cgactcttct
     1981 gagggtgact acgccatccc tccggatgcc tactccatag acacggagtg ctcgcagcct
     2041 gagcagaaac tcctgaaaac ctgctcgacg tccagtgaca acgggaaaag tgagctatta
     2101 gaaaaatctg gctacctact aaaaatgagc ggacgactca agacttggag gcggaggtgg
     2161 tttgttctta aaggcggaga actactttac tacaggtctc caagcgatgt aattcggaaa
     2221 ccccagggcc acattgaact tagtgcatcc tgcagtattt tacggggaga taacaagcaa
     2281 acggttcagc tgaccacaga gaaacacaca tactacctga cagcagattc tcccaatata
     2341 ctggaagaat ggatcaaagt gttccagaat gttctgcgag tacaagctgc taaccctctt
     2401 tgcctgcagc ccgagggcaa acccacagta aagggcctgc tcaccaaggt aaaacacggc
     2461 tactctaaga gagtctggtg cacgcttgtt ggaaagtgct tgtattattt tcggagtcag
     2521 gaggataagt tccctctagg tcagatcaaa ctctgggagg ctaaggtgga ggaggtggac
     2581 aggtcatgtg actcggatga ggactatgag accagtgggc gctgtctgtt gtccactcac
     2641 tacaccatca ttgtccaccc caaggaccag ggccctactt acctgctcat cggatctaag
     2701 cacgaaaagg aggcgtggct ttatcacctc actgttgcgg ctggaagcaa caatgtaaat
     2761 gttggatccg aatttgaaca actggtttgc aaactgctaa atatagaagg agagccctcc
     2821 tcccagatat ggagacaccc catgctgtgt cacagcaaag aaggaatcct gtgccctctg
     2881 acctcactgc cttcggaagc cctgcagaca gaggccatta agctgtttaa gacctgccag
     2941 ctctttatca acgctgtggt ggactccccc gccatcgact accatatctc tctggctcag
     3001 agcgctctgc aggtctgcct gacacatccc gagctgcaga gtgaaatttg ctgtcagctt
     3061 attaagcaga ccaggcgaag acagcagcag aatcaggccg gaccactgca gggctggcag
     3121 ctcttggcgc tctgcgttgg actcttcctt ccccaccacc ctttcctgtg gctcctccag
     3181 gtccatctgc agaggagtgc ggattccaga acagaatttg ggaaatatgc catttactgc
     3241 cagcggtgtg tggaaagaac actgcaaaac ggagaccgag aggccagacc ttccaggatg
     3301 gagatcctct ccacccttct tcgaaacccc taccatcatt ctcggccctt cagcattccc
     3361 gtgcacttca tgaacgggat ctaccaggta gttgggttcg acgcgtccac cacggtggaa
     3421 gaatttttga acactttgaa ccaggacaca ggaatgagga agccagcaca gtccgggttc
     3481 gcactgttca cagatgaccc ttctggcaga gacctggaac actgtcttca ggggaatatc
     3541 aagatctgcg atatcatttc taaatgggag caggcatcca aagaactgca gcccgggaag
     3601 tgtgagggca gcaggactgt ccgtctgact tacaaaaaca gactatattt ttcaatgcaa
     3661 gctcgtggag agactgacag agagaagctg ctgctgctgt atcagacaaa tgagcaaatc
     3721 ataaatggtc ttttccctct caacaaggat ctggcgttag aaatggcagc gctcttggct
     3781 caggtggata tcggggattt tgagagaccg ttctcaactc cagctgggca tgtgaccaac
     3841 cagtgcaagg caaaccaaac cctcaaacaa gtcgtggaga agttttaccc taaaaggtac
     3901 cgagaagggt gctctgaaga acagttaagg caactttacc agagactctc gaccagatgg
     3961 atggccctcc ggggacacag cacaactgac tgcattcgca tttacttgac agtagccagg
     4021 aagtggccat tctttggcgc caagttattc ttggccaaac ctataacacc gtcatcactt
     4081 ggcaataatt ttatctggct ggctgtccat gaaaacgggt tgagcatcct agaatacacc
     4141 tccatgaggt tagtgactgg ctatgtgtac aagagtgtga tgacctttgg aggctatcaa
     4201 gaggatttta tggtagtcat tagtacacag gcaaaagacc ggccaacaga gaagttactt
     4261 ttcgccatgg caaaacccaa gattcttgaa attacccttc tgatcgccag ttacatcaac
     4321 aacttctatc agcagaaggc agcatttcac cacctgtctg ccccggcact gctctcagcc
     4381 aaggttcagg agccccaagc caaggccatg ggcagccagc cccttctgtc caacaacaga
     4441 cctaccaaag gccccacctt actctga
//
