LOCUS       NM_001415855            3830 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus pleckstrin homology and RhoGEF domain containing
            G5 (Plekhg5), transcript variant 1, mRNA.
ACCESSION   NM_001415855 XM_039109736
VERSION     NM_001415855.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3830)
  AUTHORS   Luningschror,P., Binotti,B., Dombert,B., Heimann,P., Perez-Lara,A.,
            Slotta,C., Thau-Habermann,N., R von Collenberg,C., Karl,F.,
            Damme,M., Horowitz,A., Maystadt,I., Fuchtbauer,A., Fuchtbauer,E.M.,
            Jablonka,S., Blum,R., Uceyler,N., Petri,S., Kaltschmidt,B.,
            Jahn,R., Kaltschmidt,C. and Sendtner,M.
  TITLE     Plekhg5-regulated autophagy of synaptic vesicles reveals a
            pathogenic mechanism in motoneuron disease
  JOURNAL   Nat Commun 8 (1), 678 (2017)
   PUBMED   29084947
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3830)
  AUTHORS   Cario-Toumaniantz,C., Ferland-McCollough,D., Chadeuf,G.,
            Toumaniantz,G., Rodriguez,M., Galizzi,J.P., Lockhart,B., Bril,A.,
            Scalbert,E., Loirand,G. and Pacaud,P.
  TITLE     RhoA guanine exchange factor expression profile in arteries:
            evidence for a Rho kinase-dependent negative feedback in
            angiotensin II-dependent hypertension
  JOURNAL   Am J Physiol Cell Physiol 302 (9), C1394-C1404 (2012)
   PUBMED   22322975
  REMARK    GeneRIF: This work thus identifies a group of RhoA-GEFs that
            controls RhoA and RhoA-dependent functions in vascular smooth
            muscle cells
REFERENCE   3  (bases 1 to 3830)
  AUTHORS   Wu,C., Agrawal,S., Vasanji,A., Drazba,J., Sarkaria,S., Xie,J.,
            Welch,C.M., Liu,M., Anand-Apte,B. and Horowitz,A.
  TITLE     Rab13-dependent trafficking of RhoA is required for directional
            migration and angiogenesis
  JOURNAL   J Biol Chem 286 (26), 23511-23520 (2011)
   PUBMED   21543326
REFERENCE   4  (bases 1 to 3830)
  AUTHORS   Liu,M. and Horowitz,A.
  TITLE     A PDZ-binding motif as a critical determinant of Rho guanine
            exchange factor function and cell phenotype
  JOURNAL   Mol Biol Cell 17 (4), 1880-1887 (2006)
   PUBMED   16467373
REFERENCE   5  (bases 1 to 3830)
  AUTHORS   Marx,R., Henderson,J., Wang,J. and Baraban,J.M.
  TITLE     Tech: a RhoA GEF selectively expressed in hippocampal and cortical
            neurons
  JOURNAL   J Neurochem 92 (4), 850-858 (2005)
   PUBMED   15686487
  REMARK    GeneRIF: Tech regulates RhoA signaling pathways in developing and
            mature forebrain neurons.
REFERENCE   6  (bases 1 to 3830)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 4, 2023 this sequence version replaced XM_039109736.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.22096.1,
                                           SRR26643299.25711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000005.1  167885275-167885417
            144-273             JAXUCZ010000005.1  167890703-167890832
            274-376             JAXUCZ010000005.1  167891649-167891751
            377-437             JAXUCZ010000005.1  167892074-167892134
            438-529             JAXUCZ010000005.1  167892444-167892535
            530-666             JAXUCZ010000005.1  167892981-167893117
            667-815             JAXUCZ010000005.1  167893396-167893544
            816-1022            JAXUCZ010000005.1  167894735-167894941
            1023-1211           JAXUCZ010000005.1  167895028-167895216
            1212-1307           JAXUCZ010000005.1  167895453-167895548
            1308-1358           JAXUCZ010000005.1  167896164-167896214
            1359-1508           JAXUCZ010000005.1  167896406-167896555
            1509-1619           JAXUCZ010000005.1  167896825-167896935
            1620-1769           JAXUCZ010000005.1  167897029-167897178
            1770-1907           JAXUCZ010000005.1  167897251-167897388
            1908-2027           JAXUCZ010000005.1  167897506-167897625
            2028-2160           JAXUCZ010000005.1  167901208-167901340
            2161-2276           JAXUCZ010000005.1  167901423-167901538
            2277-2461           JAXUCZ010000005.1  167901719-167901903
            2462-3229           JAXUCZ010000005.1  167902592-167903359
            3230-3830           JAXUCZ010000005.1  167903629-167904229
FEATURES             Location/Qualifiers
     source          1..3830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3830
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /note="pleckstrin homology and RhoGEF domain containing
                     G5"
                     /db_xref="GeneID:310999"
                     /db_xref="RGD:1303132"
     exon            1..143
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3239
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin homology domain-containing family G member 5;
                     neuronal RhoA GEF protein; transcript highly enriched in
                     cortex and hippocampus; PH domain-containing family G
                     member 5; pleckstrin homology domain containing, family G
                     (with RhoGef domain) member 5"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 5 isoform 1"
                     /protein_id="NP_001402784.1"
                     /db_xref="GeneID:310999"
                     /db_xref="RGD:1303132"
                     /translation="MGTGPGVSGRRAAARPSSELPSLDSQSLWVGGHARSSESQVCHH
                     ADCQQLHHRGPLNLCEICDSKFHNTTHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSP
                     AGDLEEEDEGYTNGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIV
                     PAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPG
                     DEGKVEQGVKDSKSLSLPALRPSGAGTPVLERVDPQSRRESSLDILAPGRRRKNMSEF
                     LGDTSIPGQESPAPSSCSLPVGSSVGSSGSSESWKNRAASRFSGFFSSSPSTGAFGRE
                     VDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEDDEEEEDNSGLRLEDSWRELI
                     DGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAER
                     LFSNIPELARLHRGLWSSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCM
                     EEEGCMEYMRSLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSV
                     LRKTDEPRAKEAIITMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSND
                     EVDKFLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLV
                     TKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLIHLNEFHSAVGAYTFQASSQALC
                     RSWVDTLYNAQNQLQQLRAQLLCAQEHPGTQHLQSLEEEEDEQEEEGEESGTSAASSP
                     TILRKSSNSLDSEHCASDGSTETLAMVVVEPGETLSSPEFDRGPFSSQSDEASLSNTT
                     SSITPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFAAPHPVVEPVPVPQTLSPQPS
                     PRLRRRTPVQLLPRLPHLLKSKSEASLLQLLSGTTTSVSPPAPSRSLSELCLITMAPG
                     VRTQSSLQEGGPGWNCPGACGPCQGPPLSESENRPSHKAGGPADSARRKCREMPCGTV
                     PRVQPEPSPGISAQHRKLTLAQLYRIRTTLLLNSTLTASEV"
     exon            144..273
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            274..376
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            377..437
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            438..529
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            530..666
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            667..815
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1022
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1211
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1307
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1358
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1508
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1619
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1769
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1907
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2027
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2160
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2276
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2461
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..3229
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3830
                     /gene="Plekhg5"
                     /gene_synonym="Tech"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgtcgc ttcctccggc accatgggga caggaccggg cgtctccggg cgccgagcgg
       61 cagccaggcc cagctcagag ctgccttccc tagattccca gtccctctgg gtcgggggtc
      121 atgcccgcag cagcgagagc caggtatgcc accatgccga ctgccagcag ctgcaccacc
      181 gggggcctct gaacctgtgt gagatctgtg acagcaagtt ccacaacacc acgcattatg
      241 acgggcatgt ccgatttgac ctgcctccgc aaggttccgt cctggcccgg aatgtttcca
      301 cacggtcctg ccctccacga accagccctg ctggggacct ggaggaagaa gacgaaggct
      361 ataccaatgg aaaaggggac cggaagagcg ccggcctaaa gatctctaag aagaaagcaa
      421 ggaggaggca cacggatgac ccaagcaagg agtgcttcac cttgaaattt gacctgaacg
      481 tggacattga aacagaaatc gtgccggcca tgaagaagaa gtcactgggg gaggtgttgc
      541 tgcctgtgtt tgagaggaag ggcatagcac tgggcaaagt ggacatctac ctggatcagt
      601 ccaacacacc cctgtccctc acctttgagg cctacaggtt tgggggacac tacctgcggg
      661 tcaaagccaa gccgggggac gagggcaagg tggagcaggg agtgaaggat tccaagtccc
      721 tcagtttgcc agccctgagg cccagtgggg ctgggacccc tgtgttggaa cgtgtggacc
      781 ctcagagccg tcgagaaagc agtctggaca tcttggctcc tggccgccgc cgtaagaaca
      841 tgtctgagtt cctgggggat acgagcatcc ctgggcagga gtcccccgca ccttccagct
      901 gttctctgcc cgttggcagc agcgttggca gcagcggcag cagcgagagc tggaagaacc
      961 gggcggccag tcgcttcagt ggtttcttca gctccagccc cagcaccggg gcctttggtc
     1021 gggaggtaga caagatggag cagctggaga gcaagctaca cgcctacagt ctctttgggc
     1081 taccccggat gcccaggagg ctgcgctttg accatgactc ctgggaggaa gaggaagatg
     1141 atgaggagga ggaagataat tcaggcctga ggctggagga cagctggagg gagctcattg
     1201 atggccatga gaagctgacc cgtcggcagt gccaccaaca ggaggcggtg tgggagctcc
     1261 tgcacacaga agtctcctac atccggaaac tccgtgtgat caccaacctg ttcctgtgtt
     1321 gtcttcttaa cctgcaagag tcggggctcc tgtgtgaggt ggaggctgaa cgcttgttca
     1381 gcaacatccc tgagctcgcc cggctgcacc gaggcctgtg gagcagcgtg atggtgccgg
     1441 tgctggagaa agcgcggcgg acgcgggcgc tactgcagcc cagcgacttt ctcaaaggct
     1501 tcaagatgtt cggctcactc ttcaagccgt acatccgata ctgtatggag gaggaaggct
     1561 gcatggagta catgcgcagc ttgctgcggg acaatgatct gttccgcgcg tacgtcacgt
     1621 gggcggagaa acaccaacag tgccagcggc tgaagctgag cgacatgctg gccaagcccc
     1681 accagcggct caccaaatac ccactgctgc tcaagtccgt actgaggaag acggatgagc
     1741 cccgcgccaa ggaagccatc atcaccatga tcagctctgt agaacgcttc atacaccacg
     1801 tgaacacgtg catgcggcag cggcaggagc ggcagcgctt ggcgggggtg gtgagccgca
     1861 ttgatgccta cgaagtggtg gagggcagca acgacgaggt ggataagttc ctgaaggaat
     1921 ttctacatct ggacctgaca gcacccatgc ctggcacctc ccctgaagag acgcgacagc
     1981 tgctgctgga agggagcctg aggatgaagg aggggaaaga tagcaagatg gacgtgtact
     2041 gcttcctgtt caccgatcta ctcttggtga ccaaggctgt gaagaaagcg gagaggacga
     2101 aggtcatcag accaccgctc ctggtggaca agatcgtgtg ccgggagctt cgggaccctg
     2161 gttccttcct cctcatccac ctgaatgaat tccacagtgc tgtgggggcc tacacattcc
     2221 aggccagcag ccaggccttg tgccggagct gggtggacac tctttacaat gcacagaacc
     2281 agctacagca gctgcgcgca cagctgctct gtgcacagga gcatccgggc acccagcacc
     2341 tccaaagcct ggaagaggag gaagatgagc aggaagagga gggcgaagaa agcggtacct
     2401 cagctgccag ctcccccacc atccttcgaa agagcagcaa cagcctggac tctgagcact
     2461 gtgcctcaga tggctccact gagaccctgg ccatggtcgt ggtagagccc ggggagacac
     2521 tgtcttcccc cgagtttgac cgcggtccct tcagctccca gtcggacgag gcctctctca
     2581 gtaacactac ttcatccatc actcccacca gtgagctgct acccctgggc cccgtggacg
     2641 gccggtcctg ctccatggac tctgcctatg gcaccctgtc ccccacttcc cttcaagact
     2701 ttgcggctcc acaccctgtg gttgagccag tacccgtgcc tcagaccctc tcaccccaac
     2761 cctcaccccg cctccgccgc cgcactccgg ttcagctgct ccctcgcctg ccccacctgc
     2821 tcaagtccaa atctgaggct agcctcctac agttactgtc aggaaccacc accagcgtct
     2881 cgcccccagc tcccagtcgc agcctctcag aactgtgcct gatcactatg gcccctggag
     2941 ttaggactca gagctccctt caggaaggtg ggcctggctg gaattgtcca ggggcgtgtg
     3001 gcccctgcca gggccctccg ttgtcagagt ctgagaatag acccagccac aaggctgggg
     3061 gaccagcaga ttctgccaga aggaagtgca gagagatgcc ttgtgggact gtgccaaggg
     3121 tgcagccgga gccttcccca gggatctctg ctcaacacag gaagctgacc ctggcccagc
     3181 tctaccggat caggaccacc ctactgctta actccacgct cactgcctcg gaggtatgag
     3241 ctggagaccc ctaagggtgc cactgatgaa gggacagcag agagagctgc cttctgggga
     3301 tacggcacct gcttcactgc tgcctcggag tgtgtggaga ccaaggagac cccccaacaa
     3361 gggcaccact gtctgaggac atcagagagc ccacctcccg gaggtcacag cacctgtttg
     3421 gctgctctgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgcgc gcgcccgcgc
     3481 gtgtgccaga gcgccaggca ggatggtttc cggatcacct caaggccgat ttgcactttg
     3541 ccggactgga tggaatggag aagggccctg tagagctcca ggccttggct acaatgctcc
     3601 acccccttgt ccaggcagcc ccttgtcctc tgctcttgat gttgccggcc ctgatcctct
     3661 gggctgggct ccaaggctgg gctctcaccg tcaccttggt ttgggctcat gaaatgagtc
     3721 cgtatccctc ctggtcatgc tggcctctga ggctggggct gggctctgtc aagctgcgta
     3781 tttattgact ttggctcttc tataaagact tgtatatact cccctagaaa
//
